Folia neuropathologica最新文献

{"title":"Effect of ultra-early intervention of NDT therapy on nerve and motor development in infants at high risk of cerebral palsy","authors":"Meihua Li, Lihua Wang, Shujie Yu, Xuesong Guo, Bingbing Xun, Yu Zhang","doi":"10.5114/fn.2023.131551","DOIUrl":"https://doi.org/10.5114/fn.2023.131551","url":null,"abstract":"AMA Li M, Wang L, Yu S, Guo X, Xun B, Zhang Y. Effect of ultra-early intervention of NDT therapy on nerve and motor development in infants at high risk of cerebral palsy. Folia Neuropathologica. 2023. doi:10.5114/fn.2023.131551. APA Li, M., Wang, L., Yu, S., Guo, X., Xun, B., & Zhang, Y. (2023). Effect of ultra-early intervention of NDT therapy on nerve and motor development in infants at high risk of cerebral palsy. Folia Neuropathologica. https://doi.org/10.5114/fn.2023.131551 Chicago Li, Meihua, Lihua Wang, Shujie Yu, Xuesong Guo, Bingbing Xun, and Yu Zhang. 2023. \"Effect of ultra-early intervention of NDT therapy on nerve and motor development in infants at high risk of cerebral palsy\". Folia Neuropathologica. doi:10.5114/fn.2023.131551. Harvard Li, M., Wang, L., Yu, S., Guo, X., Xun, B., and Zhang, Y. (2023). Effect of ultra-early intervention of NDT therapy on nerve and motor development in infants at high risk of cerebral palsy. Folia Neuropathologica. https://doi.org/10.5114/fn.2023.131551 MLA Li, Meihua et al. \"Effect of ultra-early intervention of NDT therapy on nerve and motor development in infants at high risk of cerebral palsy.\" Folia Neuropathologica, 2023. doi:10.5114/fn.2023.131551. Vancouver Li M, Wang L, Yu S, Guo X, Xun B, Zhang Y. Effect of ultra-early intervention of NDT therapy on nerve and motor development in infants at high risk of cerebral palsy. Folia Neuropathologica. 2023. doi:10.5114/fn.2023.131551.","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136007882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and morphology of secondary TDP-43 proteinopathies: Part 2.","authors":"Albert Acewicz,&nbsp;Tomasz Stępień,&nbsp;Paulina Felczak,&nbsp;Sylwia Tarka,&nbsp;Teresa Wierzba-Bobrowicz","doi":"10.5114/fn.2023.128776","DOIUrl":"https://doi.org/10.5114/fn.2023.128776","url":null,"abstract":"<p><p>Transactivation (TAR) DNA binding protein 43 kDa (TDP-43) inclusions frequently occur as a comorbid pathology in several neurodegenerative disorders, including Alzheimer's disease, Huntington's disease, Lewy body disease, and progressive supranuclear palsy, and may appear in association with nondegenerative neurological etiology, for example neoplastic, paraneoplastic, traumatic, or infectious. Relationships between various pathological proteins and mechanisms associated with TDP-43-induced neurodegeneration are still not fully understood. Thus, overlap of distinct neuropathological mechanisms frequently leads to greater brain atrophy and a more severe clinical course, suggesting the importance of co-pathologies in ante-mortem diagnosing and treatment. The present review aims to discuss the incidence, morphology, and role of TDP-43 pathology in the context of other dominant, hallmark pathologies, referred to as secondary TDP-43 proteinopathies. The previous part (Part 1) focused on common neurodegenerative diseases, including Alzheimer's disease, Huntington's disease, and Lewy body disease, while the present part (Part 2) discusses TDP-43 pathology in rare neurodegenerative diseases and neurological diseases with nondegenerative etiology.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"61 2","pages":"111-120"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10017135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BCOR expression in paediatric pineoblastoma.","authors":"Joanna Trubicka,&nbsp;Maria Łastowska,&nbsp;Agnieszka Karkucińska-Więckowska,&nbsp;Magdalena Niemira,&nbsp;Maria Ejmont,&nbsp;Agnieszka Sowińska,&nbsp;Maciej Pronicki,&nbsp;Ewa Matyja,&nbsp;Wiesława Grajkowska","doi":"10.5114/fn.2023.129377","DOIUrl":"https://doi.org/10.5114/fn.2023.129377","url":null,"abstract":"<p><p>BCOR is expressed in a new brain tumour entity, i.e. 