Frontiers in Microbiology最新文献

{"title":"Microbial enzyme-driven carbon-nitrogen cycling processes of greenhouse gases in sandy sediments of river-oasis systems in arid regions.","authors":"Guoqing Lv, Junjian Wang, Lijun Hou, Xigang Liu, Mao Ye, Xiaoshuang Zhao, Yaqi Song, Zongxiao Zhang, Yonghui Wang","doi":"10.3389/fmicb.2026.1912116","DOIUrl":"https://doi.org/10.3389/fmicb.2026.1912116","url":null,"abstract":"<p><p>Arid inland rivers are important components of the land-water-ocean continuum, yet the linkages among sediment texture, microbial-mediated processes, and greenhouse gas (GHG) production remain poorly understood in sandy systems. Here, we investigated surface (0-5 cm) and subsurface (5-10 cm) sediments from the Niya River Basin, a desert-oasis agricultural river in northwestern China, by integrating sediment particle-size characterization, physicochemical measurements, extracellular enzyme assays, GHG production experiments, and multivariate analyses. We examined how sediment texture and carbon-nitrogen substrate availability regulate enzyme activities and CO₂, CH₄, and N₂O production potentials. Sediments were dominated by sand (>78%) but exhibited pronounced spatial heterogeneity in enzyme activities and GHG production. Localized hotspots of enzyme activities and CH₄/N₂O production were associated with enriched TOC, TN, and NH₄⁺. Multivariate analyses revealed depth-dependent environmental associations: surface processes were primarily linked to TOC and pH, whereas very coarse sand showed increased relative importance in subsurface sediments, particularly for GHG production. These findings demonstrate that sandy sediments in arid inland rivers are not inert environments; rather, carbon-nitrogen substrate availability and particle-size heterogeneity jointly shape microbial enzyme-mediated transformation processes and spatially variable GHG production potentials.</p>","PeriodicalId":12466,"journal":{"name":"Frontiers in Microbiology","volume":"17 ","pages":"1912116"},"PeriodicalIF":5.8,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual modulation of the NLRP3/CASPASE-1 inflammasome pathway and gut microbial metabolism: the antidepressant mechanism of puerarin.","authors":"Yu-Ting Lu, Yue-Yue Chen, Na-Na Ding, Ling-Wen Meng, Jia-Jia Yuan, Ze-Xiang Huang, Jing-Bo Hu, Jia-Xi Tong, Ying-Ren Zhang, Nan Nan, Dong-Dong Liu, Kai-Rui Tang, Xiang Luo, Xia Li, Wen-Zhi Hao, Jia-Xu Chen","doi":"10.3389/fmicb.2026.1907120","DOIUrl":"https://doi.org/10.3389/fmicb.2026.1907120","url":null,"abstract":"<p><strong>Background: </strong>Post-stroke depression (PSD) is the most common neuropsychiatric complication following stroke. Puerarin (PU), the principal bioactive compound extracted from the medicinal and edible plant <i>Pueraria lobata</i>, has shown beneficial therapeutic effects in both depression and stroke. However, the therapeutic effect of PU on PSD and its underlying mechanisms remain unclear. This study investigates the therapeutic efficacy of PU in ameliorating abnormal behaviors in PSD mice and elucidates the roles of intestinal microbiota disorder, intestinal barrier damage, activation of the NLRP3/CASPASE-1 inflammasome in the hippocampus, and dysregulated inflammatory cytokine production in the pathogenesis of PSD.</p><p><strong>Methods: </strong>To investigate the ameliorative effect of PU on behavioral abnormalities and to clarify the role of intestinal microbiota regulation in the therapeutic effects of PU in PSD mice, various methodologies were employed, including a PSD model, behavioral tests, network pharmacology, hematoxylin-and-eosin staining, ultrastructural morphology, enzyme-linked immunosorbent assay, western blotting, 16S rRNA sequencing, metabolomic analyses, and fecal microbiota transplantation (FMT).