Frontiers in Bioengineering and Biotechnology最新文献

{"title":"Electrospun nanofibers and their application as sensors for healthcare.","authors":"Yi-Sa Zhao, Jie Huang, Xingjian Yang, Weqiang Wang, Deng-Guang Yu, Hua He, Ping Liu, Kewei Du","doi":"10.3389/fbioe.2025.1533367","DOIUrl":"10.3389/fbioe.2025.1533367","url":null,"abstract":"<p><p>Electrospinning is a type of electrohydrodynamics that utilizes high-voltage electrostatic force to stretch a polymer solution into nanofibers under the influence of an electric field, with most of the fibers falling onto a collector. This technology is favored by researchers across various fields due to its simple and inexpensive device for producing nanofibers in a straightforward manner. Nanofibers prepared through electrospinning have a high specific surface area and high porosity. Electrospinning technology shows extensive potential, especially within biomedical sensors. This article provides a systematic overview of the factors influencing electrospinning, the parameters of the electrospinning process, the types of electrospun nanofibers, and the applications of electrospinning technology in the field of sensors, including wearable sensors, pressure sensors, and glucose sensors. The paper summarizes the research progress in this field and points out the direction of development for electrospinning technology, as well as the future challenges.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1533367"},"PeriodicalIF":4.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards propagation of epidermal cells for wound repair: glass, as cell culture substrate, enhances proliferation and migration of human keratinocytes.","authors":"Hady Shahin, Ingrid Steinvall, Folke Sjöberg, Moustafa Elmasry, Ahmed El-Serafi","doi":"10.3389/fbioe.2025.1547044","DOIUrl":"10.3389/fbioe.2025.1547044","url":null,"abstract":"<p><strong>Introduction: </strong>Human keratinocytes require relatively long propagation time which impedes their availability as autologous cell transplantation within a clinically reasonable timeframe. There is an unmet need for efficient xeno-free cell expansion approaches to propagate human keratinocytes as regenerative therapy.</p><p><strong>Methods: </strong>Primary human keratinocytes and HaCaT cells were cultured on glass, plastic, and animal-derived collagen I matrix for 10 days. Proliferation, migration, DNA methylation, as well as gene and protein expression were assessed to characterize the effect of the tested culture substrates on keratinocytes at the molecular and functional levels.</p><p><strong>Results: </strong>Keratinocytes cultured on glass exhibited faster proliferation, global DNA demethylation and upregulation of epidermal differentiation markers. Scratch wound assay revealed that keratinocytes cultured on glass demonstrated enhanced cell migration compared to those on plastic or collagen I. Multiplex immunoassays identified temporal and substrate-dependent variations in a panel of keratinocyte-specific secreted factors, encompassing immunomodulatory cytokines, growth factors, and angiogenic factors.</p><p><strong>Discussion: </strong>Glass, as a culture substrate, promotes epidermal differentiation and enhances keratinocyte migration. The latter is a critical factor in re-epithelialization and wound healing. Functional properties suggest that glass may optimize the inflammatory response and promote efficient wound repair, making it a promising candidate for the short-term expansion of keratinocytes for transplantation purposes. Further <i>in-vivo</i> validation is required to definitively establish the efficacy of keratinocytes cultured on glass for clinical applications.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1547044"},"PeriodicalIF":4.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A preclinical study of a novel dual-modality contrast agent in rodent models.","authors":"Xuelai Zhou, Kangli Jiang, Yuxin Han, Shuxu Yang","doi":"10.3389/fbioe.2025.1557772","DOIUrl":"10.3389/fbioe.2025.1557772","url":null,"abstract":"<p><strong>Introduction: </strong>Glioblastoma (GBM) represents the most aggressive and prevalent form of primary malignant brain tumor in adults, with surgical intervention being the primary treatment modality. To enhance surgical outcomes and extend patient survival, we have engineered a dual-modality MRI/FI contrast agent known as PL002 to aid in the surgical management of GBM.</p><p><strong>Methods: </strong>In this study, an orthotopic glioma model was established in mice via intracranial injection of U-87 MG cells. Subsequently, the model animals were intravenously injected with PL002 and placed in a 7.0T magnetic resonance imaging (MRI) device to evaluate the imaging effects. After the MRI scan, fluorescence imaging techniques were employed to observe the distribution of PL002 at both the brain tissue and cellular levels. Moreover, healthy rat models were utilized to investigate the pharmacokinetic characteristics, tissue distribution, and safety profile of PL002.