Folia neuropathologica最新文献

{"title":"Upregulated lncRNA NORAD can diagnose acute cerebral ischemic stroke patients and predict poor prognosis.","authors":"Dongliang Liu,&nbsp;Li Li,&nbsp;Juanjuan Xu,&nbsp;Wenping Luo,&nbsp;Lu Pan,&nbsp;Qilin Niu,&nbsp;Daoxiang Wei","doi":"10.5114/fn.2022.121478","DOIUrl":"https://doi.org/10.5114/fn.2022.121478","url":null,"abstract":"<p><strong>Introduction: </strong>Acute cerebral ischemic stroke (AIS) dramatically influences patients' quality of life. lncRNA NORAD (NORAD) has been studied in cerebrovascular diseases, which are potential risk factors for AIS. The specific significance of NORAD is unclear. This study aimed to assess the role of NORAD in AIS, and to provide therapeutic value for its' treatment.</p><p><strong>Material and methods: </strong>A total of 103 AIS patients and 95 healthy individuals (control) were enrolled into this study. Expression level of NORAD in the plasma of all participants was analyzed by PCR. Diagnostic potential of NORAD in AIS was evaluated by ROC analysis, while Kaplan-Meier and Cox regression analyses were conducted to assess its' prognostic value in AIS.</p><p><strong>Results: </strong>A significantly increased level of NORAD was observed in AIS patients compared with healthy individuals. The upregulation of NORAD could dramatically discriminate AIS patients from healthy individuals with high sensitivity (81.60%) and specificity (88.40%). NORAD was positively correlated with patients' high-sensitivity C-reactive protein (hs CRP, r = 0.796), matrix metalloproteinase-9 (MMP9, r = 0.757), and NIHSS scores ( r = 0.840), and negatively related to pc-ASPECTS scores ( r = -0.607). Moreover, NORAD upregulation was associated with patients' unfavorable prognosis and served as an independent prognostic biomarker, together with NIHSS and pc-ASPECTS scores of AIS patients.</p><p><strong>Conclusions: </strong>NORAD was upregulated in AIS, which can discriminate AIS patients, and was closely correlated with severe development and poor prognosis of patients.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"61 1","pages":"105-110"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9727309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADAMTS8 inhibits glioma development in vitro and in vivo.","authors":"Baosheng Zhou,&nbsp;Yong Liu,&nbsp;Guangshuo Ma,&nbsp;Xiuyu Wang,&nbsp;Binge Chang,&nbsp;Hongwei Lu,&nbsp;Xuequan Feng","doi":"10.5114/fn.2023.129380","DOIUrl":"https://doi.org/10.5114/fn.2023.129380","url":null,"abstract":"<p><strong>Introduction: </strong>In recent years, novel RNAs have been revealed to be regulators in glioma. ADAMTS8 has been reported to be reduced in brain tumours. In this study, we aimed to explore the role of ADAMTS8 in glioma.</p><p><strong>Material and methods: </strong>Online bioinformatic tools, Gepia and Chinese Glioma Genome Atlas database (CGGA) were used to analyse the differential expression of ADAMTS8, overall survival and disease-free survival rates and the correlations between ADAMTS8 and matrix metallopeptidases (MMP2 and MMP9) in glioma. RT-qPCR and western blot experiments were performed to measure the mRNA and protein expression. ADAMTS8 expression was regulated in cells through transfection. Thereafter, the effect of ADAMTS8 on cells was investigated through the cell viability, apoptosis and transwell experiments. The epithelial-mesenchymal transition (EMT)-related proteins and also MMP2 and MMP9 were examined. The subcutaneous tumour model was established to validate the suppressive role of ADAMTS8 in tumour growth.</p><p><strong>Results: </strong>ADAMTS8 expression was reduced in glioma tissues and cells. Higher expression of ADAMTS8 was correlated with higher survival rates. ADAMTS8 was correlated with MMP2 and MMP9 in glioma tissues. In glioma cells, overexpression of ADAMTS8 could inhibit the viability, invasion, migration and EMT, and MMP2 and MMP9, but promote the apoptosis of cells. The upregulation of ADAMTS8 could inhibit the tumour growth in vivo.</p><p><strong>Conclusions: </strong>ADAMTS8 was inhibited in glioma and the higher expression of ADAMTS8 might be related to better prognosis among glioma patients. Overexpression of ADAMTS8 inhibited the development of glioma in vitro and in vivo.