Food Bioscience最新文献

{"title":"Comprehensive review of anti-nutrients in Millets: Thermal and non-thermal reducing techniques","authors":"Shagolshem Mukta Singh,&nbsp;Jayasree Joshi T.,&nbsp;Sivaranjani S,&nbsp;Nelluri Puja,&nbsp;Meena Nagarajan,&nbsp;Prashant Kumar,&nbsp;Pavuluri Srinivasa Rao","doi":"10.1016/j.fbio.2025.106949","DOIUrl":"10.1016/j.fbio.2025.106949","url":null,"abstract":"<div><div>This review article provides a comprehensive overview of millet's anti-nutrients and discusses their impacts on human health and interactions with other nutrients. The anti-nutrients bind to essential minerals such as calcium, iron, zinc, and magnesium, reducing their absorption. This can lead to deficiencies, especially in diets that rely heavily on millet or other foods high in anti-nutrients. Their presence negatively impacts the growth and functioning of humans, as it prevents the absorption or utilization of other food nutrients or induces discomfort and stress in humans. The study also explained various traditional and modern processing methods, such as conventional, thermal, and non-thermal techniques, which can effectively reduce these compounds and enhance the nutritional value of millets. Developing sustainable and economically feasible methods will further facilitate the widespread adoption of these practices, making millet a more attractive and nutritious option.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"69 ","pages":"Article 106949"},"PeriodicalIF":4.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144177512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence empowered evolution in medicine food homology: Innovations, challenges, and future prospects","authors":"Lihui Zhang ,&nbsp;Binbin Liao ,&nbsp;Dahui Liu ,&nbsp;Qiyong Jiang ,&nbsp;Qing Sun","doi":"10.1016/j.fbio.2025.106928","DOIUrl":"10.1016/j.fbio.2025.106928","url":null,"abstract":"<div><div>Artificial Intelligence (AI) is revolutionizing the medicine food homology (MFH) industry by enhancing cultivation, processing, and traceability, leading to greater efficiency, quality, and sustainability. This review explores the challenges in AI's application in MFH, including accurate identification, quality management, and chemical composition variability, as well as technical hurdles in function prediction. It highlights how AI technologies, integrated with data-driven models, are addressing key aspects of MFH production such as precise quality assessment, compositional analysis, and monitoring of growth environments. AI systems are improving the accuracy of MFH production identification and boosting the prediction of functional properties. The integration of AI is bringing significant advancements in quality control, sustainability, and efficiency, ensuring better yields and enhancing traceability throughout the MFH supply chain to guarantee quality and safety.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"69 ","pages":"Article 106928"},"PeriodicalIF":4.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative approaches in microbial fermentation of underutilized crops for enhanced nutritional and bioactive functionalities","authors":"Johnmel A. Valerozo ,&nbsp;Daniel Rice ,&nbsp;Dionisio S. Bucao ,&nbsp;Rhian Jaymar D. Ramil ,&nbsp;Shirley C. Agrupis ,&nbsp;Anil Kumar Anal","doi":"10.1016/j.fbio.2025.106941","DOIUrl":"10.1016/j.fbio.2025.106941","url":null,"abstract":"<div><div>Fermentation has long played a vital role in enhancing food preservation and nutritional quality. As global food demand continues to rise, there is growing interest in utilizing sustainable plant-based sources to support food security and health. Underutilized crops—including cereals, pseudocereals, root and tuber crops, and aquatic plants—offer significant nutritional potential but are often limited by the presence of anti-nutritional factors that reduce bioavailability. Microbial activity during fermentation enhances vitamin levels, mineral bioavailability, protein digestibility, and the formation of health-promoting bioactive compounds. Technological advancements in microbial strain selection, bioprocessing methods, and green processing techniques—such as germination, ultrasonication, and microwave treatment—have further improved fermentation efficiency. The integration of artificial intelligence and multi-omics tools enables more precise microbial selection and process optimization. However, challenges remain in standardizing fermentation protocols and increasing consumer acceptance. Future research should focus on interdisciplinary strategies that bridge food science, biotechnology, and nutrition to promote the adoption of fermented underutilized crops. These innovations represent a promising pathway toward resilient, nutrient-dense, and sustainable food systems.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"69 ","pages":"Article 106941"},"PeriodicalIF":4.