</p><p><strong>Results: </strong>The molecular structure of PL002 contains both gadolinium (Gd³⁺) and indocyanine green (ICG), demonstrating optimal imaging effects within the dosage range of 10-50 mg/kg, with a half-life of 2.51 to 4.87 hours. Even at relatively low concentrations in the brain, PL002 can provide stable and sustained support for MRI and fluorescence imaging for up to 72 hours. No abnormalities were observed in rats at a dosage of 100 mg/kg.</p><p><strong>Discussion: </strong>Compared to Gadavist® and ICG, PL002 provided sustained support for MRI and FI of GBM for 72 h, with a broad therapeutic window. This dual-modality contrast agent holds significant potential and promise for applications in preoperative assessment of resection margins, real-time intraoperative guidance, and postoperative verification of the extent of resection.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1557772"},"PeriodicalIF":4.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjusting blood redistribution to suppress flow disturbances of hemodialysis arteriovenous fistula: a computational fluid dynamics analysis.","authors":"Yong-Jiang Li, Hui-Min Hou, Zheng Liu, Chun-Dong Xue, Jing-Tong Na, Qing-Mei Meng, Zhe-Yuan Li, Hai-Yang Sun, Yu-Lin Wu, Shu-Xin Liu, Kai-Rong Qin","doi":"10.3389/fbioe.2025.1551993","DOIUrl":"10.3389/fbioe.2025.1551993","url":null,"abstract":"<p><strong>Introduction: </strong>The dramatic hemodynamic disturbances induced by arteriovenous fistula (AVF) creation are universally acknowledged as the triggering factors for AVF dysfunction. The postoperative blood redistribution is greatly relevant with the flow disturbances of the AVF, such as disturbed flow, low wall shear stress (WSS), and oscillating WSS. However, the relationship between blood redistribution and hemodynamic disturbances of AVF remains unexamined. The role of clinically observed retrograde blood flow at the distal radial artery is rarely understood.</p><p><strong>Methods: </strong>In this study, an idealized AVF model was developed with clinical data collected from end-stage renal disease patients. By considering the postoperative blood redistribution, the influence of the blood flow rate ratio on hemodynamic disturbances is numerically studied.</p><p><strong>Results and discussion: </strong>The results demonstrate that the creation of the AVF can result in flow disturbances such as vortex, reciprocating flow, and low and reciprocating WSS, whose occurrence regions are consistent with clinical observations. The flow rate ratio and flow direction of the distal radial artery play important roles in regulating the low-WSS area within the AVF anastomosis, especially for the flow rate of the proximal radial artery (PRA). Moreover, the clinically observed retrograde blood flow in the distal radial artery contributes to the reduction in the low-WSS area, revealing a compensatory mechanism. This study can provide valuable insights for understanding the effect of blood redistribution on flow disturbances in the AVF, as well as the compensatory role of the retrograde distal radial artery flow, which helps optimize blood redistribution for a well-functioning AVF.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1551993"},"PeriodicalIF":4.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To investigate the effect of neck-shaft angle in surgical hip dislocation combined with femoral neck rotational osteotomy in the treatment of osteonecrosis of the femoral head and to combine with finite element analysis.","authors":"Sun Jiahao, Ma Bowen, Zhang Chiyu, Xia Tianwei, Shen Jirong, Zhang Chao","doi":"10.3389/fbioe.2025.1495292","DOIUrl":"10.3389/fbioe.2025.1495292","url":null,"abstract":"<p><strong>Background: </strong>The Neck-shaft Angle (NSA) is a reliable predictor of the outcome of internal fixation for femoral neck fractures. Surgical Hip Dislocation Combined with Femoral Neck Rotational Osteotomy (SHD-FNRO) is an effective surgical method for treating femoral head necrosis. However, the potential role of NSA in predicting the outcomes of hip preservation after SHD-FNRO has not been explored.</p><p><strong>Objective: </strong>This study aims to investigate the value of NSA in predicting the outcomes of hip preservation after SHD-FNRO by comparing the results among different patients with osteonecrosis of the femoral head (ONFH) who were treated with SHD-FNRO.</p><p><strong>Methods: </strong>We retrospectively analyzed clinical data from 33 patients (33 hips) who underwent SHD-FNRO at our hospital between January 2017 and December 2021. Based on the outcome of hip preservation, patients were divided into two groups: group A (successful hip preservation) and group B (failed hip preservation). Statistical analysis was performed to evaluate any differences between these groups. Additionally, three-dimensional models with varying NSA values were created to analyze changes in maximum displacement and stress on the osteotomy surface.</p><p><strong>Results: </strong>During a mean follow-up period of approximately 40 months, successful hip preservation was achieved in 26 patients while 7 patients experienced failure. There was a statistically significant difference in NSA between these two groups (P < 0.05). Biomechanical analysis demonstrated a close relationship between NSA and postoperative biomechanical changes.