'CNS tumour with BCOR internal tandem duplication' (HGNET BCOR) but not in several other high grade paediatric brain tumours investigated. Immunohistochemical detection of BCOR expression may therefore serve as a potential diagnostic marker. Nevertheless, in rare paediatric glioma cases recurrent EP300-BCOR fusions were detected, which resulted in strong BCOR immunopositivity. We have therefore examined other, not analysed so far, types of central nervous system (CNS) tumours, pineoblastoma and germinoma, to assess a potential involvement of BCOR in these tumours. Levels of BCOR RNA expression were investigated by NanoString nCounter system analysis in a series of altogether 66 high grade paediatric tumours, including four pineoblastoma cases. Immunohistological detection of BCOR was performed in eight pineoblastoma, five germinoma and four atypical teratoid rhabdoid tumours (ATRTs), all located in the pineal region. We detected BCOR expression in all pineoblastomas, at the RNA and protein levels, but not in germinomas and ATRTs. Further analysis of pineoblastoma samples did not reveal the presence of either BCOR internal tandem duplication or BCOR fusion involvement. Positive immunohistological BCOR nuclear reaction in pineoblastoma may therefore differentiate this type of tumour from other high grade tumours located in the pineal region.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"61 2","pages":"121-128"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10022086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The protective effect of Wnt3a on inflammatory response in oxygen-glucose deprivation/reoxygenation (OGD/R) astrocyte model.","authors":"Su-Qin Chen,&nbsp;Ang Li,&nbsp;Min-Yan Feng,&nbsp;Wen-Qing Zhong,&nbsp;Liu Yang,&nbsp;Xiao-Yu Chen,&nbsp;Xing-Er Wu","doi":"10.5114/fn.2023.130264","DOIUrl":"10.5114/fn.2023.130264","url":null,"abstract":"<p><p>Involving in the immune response after cerebral infarction, astrocytes could secrete large amounts of pro- and anti-inflammatory factors. The aim of this study is to investigate the effect of Wnt3a intervention on the inflammatory response of oxygen-glucose deprivation (OGD) followed by reoxygenation (OGD/R) astrocyte model, and to provide a new target for immunoprotective treatment of cerebral infarction. We constructed the OGD/R rat astrocyte model, the astrocytes were treated by different concentrations of glucose (25, 50, 100 mM) intervened with/without Wnt3a (25 µg/ml). Microscope was used to observe the cell survival in rat astrocytes. The relative expression of inflammatory factors (TNF-a, IL-6, HIF-a) in rat astrocytes was detected by qRT-PCR. The expression of inflammatory factors such as TNF-a, IL-6 and HIF-a in rat astrocytes was increased after OGD/R treatment. The Wnt3a intervention promoted cell survival and decreased the expression of inflammatory factors in rat astrocytes induced by OGD/R. There is a neuroprotective effect that Wnt3a intervention could reduce inflammatory response in the OGD/R rat astrocyte model.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"61 3","pages":"242-248"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41196297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts from the Conference.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"61 4","pages":"453-477"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139570146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between blood pressure variability and deep cerebral microbleeds in patients with acute ischemic stroke.","authors":"Yaya Bao,&nbsp;Jiayi Gu,&nbsp;Tian Lv,&nbsp;Miao Chen,&nbsp;Ke Zhao,&nbsp;Yue Yang,&nbsp;Dadong Gu","doi":"10.5114/fn.2023.130006","DOIUrl":"https://doi.org/10.5114/fn.2023.130006","url":null,"abstract":"<p><strong>Introduction: </strong>To observe the 24-h ambulatory blood pressure characteristics of patients with acute ischemic stroke and explore the correlation between blood pressure variability and strictly deep cerebral microbleeds (CMBs).</p><p><strong>Material and methods: </strong>A convenient sampling method was used to enrol 131 patients with acute ischemic stroke in the Department of Neurology between April 2021 and May 2022. Hospitalised patients with acute ischemic stroke were assessed retrospectively; their ambulatory blood pressure was monitored continuously for 24 h, and the relevant parameters were recorded. Magnetic susceptibility-weighted imaging was used to divide the CMBs into a strictly deep CMB group ( n = 24) and a non-CMB group ( n = 107) according to the location of the CMBs. A logistic regression analysis was performed to determine the independent correlation between the 24-h ambulatory blood pressure parameters and strictly deep CMBs. The receiver operating characteristic (ROC) was further used to analyse the predictive value of the ambulatory blood pressure parameters for strictly deep CMBs in patients with acute ischemic stroke.