Frontiers in Chemistry最新文献

{"title":"Seamless triple-mode luminescence thermometry in Lu₃(Al₄Ga₁)O₁₂:Pr: high sensitivity from 11 to 700 K.","authors":"Justyna Zeler, Joanna Trojan-Piegza, Eugeniusz Zych","doi":"10.3389/fchem.2026.1924671","DOIUrl":"10.3389/fchem.2026.1924671","url":null,"abstract":"<p><p>This study reports on the high-performance luminescence thermometry of a Lu₃(Al₄Ga₁)O₁₂:Pr (LuAGG:Pr) phosphor, demonstrating a remarkable operational range spanning from deep-cryogenic to high-temperature regimes (11-700 K). Its relative thermal sensitivity, <i>S</i> _r, remains between 0.7% and 6.5% K^-1, exceeding 1% K^-1 over the vast majority of this interval. To overcome the sensitivity bottlenecks inherent to single-parameter thermometers, we propose a multi-mode thermometric strategy that leverages three distinct physical mechanisms. At cryogenic temperatures (11-120 K), the population redistribution among the Stark levels of the ¹D₂ state yields a maximum <i>S</i> _r of 6.5% K^-1. In the intermediate range (120-320 K), sensing is governed by the Boltzmann-coupled ³P₁ and ³P₀ states, yielding a maximum <i>S</i> _r of 5.5% K^-1 when using the two-level emission ratio. Crucially, we demonstrate that the integration of the intensity ratio between the interconfigurational 5d→4f and ¹D₂→³H₄ emissions - primarily driven by multiphonon relaxation - significantly enhances performance at elevated temperatures. While Boltzmann-type distributions show declining sensitivity above room temperature, this multiphonon-driven 5d/4f ratio revitalizes the sensor, maintaining <i>S</i> _r > 1% K^-1 up to 700 K, with <i>S</i> _r peak of 2.2% K^-1 at 465 K. By strategically combining these three parameters, we achieve a continuous, high-sensitivity profile across the entire 11-700 K window, establishing LuAGG:Pr as one of the most versatile Pr³⁺ singly activated materials for advanced thermal sensing reported to date.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"14 ","pages":"1924671"},"PeriodicalIF":5.3,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of gravels on the moisture evaporation and desiccation cracks in soil.","authors":"Zhenghui Li, Juntao Bai, Xinwen Zhao, Ao Zhang, Jun He, Chen Chen","doi":"10.3389/fchem.2026.1964498","DOIUrl":"10.3389/fchem.2026.1964498","url":null,"abstract":"<p><p>Under extreme arid conditions, soil loses moisture and forms cracks, which significantly affect their mechanical and hydraulic properties (e.g., shear strength, soil structure, and hydraulic behavior). Natural soils commonly contain gravels. However, research on the effects of gravels on moisture evaporation and desiccation cracking in soil is limited. To investigate the influence of gravel content on desiccation cracking behavior, soil samples were prepared by mixing clayey soil with quartz sand (particle size predominantly between 2 mm and 5 mm). Desiccation cracking experiments were performed in a custom-built chamber with controlled temperature and humidity, equipped with an automated real-time imaging system. Computer-based image processing techniques were employed to quantitatively describe the cracking characteristics. It was found that under evaporation conditions, gravels in soil hinder the upward migration of internal moisture to the surface. This obstruction leads to the formation of menisci within surface soil pores, generating tensile stress between soil particles due to surface tension. Additionally, the presence of gravels causes uneven settlement in the soil during evaporation, resulting in additional tensile stress between particles. As a result, compared to pure clayey soil, gravels alter the tensile stress field within the soil. This alteration not only accelerates crack initiation but also shifts the initial crack location and modifies the final geometric characteristics of the cracks. Conversely, gravels inhibit the vertical growth of cracks and the lateral shrinkage of soil blocks, thereby reducing overall crack density on the soil surface. This study offers a new perspective for interpreting the mechanisms of desiccation cracking in gravel-containing clay under natural conditions.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"14 ","pages":"1964498"},"PeriodicalIF":5.3,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radical 1,2-boron shift in modern organoboron synthesis.","authors":"Yunkai Zhang, Jinduo Shen, Qiuren Wei, Xi Li, Zhongyan Cao, Kai Sun, Lingbo Qu, Bing Yu","doi":"10.3389/fchem.2026.1955064","DOIUrl":"10.3389/fchem.2026.1955064","url":null,"abstract":"<p><p>The radical-mediated 1,2-boron shift strategy has emerged as a promising and powerful approach for the construction of functionalized organoboron compounds. This review summarizes and categorizes the relevant studies based on the distinct mechanisms underlying the generation of β-boryl radicals, such as radical addition, oxidative cleavage, decarboxylation reactions, or hydrogen atom transfer (HAT). Furthermore, the reaction scopes, synthetic utilities, and underlying mechanistic pathways are thoroughly examined to provide a comprehensive overview of this evolving strategy.