</p><p><strong>Conclusion: </strong>The size of NSA is closely associated with the success rate of hip preservation when treating osteonecrosis of the femoral head using SHD-FNRO. Therefore, careful attention should be given to selecting an appropriate osteotomy surface that can adjust NSA size effectively, thus achieving better outcomes for hip preservation.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1495292"},"PeriodicalIF":4.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced surface modification techniques for titanium implants: a review of osteogenic and antibacterial strategies.","authors":"Handong Zhang, Zidong Wu, Zemin Wang, Xinfeng Yan, Xudong Duan, Huaqiang Sun","doi":"10.3389/fbioe.2025.1549439","DOIUrl":"10.3389/fbioe.2025.1549439","url":null,"abstract":"<p><p>Titanium (Ti) implants are widely used in orthopedic and dental applications due to their excellent mechanical strength, corrosion resistance, and biocompatibility. However, their limited osteointegration and susceptibility to bacterial infections remain major clinical challenges. Recent advancements in surface modification techniques have significantly improved the osteogenic and antibacterial properties of Ti implants. This review summarizes key strategies, including ion doping, hydroxyapatite (HAp) coatings, nanostructured surfaces, and graphene-based modifications. Zinc (Zn)-doped coatings increase osteoblast proliferation by 25%, enhance cell adhesion by 40%, and inhibit <i>Staphylococcus aureus</i> by 24%. Magnesium (Mg)-doped Ti surfaces enhance osteoblast differentiation, with 38% increased alkaline phosphatase (ALP) activity and a 4.5-fold increase in cell proliferation. Copper (Cu)-doped coatings achieve 99.45% antibacterial efficacy against <i>S. aureus</i> and 98.65% against <i>Escherichia coli</i> (<i>E. coli</i>). Zn-substituted HAp promotes mineralized nodule formation by 4.5-fold and exhibits 16.25% bacterial inhibition against <i>E. coli</i>. Graphene-based coatings stimulate bone marrow stem cells (BMSCs) and provide light-responsive surface potentials for enhanced osteogenesis. Despite these advancements, challenges remain in optimizing ion release kinetics and long-term stability. Future research should focus on multi-functional coatings that integrate osteogenic, antibacterial, and immunomodulatory properties to enhance clinical performance and patient outcomes.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1549439"},"PeriodicalIF":4.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of surgeon handedness on the efficacy and safety of proximal femoral nail antirotation fixation for intertrochanteric femur fractures in elderly patients: A single Center's experience.","authors":"Xiao-Feng Liu, Yong-Qiang Zheng, Liang Lin, Zhen-Yu Lin, Hong-Peng Zhang, Xiao-Peng Huang, Ze-Feng Wang, Yang-Zhen Fang, Wen-Ming Zhang, Xin-Yu Fang, Jin-Shan Zhang","doi":"10.3389/fbioe.2025.1548823","DOIUrl":"10.3389/fbioe.2025.1548823","url":null,"abstract":"<p><strong>Background: </strong>Handedness refers to the lateral preference of using one hand more than the other. Surgeon handedness has been widely discussed in operative surgery and could cause clinical discrepancy. However, in the use of proximal femoral nail antirotation (PFNA) for the treatment of intertrochanteric femur fracture (IFF), the effect of handedness on clinical outcomes is easily overlooked. In fact, when right-handed surgeons operate on right-sided IFF patients, due to the specific nature of the surgical site, they have to use their left hand to perform the opening at the proximal end of the femur and insert the main nail. This study aimed to investigate the influence of surgeon handedness on the efficacy and safety of PFNA fixation for elderly patients with IFF.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the basic data of 182 elderly patients with IFF who underwent surgical treatment in our department from January 2020 to December 2022 and had a minimum follow-up duration of 1 year. Equal numbers of left and right PFNA fixation were performed by four surgeons, two right-handed and two left-handed. Dominant group refers to a left IFF for a right-handed surgeon and a right IFF for a left-handed surgeon. Otherwise, it is called a non-dominant group. The patients were divided into the dominant group (90 cases) and the non-dominant group (92 cases), and differences between the two groups were analyzed.</p><p><strong>Results: </strong>In terms of surgical safety, the dominant group had significantly shorter average operation time and lower blood loss compared to the non-dominant group (P < 0.05). In the final follow-up, the average Harris score of the dominant group was 84.60 ± 4.35, and that of the non-dominant group was 82.63 ± 4.98. The Harris score of the dominant group was significantly higher than that of the non-dominant group (P < 0.05). According to the 1-year follow-up results, there were 86 survivors and 4 deaths in the dominant group, and 80 survivors and 12 deaths in the non-dominant group. Although the non-dominant group (13.04%) had a higher mortality rate than the dominant group (4.44%), the difference between the two groups was not statistically significant (P > 0.05).</p><p><strong>Conclusion: </strong>Surgeon handedness is a factor that influences the efficacy and safety of PFNA fixation for patients with IFF.