</p><p><strong>Results: </strong>Oral administration of PU could effectively alleviate depressive-like behaviors in PSD mice, repair the damaged colonic mucosa, and increase the expression of occludin and ZO-1. Network pharmacology analysis indicated that the NLRP3/CASPASE-1 inflammasome pathway was a potential therapeutic target of PU, and PU inhibited activation of the hippocampal NLRP3/CASPASE-1 inflammasome. Additionally, PU suppressed pro-inflammatory cytokines in both the hippocampus and serum. PU restored the intestinal microbiota and regulated the microbial metabolism of PSD mice. More importantly, fecal microbiota transplantation from PSD mice reproduced depressive-like behaviors, while fecal microbiota transplantation from PU-treated mice (PU-FMT) prominently relieved depressive-like behaviors in PSD mice.</p><p><strong>Conclusion: </strong>Our findings indicate that PU reduces depressive-like behaviors in PSD mice by modulating the intestinal microbiota and microbial metabolism and inhibiting the NLRP3/CASPASE-1 inflammasome.</p>","PeriodicalId":12466,"journal":{"name":"Frontiers in Microbiology","volume":"17 ","pages":"1907120"},"PeriodicalIF":5.8,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rumen-host crosstalk: an amplifier of systemic pathology in heat-stressed ruminants.","authors":"Yuyan Wang, Chunjia Jin, Qian Li, Ye Yu, Binlong Fu, Runqi Fu, Zhengyuan Cai, Xitong An, Jing Leng","doi":"10.3389/fmicb.2026.1912454","DOIUrl":"https://doi.org/10.3389/fmicb.2026.1912454","url":null,"abstract":"<p><p>Heat stress (HS) is a primary environmental constraint threatening ruminant production, welfare and reproductive efficiency amid global warming. Current studies mostly focus on either systemic physiological damage or local ruminal dysfunction separately, while the bidirectional crosstalk between the rumen and host, as well as its amplifying effect on systemic pathology, remains to be systematically elucidated. This review integrates the latest evidence to construct a mechanistic framework centered on the neuro-endocrine-immune network, which acts as the core hub mediating rumen-host interactions under HS. Upon HS exposure, hyperactivation of the hypothalamic-pituitary-adrenal (HPA) and sympatho-adreno-medullary (SAM) axis drives systemic oxidative stress, immune dysfunction and chronic low-grade inflammation, disrupting whole-body homeostasis. Concurrently, HS reshapes the structure and functional profiles of rumen microbiota via three synergistic pathways: direct thermal sensing, host neuroendocrine regulation, and ruminal microenvironmental disturbance, thereby further impairing rumen fermentation homeostasis and epithelial barrier integrity, and triggering pathological endotoxin translocation. Critically, the neuro-endocrine-immune network transduces localized ruminal pathological signals into systemic metabolic and inflammatory disorders, and forms a self-perpetuating vicious cycle: systemic stress in turn aggravates ruminal ischemia, microbial dysbiosis and barrier damage, amplifying the initial pathological damage. By delineating this rumen-host pathological amplifier framework, this review provides targeted theoretical guidance for the development of multi-node intervention strategies to mitigate HS-associated production losses in ruminants.</p>","PeriodicalId":12466,"journal":{"name":"Frontiers in Microbiology","volume":"17 ","pages":"1912454"},"PeriodicalIF":5.8,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A chimeric, half-life extended lysin with a unique mode of action.","authors":"Zehra Visram, Donaat Kestemont, Benedikt Bauer, Renping Qiao, Svetlana Durica-Mitic, Andrea Majoros-Hashempour, Julia Schmidt, Rocío Berdaguer, Karsten Krey, Michele Mutti, Manuel Zerbs, Marina von Freyberg, Lorenzo Corsini, Adriana Badarau","doi":"10.3389/fmicb.2026.1880134","DOIUrl":"https://doi.org/10.3389/fmicb.2026.1880134","url":null,"abstract":"<p><p>Anti-staphylococcal lytic agents, such as lysostaphin (LSN), a glycyl-glycyl (Gly-Gly) peptidase, have long been considered for the management of chronic and complicated bacterial infections typically resistant to conventional antibiotics, but their use is restricted by poor pharmacokinetic properties. We generated half-life extended lysostaphin constructs by fusing the lysin - either alone or chimerized with an additional enzymatic cysteine, histidine-dependent