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential anticancer therapeutic targets of resveratrol and its role in the therapy of hepatocellular carcinoma","authors":"Wasnaa H. Mohammed ,&nbsp;Ghassan M. Sulaiman ,&nbsp;Hamdoon A. Mohammed","doi":"10.1016/j.fbio.2025.106935","DOIUrl":"10.1016/j.fbio.2025.106935","url":null,"abstract":"<div><div>Resveratrol (RES) is a stilbene natural phytoestrogen with anti-cancer, antioxidant, cardioprotective, and anti-inflammatory properties. This review explores the therapeutic potential of RES in hepatocellular carcinoma (HCC) by emphasizing its mechanisms of action. Plant-based natural sources of RES, such as cereals, fruits, and vegetables, have been found to be effective and safe in treating various illnesses, including cancer and inflammation. Literature suggested that RES may protect the liver from developing hepatocellular carcinoma (HCC) in its early stages. The compound also induces apoptosis in abnormally growing hepatocytes. Moreover, RES also significantly reduces angiogenesis and metastasis, which are two hallmarks of advanced cancer stages. RES caused apoptosis and prevented HCC cell lines (HepG2) from proliferating, migrating, and invading. Additionally, RES has been shown to greatly enhance the effectiveness of chemotherapy drugs by working together with them and making cancer cells more sensitive to treatment. Therefore, several targets have been connected to RES as molecular mechanisms by which the compound induces combat against hepatocellular carcinoma (HCC). This review discusses RES's natural sources, biosynthesis, bioavailability, and improved synthetic derivatives, as well as a comprehensive overview of the metabolic and cellular signaling pathways influenced by RES in HCC. The review also discussed the beneficial role of RES in liver disorders. We also want to identify future studies that will maximize the therapeutic potential of RES in HCC.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"69 ","pages":"Article 106935"},"PeriodicalIF":4.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valorisation of spent coffee grounds in the context of prebiotic potential: a review","authors":"Manxi Huang,&nbsp;Afroditi Chatzifragkou,&nbsp;Robert A. Rastall","doi":"10.1016/j.fbio.2025.106936","DOIUrl":"10.1016/j.fbio.2025.106936","url":null,"abstract":"<div><div>Spent coffee grounds (SCGs) are the solid residues generated after coffee brewing and have been widely researched due to their rich carbohydrate content. Beyond energy generation, there is a growing interest in developing functional food ingredients. This review focuses on assessing various extraction methods for SCG-derived compounds in terms of their prebiotic potential.</div><div>One common type of functional carbohydrate extracted from SCGs is mannooligosaccharides (MOS), primarily obtained through single-stage and enhanced extraction strategy. Single-stage extraction often uses one method, with integrated mechanism and yields oligosaccharides and monosaccharides. On the other hand, the enhanced extraction combines pre-treatments and enzymatic hydrolysis to increase the SCG extractability and selectively degrade polysaccharides. This method yields fewer undesired by-products and aims to avoid complete hydrolysis of SCG into monosaccharides.</div><div>In this review, several research gaps were identified in relation to fully valorise SCG. First, there is a critical gap in standardized analytical methods for accurately determining the profile of extracted oligosaccharides. Developing and adopting validated techniques is essential for a reliable characterization of these compounds. Second, the efficacy of pretreatment processes on SCG remains challenging to assess due to the lack of uniform evaluation criteria. Establishing such criteria would help compare across studies, ensuring more consistent assessment of pretreatment outcomes. Finally, the criteria for confirming prebiotic potential in SCG-derived compounds are not well understood. It is essential to adhere to established definitions of the term ‘prebiotic’ and to apply validated methodologies to assess their prebiotic status.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"69 ","pages":"Article 106936"},"PeriodicalIF":4.