Frontiers in Chemistry最新文献_第3页

Recent advances in cancer detection using dynamic, stimuli-responsive supramolecular chemosensors. a focus review. 利用动态刺激响应超分子化学传感器检测癌症的最新进展。

IF 3.8 3区化学

Frontiers in Chemistry Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI: 10.3389/fchem.2024.1478034

Kotaro Matsumoto, Keiichi Nakagawa, Daisuke Asanuma, Gaku Fukuhara

引用次数: 0

Editorial: Carbon-based materials: powering the future of energy and environmental progress. 社论：碳基材料：为未来的能源和环境进步提供动力。

IF 3.8 3区化学

Frontiers in Chemistry Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI: 10.3389/fchem.2024.1481960

Nimra Nadeem, Muhammad Zahid, Qamar Abbas, Asim Jilani

引用次数: 0

Stemona alkaloid derivative induce ferroptosis of colorectal cancer cell by mediating carnitine palmitoyltransferase 1. 茎叶生物碱衍生物通过介导肉碱棕榈酰基转移酶1诱导结直肠癌细胞铁变态反应

IF 3.8 3区化学

Frontiers in Chemistry Pub Date : 2024-10-03 eCollection Date: 2024-01-01 DOI: 10.3389/fchem.2024.1478674

He Yang, Ling Wang, Mengcheng Zhang, Xingkang Wu, Zhenyu Li, Kaiqing Ma

{"title":"Stemona alkaloid derivative induce ferroptosis of colorectal cancer cell by mediating carnitine palmitoyltransferase 1.","authors":"He Yang, Ling Wang, Mengcheng Zhang, Xingkang Wu, Zhenyu Li, Kaiqing Ma","doi":"10.3389/fchem.2024.1478674","DOIUrl":"https://doi.org/10.3389/fchem.2024.1478674","url":null,"abstract":"Accumulation of acylcarnitines is a characteristic feature of various metabolic disorders affecting fatty acid metabolism. Despite extensive research, no specific molecules have been identified to induce ferroptosis through the regulation of acylcarnitine metabolism. In this study, acylcarnitine accumulation was identified based on cell metabolomics study after the treatment with Stemona alkaloid derivative (SA-11), which was proved to induce ferroptosis in our previous research. Furthermore, the CPT-1 level was proved to significantly increase, while the CPT-2 level indicated no significant difference, which resulted in the accumulation of acylcarnitine. Besides, the ferroptosis-inducing ability of SA-11 was significantly enhanced by the addition of exogenous acylcarnitine, presumably due to the production of additional ROS. This hypothesis was corroborated by the observation of increased ROS levels in HCT-116 cells treated with SA-11 compared to the control group. These findings suggest that targeting acylcarnitine metabolism, particularly through CPT-1, may offer a novel therapeutic strategy for cancer treatment by enhancing ferroptosis induction.","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11484037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improvements in the utilization of calcium carbonate in promoting sustainability and environmental health. 提高碳酸钙的利用率，促进可持续性和环境健康。

IF 3.8 3区化学

Frontiers in Chemistry Pub Date : 2024-10-03 eCollection Date: 2024-01-01 DOI: 10.3389/fchem.2024.1472284

Jackson Comes, Emir Islamovic, Carlos Lizandara-Pueyo, Jong Seto

引用次数: 0

In vivo self-assembled albumin nanoparticle elicit antitumor immunity of PD-1 inhibitor by imaging and clearing tumor-associated macrophages. 体内自组装白蛋白纳米粒子通过成像和清除肿瘤相关巨噬细胞，激发 PD-1 抑制剂的抗肿瘤免疫力。

IF 3.8 3区化学

Frontiers in Chemistry Pub Date : 2024-10-03 eCollection Date: 2024-01-01 DOI: 10.3389/fchem.2024.1469568

Cheng Yu, Linan Hu, Qilin Yu, Yulu Ren, Minping Zhang, Lujing Gao, Shiyi Lyu, Junli Wang, Enhua Xiao, Zhu Chen, Quanliang Shang, Pengfei Xu

{"title":"In vivo self-assembled albumin nanoparticle elicit antitumor immunity of PD-1 inhibitor by imaging and clearing tumor-associated macrophages.","authors":"Cheng Yu, Linan Hu, Qilin Yu, Yulu Ren, Minping Zhang, Lujing Gao, Shiyi Lyu, Junli Wang, Enhua Xiao, Zhu Chen, Quanliang Shang, Pengfei Xu","doi":"10.3389/fchem.2024.1469568","DOIUrl":"https://doi.org/10.3389/fchem.2024.1469568","url":null,"abstract":"Eliciting anti-tumor immune responses and improving the tumor microenvironment crucial for boosting the effectiveness of anti-PD-1 immunotherapy. Tumor-associated macrophages (TAMs), the primary types of immune cells infiltrating tumors, play a critical role in the formation of an immunosuppressive microenvironment. In this study, we constructed a novel Evans Blue (EB)-based in vivo self-assembled nanocarrier system, mUNO-EB-ICG-Fc@Alb nanoparticles (designated as MA NPs), for targeted imaging and clearance of M2-TAMs to elicit antitumor immunotherapy of PD-1 inhibitor. In vitro experiments demonstrated the specific fluorescence imaging and killing effect of MA NPs on M2-TAMs. In vivo experiments shown that MA NPs-induced chemodynamic therapy (CDT) successfully reversed the tumor immunosuppressive microenvironment (ITM), promoted intratumoral infiltration of T lymphocytes, and ultimately enhancing the anti-tumor immunotherapy effect of PD-1 inhibitors. This study might provide good inspiration for improving the therapeutic efficacy of cancer immunotherapy.","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11484263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stepwise emergence of CO gas sensing response and selectivity on SnO₂ using C supports and PtO_x decoration. 使用 C 支持物和 PtOx 装饰逐步提高 SnO2 上的 CO 气体传感响应和选择性。

