Fluids and Barriers of the CNS最新文献

{"title":"Correction: Role of cerebroventricular size and surgical placement in modulating catheter flow distribution.","authors":"Christopher W Roberts, Brandon G Rocque, Leopold Arko Iv, Neena I Marupudi, Sandeep Sood, Elise Yoon, Elliot Widd, Bryn A Martin, Carolyn A Harris","doi":"10.1186/s12987-026-00810-9","DOIUrl":"10.1186/s12987-026-00810-9","url":null,"abstract":"","PeriodicalId":12321,"journal":{"name":"Fluids and Barriers of the CNS","volume":"23 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13122966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebrovascular claudin-5 isoform expression correlates with worsened stroke outcomes following thromboembolic stroke.","authors":"Trevor S Wendt, Henrik Andersson, Kajsa Arkelius, Saema Ansar","doi":"10.1186/s12987-026-00798-2","DOIUrl":"10.1186/s12987-026-00798-2","url":null,"abstract":"","PeriodicalId":12321,"journal":{"name":"Fluids and Barriers of the CNS","volume":"23 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the additive properties of differential pressure valves in a novel benchtop shunt model.","authors":"Sai Chandan Reddy, Dipankar Biswas, S Farzad Maroufi, Gwendolyn Williams, Nyle Dar, Michael Meggyesy, Ryan P Lee, Ian Suk, Mark Luciano","doi":"10.1186/s12987-026-00803-8","DOIUrl":"10.1186/s12987-026-00803-8","url":null,"abstract":"<p><strong>Objective: </strong>Cerebrospinal fluid (CSF) over-drainage is an unintended sequela of using a shunt valve to treat hydrocephalus, and a second valve may be added in series to better control drainage. In this study, we tested whether the opening pressures of two valves in series-Codman Hakim ball valve (HBV) and the Miethke M.blue^Ⓡ adjustable gravitational valve (AGV)-can be treated as being additive using a novel in vitro benchtop model.</p><p><strong>Methods: </strong>Six dual-valve circuits were tested in triplicates for different combinations of HBV and AGV settings adding up to a summed opening pressure (OP) of either 20 or 40 cmH₂O. This \"theoretical\" sum was based on the addition of the nominal OP settings as stated by the manufacturer. Kruskal-Wallis tests and linear mixed-effect models were employed to analyze the flow rates for HBV-AGV settings with the same theoretical OP.</p><p><strong>Results: </strong>Kruskal-Wallis analysis demonstrated that HBV-AGV settings for each circuit, at a theoretical OP of 20 and 40 cmH₂O, showed statistically significant differences in flow rate. In linear mixed-effects models, as HBV OP was increased and composed a larger fraction of the theoretical OP, the flow rate decreased (effect size: -1.567 × 10^- 3 mL/min/cmH₂O, standard error: 1.663 × 10^- 4 mL/min/cmH₂O, p < 2 × 10^- 16 at 20 cmH₂O, and effect size: -3.735 × 10^- 3 mL/min/cmH₂O, standard error: 1.475 × 10^- 4 mL/min/cmH₂O, p < 2 × 10^- 16 at 40 cmH₂O, respectively).</p><p><strong>Conclusion: </strong>An analysis of the flow data demonstrated statistically significant differences between combinations of HBV-AGV settings adding up to the same theoretical opening pressure. These findings suggest that in practice, the nominal OPs of Hakim and M.blue^Ⓡ valves may not be additive. Clinicians should be aware that drainage patterns can change when adjusting OPs of Hakim^Ⓡ and M.blue^Ⓡ valves under the assumption that HBV-AGV settings with the same summed theoretical OP behave alike.</p>","PeriodicalId":12321,"journal":{"name":"Fluids and Barriers of the CNS","volume":"23 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13126923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CSF Aquaporin-4 levels in controls and in idiopathic normal pressure hydrocephalus before and after shunt surgery.","authors":"Johan Eriksson De Ryst, Sofia Bergström, Sara Mravinacova, David Bäckström, Sara Qvarlander, Anna Månberg, Anders Eklund, Jan Malm","doi":"10.1186/s12987-026-00809-2","DOIUrl":"https://doi.org/10.1186/s12987-026-00809-2","url":null,"abstract":"<p><strong>Background: </strong>Aquaporin-4 (AQP4) is crucial for brain fluid regulation and glymphatic system function. Idiopathic normal pressure hydrocephalus (INPH) is characterized by impaired CSF flow and is treated with shunt surgery. This study investigated AQP4 levels in INPH patients to explore its role in pathophysiology and as a potential biomarker for shunt response.</p><p><strong>Methods: </strong>CSF samples from 233 INPH patients and 29 controls were analysed. AQP4 levels were compared between preoperative patients and controls, before and after shunt surgery (110 patients), and between shunt responders and non-responders (204 patients). A bead-based assay was used to measure AQP4, and outcomes were assessed by postoperative changes in maximum gait velocity.