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"61 2","pages":"144-152"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10022088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of chemotherapies on the crosstalk interaction between CD8 cytotoxic T-cells and MHC-I peptides in the microenvironment of WHO grade 4 astrocytoma.","authors":"Nadeem Butt,&nbsp;Maryam Enani,&nbsp;Maryam Alshanqiti,&nbsp;Alaa Alkhotani,&nbsp;Taghreed Alsinani,&nbsp;Mohammed Matoog Karami,&nbsp;Motaz M Fadul,&nbsp;Majid Almansouri,&nbsp;Amber Hassan,&nbsp;Saleh Baeesa,&nbsp;Ahmed K Bamaga,&nbsp;Shadi Alkhayyat,&nbsp;Eyad Faizo,&nbsp;Maher Kurdi","doi":"10.5114/fn.2023.131014","DOIUrl":"https://doi.org/10.5114/fn.2023.131014","url":null,"abstract":"<p><strong>Introduction: </strong>CD8 + T-cells and MHC-I have been detected in brain gliomas with a significant outcome. The effect of chemotherapies on the crosstalk interaction between CD8 + T-cells and MHC-I has never been explored.</p><p><strong>Material and methods: </strong>The protein expression profiling of CD8 cytotoxic T-cells and the gene expression assay of MHC-I in 35 patients diagnosed with WHO grade 4 astrocytoma were performed. The impact of these two factors on tumor recurrence was analyzed.</p><p><strong>Results: </strong>IDH was wildtype in 13 tumors. MHC-I protein expression was absent or low in 34 tumors and dense in a single case. MHC-I gene expression was upregulated in 10 tumors and 25 tumors showed MHC-I gene downregulation. Temozolomide (TMZ) was given to 24 patients and 11 patients received TMZ plus other chemotherapies. No statistically significant association was observed between IDH mutation and CD8 + T-cells ( p = 0.383). However, this association was significant in recurrence-free interval (RFI) ( p = 0.012). IDH-wildtype tumors with highly infiltrated CD8 + T-cells or IDH-mutant tumors with low CD8 + T-cells showed late tumor recurrence. There was a statistically significant difference in RFI between tumors with different MHC-I expression and CD8 + T-cell counts after treatment with TMZ or TMZ plus ( p = 0.026).</p><p><strong>Conclusions: </strong>No association between IDH mutation and CD8+ cytotoxic T-cell was found. IDH is directly linked to tumor recurrence regardless of CD8 + T-cells infiltration. TMZ plus other adjuvants is proved to be more effective in improving patient survival and delaying tumor recurrence, as compared to using TMZ alone. Nonetheless, none-TMZ adjuvants may increase tumor sensitization to cytotoxic T-cells more than TMZ.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"61 3","pages":"317-325"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41196296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise attenuates mitochondrial autophagy and neuronal degeneration in MPTP induced Parkinson's disease by regulating inflammatory pathway.","authors":"Zhiwei Li, Hua Lv, Xiaoli Cui, Wei Di, Xiansong Cheng, Jun Liu, Alok Tripathi","doi":"10.5114/fn.2023.132424","DOIUrl":"10.5114/fn.2023.132424","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a chronic neuronal loss of dopamine and drugs used for its management has several limitations. The present report determines the effect of exercise on mitochondrial autophagy against PD. Parkinson's disease was induced by 15 doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 30 mg/kg, i.p.) for 3 weeks, on five consecutive days in a week. Exposure of exercise was provided for 40 min for a period of 2 weeks after PD confirmation. Assessment of behaviour was performed to evaluate the effect of exercise on motor function and cognitive function in PD rats. Levels of reactive oxygen species (ROS) and inflammatory cytokines were assessed in PD rats using enzyme linked immunosorbent assay (ELISA). Expression of myocyte-specific enhancer factor 2D (MEF2D) and NADH dehydrogenase 6 (ND6) was estimated in PD rats. Exposure to exercise ameliorates the altered motor function and cognitive function in PD rats. There was a reduction in ROS and cytokine levels in the brain tissue of the exercise group compared to the negative control group. Exercise ameliorates the altered expression of apoptotic proteins and mRNA expression of MEF2D and ND6 in the brain tissue of MPTP induced PD rats. In conclusion, data of study reveal that exercise protects the mitochondrial autophagy in PD rats by reducing inflammatory cytokines and oxidative stress.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":" ","pages":"426-432"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139086556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PF4 induces inflammatory response through NF-kB signal pathway in rats with intracerebral haemorrhage","authors":"Na Hu, Ran An, Kun Yu, Yanzhong Chang, Weijuan Gao","doi":"10.5114/fn.2023.130449","DOIUrl":"https://doi.org/10.5114/fn.2023.130449","url":null,"abstract":"AMA Hu N, An R, Yu K, Chang Y, Gao W. PF4 induces inflammatory response through NF-kB signal pathway in rats with intracerebral haemorrhage. Folia Neuropathologica. 