Food Bioscience最新文献

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Investigating characteristic fingerprints and volatile flavor compound variations during the fermentation of Guangxi bamboo shoot using HS-GC-IMS and HS-SPME-GC-MS 利用 HS-GC-IMS 和 HS-SPME-GC-MS 研究广西竹笋发酵过程中的特征指纹和挥发性风味化合物变化
IF 4.8 1区 农林科学
Food Bioscience Pub Date : 2024-09-07 DOI: 10.1016/j.fbio.2024.105071
{"title":"Investigating characteristic fingerprints and volatile flavor compound variations during the fermentation of Guangxi bamboo shoot using HS-GC-IMS and HS-SPME-GC-MS","authors":"","doi":"10.1016/j.fbio.2024.105071","DOIUrl":"10.1016/j.fbio.2024.105071","url":null,"abstract":"<div><p>Fermentation assumes a crucial role in the flavor formation of Guangxi fermented bamboo shoots (GFBS). However, the dynamics of volatile organic compounds (VOCs) during GFBS fermentation remain poorly understood. Thus, we used HS-GC-IMS and HS-SPME-GC-MS to investigate the changes in VOCs composition during GFBS fermentation, providing clear differentiation for the fermentation stages of GFBS. We identified 96 VOCs by GC-MS and 26 VOCs by GC-IMS, among which 11 VOCs were concurrently detected by both methods. Most of these VOCs were produced during the early and mid-fermentation stages. In addition, 24 VOCs were marker VOCs of GFBS during different fermentation stages. Notably, acetic acid, nonenal, (+)-beta-cedrene, 2-pinene, 2, 6-dimethylpyrazine, and trimethylbenzene can be used as markers for the late fermentation of GFBS. These results not only illuminate the complex changes in VOCs, but also provide valuable insights for enhancing fermentation techniques to enhance the flavor quality of GFBS.</p></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in extraction, structural design, functional activity and application of yeast protein peptides 酵母蛋白肽的提取、结构设计、功能活性和应用研究进展
IF 4.8 1区 农林科学
Food Bioscience Pub Date : 2024-09-07 DOI: 10.1016/j.fbio.2024.105026
{"title":"Advances in extraction, structural design, functional activity and application of yeast protein peptides","authors":"","doi":"10.1016/j.fbio.2024.105026","DOIUrl":"10.1016/j.fbio.2024.105026","url":null,"abstract":"<div><div>Bioactive peptides are protein fragments released from proteins with diverse functions and significant physiological roles. Yeast consists of 40–60% protein and serves as a high-quality source of microbial proteins. Depending on the variety of the yeasts, the various bioactive peptides can be produced through processes such as enzymolysis, autolysis, fermentation, and secondary metabolite release, and they exhibit different functional properties such as hypoglycemic, antioxidant, antihypertensive, and immune-enhancing activities. The conventional enzymatic process of extracting active peptides from proteins is laborious and time-consuming and often needs more determination of peptide functions. The primary objective of this review is to delve into the precise design of active peptides utilizing computer simulation technology. Also, the review covers the extraction and purification processes of yeast functional peptides, explores the relationship between structural features and the active efficacy of yeast peptides, and discusses the applications of these peptides in food and medicine. This review is expected to be beneficial for providing a theoretical foundation for the further development and utilization of yeast peptides.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipid digestion profiles of pickering emulsion gels stabilized by β-glucans microgel particles 用β-葡聚糖微凝胶颗粒稳定的皮克林乳液凝胶的脂质消化曲线
IF 4.8 1区 农林科学
Food Bioscience Pub Date : 2024-09-07 DOI: 10.1016/j.fbio.2024.105069