</p><p><strong>Results: </strong>The results showed that the night systolic blood pressure standard deviation and the night diastolic blood pressure standard deviation (NDBP-SD) in the strictly deep CMB group were higher than those in the non-CMB group ( p < 0.05). The multiple logistic regression analysis indicated that the NDBP-SD (odds ratio [OR] = 1.205, 95% confidence interval [CI]: 1.011-1.436, p = 0.038) was an independent risk factor for strictly deep CMBs in patients. The ROC curve analysis revealed that the area under the curve value of the NDBP-SD was 0.682, and the intercept was 7.81. When NDBP-SD is ≥ 7.81, the occurrence of strictly deep CMBs is closely related (OR = 3.872, 95% CI: 1.347-11.125, p = 0.012).</p><p><strong>Conclusions: </strong>The NDBP-SD is an independent risk factor for strictly deep CMBs in patients with acute ischemic stroke. When NDBP-SD is > 7.81, it may promote the production of strictly deep CMBs.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"61 3","pages":"309-316"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41196289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of COVID-19 on the treatment of patients with acute ischemic stroke: a retrospective observational study.","authors":"Wei Chen,&nbsp;Fangju Lin,&nbsp;Wei Zhao,&nbsp;Baoling Yang,&nbsp;Weihua Jia","doi":"10.5114/fn.2023.124565","DOIUrl":"https://doi.org/10.5114/fn.2023.124565","url":null,"abstract":"<p><strong>Introduction: </strong>Since December 2019, coronavirus 2019 (COVID-19) has rapidly spread to become a global pandemic, exerting a great pressure on medical staff worldwide. This study aimed to observe whether COVID-19 influenced the diagnosis and treatment of ischemic stroke (IS).</p><p><strong>Material and methods: </strong>This study retrospectively analysed the clinical data (number of emergencies, time from onset to treatment, and door-to-needle time [DNT]) of patients with acute IS (AIS) treated in our hospital within six months of the first case of COVID-19 reported in the city; the derived data were then compared with the situation of patients during the same period in 2019.</p><p><strong>Results: </strong>The results showed that the number of medical visits during the period of COVID-19 decreased by 44.3%, and the median time from the onset of IS to emergency treatment was 35 min longer than that during the same period in 2019. The median time from entering the emergency department to the completion of cranial computerized tomography was 8 min shorter than during the same period in 2019, and the median time of DNT was relatively shorter than that during the same period in 2019.</p><p><strong>Conclusions: </strong>The pandemic situation of COVID-19 significantly reduced the number of patients with AIS and prolonged the travel time to the hospital whereas most of the stroke treatment services were maintained.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"61 2","pages":"163-167"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10022087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteopontin expression and the effect of anti-VLA-4 mAb treatment in experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis.","authors":"Grażyna Pyka-Fościak,&nbsp;Jan A Litwin,&nbsp;Grzegorz J Lis","doi":"10.5114/fn.2023.129180","DOIUrl":"https://doi.org/10.5114/fn.2023.129180","url":null,"abstract":"<p><strong>Introduction: </strong>Osteopontin (OPN) is involved in the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). The aim of this study was to investigate the expression of OPN in spinal cords of mice in the successive phases of EAE, to compare it with the density of inflammatory cells, oligodendrocytes and with the expression of interleukin (IL)-17A and to assess the effect of anti-α4β1 integrin (VLA-4) treatment.</p><p><strong>Material and methods: </strong>Experimental autoimmune encephalomyelitis (EAE) mice were injected with anti-VLA-4 antibodies or, as treatment control, with immunoglobulin G (IgG). Spinal cords were sectioned and immunostained for OPN, CD45 (overall leukocytes), CD3 (T cells), Iba1 (activated macrophages/microglia), IL-17A, and CNP1 (oligodendrocytes). Microscopic images were analysed and the percentage of immunopositive areas encompassing the whole spinal cord cross-sectional area were assessed in images for each antigen.