2023. doi:10.5114/fn.2023.130449. APA Hu, N., An, R., Yu, K., Chang, Y., & Gao, W. (2023). PF4 induces inflammatory response through NF-kB signal pathway in rats with intracerebral haemorrhage. Folia Neuropathologica. https://doi.org/10.5114/fn.2023.130449 Chicago Hu, Na, Ran An, Kun Yu, Yanzhong Chang, and Weijuan Gao. 2023. \"PF4 induces inflammatory response through NF-kB signal pathway in rats with intracerebral haemorrhage\". Folia Neuropathologica. doi:10.5114/fn.2023.130449. Harvard Hu, N., An, R., Yu, K., Chang, Y., and Gao, W. (2023). PF4 induces inflammatory response through NF-kB signal pathway in rats with intracerebral haemorrhage. Folia Neuropathologica. https://doi.org/10.5114/fn.2023.130449 MLA Hu, Na et al. \"PF4 induces inflammatory response through NF-kB signal pathway in rats with intracerebral haemorrhage.\" Folia Neuropathologica, 2023. doi:10.5114/fn.2023.130449. Vancouver Hu N, An R, Yu K, Chang Y, Gao W. PF4 induces inflammatory response through NF-kB signal pathway in rats with intracerebral haemorrhage. Folia Neuropathologica. 2023. doi:10.5114/fn.2023.130449.","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"135 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136007874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of ultra-early intervention of NDT therapy on nerve and motor development in infants at high risk of cerebral palsy","authors":"Meihua Li, Lihua Wang, Shujie Yu, Xuesong Guo, Bingbing Xun, Yu Zhang","doi":"10.5114/fn.2023.131551","DOIUrl":"https://doi.org/10.5114/fn.2023.131551","url":null,"abstract":"AMA Li M, Wang L, Yu S, Guo X, Xun B, Zhang Y. Effect of ultra-early intervention of NDT therapy on nerve and motor development in infants at high risk of cerebral palsy. Folia Neuropathologica. 2023. doi:10.5114/fn.2023.131551. APA Li, M., Wang, L., Yu, S., Guo, X., Xun, B., & Zhang, Y. (2023). Effect of ultra-early intervention of NDT therapy on nerve and motor development in infants at high risk of cerebral palsy. Folia Neuropathologica. https://doi.org/10.5114/fn.2023.131551 Chicago Li, Meihua, Lihua Wang, Shujie Yu, Xuesong Guo, Bingbing Xun, and Yu Zhang. 2023. \"Effect of ultra-early intervention of NDT therapy on nerve and motor development in infants at high risk of cerebral palsy\". Folia Neuropathologica. doi:10.5114/fn.2023.131551. Harvard Li, M., Wang, L., Yu, S., Guo, X., Xun, B., and Zhang, Y. (2023). Effect of ultra-early intervention of NDT therapy on nerve and motor development in infants at high risk of cerebral palsy. Folia Neuropathologica. https://doi.org/10.5114/fn.2023.131551 MLA Li, Meihua et al. \"Effect of ultra-early intervention of NDT therapy on nerve and motor development in infants at high risk of cerebral palsy.\" Folia Neuropathologica, 2023. doi:10.5114/fn.2023.131551. Vancouver Li M, Wang L, Yu S, Guo X, Xun B, Zhang Y. Effect of ultra-early intervention of NDT therapy on nerve and motor development in infants at high risk of cerebral palsy. Folia Neuropathologica. 2023. doi:10.5114/fn.2023.131551.","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136007882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and morphology of secondary TDP-43 proteinopathies: Part 2.","authors":"Albert Acewicz,&nbsp;Tomasz Stępień,&nbsp;Paulina Felczak,&nbsp;Sylwia Tarka,&nbsp;Teresa Wierzba-Bobrowicz","doi":"10.5114/fn.2023.128776","DOIUrl":"https://doi.org/10.5114/fn.2023.128776","url":null,"abstract":"<p><p>Transactivation (TAR) DNA binding protein 43 kDa (TDP-43) inclusions frequently occur as a comorbid pathology in several neurodegenerative disorders, including Alzheimer's disease, Huntington's disease, Lewy body disease, and progressive supranuclear palsy, and may appear in association with nondegenerative neurological etiology, for example neoplastic, paraneoplastic, traumatic, or infectious. Relationships between various pathological proteins and mechanisms associated with TDP-43-induced neurodegeneration are still not fully understood. Thus, overlap of distinct neuropathological mechanisms frequently leads to greater brain atrophy and a more severe clinical course, suggesting the importance of co-pathologies in ante-mortem diagnosing and treatment. The present review aims to discuss the incidence, morphology, and role of TDP-43 pathology in the context of other dominant, hallmark pathologies, referred to as secondary TDP-43 proteinopathies. The previous part (Part 1) focused on common neurodegenerative diseases, including Alzheimer's disease, Huntington's disease, and Lewy body disease, while the present part (Part 2) discusses TDP-43 pathology in rare neurodegenerative diseases and neurological diseases with nondegenerative etiology.