{"title":"Lipid digestion profiles of pickering emulsion gels stabilized by β-glucans microgel particles","authors":"","doi":"10.1016/j.fbio.2024.105069","DOIUrl":"10.1016/j.fbio.2024.105069","url":null,"abstract":"<div><p>Pickering emulsion gels (PEGs) stabilized by microgel particles (MPs) have a wide range of applications. However, the extent and mechanisms of lipid digestion in these PEGs are still unclear. In this study, we explored how the concentration of β-glucans MPs and different stabilizers influence the lipid digestion profiles. Our findings revealed a significant role of β-glucans MPs in modulating lipid digestion, with a reduction in lipid digestion rate and extent correlated with an increase in MPs concentration. Notably, compared to droplets stabilized by other agents, emulsions stabilized by β-glucans MPs exhibited the lowest initial release rate (0.81 ± 0.08 FFA%/min) and final degree of digestion (18.96% ± 0.42%) of free fatty acids. Lipid droplets stabilized by β-glucan MPs were able to effectively resist the effects of high ionic strength and complex components in the oral and gastric environments, maintaining their structural integrity and preventing droplet aggregation. Our results indicated that β-glucans MPs are not only effective stabilizers but also provide a novel approach to controlling lipid digestibility.</p></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142172423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary heme-enriched Corynebacterium extract exerts health benefits by reshaping gut microbiota 膳食血红素富集棒状杆菌提取物通过重塑肠道微生物群对健康有益
IF 4.8 1区 农林科学
Food Bioscience Pub Date : 2024-09-06 DOI: 10.1016/j.fbio.2024.105062
{"title":"Dietary heme-enriched Corynebacterium extract exerts health benefits by reshaping gut microbiota","authors":"","doi":"10.1016/j.fbio.2024.105062","DOIUrl":"10.1016/j.fbio.2024.105062","url":null,"abstract":"<div><p>We previously reported that a heme-enriched <em>Corynebacterium</em> extract (hSCP) alleviated weight gain and lowered subcutaneous fat mass in a murine model. To understand the mechanisms underlying the beneficial effects of dietary hSCP, we investigated the histological and microbiological changes in the guts of mice after hSCP administration in this study. Dietary hSCP lowered serum triglyceride and cholesterol levels and restrained adipose tissue expansion in mice fed a normal diet (ND) or a high-fat diet (HFD). The colonic mucosa was prominently lined with acidic and neutral mucin-enriched goblet cells and Muc2 transcription was increased by dietary hSCP in HFD-fed mice. Given the nutritional content of hSCP, microbial shifts triggered by dietary hSCP were dissected from the cecum and colon of the mice. Bacterial community compositions in the luminal contents were significantly reshaped by hSCP supplementation in HFD-fed mice and also differed between intestinal loci, that is, the cecum and colon. Dietary hSCP enriched short-chain fatty acid-producing bacterial genera in ND-fed mice, while attenuating other mucin-degrading bacteria in HFD-fed mice. The addition of hSCP to a co-culture of a defined microbiota community promoted <em>Lactobacillus gasseri</em> proliferation compared with nine other species. An <em>in vitro</em> culture medium supplemented with hSCP increased bile salt hydrolase activity and cholesterol assimilation by <em>L. gasseri</em>, which is reminiscent of the beneficial effects of <em>Lactobacillus</em> spp. as cholesterol-lowering probiotics. Our findings demonstrate the potential of hSCP as a dietary supplement with beneficial effects on lipid metabolism and gut health.</p></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212429224014925/pdfft?md5=88d9a89574782eebe783672b90c48b74&pid=1-s2.0-S2212429224014925-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142158336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interesterified palm oil leads to distinct variation in the intestinal microbiota of mice 酯化棕榈油导致小鼠肠道微生物群发生明显变化
IF 4.8 1区 农林科学
Food Bioscience Pub Date : 2024-09-06 DOI: 10.1016/j.fbio.2024.105032