amidohydrolases/peptidases (CHAP) domain - to the human IgG1 Fc fragment. The Fc-CHAP-LSN constructs retain high potency against <i>Staphylococcus aureus</i> and coagulase negative staphylococcal strains <i>in vitro</i> and are efficacious in <i>S. aureus ex vivo</i> biofilm models and <i>in vivo</i> sepsis models. A detailed investigation of the Fc-CHAP-LSN mode of action revealed that upon binding to the bacterial cell, but not in solution, LSN mediates its own release by cleaving the Gly-Gly CHAP-LSN linker. The bactericidal activity of Fc-CHAP-LSN is driven by the LSN-catalyzed and target cell-dependent release of free LSN. The half-life extended lysin acts as a pro-drug, unveiling a novel mechanism of targeted release and an alternative approach to half-life extension.</p>","PeriodicalId":12466,"journal":{"name":"Frontiers in Microbiology","volume":"17 ","pages":"1880134"},"PeriodicalIF":5.8,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detachable dissolving microneedles loaded with <i>Silviavirus</i> phage Pelagios enhance antibacterial efficacy against methicillin resistant <i>Staphylococcus aureus</i> in <i>ex vivo</i> porcine skin.","authors":"Anirut Yuttagat, Arnon Songloilib, Arrita Rueangrit, Talinee Chuesanga, Lalitwadee Chotuk, Komwit Surachat, Rattanaruji Pomwised, Ekachai Dumkliang, Ampapan Naknaen","doi":"10.3389/fmicb.2026.1928352","DOIUrl":"https://doi.org/10.3389/fmicb.2026.1928352","url":null,"abstract":"<p><p>Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) wound infections remain a major clinical challenge due to antibiotic resistance and biofilm persistence. Although phage therapy has re-emerged as a promising alternative, its efficacy is limited by poor stratum corneum penetration following conventional topical application. Here, we isolated and characterized a lytic MRSA phage, Pelagios, and evaluated its transdermal delivery using detachable dissolvable microneedles (DDMNs). Genomic analyses classified Pelagios within the genus <i>Silviavirus</i> of the family Herelleviridae and indicated that it may represent a novel species. The phage displayed rapid adsorption (∼15 min), a short latent period (∼20 min), a burst size of ∼102 PFU/cell, and stability across physiologically relevant temperature (4 °C -45 °C) and pH conditions (pH 4-10). Whole-genome sequencing confirmed the absence of toxin genes, virulence factors, antimicrobial resistance determinants, and lysogeny-associated genes, supporting its genomic safety. Pelagios exhibited broad lytic activity against multiple clinical MRSA isolates and significantly reduced planktonic bacterial populations both <i>in vitro</i> and in <i>ex vivo</i> porcine skin models in a dose-independent manner. It also effectively inhibited MRSA biofilm formation, although eradication of established biofilms was limited. Phage-loaded DDMNs fabricated from hyaluronic acid and gelatin achieved efficient skin penetration, rapid dissolution, complete needle detachment, and markedly improved phage stability at 4 °C. In <i>ex vivo</i> infection models, DDMN-mediated delivery significantly enhanced antibacterial and biofilm-eradicating efficacy compared with free phage suspension. These findings demonstrate that Pelagios delivered via DDMNs constitutes a safe and effective strategy for treating MRSA-associated wound and biofilm infections.</p>","PeriodicalId":12466,"journal":{"name":"Frontiers in Microbiology","volume":"17 ","pages":"1928352"},"PeriodicalIF":5.8,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13541741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole-cell-catalyzed cinnamoylation of phillyrin in natural deep eutectic solvent-based co-solvent systems.","authors":"Rongling Yang, Ziling Huang, Yuli Tong, Dong Xu, Xiaoyan Li, Yanjin Li, Chun Zhu, Xiangjie Zhao","doi":"10.3389/fmicb.2026.1906247","DOIUrl":"https://doi.org/10.3389/fmicb.2026.1906247","url":null,"abstract":"<p><p>Phillyrin is a critical bioactive constituent of <i>Forsythiae Fructus</i>, exhibiting multiple pharmacological properties, but suffers from poor membrane permeability and low oral