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and advances in liposome formulation technology with an emphasis on ensuring safety and quality in food and drug applications","authors":"Pawan Prabhakar ,&nbsp;Soubhagya Tripathy ,&nbsp;Deepak Kumar Verma ,&nbsp;Smita Singh ,&nbsp;Mamta Thakur ,&nbsp;Amit Kumar Singh ,&nbsp;Prem Prakash Srivastav ,&nbsp;Mamoni Banerjee ,&nbsp;Ami R. Patel ,&nbsp;Mónica L. Chávez González ,&nbsp;Gemilang Lara Utama ,&nbsp;José Sandoval-Cortés ,&nbsp;Cristobal Noe Aguilar","doi":"10.1016/j.fbio.2025.106913","DOIUrl":"10.1016/j.fbio.2025.106913","url":null,"abstract":"<div><div>Liposomes (LPs) are capable of transporting a wide range of bioactive compounds (BACs) that have significant applications in the pharmaceutical, food, and cosmetic industries. These BACs can be administered through various routes, including parenteral (injection), oral ingestion, or transdermal absorption. In addition, there have been limited studies conducted on the toxicological and safety aspects of LPs. This highlights the need for more research to be conducted on the potential risks of oral exposure before considering their use in food applications. Therefore, the purpose of this review is to present the latest information on the composition of LP, the materials used to coat LPs for applications in the pharmaceutical and food industries to enhance the stability of LPs containing delicate BACs, and the absorption of LPs and commercially available liposomal products produced using different technologies in the market. In addition, this paper revisits various advanced technologies used in the field of food and nutraceutical processing. These technologies include the supercritical fluid method, supercritical antisolvent method, supercritical reverse phase evaporation method, micro-fluidization, and ultrasonication. The article also discusses the applications of these technologies.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"69 ","pages":"Article 106913"},"PeriodicalIF":4.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable Agaricus bisporus preservation: A novel approach using biopolymeric nanoparticle-stabilized essential oil coatings","authors":"Liela M. Ali ,&nbsp;Engy Shams-Eldin ,&nbsp;Entsar S. Abdou ,&nbsp;Reham M. Kamel","doi":"10.1016/j.fbio.2025.106921","DOIUrl":"10.1016/j.fbio.2025.106921","url":null,"abstract":"<div><div>This study developed stable Pickering emulsions of tea tree oil (TTO) using chitosan-Arabic gum nanoparticles (Ch-AG NPs) as stabilizers and evaluated their effectiveness as edible coatings for preserving <em>Agaricus bisporus</em> mushrooms during storage. Ch-AG NPs were synthesized at three different weight ratios (1:1, 1:2, and 2:1), with the optimal 1:2 ratio yielding the smallest particle size (122.4 nm) and a contact angle of 85.5°, which is ideal for oil-in-water emulsion stabilization. Pickering emulsions were formulated with varying TTO volume fractions (0.5 %, 0.7 %, 1.0 %, and 1.5 %), and increasing TTO content enhanced film properties by increasing thickness, tensile strength, and elongation at break while reducing the water vapor transmission rate (WVTR). Specifically, at 1.0 % TTO, tensile strength doubled, and WVTR decreased by 37 % compared to the control, indicating improved water resistance and mechanical strength. When applied as coatings, emulsions with 0.7 % and 1.0 % TTO effectively minimized weight loss, maintained firmness, reduced decay incidence, and slowed browning. After seven days of storage, mushrooms coated with Ch-AG-1.0TTO exhibited the lowest weight loss (0.34 %), the highest firmness (2.75 N), and a decay incidence of just 16.66 %, significantly outperforming the control (9.51 % weight loss, 83.45 % decay incidence). These findings highlight the potential of Ch-AG-TTO emulsions as natural preservative coatings to extend the shelf life of mushrooms, offering an eco-friendly and effective alternative for food preservation. This approach demonstrates the promising application of biopolymeric nanoparticles in sustainable food packaging, contributing to reduced food waste, improved storage stability, and enhanced food safety.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"71 ","pages":"Article 106921"},"PeriodicalIF":4.8,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on the preparation and synthesis strategies, mechanism and applications of different glucosamine salts and derivatives","authors":"Tong Zhang ,&nbsp;Haoyue Yang ,&nbsp;Guantian Li ,&nbsp;Kecheng Li ,&nbsp;Song Liu ,&nbsp;Huahua Yu ,&nbsp;Ronge Xing","doi":"10.1016/j.fbio.2025.106923","DOIUrl":"10.1016/j.fbio.2025.106923","url":null,"abstract":"<div><div>Glucosamine (GlcN), a naturally occurring amino monosaccharide, has demonstrated significant biological activities and has been widely applied in pharmaceutical, nutraceutical, and cosmetic industries. However, the inherent instability of pure GlcN necessitates its stabilization through salt formation, primarily as hydrochloride and sulfate salts. Currently, these salts are predominantly obtained through chemical hydrolysis of chitin, a polysaccharide derived from crustacean exoskeletons. Recent studies have revealed that different salt forms exhibit distinct biological activities, with some organic salts demonstrating superior bioactivity compared to traditional inorganic salts. This highlights the importance of investigating green preparation methods, diverse salt formation techniques, and comparative bioactivity assessments. This review systematically examines recent advancements in the preparation methodologies, derivatisation approaches, and application potentials of various GlcN salts, with particular emphasis on sustainable production technologies and structure-activity relationships.