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1548823"},"PeriodicalIF":4.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CGT 4.0: a distant dream or inevitable future? Smart process automation is critical to make efficient scalability of CGT manufacturing a reality.","authors":"Aleksander Szarzynski, Oliver Spadiut, Matthias Reisbeck, Gerhard Jobst, Rachel L Paterson, Anna Kamenskaya, Emilie Gateau, Hanna P Lesch, Luc Henry, Bence Kozma","doi":"10.3389/fbioe.2025.1563878","DOIUrl":"10.3389/fbioe.2025.1563878","url":null,"abstract":"","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1563878"},"PeriodicalIF":4.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable organic-inorganic hybrid hydrogels for bone defect repair.","authors":"Huan Zhang, Shuo Ding, Huai Xue, Shuguang Wang, Xiaoyu Quan, Dong Zhang, Xiao Liu, Hai Tang","doi":"10.3389/fbioe.2025.1563546","DOIUrl":"10.3389/fbioe.2025.1563546","url":null,"abstract":"<p><p>Bone defects caused by trauma, tumor resection, and surgery present significant clinical challenges, often resulting in complications such as delayed union, nonunion, and even long-term functional impairment. Current treatments, including autografts and allografts, are limited by donor site morbidity, immune rejection, and pathogen transmission, highlighting the need for developing reliable synthetic alternatives. To address these challenges, we report a binary composite hydrogel combining gelatin methacryloyl (GelMA) and κ-Carrageenan, reinforced with calcium phosphate cements (CPC). GelMA ensures rapid gelation and biocompatibility, κ-carrageenan improves injectability, and CPC enhances mechanical strength and osteogenic activity, collectively creating a robust and versatile hydrogel system. Furthermore, the hydrogel's injectable, adaptive, and self-healing characteristics enable it to conform to irregular bone defect sites, providing mechanical support and osteogenic stimulation. It also releases bioactive components to accelerate bone regeneration. With exceptional toughness and resilience, this hydrogel recovers its shape after deformation, positioning it as a promising candidate for clinical bone defect repair applications.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1563546"},"PeriodicalIF":4.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The triadic relationship between spinal posture, loading, and degeneration.","authors":"Marie-Rosa Fasser, Pascal R Furrer, Luca Fisler, Lukas Urbanschitz, Jess G Snedeker, Mazda Farshad, Jonas Widmer","doi":"10.3389/fbioe.2025.1444540","DOIUrl":"10.3389/fbioe.2025.1444540","url":null,"abstract":"<p><strong>Introduction: </strong>Degenerative changes in the lumbar spine may affect many structures, among them the intervertebral discs and the facet joints. The individual load distribution within the spine linked to posture and mass distribution is a probable cause of disease. This study had a dual aim: first, to systematically summarize previously reported associations between sagittal balance parameters and the occurrence of lumbar spine degeneration. Second, to complement these insights with additional biomechanical findings meant to elucidate the link between spine load and alignment as well as selected demographic descriptors.</p><p><strong>Methods: </strong>A systematic literature search was performed on PubMed to identify clinical studies that quantified the association between spinal alignment and the occurrence of disc herniation, disc degeneration, facet joint degeneration, and spondylolisthesis. Further, a previously published musculoskeletal model was used to link sagittal spinal alignment and subject characteristics to joint loading within the lumbar spine for a cohort of 144 subjects.</p><p><strong>Results: </strong>The literature review yielded 49 publications evaluating the relationship between spinal alignment and the occurrence of pathologies in the lumbar spine. The results indicate that a straight spine might negatively affect the health status of the intervertebral disc, likely because of a lack of damping and associated high compressive loads. These loads further show a major dependence on body weight. On the other hand, facet degeneration and spondylolisthesis may be linked to higher anterior-posterior shear forces acting on the relevant spinal structures because of a generally more sagittally curved spine. A straight lumbar spine is more likely to stress the disc, whereas highly curved spines with a high pelvic incidence are more likely to stress the posterior structures. The biggest influencing factors on the resulting force and consequently potentially the wear of the anatomical structures are the intervertebral inclination from an anatomical point of view and the weight from a demographic point of view.</p><p><strong>Discussion: </strong>Information concerning spinal loading resulting from spinal alignment and body descriptors could impact both conservative treatment and operative planning for patients afflicted by spine disease through targeted changes in posture.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1444540"},"PeriodicalIF":4.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}