Experimental and Сlinical Urology最新文献

{"title":"Possibilities of the thulium fiber laser for the simultaneous treatment of patients with large volume BPH and bladder stones.","authors":"V. Dubrovin, A. Tabakov, R. Shakirov, A. Egoshin, O.V. Mihailovsky","doi":"10.29188/2222-8543-2022-15-3-64-69","DOIUrl":"https://doi.org/10.29188/2222-8543-2022-15-3-64-69","url":null,"abstract":"Introduction. Treatment of the patients with large volume BPH and bladder stones is an urgent problem of endoscopic treatment. The aim of the study is to evaluate the possibility of simultaneous enucleation of the prostate and cystolithotripsy using the thulium fiber laser. Material and methods. Operated on 43 patients aged 69,1 (61-79), with volume prostate 98,5 (83-155) cm3 and bladder stones 16,5 (5-35) mm. Results. The total operation time was on average 101,5 (45-158) minutes, the time of enucleation with morcellation– 85,5 (35-120) min., cystolithotripsy– 15,6 (0,5-38) min. Damage to the prostate capsule was observed in 6 (13,9%) cases, in 3 (6,9%) cases– bladder mucosa, which did not require interrupting the operation. The duration of urethral drainage was 3,8 (3-6) days, Q max 1 month after surgery was 15,4 (12-24) ml/sec. The duration of hospitalization averaged 7,4 (5-14) days. Conclusions. The use of a thulium fiber laser allows efficient and safe simultaneous treatment of patients with large volume BPH, complicated by bladder stones.","PeriodicalId":123040,"journal":{"name":"Experimental and Сlinical Urology","volume":"56 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114162224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of prostate cancer in the Yaroslavl region in 2012-2021.","authors":"П.В. Нестеров, А.В. Ухарский, И.В. Иванова, О.В. Егорова, Н.С. Корзина, P. V. Nesterov, A. V. Ukharsky, I. V. Ivanova, O. V. Egorova, N. S. Korzina, Эпидемиологическое Исследование","doi":"10.29188/2222-8543-2022-15-3-10-17","DOIUrl":"https://doi.org/10.29188/2222-8543-2022-15-3-10-17","url":null,"abstract":"Introduction. According to the International Agency for Research on Cancer, the total number of primary cases of cancer in the world in the second decade of the 21st century exceeded 14 million cases, and the number of deaths is more than 8 million annually. The aim of the study was to investigate the dynamics of epidemiological indicators in patients with prostate cancer (PСa) in the Yaroslavl region for 10 years in the period from 2012 to 2021. Materials and methods. The analysis of demographic indicators in the Yaroslavl region is carried out. For the period from 2012 to 2021, a retrospective analysis of the primary diagnosis of 3566 PСa patients and the death of 1270 men in the Yaroslavl region was carried out. The contingents of patients with PСa were studied depending on the size and composition of the population of the region. Data from the population cancer registry database and basic reporting forms were used for the analysis. Results. In the Yaroslavl region, a regressive type of population has been identified, there is a pronounced tendency to aging and population decline. There was an increase in the absolute number of newly diagnosed PСa patients by an average of 35.2% over the specified period. In the period from 2019-2021, a decrease in the number of patients with stages I–II of tumor lesion, an increase in neglected cases was revealed. The annual detection of patients with stage III was consistently low, below the national average (13.0 – 19.5%). Advanced forms of PСa are detected in a significant number of cases with a sharp increase in the period from 2019 to 2021 to 39.2%. The number of men who survived the 5-year follow-up period increased by 54.4%. The annual mortality rate remained stable, but exceeded the average for the Russian Federation. The mortality rate of patients from PСa remained stable with a slight increase in the period 2019-2021 to 2.3 – 2.7 per 10,000 population. Conclusion. It is advisable to develop and implement a regional program for early diagnosis and screening of PСa based on a set of simple and publicly available methods.","PeriodicalId":123040,"journal":{"name":"Experimental and Сlinical Urology","volume":"326 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124300600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological activity of a drug, polypeptides derived from testes in a model of oxidative stress in vitro.","authors":"Y. Khochenkova, Yu. S. Machkova, D. Khochenkov, E. Safarova, N. A. Bastrikova","doi":"10.29188/2222-8543-2022-15-3-18-26","DOIUrl":"https://doi.org/10.29188/2222-8543-2022-15-3-18-26","url":null,"abstract":"Introduction. Male infertility is one of the main causes of forced childlessness of couples around the world. Currently, a limited number of drugs for the treatment of male infertility are available on the market. Biologically active supplements (dietary