bioavailability. In this study, we developed a novel, green method employing whole-cell biocatalysts and natural deep eutectic solvents (NADESs) for the cinnamoylation of phillyrin to improve its liposolubility and bioactivity. <i>Aspergillus oryzae</i> whole cells showed high catalytic activity and stability in co-solvent systems containing hydrophobic NADESs. The NADES-tetrahydrofuran (50%, v/v) mixture maintained a high conversion rate (97.32-99.00%) and excellent 6'-regioselectivity (>99%) under optimal conditions (20 mg·mL^-1 whole-cell dosage, 15:1 vinyl cinnamate/phillyrin, at 50 °C). Crucially, <i>Aspergillus oryzae</i> whole-cell biocatalysts exhibited markedly enhanced operational stability across all tested NADES-tetrahydrofuran (50%, v/v) reaction systems, retaining 80.09-97.95% of their original activity after six consecutive batch cycles. This study successfully combined hydrophobic NADESs with a whole-cell biocatalytic system, achieving efficient and regioselective cinnamoylation of phillyrin.</p>","PeriodicalId":12466,"journal":{"name":"Frontiers in Microbiology","volume":"17 ","pages":"1906247"},"PeriodicalIF":5.8,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13541702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Materials, adaptation, and evolution: how anthropogenic activities impact microbial resistance.","authors":"Paolo Pellegrino, Fabrizio Damiano, Chiara Leo, Matteo Calcagnile","doi":"10.3389/fmicb.2026.1960288","DOIUrl":"https://doi.org/10.3389/fmicb.2026.1960288","url":null,"abstract":"","PeriodicalId":12466,"journal":{"name":"Frontiers in Microbiology","volume":"17 ","pages":"1960288"},"PeriodicalIF":5.8,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13541906/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Biofilms in aquatic environments and new strategies for microbial biofilm control.","authors":"Jorge T Antunes, Inês Bezerra Gomes, Lorenzo Proia","doi":"10.3389/fmicb.2026.1960548","DOIUrl":"https://doi.org/10.3389/fmicb.2026.1960548","url":null,"abstract":"","PeriodicalId":12466,"journal":{"name":"Frontiers in Microbiology","volume":"17 ","pages":"1960548"},"PeriodicalIF":5.8,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13541691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot-scale purple phototrophic bacteria for wastewater treatment and resource recovery: an evidence-based framework for reactor selection and scale-up.","authors":"Sultan Shaikh, Gordon McKay","doi":"10.3389/fmicb.2026.1917392","DOIUrl":"https://doi.org/10.3389/fmicb.2026.1917392","url":null,"abstract":"<p><p>Purple non-sulfur bacteria (PNSB), a major subgroup of purple phototrophic bacteria (PPB), have emerged as a promising platform for integrating wastewater treatment with resource recovery through the simultaneous production of value-added products, including single-cell protein (SCP), polyhydroxyalkanoates (PHAs), hydrogen, lipids, pigments, and other biomass-derived compounds. Although substantial progress has been achieved at laboratory scale, pilot-scale development remains fragmented across wastewater types, reactor configurations, operating conditions, and performance metrics, limiting cross-study comparison and practical technology selection. This review systematically synthesizes evidence from 15 pilot-scale studies ranging from 50 L to over 9,600 L, including flat-plate photobioreactors, tubular reactors, raceway ponds, membrane photobioreactors, integrated UASB-PPB systems, baffled reactors, and a stirred polypropylene-box photobioreactor operated under natural, filtered, or artificial illumination. Reported resource recovery outcomes include SCP contents of 42-65%, PHAs up to 36% of volatile suspended solids, hydrogen yields of 0.35-0.60 mol H₂ mol⁻¹ acetic acid, lipids up to 25%, and substantial pigment accumulation. Across these systems, <i>Rhodopseudomonas</i>, <i>Rhodobacter</i>, and <i>Blastochloris</i> consistently emerged as dominant genera supported by fermentative microbial consortia. The principal novelty of this review is the development of an evidence-based decision-support framework