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"14 ","pages":"1955064"},"PeriodicalIF":5.3,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in activated carbon magnetic composites (ACMCs): synthesis, characterization, performance as efficient adsorbents and other applications.","authors":"Zakaria Al-Qodah, Asma Eskhan, Ibrahim Suleiman, Zaid A Al-Anber, Ahmad T Shawaqfeh","doi":"10.3389/fchem.2026.1931555","DOIUrl":"https://doi.org/10.3389/fchem.2026.1931555","url":null,"abstract":"<p><p>Activated carbon (AC) is widely recognized material for its high porosity, expansive specific surface area, and an exceptional adsorption capacity. To explore these traits, the impregnation of magnetic particles into AC matrix has emerged as a key innovative strategy to produce composites with enhanced performance as adsorbents or catalysts. The literature survey indicates a surge in publications post-2010, to produce adsorbents of high capacity and selectivity as dominant subject areas. The resulting AC magnetic composites (ACMCs) simplifies the recovery via an external magnetic field and extend ACMCs to other application beyond traditional water treatment. The applications of ACMCs have primarily centered on adsorption, to remove both organic and inorganic pollutants, these composites have shown remarkable performance as catalysts, biocatalyst support, and magnetic solid-phase extraction. In most applications, iron and iron oxides have served as the main magnetic materials. This review provides a comprehensive analysis of the diverse synthesis pathways used to fabricate ACMCs, alongside the essential characterization techniques required to evaluate their structural and chemical properties. Furthermore, it summarizes the kinetic and isotherm models applied to ACMCs systems, while exploring how statistical tools and machine learning methods are being deployed to optimize operational parameters. This unpreceded integration of structural, kinetic, and optimization offers a definitive roadmap of ACMCs literature since the year 2000, serving as a vital cornerstone for future research.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"14 ","pages":"1931555"},"PeriodicalIF":5.3,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149180402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Zinc-vacancy defects in ZnO nanorods induced visible-light activity of photoelectrochemical glucose sensing: experimental and DFT+U analysis.","authors":"Trung Tin Tran, Huynh Nhu Nguyen Thi, Trung Nghia Tran, Tran Viet Cuong, Quang Vinh Lam","doi":"10.3389/fchem.2026.1997693","DOIUrl":"https://doi.org/10.3389/fchem.2026.1997693","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fchem.2026.1856857.].</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"14 ","pages":"1997693"},"PeriodicalIF":5.3,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13648196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lysosomes as chemical and metabolic organizers of central nervous system injury and repair.","authors":"Tengfei Zhao, Hanxu Huang, Yifan Wang, Yuliang Zhong, Zhiwei Zhong, Deting Xue, Wei Zhu, Kan Xu","doi":"10.3389/fchem.2026.1891677","DOIUrl":"10.3389/fchem.2026.1891677","url":null,"abstract":"<p><p>Lysosomes are degradative, metabolic and signaling organelles in central nervous system (CNS) cells and play essential roles in neural homeostasis, injury responses and disease progression. Changes in lysosomal function are required for neurons, microglia, astrocytes and oligodendrocyte-lineage cells to adapt to proteotoxic stress, lipid overload, mitochondrial damage and inflammatory stimulation. Therefore, lysosomal activity in the CNS is regulated by diverse chemical and cellular cues, including luminal acidification, hydrolase maturation, ion transport, membrane integrity, lipid handling and transcriptional lysosome biogenesis. Here, we summarize current knowledge of lysosomal organization and function in neural cells, including lysosomal membrane signaling, vacuolar H⁺-ATPase (V-ATPase)-dependent acidification, ion and redox regulation, lysosomal membrane quality control, and metabolic recycling of proteins, lipids, glycans and damaged organelles. We then survey pathological lysosomal remodeling in spinal cord injury, traumatic brain injury, Alzheimer's disease, Parkinson's disease and related neurological disorders. Across these conditions, lysosomal remodeling may initially support cargo clearance and stress adaptation, but becomes maladaptive when degradative capacity, membrane repair or lipid-processing ability fails to meet cellular demand. Finally, we discuss lysosome-oriented therapeutic strategies for neural repair, including restoration of lysosomal acidification and hydrolase activity, transcription factor EB/transcription factor E3 (TFEB/TFE3)-mediated lysosomal biogenesis, regulation of lysosomal ion channels, enhancement of myelin lipid turnover, and lysosome-responsive nanomedicine. This Review highlights lysosomes as active organizers of CNS injury and repair rather than passive endpoints of degradation.