Forensic Science, Medicine and Pathology最新文献_第2页

Tattoo-associated toxic shock syndrome: potential role of hematological biomarkers in risk stratification. 纹身相关中毒性休克综合征：血液学生物标志物在危险分层中的潜在作用。

IF 1.4 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-09-20 DOI: 10.1007/s12024-025-01092-7

Daniel Matovu

引用次数: 0

Commentary on: Byard RW. A forensic overview of deaths in mountainous terrain. 评论：Byard RW。山区死亡案件的法医概览。

IF 1.4 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-09-18 DOI: 10.1007/s12024-025-01084-7

Burkhard Madea, Elke Doberentz

引用次数: 0

Comment on "estimation of bloodstains time since deposition based on ATR-FTIR spectroscopy in forensic laboratories". 对“基于ATR-FTIR光谱法在法医实验室中估计血迹沉积时间”的评论。

IF 1.4 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-09-18 DOI: 10.1007/s12024-025-01083-8

Koyel Roy, Sunil, Jiyauddin Md

引用次数: 0

Comment on "exploring minimally invasive tissue sampling as an alternative to conventional autopsy in neonatal deaths". 关于“探索微创组织取样作为新生儿死亡中传统尸检的替代方法”的评论。

IF 1.4 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-09-18 DOI: 10.1007/s12024-025-01089-2

Koyel Roy, Anju Singh, Sanjeeb Mallick

引用次数: 0

Comment on "macroscopic findings of the skull and brain in fire fatalities - an update". 评论“火灾死亡中头骨和大脑的宏观发现——最新进展”。

IF 1.4 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-09-18 DOI: 10.1007/s12024-025-01082-9

Ashok Kumar Sah, Rajesh Prasad Jayaswal, Ranjay Kumar Choudhary

引用次数: 0

"Detection of sedative and antipsychotic in exhumed institutionalized patients: a forensic toxicological case series". 在被挖掘出来的住院病人中检测镇静剂和抗精神病药物：法医毒理学案例系列。

IF 1.4 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-09-18 DOI: 10.1007/s12024-025-01081-w

Gianmarco Argentiero, Luca Morini, Marcello Benevento, Laura Ambrosi, Simona Nicolì, Davide Ferorelli, Biagio Solarino

{"title":"\"Detection of sedative and antipsychotic in exhumed institutionalized patients: a forensic toxicological case series\".","authors":"Gianmarco Argentiero, Luca Morini, Marcello Benevento, Laura Ambrosi, Simona Nicolì, Davide Ferorelli, Biagio Solarino","doi":"10.1007/s12024-025-01081-w","DOIUrl":"https://doi.org/10.1007/s12024-025-01081-w","url":null,"abstract":"Post-mortem toxicological analysis in exhumed bodies presents considerable methodological and interpretative difficulties. These limitations become particularly relevant in judicial contexts involving elderly individuals in long-term care, where pharmacological regimens may be deliberately omitted from medical records. This study investigates a series of 15 exhumed cases in which the detection of sedative and antipsychotic drugs, particularly Midazolam and Promazine, raised concerns of potentially unauthorized or inappropriate administration. All cases underwent full forensic autopsy, including external examination and sampling of available biological matrices. Toxicological analyses were performed using GC-MS and LC-MS/MS platforms. Quantitative results were evaluated alongside pathological findings to assess potential contribution to the cause of death. Advanced decomposition affected all cases, severely compromising morphological and histological evaluation. Autopsy findings revealed multiple chronic conditions, consistent with age-related comorbidities. Toxicological screening identified Midazolam, its metabolite α-hydroxy-midazolam, and Promazine in various tissues. However, only one subject had a documented prescription for these agents. In the remaining 14, no therapeutic indication was recorded. All concentrations were interpreted with caution due to decomposition-related artifacts. The interpretation of drug levels in decomposed exhumed bodies is limited by post-mortem redistribution, instability of substances, and the absence of validated reference ranges for degraded matrices. Toxicological positivity, in the absence of medical justification, may support hypotheses of unauthorized administration but cannot by itself establish a causal relationship with death. These findings underscore the need for cautious interpretation and further research on drug behaviour in post-mortem decomposed tissue.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential diagnosis of perianal herpes: sexual abuse or autoinoculation? 肛周疱疹的鉴别诊断：性虐待还是自体接种？

IF 1.4 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-09-11 DOI: 10.1007/s12024-025-01086-5