{"title":"Interesterified palm oil leads to distinct variation in the intestinal microbiota of mice","authors":"","doi":"10.1016/j.fbio.2024.105032","DOIUrl":"10.1016/j.fbio.2024.105032","url":null,"abstract":"<div><p>Interesterified fat (IF) has been established as a substitute for trans-fat in ultra-processed foods. Preclinical studies have demonstrated that IF increases intestinal barrier permeability and bacterial translocation, but it is still unknown its impacts on the intestinal microbiota. Thus, this study aimed to evaluate if IF modulates the intestinal microbiota and the production of short-chain fatty acids (SCFAs) by the intestinal bacteria of male Swiss mice fed control or high-fat diet, with or without IF. Animals were divided into groups that received anormolipidic control diet (10% of calories from lipids) or high-fat diet (45% of calories from lipids) containing unmodified fat or IF, both obtained from palm oil: CT (Control diet); ICT (Interesterified Control diet); HF (High-fat diet); IHF (Interesterified High-fat diet) for eight weeks. Fecal samples were collected directly from the animals' colons for processing. The SCFA production was analyzed by gas chromatography. For microbiota diversity, bioinformatics analysis was carried out. Significant differences in microbiota composition at the phylum level were not observed between diet groups. However, a reduction in abundance of the <em>Lactobacillus</em> and <em>Enterococcus</em> genera, and an increase in the <em>Peptococcus</em> genus were found in high-fat diet groups. Interestingly, in the normolipid diet group with IF (ICT group), the animals showed microbiota composition similar to those found in animals that consumed high-fat diets. These alterations negatively interfered with the production of acetate and butyrate and may influence intestinal homeostasis and compromise metabolism. This study opens important discussions about the physiological impact of IF in health.</p></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sinensetin from citrus peel alleviates DSS-induced inflammation by regulating gut microbiota and serum metabolism in mice 柑橘皮中的西奈素通过调节小鼠肠道微生物群和血清代谢来缓解 DSS 诱导的炎症
IF 4.8 1区 农林科学
Food Bioscience Pub Date : 2024-09-06 DOI: 10.1016/j.fbio.2024.105066
{"title":"Sinensetin from citrus peel alleviates DSS-induced inflammation by regulating gut microbiota and serum metabolism in mice","authors":"","doi":"10.1016/j.fbio.2024.105066","DOIUrl":"10.1016/j.fbio.2024.105066","url":null,"abstract":"<div><p>Sinensetin is a polymethoxylated flavone, which is considered to be an important functional composition in citrus peels. In this study, the anti-inflammatory effect and potential mechanism of sinensetin were evaluated by multi-omics analysis in the dextran sulfate sodium (DSS)-induced colitis model. The results showed that sinensetin significantly inhibited inflammation and alleviated gut microbiota imbalance in the DSS-induced mice. Sinensetin supplementation increased the abundance of <em>Faecalibaculum</em>, <em>Colidextribacter</em>, <em>Lachnospiraceae_NK4A136_group</em>, <em>norank_f_norank_Clostridia_UCG-014</em> and <em>Christensenella</em>, reduced abundance of <em>Bacteroides</em>, <em>Escherichia-Shigella</em>, <em>Parasutterella</em> and <em>Clostridium_sensu_stricto_1</em>. The metabolome of serum samples showed 117 differential metabolites were significantly altered by sinensetin supplementation in colitis mice, and 24 of these metabolites were involved in the Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathway. KEGG predictions based on both gut microbiota and serum metabolites suggested that cysteine and methionine metabolism are mainly affected by sinensetin supplementation. These results indicate that sinensetin inhibit DSS-induced colitis by modulating gut microbiota and ameliorating serum metabolism.</p></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142172421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural characterization and prebiotic activity evaluation of novel fucosylated disaccharides prepared from bacterial exopolysaccharides 从细菌外多糖制备的新型岩藻糖基化二糖的结构表征和益生活性评估