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"14 ","pages":"1891677"},"PeriodicalIF":5.3,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13644168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Operational challenges of industrial wastewater treatment plants in a multi-river province of China: implications for problem identification and management.","authors":"Zhilong Dong, Jing Zhou, Nan Li, Yi Huang, Fengli Tang, Long Sun, Wei Tao, Bowen Dong, Chengcheng Wen","doi":"10.3389/fchem.2026.1955505","DOIUrl":"10.3389/fchem.2026.1955505","url":null,"abstract":"<p><strong>Introduction: </strong>Industrial wastewater treatment plants are the primary sources of pollution in receiving water bodies, and their operational status directly affects the river water quality security, especially in provinces with multiple rivers. However, most reports focus on individual case studies and fail to conduct systematic research across basin and regional scales to support water environment risk assessment and control for decision-making and administrators.</p><p><strong>Methods: </strong>Given this, this study aimed to sort out the operational problems of industrial WWTPs and corresponding countermeasures at both basin and provincial scales, based on a 3-year investigation conducted in Gansu Province.</p><p><strong>Results: </strong>A comprehensive profile of operational problems, involving three common and 15 specific aspects, was developed at both basin and provincial scales. At the provincial scale, operational problems of WWTPs mainly included high dependence treatment rate (50.0%), low-load operation in terms of influent quantity (47.4%) and quality (e.g., chemical oxygen demand: 41.7%), a high proportion of WWTPs with a compliance rate below 90% (34.4%), high unit sludge yield (2.02 t/10⁴ m³), and high operational costs (3.91 CNY/m³). Major operational problems of WWTPs varied across the three basins. For example, design- and influence-related problems were more prominent in the Yellow River basin, whereas influentrelated and actual-operational performance problems were more prevalent in the Northwest River basin. Low loads of influent quantity and quality were the primary factors influencing the operational performance of WWTPs, followed by the operational level and design. These results suggest that for enhancing the operational efficiency of industrial WWTPs, three important steps are required to be implemented: (i) optimizing operational performance, (ii) increasing influent loads in terms of quantity and quality, and (iii) addressing design deficiencies.</p><p><strong>Discussion: </strong>Collectively, these measures can facilitate a shift from an effluent compliance-oriented approach to comprehensive process-based optimization and management. This study also provides a useful framework for investigating industrial WWTPs and identifying and addressing operational challenges.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"14 ","pages":"1955505"},"PeriodicalIF":5.3,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13642841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multivariate statistical analysis of chemical components, origin, variety, and sensory quality of domestic cigar tobacco leaves.","authors":"Cai Wen, An Hongyue, Liu Jie, Zhang Qianying, Huang Mingyue, Chai Zhishun, Zhu Beibei, Huo Danqun, Li Dongliang","doi":"10.3389/fchem.2026.1910376","DOIUrl":"10.3389/fchem.2026.1910376","url":null,"abstract":"<p><strong>Introduction: </strong>To achieve precise quality control and targeted optimization of cigar tobacco leaves, this study established an integrated analytical framework combining multi-source chemical detection with multivariate statistical analysis, using domestic cigar tobacco leaves from 9 origins and 3 varieties (27 samples in total).</p><p><strong>Methods: </strong>Gas chromatography-mass spectrometry (GC-MS/MS) was employed for untargeted semi-quantitative profiling of volatile components. Liquid chromatography-tandem mass spectrometry (LC-MS/MS/MS) was used for the quantitative determination of characteristic alkaloids and nitrogen-containing heterocycles. Biochemical assay kits were used to measure total protein and total starch contents. Based on the obtained multi-dimensional chemical data, principal component analysis (PCA) was applied for dimensionality reduction and visualization to explore the distribution patterns of tobacco leaves from different origins and varieties in the chemical composition space. Meanwhile, Spearman's rank correlation coefficients were calculated using R software to investigate the associations between chemical components and sensory/burning indicators, including sweetness and moistness, ash cohesion, burnability, cleanliness, and delicacy.</p><p><strong>Results: </strong>The PCA score plots revealed relatively independent clusters for samples from Sichuan and Hainan Tunchang, while samples from some origins (e.g., Hainan Danzhou, Hubei Yichang, and Hubei Danjiangkou) were positioned close to each other, suggesting certain chemical similarities. Spearman correlation analysis identified several chemical components (e.g., esters, phenols, and alkaloids) that showed strong correlations with specific sensory attributes. Among these, four candidate chemical markers-methyl stearate, pyridinylpyrrolone, 2,3'-bipyridine, and 2-(3-pyridyl)-2-pyrroline-met the predefined criteria for further investigation.