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"61 2","pages":"111-120"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10017135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BCOR expression in paediatric pineoblastoma.","authors":"Joanna Trubicka,&nbsp;Maria Łastowska,&nbsp;Agnieszka Karkucińska-Więckowska,&nbsp;Magdalena Niemira,&nbsp;Maria Ejmont,&nbsp;Agnieszka Sowińska,&nbsp;Maciej Pronicki,&nbsp;Ewa Matyja,&nbsp;Wiesława Grajkowska","doi":"10.5114/fn.2023.129377","DOIUrl":"https://doi.org/10.5114/fn.2023.129377","url":null,"abstract":"<p><p>BCOR is expressed in a new brain tumour entity, i.e. 'CNS tumour with BCOR internal tandem duplication' (HGNET BCOR) but not in several other high grade paediatric brain tumours investigated. Immunohistochemical detection of BCOR expression may therefore serve as a potential diagnostic marker. Nevertheless, in rare paediatric glioma cases recurrent EP300-BCOR fusions were detected, which resulted in strong BCOR immunopositivity. We have therefore examined other, not analysed so far, types of central nervous system (CNS) tumours, pineoblastoma and germinoma, to assess a potential involvement of BCOR in these tumours. Levels of BCOR RNA expression were investigated by NanoString nCounter system analysis in a series of altogether 66 high grade paediatric tumours, including four pineoblastoma cases. Immunohistological detection of BCOR was performed in eight pineoblastoma, five germinoma and four atypical teratoid rhabdoid tumours (ATRTs), all located in the pineal region. We detected BCOR expression in all pineoblastomas, at the RNA and protein levels, but not in germinomas and ATRTs. Further analysis of pineoblastoma samples did not reveal the presence of either BCOR internal tandem duplication or BCOR fusion involvement. Positive immunohistological BCOR nuclear reaction in pineoblastoma may therefore differentiate this type of tumour from other high grade tumours located in the pineal region.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"61 2","pages":"121-128"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10022086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The protective effect of Wnt3a on inflammatory response in oxygen-glucose deprivation/reoxygenation (OGD/R) astrocyte model.","authors":"Su-Qin Chen,&nbsp;Ang Li,&nbsp;Min-Yan Feng,&nbsp;Wen-Qing Zhong,&nbsp;Liu Yang,&nbsp;Xiao-Yu Chen,&nbsp;Xing-Er Wu","doi":"10.5114/fn.2023.130264","DOIUrl":"10.5114/fn.2023.130264","url":null,"abstract":"<p><p>Involving in the immune response after cerebral infarction, astrocytes could secrete large amounts of pro- and anti-inflammatory factors. The aim of this study is to investigate the effect of Wnt3a intervention on the inflammatory response of oxygen-glucose deprivation (OGD) followed by reoxygenation (OGD/R) astrocyte model, and to provide a new target for immunoprotective treatment of cerebral infarction. We constructed the OGD/R rat astrocyte model, the astrocytes were treated by different concentrations of glucose (25, 50, 100 mM) intervened with/without Wnt3a (25 µg/ml). Microscope was used to observe the cell survival in rat astrocytes. The relative expression of inflammatory factors (TNF-a, IL-6, HIF-a) in rat astrocytes was detected by qRT-PCR. The expression of inflammatory factors such as TNF-a, IL-6 and HIF-a in rat astrocytes was increased after OGD/R treatment. The Wnt3a intervention promoted cell survival and decreased the expression of inflammatory factors in rat astrocytes induced by OGD/R. There is a neuroprotective effect that Wnt3a intervention could reduce inflammatory response in the OGD/R rat astrocyte model.</p>","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"61 3","pages":"242-248"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41196297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts from the Conference.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12370,"journal":{"name":"Folia neuropathologica","volume":"61 4","pages":"453-477"},"PeriodicalIF":2.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139570146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}