supplements) containing L-carnitine are often used in the complex therapy. The results of determining the therapeutic activity of a new drug, a peptide complex obtained from cattle testes (PP-R-001) for the treatment of male infertility and comparing its effectiveness with L-carnitine in the models of oxidative stress induction in cell cultures are presented. Material and methods. The study was carried out on cell lines of transplanted piglet testicle (PTP) and bovine embryonic testicle (TEB). Two experimental approaches were used to induce oxidative stress (OS) in testicular cells: co-culturing cells of either PTP or TEB with cisplatin (cis-Pt) or hydrogen peroxide (H2O2). The protective effect of the PP-R-001 peptide complex was assessed by the induction of apoptosis and testicular cell death, migration activity, the number of cells with DNA double-strand breaks, the level of reactive oxygen species, mitochondrial activity of cells under OS conditions. Results. The effect of PP-R-001 significantly exceeded the effect of L-carnitine on the survival rate and decrease of apoptotic cell number of PTP and TEB under OS conditions. PP-R-001 significantly increased the migration activity of both cell lines. It was found that PP-R-001 significantly reduced the level of intracellular lesions that lead to apoptotic death of TEB and PTP cells exposed to both cis-Pt and H2O2: the drug increased the activity of mitochondria and decreased the number of DNA double-strand breaks and reactive oxygen species (ROS). Conclusion. The data obtained indicate that PP-R-001 has a multimodal effect on testicular TEB and PTP cells in the oxidative stress models, which is superior to the effect of L-carnitine widely used in male fertility supplements.","PeriodicalId":123040,"journal":{"name":"Experimental and Сlinical Urology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130590042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Active surveillance for intermediate-risk рrostate сancer.","authors":"S. P. Kokin, K. Nyushko, B. Alekseev, O. Mailyan","doi":"10.29188/2222-8543-2022-15-3-55-63","DOIUrl":"https://doi.org/10.29188/2222-8543-2022-15-3-55-63","url":null,"abstract":"Introduction. Prostate cancer (PСa) is one of the most common malignant diseases in men in the world. Radical prostatectomy remains the «gold standard» for treating this pathology. Good long-term oncological results Active follow-up of low-risk patients, as well as modification of the Gleason scale, suggested the possibility of using AS in carefully selected patients with intermediate-risk PCa. The introduction of molecular genetic markers into practice will allow a personalized choice of a treatment method. Purpose. Conduct a systematic review of the literature on the analysis of active surveillance in patients with PCa of an intermediate risk group, existing molecular genetic markers for additional risk stratification. Materials and methods. A systematic review of publications on active surveillance in prostate cancer, published in the PubMed, Cochrane, e-Library databases, was performed. Databases were searched using the following keywords: active surveillance, prostate cancer, intermediate risk, molecular genetic markers. Results. This review selected 39 articles, of which 24 are devoted to Active Surveillance, 15 molecular genetic markers of PCа aggressiveness. In the analysis of active surveillance, parameters such as the percentage of patients without active (radical) treatment, overall survival, tumor-specific survival, and metastasis-free survival were evaluated. Conclusions. Currently, AS in prostate cancer can be used for carefully selected group of patients at an intermediate risk group, the introduction of modern molecular genetic markers will allow more accurate determination of the amount of treatment without worsening long-term oncological results.","PeriodicalId":123040,"journal":{"name":"Experimental and Сlinical Urology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127789325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technical aspects of ultrasound diagnostics of varicocele and analysis of European clinical guidelines.","authors":"S. Gamidov, N. Druzhinina, T. Shatylko, A. Popova, R. Safiullin","doi":"10.29188/2222-8543-2022-15-3-102-108","DOIUrl":"https://doi.org/10.29188/2222-8543-2022-15-3-102-108","url":null,"abstract":"Introduction. Varicocele is detected in 15% of healthy men, in 35% of men with primary infertility and in 80% of men with secondary infertility. The main non-invasive method to identify this pathology is ultrasound (US) with Doppler. Мaterials and methods. In this article, we reviewed and discussed the technical aspects of performing US diagnostics of varicocele, based on the clinical guidelines of the European Society for Urogenital Radiology. Results. The algorithm of US examination for the diagnosis of varicocele