IF 3.8 3区化学

Frontiers in Chemistry Pub Date : 2024-10-03 eCollection Date: 2024-01-01 DOI: 10.3389/fchem.2024.1469520

Yong Hwan Kim, Seung Yong Lee, Yunseong Ji, Jeong Ho Lee, Dae Woo Kim, Byeongdeok Lee, Changhyun Jin, Kyu Hyoung Lee

{"title":"Stepwise emergence of CO gas sensing response and selectivity on SnO2 using C supports and PtOx decoration.","authors":"Yong Hwan Kim, Seung Yong Lee, Yunseong Ji, Jeong Ho Lee, Dae Woo Kim, Byeongdeok Lee, Changhyun Jin, Kyu Hyoung Lee","doi":"10.3389/fchem.2024.1469520","DOIUrl":"https://doi.org/10.3389/fchem.2024.1469520","url":null,"abstract":"Room temperature gas sensing is crucial for practical devices used in indoor environments. Among various materials, metal oxides are commonly used for gas sensing, but their strong insulating properties limit their effectiveness at room temperature. To address this issue, many studies have explored diverse methods such as nanoparticle decoration or conductive support, etc. Here, we report the emergence of gas-sensing functionality at room temperature with improved CO gas selectivity on SnO2 nanoparticles through sequential steps by using amorphous carbon (a-C) support and PtOx decoration. The SnO2 decorated on amorphous carbon shows enhanced gas adsorption compared to inactive gas sensing on SnO2 decorated carbon support. The higher Vo site of SnO2 on a-C induces gas adsorption sites, which are related to the higher sp2 bonding caused by the large density of C defects. The ambiguous gas selectivity of SnO2/a-C is tailored by PtOx decoration, which exhibits six values of sensing responses (Rg/Ra or Ra/Rg) under CO gas at room temperature with higher selectivity. Compared to PtOx/a-C, which shows no response, the enhanced CO gas sensing functionality is attributed to the CO adsorption site on PtOx-decorated SnO2 particles. This report not only demonstrates the applicability of CO gas sensing at room temperature but also suggests a strategy for using SnO2 and carbon compositions in gas sensing devices.","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11484019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient phosphate removal from water using ductile cast iron waste: a response surface methodology approach. 利用球墨铸铁废料高效去除水中的磷酸盐：一种响应面方法。

IF 3.8 3区化学

Frontiers in Chemistry Pub Date : 2024-10-02 eCollection Date: 2024-01-01 DOI: 10.3389/fchem.2024.1458420

Mai Hassan Roushdy, Nada Amr Elkhashab, Ahmed Ibrahim Osman, Dalia Amer Ali

{"title":"Efficient phosphate removal from water using ductile cast iron waste: a response surface methodology approach.","authors":"Mai Hassan Roushdy, Nada Amr Elkhashab, Ahmed Ibrahim Osman, Dalia Amer Ali","doi":"10.3389/fchem.2024.1458420","DOIUrl":"https://doi.org/10.3389/fchem.2024.1458420","url":null,"abstract":"Water scarcity is a critical issue worldwide. This study explores a novel method for addressing this issue by using ductile cast iron (DCI) solid waste as an adsorbent for phosphate ions, supporting the circular economy in water remediation. The solid waste was characterized using XRD, XRF, FTIR, and particle size distribution. Wastewater samples of different phosphate ion concentrations are prepared, and the solid waste is used as an adsorbent to adsorb phosphate ions using different adsorbent doses and process time. The removal percentage is attained through spectrophotometer analysis and experimental results are optimized to get the optimum conditions using Design Expert V13. The pseudo-second order (PSO) kinetics model and Langmuir isotherm were fitted with the experimental results with maximum adsorption capacity (qmax = 0.28 mg/g). The thermodynamic analysis indicated that this adsorption process was spontaneous based on the negative value of Gibbs free energy (∆G). Additionally, the positive values of enthalpy (∆H) indicated the endothermic nature of this adsorption system. It was able to reach the highest adsorption percentage of 98.9 (%) for phosphate ions from aqueous solutions using response surface methodology (RSM) with optimum conditions of 10 mg/L phosphate ion concentration, pH = 8, normal room temperature, 9 min adsorption, and 0.5 g/L adsorbent dosage.","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11479870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorinated aggregated nanocarbon with high discharge voltage as cathode materials for alkali-metal primary batteries. 作为碱金属原电池阴极材料的高放电电压含氟聚合纳米碳。