Youssef Nouma, Hana Harzallah, Malek Zribi

引用次数: 0

Age prediction of hematoma using hyperspectral imaging (HSI). 利用高光谱成像（HSI）预测血肿年龄。

IF 1.4 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-09-11 DOI: 10.1007/s12024-025-01076-7

S Al-Arami, St Lüdtke, J Dreßler, C Babian

{"title":"Age prediction of hematoma using hyperspectral imaging (HSI).","authors":"S Al-Arami, St Lüdtke, J Dreßler, C Babian","doi":"10.1007/s12024-025-01076-7","DOIUrl":"https://doi.org/10.1007/s12024-025-01076-7","url":null,"abstract":"Hyperspectral imaging (HSI) analyzes the reflected light spectrum of an object, providing insights into its material composition. In this experimental, prospective study, standardized hematomas were created in subjects and observed over 21 days using a portable hyperspectral camera, aiming to correlate changes in the reflected light spectrum with hematoma age and enable an objective method for age determination of hematomas. In 25 young and healthy subjects, a hematoma was induced by injecting 3 ml of autologous blood on the volar side of the forearm. The hematomas were documented over a 7-day period in 24-hour intervals and then for an additional 14 days in 48-hour intervals using a portable HSI camera covering the wavelength range from 400 nm to 1000 nm. The datasets from the hematomas were normalized using the spectrum of unaffected skin. Lasso regression models were trained on the normalized data to identify age-dependent changes in the reflection spectra and to make age predictions for hematomas of unknown age. The different regression models were compared based on their predictive accuracy and then evaluated against the actual hematoma age. The best age prediction model based on HSI recordings achieved a mean prediction error of 3.35 days over a 21-day observation period.Expanding the data set and methodology, as well as combining them with other techniques and testing on naturally occurring hematomas of various sizes and locations, are necessary steps to transfer this method into practical application.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of organ sampling for forensic pathology: should heart and brain be retained whole? 器官取样对法医病理学的影响：心脏和大脑是否应该保持完整？

IF 1.4 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-09-11 DOI: 10.1007/s12024-025-01074-9

G Provenzano, L Pestourie, C Guilbeau-Frugier, Norbert Telmon, P Saint-Martin, Eulalie Pefferkorn

{"title":"Impact of organ sampling for forensic pathology: should heart and brain be retained whole?","authors":"G Provenzano, L Pestourie, C Guilbeau-Frugier, Norbert Telmon, P Saint-Martin, Eulalie Pefferkorn","doi":"10.1007/s12024-025-01074-9","DOIUrl":"https://doi.org/10.1007/s12024-025-01074-9","url":null,"abstract":"Retention and histological examination of major organs-particularly the heart and brain-are standard components of medico-legal autopsies aimed at determining the cause and manner of death. However, in France, the lack of standardized national guidelines has resulted in significant variability in these practices, raising both ethical and practical concerns. Families often express distress over the removal and destruction of symbolic organs, especially the heart and brain, for histological purposes. In this context, it is essential to avoid unnecessary organ retention, ensuring that medico-legal procedures remain ethically sound and sensitive to the needs of grieving families. This study retrospectively analyzed 142 autopsy cases performed at a French medico-legal institute between 2020 and 2022 to evaluate the diagnostic utility of histological sampling and the systematic retention of the entire heart and brain. Histology was found to contribute significantly to forensic conclusions in 49% of cases, although full organ retention was rarely indispensable. Notably, brain histology yielded diagnostic information in only 14% of cases, whereas heart histology was more informative, contributing in 44% of cases. Moreover, in most instances, the diagnostic value obtained from entire organs could have been achieved with a single tissue sample. These findings support a more selective approach to organ sampling, informed by macroscopic findings and clinical history, in order to fulfill diagnostic objectives while maintaining ethical integrity. The study highlights the pressing need for clear, evidence-based protocols in forensic histological practice to optimize resource utilization and respect the emotional concerns of bereaved families.","PeriodicalId":12449,"journal":{"name":"Forensic Science, Medicine and Pathology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal volvulus and obstruction due to combined button battery and magnet ingestion: a medico-legal case report. 钮扣电池与磁铁联合误食致肠扭转梗阻：一例医学-法律案例报告。

IF 1.4 4区医学

Forensic Science, Medicine and Pathology Pub Date : 2025-09-06 DOI: 10.1007/s12024-025-01078-5

Anna Milaszkiewicz, Jacek Baj, Biagio Solarino, Grzegorz Teresiński

引用次数: 0