</p><p><strong>Discussion: </strong>It should be emphasized that, due to the limited sample size (27 samples, with only 3 samples per origin), the PCA results are exploratory in nature and do not support definitive conclusions regarding origin discrimination. The correlation findings are hypothesis-generating and require independent validation with larger sample sets. This study provides preliminary data and candidate chemical targets for future research on cigar tobacco leaf quality with expanded sample sizes and validated analytical methods.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"14 ","pages":"1910376"},"PeriodicalIF":5.3,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13642712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lanthanum-modified shale powder/alginate composite hydrogel beads for fluoride-contaminated groundwater treatment.","authors":"Sitong Liu, Shaoxiong Li, Xu Bi, Guangying Feng, Zhao Wang, Qiusheng Yuan, Yue Xu, Ningyi Li","doi":"10.3389/fchem.2026.1962172","DOIUrl":"10.3389/fchem.2026.1962172","url":null,"abstract":"<p><p>Excessive fluoride (F^-) in groundwater poses a serious threat to human health, necessitating the development of efficient defluorination materials. In this study, a novel composite hydrogel bead (La-SP/SA) was fabricated by incorporating shale powder (SP) into sodium alginate (SA) matrix followed by crosslinking with lanthanum chloride. The synthesis conditions were determined as SP dosage 4.0%, La³⁺ concentration 0.2 mol L^-1, and crosslinking time 12 h. Under adsorbent dosage of 0.7 g L^-1, initial F^- concentration of 9.0 mg L^-1, and pH of 5.0, La-SP/SA achieved an excellent removal efficiency of 94.33% (12.18 mg g^-1), with a residual F^- concentration meeting both the WHO guideline and Chinese standard. Kinetic analysis revealed that the adsorption process followed the pseudo-second-order model, characteristic of chemisorption-dominated systems. The composite hydrogel beads exhibited excellent selectivity toward F^- in the presence of coexisting anions (Cl^-, SO₄ ^2-, HCO₃ ^-, and NO₃ ^-) and maintained over 98.01% of initial adsorption capacity over 5 days across pH 4.0-9.0. Mechanistic investigations using SEM-EDS, FTIR, XRD, and XPS demonstrated that F^- removal occurred via a synergistic mechanism involving electrostatic interaction, ion exchange, inner-sphere complexation, chemical precipitation, and chemisorption. This work provides a promising strategy for fluoride-contaminated groundwater remediation while enabling the resource utilization of shale waste.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"14 ","pages":"1962172"},"PeriodicalIF":5.3,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13642737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Active targeting towards bone cancer and metastases by pamidronate-bridged dinuclear platinum(II) complexes.","authors":"Anna Maria Di Cosola, Alessandra Barbanente, Luisa D'Anna, Simona Rubino, Alessio Terenzi, Mauro Niso, Nicola Margiotta","doi":"10.3389/fchem.2026.1945537","DOIUrl":"10.3389/fchem.2026.1945537","url":null,"abstract":"<p><p>Bisphosphonates (BPs) are clinically established bone-seeking agents that strongly bind to hydroxyapatite and selectively accumulate at sites of active bone remodeling. Among nitrogen-containing BPs, pamidronate (PAM) is widely used for the management of cancer-related bone complications and has also been associated with antiproliferative and pro-apoptotic effects in several tumor models. These properties make PAM an attractive ligand for the development of potential bone-targeted anticancer agents, particularly in the context of primary bone tumors and bone metastases, which are difficult to treat and are frequently associated with severe pain and skeletal complications. Platinum-based chemotherapeutics are effective anticancer agents, but their clinical use is often limited by poor tissue selectivity, systemic toxicity, and drug resistance. In this work, we report the synthesis and full characterization of two novel dinuclear platinum(II)-PAM complexes in which PAM acts as a bridging ligand between two platinum centers containing either an oxaliplatin-derived [Pt(1<i>R</i>,2<i>R</i>-diaminocyclohexane)]²⁺ unit or a kiteplatin-derived [Pt(<i>cis</i>-1,4-diaminocyclohexane)]²⁺ unit. The new compounds were characterized by multinuclear NMR spectroscopy and ESI-MS, and their chemical stability was investigated under physiological and mildly acidic conditions. Their reactivity toward DNA models and their <i>in vitro</i> antiproliferative activity against breast adenocarcinoma and osteosarcoma cells were also evaluated. Overall, these results highlight the influence of both the bisphosphonate scaffold and the diamine carrier ligand on the chemical and biological properties of dinuclear platinum(II) complexes, supporting their further investigation as potential agents for the treatment of bone malignancies.</p>","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":"14 ","pages":"1945537"},"PeriodicalIF":5.3,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}