IF 3.8 3区化学

Frontiers in Chemistry Pub Date : 2024-10-02 eCollection Date: 2024-01-01 DOI: 10.3389/fchem.2024.1484668

Huixin Chen, Ke Yan, Yan Zou, Qi Xia, Xiaoyu Kang, Hongjun Yue, Ding Chen

{"title":"Fluorinated aggregated nanocarbon with high discharge voltage as cathode materials for alkali-metal primary batteries.","authors":"Huixin Chen, Ke Yan, Yan Zou, Qi Xia, Xiaoyu Kang, Hongjun Yue, Ding Chen","doi":"10.3389/fchem.2024.1484668","DOIUrl":"https://doi.org/10.3389/fchem.2024.1484668","url":null,"abstract":"Due to its exceptionally high theoretical energy density, fluorinated carbon has been recognized as a strong contender for the cathode material in lithium primary batteries particularly valued in aerospace and related industries. However, CF x cathode with high F/C ratio, which enables higher energy density, often suffer from inadequate rate capability and are unable to satisfy escalating demand. Furthermore, their intrinsic low discharge voltage imposes constraints on their applicability. In this study, a novel and high F/C ratio fluorinated carbon nanomaterials (FNC) enriched with semi-ionic C-F bonds is synthesized at a lower fluorination temperature, using aggregated nanocarbon as the precursor. The increased presence semi-ionic C-F bonds of the FNC enhances conductivity, thereby ameliorating ohmic polarization effects during initial discharge. In addition, the spherical shape and aggregated configuration of FNC facilitate the diffusion of Li+ to abundant active sites through continuous paths. Consequently, the FNC exhibits high discharge voltage of 3.15 V at 0.01C and superior rate capability in lithium primary batteries. At a high rate of 20C, power density of 33,694 W kg-1 and energy density of 1,250 Wh kg-1 are achieved. Moreover, FNC also demonstrates notable electrochemical performance in sodium/potassium-CF x primary batteries. This new-type alkali-metal/CF x primary batteries exhibit outstanding rate capability, rendering them with vast potential in high-power applications.","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11479893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142486067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal-organic framework (MOF) integrated Ti₃C₂ MXene composites for CO₂ reduction and hydrogen production applications: a review on recent advances and future perspectives. 用于二氧化碳还原和制氢应用的金属有机框架 (MOF) 集成 Ti3C2 MXene 复合材料：最新进展和未来展望综述。

IF 3.8 3区化学

Frontiers in Chemistry Pub Date : 2024-10-01 eCollection Date: 2024-01-01 DOI: 10.3389/fchem.2024.1448700

Beenish Tahir, Abdulrahman Alraeesi, Muhammad Tahir

{"title":"Metal-organic framework (MOF) integrated Ti3C2 MXene composites for CO2 reduction and hydrogen production applications: a review on recent advances and future perspectives.","authors":"Beenish Tahir, Abdulrahman Alraeesi, Muhammad Tahir","doi":"10.3389/fchem.2024.1448700","DOIUrl":"https://doi.org/10.3389/fchem.2024.1448700","url":null,"abstract":"Titanium carbide (Ti3C2) MXenes due to their structural and optical characteristics rapidly emerged as the preferred material, particularly in catalysis and energy applications. On the other hand, because of its enormous surface/volume ratio and porosity, Metal-organic Frameworks (MOFs) show promise in several areas, including catalysis, delivery, and storage. The potential to increase the applicability of these magic compounds might be achieved by taking advantage of the inherent flexibility in design and synthesis, and optical characteristics of MXenes. Thus, coupling MOF with Ti3C2 MXenes to construct hybrid composites is considered promising in a variety of applications, including energy conversion and storage. This paper presents a systematic discussion of current developments in Ti3C2 MXenes/MOF composites for photocatalytic reduction of CO2, and production of hydrogen through water splitting. Initially, the overview and characteristics of MXenes and MOFs are independently discussed and then a detailed investigation of efficiency enhancement is examined. Different strategies such as engineering aspects, construction of binary and ternary composites and their efficiency enhancement mechanism are deliberated. Finally, different strategies to explore further in various other applications are suggested. Although Ti3C2 MXenes/MOF composites have not yet been thoroughly investigated, they are potential photocatalysts for the production of solar fuel and ought to be looked into further for a range of applications.","PeriodicalId":12421,"journal":{"name":"Frontiers in Chemistry","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11473348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: Natural products from plants or microorganisms for treatment of non- communicable diseases. 社论：用于治疗非传染性疾病的植物或微生物天然产品。

IF 3.8 3区化学

Frontiers in Chemistry Pub Date : 2024-10-01 eCollection Date: 2024-01-01 DOI: 10.3389/fchem.2024.1496038

Sakina Yagi, Dominique Laurain-Mattar, Gokhan Zengin

引用次数: 0