</p><p><strong>Results: </strong>In unadjusted analyses, preoperative AQP4 levels were lower in INPH patients than in controls; however, this difference did not remain after adjustment for pre-analytical and demographic confounders (p = 0.87). Postoperative AQP4 levels were higher (median 1646 AU IQR 1347-1976) than preoperative levels (1166 AU IQR: 976-1345; p < 0.001) and the magnitude of increase showed a modest correlation with gait improvement (rₛ = 0.22, p = 0.022). Shunt responders had lower preoperative AQP4 levels median 1089 AU, IQR 971-1277) than non-responders (median 1213 AU, IQR 1074-1361; p = 0.008). Pre-analytical factors, including storage duration and sample processing, were strong determinants of measured AQP4 levels.</p><p><strong>Conclusions: </strong>CSF AQP4 levels in INPH did not differ from those in controls and were highly sensitive to pre-analytical sample handling. CSF AQP4 levels increased following shunt surgery. A potential prognostic value of CSF AQP4 is suggested but requires further investigation.</p>","PeriodicalId":12321,"journal":{"name":"Fluids and Barriers of the CNS","volume":"23 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13101227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic multiphysics modeling reveals how blood pulsation drives CSF flow, pressure, and brain deformation under physiological and injection conditions.","authors":"Zhuogen Li, Keyu Feng, Hector Gomez","doi":"10.1186/s12987-026-00804-7","DOIUrl":"10.1186/s12987-026-00804-7","url":null,"abstract":"","PeriodicalId":12321,"journal":{"name":"Fluids and Barriers of the CNS","volume":"23 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13088591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of HIV and azidothymidine on Alzheimer's-like pathology and amyloid beta transporters in hu-PBL-NSG mice, brain endothelial amyloid beta uptake and endothelial barrier integrity.","authors":"Biju Bhargavan, Narendran Annadurai, Georgette D Kanmogne","doi":"10.1186/s12987-026-00807-4","DOIUrl":"https://doi.org/10.1186/s12987-026-00807-4","url":null,"abstract":"","PeriodicalId":12321,"journal":{"name":"Fluids and Barriers of the CNS","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel paracellular marker based on ᴅ-dipeptide structure for highly sensitive quantification with UPLC-MS/MS for in vitro and in vivo blood-brain barrier permeability analysis.","authors":"Cindy Bay, Eric Mühlberg, Philipp Uhl, Julia Carolin Stingl, Gzona Bajraktari-Sylejmani, Jürgen Burhenne, Johanna Weiss, Max Sauter","doi":"10.1186/s12987-026-00806-5","DOIUrl":"10.1186/s12987-026-00806-5","url":null,"abstract":"","PeriodicalId":12321,"journal":{"name":"Fluids and Barriers of the CNS","volume":"23 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13067629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain ventricle morphology markers in predicting shunt surgery outcome in idiopathic normal-pressure hydrocephalus.","authors":"Andrius Penkauskas, Eemeli Kuukkanen, Anssi Lipponen, Juhana Hakumäki, Juha Koikkalainen, Jyrki Lotjonen, Lauri Erkkilä, Jussi Tohka, Pauli Miettinen, Ville Leinonen","doi":"10.1186/s12987-026-00788-4","DOIUrl":"10.1186/s12987-026-00788-4","url":null,"abstract":"","PeriodicalId":12321,"journal":{"name":"Fluids and Barriers of the CNS","volume":"23 1","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13063911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-onset ventriculomegaly and neuroimmune alterations in Hoatz-deficient mice.","authors":"Keishi Narita, Yoshichika Yoshioka, Sayed Sharif Abdali, Masahiro Ohgidani, Shohei Komaki, Masato Hirakawa, Atsushi Shimizu, Tomoyuki Saino","doi":"10.1186/s12987-026-00796-4","DOIUrl":"https://doi.org/10.1186/s12987-026-00796-4","url":null,"abstract":"","PeriodicalId":12321,"journal":{"name":"Fluids and Barriers of the CNS","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-hemorrhagic hydrocephalus of prematurity is associated with disruption of tight junctions and increased macrophage activity in the choroid plexus.","authors":"Maria Garcia-Bonilla, Rajiv Swarup, Owen W Limbrick, Habeebah Z Vohra, Ayodamola Otun, Konrad McKalip, William Bernhardt, Kirill Shumilov, Marie Michenkova, Jayne Crouthamel, Mackenzie Newman, Krikor Dikranian, James P McAllister Ii, David D Limbrick","doi":"10.1186/s12987-026-00800-x","DOIUrl":"https://doi.org/10.1186/s12987-026-00800-x","url":null,"abstract":"","PeriodicalId":12321,"journal":{"name":"Fluids and Barriers of the CNS","volume":" ","pages":""},"PeriodicalIF":6.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147591029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}