IF 4.8 1区 农林科学
Food Bioscience Pub Date : 2024-09-06 DOI: 10.1016/j.fbio.2024.105055
{"title":"Structural characterization and prebiotic activity evaluation of novel fucosylated disaccharides prepared from bacterial exopolysaccharides","authors":"","doi":"10.1016/j.fbio.2024.105055","DOIUrl":"10.1016/j.fbio.2024.105055","url":null,"abstract":"<div><p>The deoxyhexose sugar <span>l</span>-fucose and fucosylated oligosaccharides (FCO) are essential for various biological processes in human body and associated gut microbiota. Bacterial exopolysaccharides offer a promising new source for preparing functional oligosaccharides. Here, FCO were obtained through acidolysis of fucose-containing exopolysaccharides with a molecular weight of 5.9 × 10<sup>3</sup> kDa, derived from <em>Clavibacter michiganensis</em> M2. Structural analysis revealed that the main disaccharide components of FCO exhibited a molecular weight of 326 Da and a monosaccharide composition of fucose, galactose, and glucose in a 3:1:2 ratio. Nuclear magnetic resonance indicated that the disaccharide fragments consisted of two backbones of α-<em>Galp</em>-(1 → 2)-α-<em>Fucp</em> and β-<em>Glcp</em>-(1 → 4)-β-<em>Fucp</em>, respectively. <em>In vitro</em> fermentation of FCO with human fecal cultures resulted in an increased abundance of <em>Bifidobacterium</em> and <em>Bacteroides</em>, and a reduction in <em>Escherichia-Shigella</em> and <em>Fusobacterium</em>. This research outlines a novel structural fucosylated oligosaccharide and its preparation method, suggesting its potential application as a promising new prebiotic.</p></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142158277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phosvitin phosphopeptides and peptides-calcium chelate promote calcium deposition in a three-cell co-culture system by modulating the OPG/RANKL/RANK signaling pathway Phosvitin 磷酸肽和肽钙螯合物通过调节 OPG/RANKL/RANK 信号通路促进三细胞共培养系统中的钙沉积
IF 4.8 1区 农林科学
Food Bioscience Pub Date : 2024-09-06 DOI: 10.1016/j.fbio.2024.105065
{"title":"Phosvitin phosphopeptides and peptides-calcium chelate promote calcium deposition in a three-cell co-culture system by modulating the OPG/RANKL/RANK signaling pathway","authors":"","doi":"10.1016/j.fbio.2024.105065","DOIUrl":"10.1016/j.fbio.2024.105065","url":null,"abstract":"<div><p>Phosvitin (PV) is a highly phosphorylated protein found in egg yolk. PV hydrolysate (PPP) has excellent calcium-binding capacity, although its ability to promote calcium deposition and the underlying mechanism are unclear. This study aimed to explore the calcium deposition capacity and mechanisms of PPP and PPP-Ca. The fraction 3 (PPP3) was isolated by anion-exchange chromatography and exhibited the best calcium-binding activity (98.11 ± 0.91%). To mimic the microenvironment of bone formation, a three-cell co-culture model of intestinal epithelial cells-osteoblasts-osteoclasts (Caco-2/MC3T3-E1/RAW264.7) was established. The alkaline phosphatase results indicated that PPP3 and PPP3-Ca significantly promoted osteoblasts differentiation compared to CaCl<sub>2</sub>. Correspondingly, PPP3, PPP3-Ca, and CaCl<sub>2</sub> reduced tartrate resistant acid phosphatase content by 43.84%, 46.92% and 17.21%, respectively, suggesting that PPP3 and PPP3-Ca effectively inhibited osteoclasts differentiation. The molecular mechanism by which PPP3 and PPP3-Ca inhibited osteoclasts bone resorption involved regulating mRNA expression of the OPG/RANKL/RANK pathway. Notably, PPP3-Ca demonstrated higher pro-calcium deposition in co-cultured cells, about 1.70 times higher than CaCl<sub>2</sub>. PPP3-Ca dependent high phosphorylation exerted a pro-mineralization effect, as analyzed by scanning electron microscopy and energy dispersive spectroscopy. Overall, this study suggested that PPP3-Ca as organic calcium was more effective than CaCl<sub>2</sub> in promoting calcium deposition.</p></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142162695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fabrication of a novel electrochemical aptasensor based on conductive polymers and graphite sheet for measuring tetracycline antibiotic in milk, egg, and honey 基于导电聚合物和石墨片的新型电化学传感器的制作,用于测量牛奶、鸡蛋和蜂蜜中的四环素抗生素含量