</p><p><strong>Results: </strong>Osteopontin was expressed by inflammatory cells and by a minority of neurons and blood vessels. Most of the studied parameters followed the temporal pattern of clinical scores: increase in the peak phase and decrease in the chronic phase. Only OPN and IL-17A remained at a high level in the chronic phase, while CNP1 expression gradually decreased in the successive phases. Anti-VLA-4 treatment lowered the expression of the studied antigens in the peak and chronic phases with the exception of oligodendrocyte marker CNP1 which in both phases showed an increased expression.</p><p><strong>Conclusions: </strong>Involvement of OPN is particularly significant in advanced EAE. Anti-VLA-4 treatment not only inhibits migration of myelin-reactive T cells, but also downregulates OPN and inhibits loss of oligodendrocytes.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"61 2","pages":"129-137"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10028481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current study on diagnosis and treatment of Alzheimer's disease by targeting amyloid b-protein.","authors":"Kai-Ye Hua,&nbsp;Wei-Jiang Zhao","doi":"10.5114/fn.2022.119778","DOIUrl":"https://doi.org/10.5114/fn.2022.119778","url":null,"abstract":"<p><p>Alzheimer's disease (AD), also known as senile dementia, is a degenerative disease of the central nervous system and is characterized by insidious onset and a chronic progressive course. It is the most common type of senile dementia. Studies have proved that the deposition of amyloid b (Ab) in the brain is one of the initiating factors correlated to the pathology of AD, and it acts as one of the critical factors leading to the onset of AD. A large number of long-term studies have shown that Ab may be a therapeutic target for a breakthrough in the treatment of AD. This review elucidates the important role of Ab in the development of AD, current research on the role of Ab in AD pathogenesis, and treatment of AD by targeting Ab.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"61 1","pages":"8-15"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9742711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss of lncRNA UCA1 ameliorates the injury managed by cerebral ischemia-reperfusion by sponging miR-18a-5p.","authors":"Jingyi Yan,&nbsp;Yang Gao,&nbsp;Jianyuan Huang,&nbsp;Wei Gao,&nbsp;Yang Li,&nbsp;Baishun Lin","doi":"10.5114/fn.2022.122497","DOIUrl":"https://doi.org/10.5114/fn.2022.122497","url":null,"abstract":"<p><strong>Introduction: </strong>Acute ischemic stroke (AIS) is a disease with high morbidity and mortality in the clinic. The current experiments aimed to study the effects of UCA1 interfering miR-18a-5p on cerebral ischemia-reperfusion (CI/R).</p><p><strong>Material and methods: </strong>For rat models undergoing middle cerebral artery infarction (MCAO) surgery, the expression of UCA1 and miR-18a-5p was evaluated by qRT-PCR, and underlying function was identified by detecting infarct size, neurological scores, and inflammation. Luciferase report was applied to verify the relationship between UCA1 and miR-18a-5p. In the cell models, the impacts of UCA1 and miR-18a-5p were validated by CCK-8 assay, flow cytometry analysis, and ELISA. In patients with AIS, Pearson correlation was carried out to unveil the association between UCA1 and miR-18a-5p.</p><p><strong>Results: </strong>The expression of UCA1 was at high levels and miR-18a-5p was at low levels in AIS patients. UCA1 knockdown showed a protective role in infarct size, neurofunction, and inflammation via binding miR-18a-5p. MiR-18a-5p participated in the regulation of UCA1 on cell viability, cell apoptosis, lactate dehydrogenase (LDH) levels, and inflammation. In patients with AIS, overexpression of UCA1 and underexpression of miR-18a-5p had a reverse correlation.</p><p><strong>Conclusions: </strong>Elimination of UCA1 was favourable to the recovery of the rat model and cells from CI/R damage by efficaciously sponging miR-18a-5p.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"61 1","pages":"77-87"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9727310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}