Upregulated lncRNA NORAD can diagnose acute cerebral ischemic stroke patients and predict poor prognosis.

IF 1.5 4区医学 Q4 NEUROSCIENCES

Folia neuropathologica Pub Date : 2023-01-01 DOI:10.5114/fn.2022.121478

Dongliang Liu, Li Li, Juanjuan Xu, Wenping Luo, Lu Pan, Qilin Niu, Daoxiang Wei

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引用次数: 1

Abstract

Introduction: Acute cerebral ischemic stroke (AIS) dramatically influences patients' quality of life. lncRNA NORAD (NORAD) has been studied in cerebrovascular diseases, which are potential risk factors for AIS. The specific significance of NORAD is unclear. This study aimed to assess the role of NORAD in AIS, and to provide therapeutic value for its' treatment.

Material and methods: A total of 103 AIS patients and 95 healthy individuals (control) were enrolled into this study. Expression level of NORAD in the plasma of all participants was analyzed by PCR. Diagnostic potential of NORAD in AIS was evaluated by ROC analysis, while Kaplan-Meier and Cox regression analyses were conducted to assess its' prognostic value in AIS.

Results: A significantly increased level of NORAD was observed in AIS patients compared with healthy individuals. The upregulation of NORAD could dramatically discriminate AIS patients from healthy individuals with high sensitivity (81.60%) and specificity (88.40%). NORAD was positively correlated with patients' high-sensitivity C-reactive protein (hs CRP, r = 0.796), matrix metalloproteinase-9 (MMP9, r = 0.757), and NIHSS scores ( r = 0.840), and negatively related to pc-ASPECTS scores ( r = -0.607). Moreover, NORAD upregulation was associated with patients' unfavorable prognosis and served as an independent prognostic biomarker, together with NIHSS and pc-ASPECTS scores of AIS patients.

Conclusions: NORAD was upregulated in AIS, which can discriminate AIS patients, and was closely correlated with severe development and poor prognosis of patients.

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lncRNA - NORAD表达上调可以诊断急性缺血性脑卒中患者，预测预后不良。

简介:急性脑缺血(AIS)严重影响患者的生活质量。lncRNA - NORAD (NORAD)在AIS的潜在危险因素脑血管疾病中得到了研究。北美防空司令部的具体意义尚不清楚。本研究旨在评估NORAD在AIS中的作用，并为其治疗提供治疗价值。材料与方法:本研究共纳入103例AIS患者和95例健康个体(对照组)。采用PCR分析所有受试者血浆中NORAD的表达水平。采用ROC分析评估NORAD在AIS中的诊断潜力，并采用Kaplan-Meier和Cox回归分析评估其在AIS中的预后价值。结果:与健康个体相比，AIS患者的NORAD水平显著升高。NORAD表达上调可显著区分AIS患者与健康个体，具有较高的敏感性(81.60%)和特异性(88.40%)。NORAD与患者高敏c反应蛋白(hs CRP, r = 0.796)、基质金属蛋白酶-9 (MMP9, r = 0.757)、NIHSS评分呈正相关(r = 0.840)，与pc-ASPECTS评分呈负相关(r = -0.607)。此外，NORAD上调与患者的不良预后相关，并与AIS患者的NIHSS和pc-ASPECTS评分一起作为独立的预后生物标志物。结论:NORAD在AIS中表达上调，具有鉴别AIS患者的作用，且与AIS患者严重发展及预后不良密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Folia neuropathologica 医学-病理学

CiteScore

2.50

自引率

5.00%

发文量

审稿时长

>12 weeks

期刊介绍： Folia Neuropathologica is an official journal of the Mossakowski Medical Research Centre Polish Academy of Sciences and the Polish Association of Neuropathologists. The journal publishes original articles and reviews that deal with all aspects of clinical and experimental neuropathology and related fields of neuroscience research. The scope of journal includes surgical and experimental pathomorphology, ultrastructure, immunohistochemistry, biochemistry and molecular biology of the nervous tissue. Papers on surgical neuropathology and neuroimaging are also welcome. The reports in other fields relevant to the understanding of human neuropathology might be considered.