was analysed. It consists of 24 recommendations, which allows to increase the diagnostic value of US examination, as well as to reduce the frequency of diagnostic mistakes. Conclusions. US examination remains the most widely used imaging method of varicocele diagnostics. The described algorithm of this study may be useful for US diagnostics specialists.","PeriodicalId":123040,"journal":{"name":"Experimental and Сlinical Urology","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116480118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenetic justification of the use of 5-alpha reductase inhibitors in the treatment of benign prostatic hyperplasia.","authors":"O. Zolotukhin, A. Esin, Y. Madykin","doi":"10.29188/2222-8543-2022-15-3-94-101","DOIUrl":"https://doi.org/10.29188/2222-8543-2022-15-3-94-101","url":null,"abstract":"Introduction. Benign prostatic hyperplasia (BPH) is one of the commonest urological diseases. Aim. To review current research on the use of 5-alfa-reductase inhibinors (5-ARI) in the treatment of BPH: finasteride and dutasteride. Materials and methods. We have done a search and analysis of publications for last 20 years using elibrary, PubMed, Cochrane Collaboration and Embase databases. The inclusion criteria were: prospective (cohort) studies and randomized clinical trials (RCTs). The total number of sources included in this review was 36. Results and discussion. The review highlights the following sections: clinical and side effects of 5-ARI inhibitors, evaluation of the effectiveness of therapy with 5-ARI inhibitors and the reasons for its inefficiency, conclusions. The analysis of works devoted to the clinical effects of 5-ARI showed the absence of a complete cure for BPH against the background of modern pharmacotherapy with a moderate positive effect in most patients. The known side effects of 5-ARI suggest there are additional mechanisms of those medications besides of inhibiting the enzyme 5-alpha-reductase and new studies are needed to identify them. The lack of generally accepted indicators for 5-ARI effectiveness monitoring makes it difficult to assess it. And the insufficient effectiveness of drug treatment of BPH may be associated with the inability to classify the pathophysiological diversity of the disease and its phenotypes. Conclusions. New studies are needed to study the individual specific composition of the pancreatic tissue and a deeper understanding of the pathogenesis of the disease, which will improve the results of drug therapy and develop individual therapeutic solutions for patients.","PeriodicalId":123040,"journal":{"name":"Experimental and Сlinical Urology","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131711875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of prostatic peptides on the lomefloxacin transmembrane influx.","authors":"A. Dukhanin","doi":"10.29188/2222-8543-2022-15-3-28-34","DOIUrl":"https://doi.org/10.29188/2222-8543-2022-15-3-28-34","url":null,"abstract":"Introduction. The use of peptides that penetrate the cell without the participation of membrane proteins and are capable of intracellular transport of low molecular weight substances associated with them opens up a new stage in the development of targeted drug delivery to therapeutic targets. Aim. Evaluation of the effect of prostatic peptides of Vitaprost® (prostate extract) on the transmembrane transport of the antimicrobial drug lomefloxacin. Material and methods. In the first series, the effects of prostatic peptides on the ability of lomefloxacin to pass through artificial membranes by passive diffusion (PAMPA method – parallel artificial membrane permeability assay) were studied. In the second series, the effects of prostatic peptides on the cell permeability of lomefloxacin were studied in the Caco-2 model. Results. Comparative study of effective membrane permeability (logPe). for lomefloxacin in the absence (control group) and presence of prostatic peptides (a mixture of prostate extract at a concentration of 10 mg/ml) showed that the combined use of lomefloxacin and prostatic peptides leads to a significant increase in the logPe value, an increase of 29% on average. The specific nature of the identified interaction was confirmed: the addition of beta-mercaptoethanol (BME) to the donor compartment did not affect the permeability of pure lomefloxacin, but suppressed the cargo effect of prostatic peptides. The permeability coefficient (Papp) calculated on the Caco-2 model for lomefloxacin in combination with peptides was 13.04±1.80×10-6 cm/s, while for lomefloxacin it was 10.31±0.76×10-6 cm/s. Conclusion. Comparison of the obtained data of two series of experiments indicates the presence of a direct cargo effect of prostatic peptides on the transmembrane transport of lomefloxacin in vitro.","PeriodicalId":123040,"journal":{"name":"Experimental and Сlinical