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"69 ","pages":"Article 106923"},"PeriodicalIF":4.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular vesicles from Lactiplantibacillus plantarum: A novel approach to lowering 5-ASA dosage in ulcerative colitis","authors":"Yunjing Tao ,&nbsp;Huijuan Ren ,&nbsp;Weilin Chen ,&nbsp;Ya Gao ,&nbsp;Sheng Liu ,&nbsp;Kangliang Sheng ,&nbsp;Yongzhong Wang","doi":"10.1016/j.fbio.2025.106917","DOIUrl":"10.1016/j.fbio.2025.106917","url":null,"abstract":"<div><div>5-ASA remains the main treatment for UC but faces challenges such as side effects and poor compliance. To address these issues, reducing the dosage and minimizing adverse reactions are pressing priorities. <em>Lactiplantibacillus plantarum</em>, a food-derived probiotic, is recognized for its biological safety. Its extracellular vesicles (LP-EVs), as a new biological agent, have more stable properties than probiotics. Therefore, this study aimed to evaluate whether combination therapy consisting of dose-reduced 5-ASA and LP-EVs could achieve the goal of reducing the 5-ASA dosage without compromising therapeutic efficacy. The combination of LP-EVs and 5-ASA was tested <em>in vivo</em>. The mRNA levels of inflammatory cytokines and tight junction proteins were measured by RT-qPCR. Changes in gut microbiota were analyzed via 16S rRNA sequencing. Results demonstrated that the combined treatment significantly improved colonic tissue barrier function and reduced inflammation in the colitis mouse model, as indicated by improvements in body weight and colon length, along with decreased DAI and histopathology scores. The combination therapy significantly suppressed pro-inflammatory cytokines (<em>IL-1β</em>, <em>IL-6</em>, <em>IL-18</em>, and <em>TNF-α</em>), while upregulating the anti-inflammatory cytokine <em>IL-10</em> and tight junction proteins (<em>ZO-1</em>, <em>Occludin</em>, and <em>Claudin-1</em>). This treatment also activated <em>GPR35</em> and <em>AHR</em> levels. Gut microbiota analysis revealed enrichment of <em>Romboutsia</em> and <em>Muribaculum</em>, suppression of <em>Clostridium</em>, <em>Anaerostipes</em>, and <em>Helicobacter</em>. These findings suggest that the combination of half-dose 5-ASA and LP-EVs is non-inferior to full-dose 5-ASA in alleviating colitis symptoms. This study presents a promising combination therapy for UC using half-dose 5-ASA and LP-EVs, providing a strategy to reduce the required dosage of 5-ASA.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"69 ","pages":"Article 106917"},"PeriodicalIF":4.8,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperspectral imaging-based quality assessment of salted radish with spectral feature selection","authors":"Jong-Jin Park ,&nbsp;Jeong-Seok Cho ,&nbsp;Gyuseok Lee ,&nbsp;Seul-Ki Park ,&nbsp;Dae-Yong Yun ,&nbsp;Hyo Jin Kim ,&nbsp;Jeong-Hee Choi ,&nbsp;Kee-Jai Park ,&nbsp;Jeong-Ho Lim","doi":"10.1016/j.fbio.2025.106912","DOIUrl":"10.1016/j.fbio.2025.106912","url":null,"abstract":"<div><div>This study aimed to use hyperspectral imaging in nondestructive monitoring of the changes in radish quality during salting process and to enhance the efficiency and accuracy of the prediction models through feature selection techniques. Hyperspectral imaging was utilized to predict the salinity, moisture content, and work of penetration (WOP) of radishes. Salinity increased with the prolonged salting time, whereas the moisture content and WOP decreased. Prediction using a partial least squares regression (PLSR) model based on full-wavelength hyperspectral data, resulted in the R_p² values for salinity, moisture content, and WOP being 0.909, 0.725, and 0.705, respectively. Feature selection methods, including competitive adaptive reweighted sampling (CARS), uninformative variable elimination (UVE), and their combinations, were applied to extract informative wavelengths for each quality parameter. With UVE + CARS, high R_p² values were achieved for salinity (0.934) and moisture content (0.846) using only 32.2 % and 25.7 % of the full-wavelengths, respectively. Similarly, R_p² values for WOP (0.717) improved with CARS, utilizing 31.8 % of the full-wavelengths. Hyperspectral imaging, coupled with suitable feature selection, not only improved the efficiency and accuracy of quality assessment during the salting process but also enabled the simultaneous prediction of key chemical and physical attributes of salted radishes with informative wavelength selection. This approach provides an efficient strategy for monitoring the quality of salted vegetables, offering valuable insights for optimizing industrial salting processes and advancing real-time quality control applications.</div></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":"69 ","pages":"Article 106912"},"PeriodicalIF":4.8,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}