integrating wastewater characteristics, target products, reactor selection, technology readiness, and operational priorities. The framework identifies flat-plate photobioreactors as the preferred configuration for SCP production, integrated UASB-PPB systems for PHA recovery, and tubular and baffled photobioreactors for hydrogen production, while multi-criteria assessment ranks flat-plate photobioreactors, integrated UASB-PPB systems, and raceway ponds as the most promising configurations for pilot-scale implementation. The analysis further identifies light management, biomass harvesting, nutrient control, and process integration as the principal barriers to commercialization, providing practical guidance for reactor selection and accelerating the transition of PPB-based wastewater biorefineries toward commercial deployment.</p>","PeriodicalId":12466,"journal":{"name":"Frontiers in Microbiology","volume":"17 ","pages":"1917392"},"PeriodicalIF":5.8,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13543492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding the functional diversity of plant growth-promoting bacterial communities in the soils of Western Ghats, Tamil Nadu, India.","authors":"Manikandan Murugesan, Sugitha Thankappan, Vellaichamy Mageshwaran, Rajendran Ramasamy, Arvinth Singaram","doi":"10.3389/fmicb.2026.1865342","DOIUrl":"https://doi.org/10.3389/fmicb.2026.1865342","url":null,"abstract":"<p><p>Western ghats in India, one of the world's biodiversity hot spots is the reservoirs of microbial resources having agricultural and industrial significance. However, the diversity of plant growth-promoting microbial communities associated with the plants and soil in the Western Ghats is untapped vault. The current emphasis on natural farming is more depending on the indigenous microbial communities and their metabolic functions towards sustainable one -health. With this background, the present study examines the bacterial diversity of soils from the Western Ghats of Nilgiris, Coimbatore and Dindigul regions. Among the 10 soil samples collected (S1 to S10), three soil samples (S2, S4 and S6) representing respective three regions were subjected for metagenomic studies based on their distinct soil chemical and biological properties. The computational analysis of the metagenome revealed the core genus <i>Bradhyrhizobium</i> in all soil samples, while <i>Trebonia</i>, <i>Arthrobacter, Streptomyces,</i> and <i>Pseudomonas</i> are the next most abundant genera, which varied substantially. The results collectively demonstrate that soil sample from Dindigul harbours the richest and most diverse microbial community among the three regions. In culturable studies, a total of 101 bacterial isolates were obtained from 10 soil samples (S1 to S10). Among them four Gram-negative bacterial isolates showed potential plant growth-promoting attributes, such as Ammonia, Indole Acetic Acid, Hydrogen cyanide and siderophore production, phosphorus, potassium, and zinc solubilization. The 16S rDNA analysis revealed that the bacterial isolates were <i>Pseudomonas glycinae</i> S6B1, <i>Pseudomonas tolaasii</i> S2B3, <i>Pseudomonas azotoformans</i> S9H10, and <i>Pseudomonas poae</i> S10B2. The isolate, S10B2, exhibited the maximum inhibition, with 81.25%, 70.1%, and 35% against plant pathogenic fungi, <i>Rhizoctonia solani</i>, <i>Sclerotium rolfsii</i>, and <i>Fusarium oxysporum</i>, respectively, indicating strong biocontrol potential. The effect of bacterial inoculants on chick pea (<i>Cicer arietinum</i> var. JG 62), showed that <i>P. glycinae</i> S6B1 significantly promoted plant growth such as root length, shoot length, and fresh/dry biomass. These findings unlock the core microbiome of soils of Western Ghats, which can be utilized to develop a synthetic microbial consortium to boost agricultural productivity.</p>","PeriodicalId":12466,"journal":{"name":"Frontiers in Microbiology","volume":"17 ","pages":"1865342"},"PeriodicalIF":5.8,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13541767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}