Urology","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128777623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ureteroureterostomy in case of renal duplication.","authors":"E. A. Kondrateva, I. M. Kagantsov, S. Karavaeva, E. Gurkina, T. Pervunina","doi":"10.29188/2222-8543-2022-15-3-148-155","DOIUrl":"https://doi.org/10.29188/2222-8543-2022-15-3-148-155","url":null,"abstract":"Introduction. Kidney duplication is one of the most common urological developmental anomalies, the incidence of which is 0.8%. At the same time, various types of obstructive uropathy can be a concomitant pathology in such a situation. There are various methods for correcting obstructive uropathy. Currently, more and more often in the treatment of obstructive uropathy of one of the segments of the doubled kidney, a method such as ureteroureterostomy is used. However, there is still no consensus on which treatment tactics in this case is the most optimal. The aim of our work was to analyze literature about using ureteroureterostomy in patients with obstructive uropathies of a duplicated kidney, as well as to compare this technique with others. Materials and methods. Search results were analyzed in the scientific databases e-Library, PubMed, Medline, Web of Science, Embase, Cochrane Library and PEDro according to the following. keywords: «renal duplication», «heminephrectomy», «ureteroureterostomy», «obstructive uropathies». In total it was found 157 publications, after analyzing the literature, 33 papers were selected for review, most fully reflecting the topic. Results. Heminephrectomy is still popular for severely reduced or absent duplex kidney function, but it has complications such as decreased function of the remaining segment, pseudocyst formation, stump, urinoma, segmental hematoma, ureteral stricture, and vesicoureteral reflux into the remaining segment. Ureteroureterostomy, as an alternative method for correcting obstructive uropathies of a double kidney, has been recognized as effective and safe in many studies. Data are presented to prove that ureteroureterostomy is applicable for any function of the affected segment. In this article, various techniques for ureteroureterostomy are consecrated, from open intervention to robotic one. In addition, research data on the safety of ureteroureteroanastomosis in case of a pronounced discrepancy between the diameters of the ureters are presented. Among the complications of ureteroureteroanastomosis, cultitis, urine leakage in the anastomosis zone, urinoma, and stenosis of the anastomosis can be noted. The predictors of an unfavorable outcome of the proposed method were identified. These include ectopic ureterocele, hydronephrosis of both segments of the duplex kidney, as well as simultaneous ureteroureterostomy and reimplantation of the recipient ureter. Conclusions. Ureteroureterostomy in patients with various pathologies inherent in duplication of the kidney is an effective and safe technique that allows preserving the function of the segment and adequately draining it. The use of this technique does not depend on the presence of a decrease or lack of function of one of the segments.","PeriodicalId":123040,"journal":{"name":"Experimental and Сlinical Urology","volume":"2018 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128037859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opportunities to increase early diagnostics and treatment compliance of BPH progression.","authors":"M. Evdokimov, L. Spivak","doi":"10.29188/2222-8543-2022-15-3-110-116","DOIUrl":"https://doi.org/10.29188/2222-8543-2022-15-3-110-116","url":null,"abstract":"Introduction. Benign prostatic hyperplasia (BPH) is one of the most common diseases of the genitourinary system in men. Severe symptoms of lower urinary tract dysfunction (LUTS), which develop with BPH, worsen the quality of life. Prophylactic examinations, dynamic monitoring and necessary treatment: conservative (nonpharmacological and pharmacological treatment) or surgical treatment are necessary to control the course of the disease. Bioregulatory peptides can be used for early control of LUTS. The aim of the work was to assess the efficacy of early diagnosis and adherence to drug prophylaxis of BPH development and progression using different methods including bioregulatory peptides. Materials and methods. Data of the clinical examination and periodic medical examinations of 1675 men who were enrolled in the program «Complex of measures to increase the efficiency of early diagnostics of BPH and increase adherence to medical prophylaxis of BPH development and progression» were analyzed. After full clinical examination, depending on indications, patients were recommended surgical or conservative treatment – non-medication (behavioral) or medication (α1-adrenoblockers + muscarinic receptor antagonists, 5α-reductase inhibitors or Vitaprost preparations). The patients