IF 4.8 1区 农林科学
Food Bioscience Pub Date : 2024-09-06 DOI: 10.1016/j.fbio.2024.105068
{"title":"Fabrication of a novel electrochemical aptasensor based on conductive polymers and graphite sheet for measuring tetracycline antibiotic in milk, egg, and honey","authors":"","doi":"10.1016/j.fbio.2024.105068","DOIUrl":"10.1016/j.fbio.2024.105068","url":null,"abstract":"<div><p>In this research, an electrochemical aptasensor was made for the detection of tetracycline (TET) antibiotic in food samples. The graphite sheet was modified for the first time by electrochemical co-polymerization of anthranilic acid and aniline, which increases the active surface and electrical conductivity of the electrode and is also a suitable substrate for covalent bonding with aptamers. This electrode was examined and characterized by electrochemical methods, Fourier transform infrared (FTIR) spectroscopy, atomic force microscopy (AFM), field emission scanning electron microscopy (FESEM), and X-ray energy dispersive (EDS) techniques. Then, the Apt-TET aptamer sequence was self-assembled on the electrode to increase the selectivity of the electrode response. The optimization of important parameters including the TET detection time, aptamer immobilization time, and Apt-TET aptamer concentration was performed. The aptasensor was used to measure the TET by differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS) techniques in 0.1 M KCl solution in the presence of Fe(CN)<sub>6</sub><sup>4−/3-</sup> redox prob. The proposed aptasensor has a very wide linear range from 1 × 10<sup>−6</sup> to 1 × 10<sup>−16</sup> M with a detection limit of 3.3 × 10<sup>−17</sup> M. The developed aptasensor was successfully applied for the determination of TET in milk, egg, and honey samples.</p></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142162690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Apple vescicles: Revolutionary gut microbiota treatment for Inflammatory Bowel Disease 苹果囊泡治疗炎症性肠病的革命性肠道微生物群疗法
IF 4.8 1区 农林科学
Food Bioscience Pub Date : 2024-09-05 DOI: 10.1016/j.fbio.2024.105052
{"title":"Apple vescicles: Revolutionary gut microbiota treatment for Inflammatory Bowel Disease","authors":"","doi":"10.1016/j.fbio.2024.105052","DOIUrl":"10.1016/j.fbio.2024.105052","url":null,"abstract":"<div><p>Inflammatory bowel disease (IBD) causes chronic inflammation of the digestive system and can affect both humans and household pets like dogs. Despite extensive research, a definitive cure remains elusive. This study investigates the therapeutic potential of apple-derived extracellular vesicles (ADEVs) in canine IBD. ADEVs, isolated from 'Golden Delicious' apples, were orally administered to dogs with IBD over a ten-day period. Microbiota analysis, clinical assessments, endoscopic examinations, and ultrasound imaging showed a significant reduction in disease severity and post-treatment symptoms. The results indicate that ADEVs regulate intestinal microorganism growth and interact with host cells. In particular IgA and calprotectine level riched physiological level, as well as microbiota and intestinal mucose. These results can explained thanks to the soothing effect of ADEVs on IBD may be due to a synergistic regulatory impact on both intestinal flora and the host's inflammatory response. Overall, these findings suggest a promising new avenue for IBD treatment.</p></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2212429224014822/pdfft?md5=e16d8c1d392877a663bbe3c3a85ce8bd&pid=1-s2.0-S2212429224014822-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142151302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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