were observed for 4 years. Efficacy and safety of the use of bioregulatory peptides (Vitaprost®) in patients with BPH and LUTS were compared with the results of treatment in patients who chose behavioral therapy (active observation). Results. Behavioral therapy was used in 221 patients with mild to moderate symptoms, 312 patients were prescribed Vitaprost® Forte and Vitaprost® tablets. Active observation was more often chosen by patients of the youngest group (40-44 years). During Vitaprost® application there were improved IPSS questionnaire indexes, maximal urination rate increased, residual urine volume and prostate volume decreased. Worsening and increase of severity of complaints, according to IPSS questionnaire, decrease of maximum urinary flow rate and increase of residual urine volume and prostate volume were registered in actively observed group of patients. Conclusions. Timely initiation of therapy with Vitaprost® Forte and Vitaprost® tablets in patients with BPH has a favorable efficacy and safety profile. Further analysis of the data received as a result of the regional program is supposed to be carried out to evaluate its results.","PeriodicalId":123040,"journal":{"name":"Experimental and Сlinical Urology","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124647879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for nephrolithiasis after radical cystectomy with intestinal plasty of the bladder.","authors":"M. Prosyannikov, N. V. Anokhin, D. Voytko, I. Shevchuk, T. Perepanova, O. Konstantinova, A. Sivkov, B. Alekseev, O. Apolikhin, A. Kaprin","doi":"10.29188/2222-8543-2022-15-3-70-81","DOIUrl":"https://doi.org/10.29188/2222-8543-2022-15-3-70-81","url":null,"abstract":"Introduction. Some studies have shown that urolithiasis is much more common in the group of patients who underwent radical cystectomy (RC) with intestinal plastic bladder than the average for the population. The aim of this study included the search of the frequency of urinary stones formation in patients after RC, depending on the type of intestinal plasty of the bladder and the type of urinary diversion, the analysis of risk factors for lithogenesis, the search for metabolic lithogenic disorders in this category of patients, and the assessment of the severity of the identified changes. Materials and methods. The work analyzed the data of 214 patients (169 men and 45 women) who were operated from 2008 to 2021 with a diagnosis of bladder cancer. Patients underwent RC with the formation of a hetero- or orthotopic ileoconduit. We analyzed the indicators of general urine analysis, biochemical blood test, bacteriological analysis of urine for flora, performed both before RC and in the late postoperative period. Also The results of ultrasound of the kidneys, bladder (reservoir), MSCT of the kidneys performed before RC and in the late postoperative period were studied. We selected 37 patients from the general group in random order, who prospectively underwent a biochemical blood test, a biochemical analysis of daily urine, and an assessment of the acid-base composition of venous blood. Statistical analysis was performed by calculating the relative risk, as well as calculating the t-test for independent groups using the computer program Statistica 10.0 (StatSoft USA). Results. Urinary stones of the upper urinary tract after RC, ortho- and heterotopic intestinal plastics of the bladder in the late postoperative period (more than 1 year) were diagnosed in 27 out of 214 patients (12.6%). The relative risk of urolithiasis in patients with pyelectasis before surgery is 3.87 times higher than in patients without changes in pelvicalyceal system at the preoperative stage (p=0.0004). In patients after RC with impaired renal function in stages III-V (GFR 60 ml/min (p=0.005). RC patients with a BMI >30 had a 2.431-fold higher risk of urinary stone formation than those with a BMI 7.0, diagnosed after surgical treatment (p=0.003). The relative risk of developing urolithiasis in patients with urine pH >7.0 detected before surgery is 4.85 (p<0.0001). There was a trend towards an increase in the number of urolithiasis cases in patients who underwent RC with bacteriuria diagnosed after surgery according to urine culture (in patients with identified Enterococcus spp., Enterobacter cloacae, Providencia rettgeri (p<0.05)) compared with patients in of which sterile urine was detected. In patients suffering from urolithiasis after undergoing RC, compared with the control group of patients in the biochemical analysis of blood, there is a statistically significant difference between the level of creatinine (p=0.033), a decrease in the level of GFR from 79.9 to 68.7 (p=0.046). ","PeriodicalId":123040,"journal":{"name":"Experimental and Сlinical Urology","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114741059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}