Extremophiles最新文献_第5页

Metal-induced biofilm formation by radiation resistant bacteria Deinococcus radiodurans and Deinococcus indicus. 耐辐射球菌和耐辐射球菌金属诱导的生物膜形成。

IF 2.2 3区生物学

Extremophiles Pub Date : 2025-10-28 DOI: 10.1007/s00792-025-01403-4

André G Gouveia, Amin Taoufiq, Wilson Antunes, Célia V Romão

{"title":"Metal-induced biofilm formation by radiation resistant bacteria Deinococcus radiodurans and Deinococcus indicus.","authors":"André G Gouveia, Amin Taoufiq, Wilson Antunes, Célia V Romão","doi":"10.1007/s00792-025-01403-4","DOIUrl":"10.1007/s00792-025-01403-4","url":null,"abstract":"Biofilms confer structural and functional advantages, playing a crucial role in the survival and resilience of microorganisms in diverse environments. Given its critical importance, most efforts focus on pathogenic bacteria and common bacterial isolates overlooking the natural diversity of extremophilic groups, as the case of highly radiation resistant members of the Deinococcus genus. Here, we investigated the ultrastructural features Deinococcus radiodurans and Deinococcus indicus growing under two commonly used medium formulations TGY and M53 and differentially supplemented with metal ions. Specie-level pleomorphic behavior in Deinococcus spp. was positively correlated to media culture, inducing distinct morphological alterations with multicellular clustering in D. radiodurans under M53, while cell elongation and swelling in D. indicus grown under TGY conditions. Ultrastructure analysis provided information of biofilm structure, in which extracellular polymeric substance (EPS) matrix was only observed in D. radiodurans and enhanced under Mn and Fe supplementation, while D. indicus showed high surface adhesion. Compared to reported biofilms, both species showed abundant membrane vesicles (MVs), providing a rational basis for biofilm cohesion and cell adhesion in this species. Arsenic used as toxic metal condition, did not impact biofilm structure, opening new avenues for potential bioremediation approaches.","PeriodicalId":12302,"journal":{"name":"Extremophiles","volume":"29 3","pages":"38"},"PeriodicalIF":2.2,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145388309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diversity of culturable fungi in Antarctic lakes and their potential for producing compounds of biotechnological interest. 南极湖泊中可培养真菌的多样性及其产生生物技术化合物的潜力。

IF 2.2 3区生物学

Extremophiles Pub Date : 2025-10-23 DOI: 10.1007/s00792-025-01405-2

Láuren Machado Drumond de Souza, Júlia de Paula Muzetti Ribeiro, Debora Luiza Costa Barreto, Elisa Amorim Amâncio Teixeira, Camila Rodrigues de Carvalho, Juan Manuel Lirio, Silvia H Coria, Peter Convey, Fábio Soares de Oliveira, Charles L Cantrell, Stephen Oscar Duke, Carlos Augusto Rosa, Luiz Henrique Rosa

{"title":"Diversity of culturable fungi in Antarctic lakes and their potential for producing compounds of biotechnological interest.","authors":"Láuren Machado Drumond de Souza, Júlia de Paula Muzetti Ribeiro, Debora Luiza Costa Barreto, Elisa Amorim Amâncio Teixeira, Camila Rodrigues de Carvalho, Juan Manuel Lirio, Silvia H Coria, Peter Convey, Fábio Soares de Oliveira, Charles L Cantrell, Stephen Oscar Duke, Carlos Augusto Rosa, Luiz Henrique Rosa","doi":"10.1007/s00792-025-01405-2","DOIUrl":"10.1007/s00792-025-01405-2","url":null,"abstract":"We evaluated the diversity and biotechnological potential of culturable fungi from sediments of Florencia and Katerina lakes, James Ross Island, maritime Antarctica. A total of 57 fungal isolates, belonging to 24 taxa (16 from Florencia and 8 from Katerina) were identified. Ascomycota was the dominant phylum, followed by Mortierellomycota and Basidiomycota. The main genera included Cladosporium, Dactylaria, Glaciozyma, Graphium, Leucosporidium, Mortierella, Penicillium, Pseudeurotium, Pseudogymnoascus, Tetracladium and Thelebolus. Pseudogymnoascus sp. 1 and Thelebolus species were the most frequent. Florencia Lake showed greater taxonomic richness and diversity than Katerina Lake. Of all taxa, 12 were exclusive to Florencia, 4 to Katerina, and 4 were shared. All fungal isolates were screened for the production of 11 industrially relevant enzymes; inulinase was the most common, followed by protease, invertase, gelatinase and pectinase. Eight isolates (Pseudogymnoascus and Thelebolus) produced biosurfactants and 50 contained intracellular lipid bodies. A Penicillium palitans isolate fully inhibited germination of Allium schoenoprasum seeds, and NMR analysis confirmed (-)-palitantin as the active compound. These results confirm that Antarctic lake sediments harbor diverse fungi with potential for producing enzymes, biosurfactants, lipids and bioactive metabolites, reinforcing the value of studying extremophilic fungi as a source of bioproducts in the context of fragile ecosystems affected by climate change.","PeriodicalId":12302,"journal":{"name":"Extremophiles","volume":"29 3","pages":"36"},"PeriodicalIF":2.2,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145344278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolation, screening, and molecular identification of culturable halophilic bacteria with enzymatic and antimicrobial potential from the saline soils of Arzew salt lake, Algeria. 阿尔及利亚Arzew盐湖盐渍土中具有酶促和抗菌潜力的可培养嗜盐细菌的分离、筛选和分子鉴定。

IF 2.2 3区生物学

Extremophiles Pub Date : 2025-10-23 DOI: 10.1007/s00792-025-01401-6

Amina Meglali, Lotfi Ghellai, Taha Ahmed Benabbou

{"title":"Isolation, screening, and molecular identification of culturable halophilic bacteria with enzymatic and antimicrobial potential from the saline soils of Arzew salt lake, Algeria.","authors":"Amina Meglali, Lotfi Ghellai, Taha Ahmed Benabbou","doi":"10.1007/s00792-025-01401-6","DOIUrl":"10.1007/s00792-025-01401-6","url":null,"abstract":"Halophilic microorganisms from extreme environments are increasingly recognized as promising sources of industrial enzymes and antimicrobial compounds. However, many saline ecosystems remain unexplored. In this study, the bacteriological profile of the extreme salt lake of Arzew (Oran, Algeria) was investigated for the first time. Twenty-nine halophilic bacterial strains were isolated from five saline soil samples around the lake and were preliminarily screened for the production of nine industrially relevant enzymes and antimicrobial activities. The enzymatic screening revealed that 69% of the isolates showed single or combined hydrolytic activities, with gelatinase, protease, inulinase, and lipase activities being the most prevalent. The antimicrobial screening showed significant activity against Gram-positive pathogens, Aspergillus niger, Fusarium sp., and Phytophthora infestans. Four of the most potent strains were selected for further phenotypic and molecular characterization. Based on 16S rRNA gene sequencing, the results showed that three isolates belonged to the genus Streptomyces and one representative isolate to the Nocardiopsis genus. Both phylotypes demonstrated tolerance to wide ranges of salt, pH, and temperature. Notably, isolate O61 displayed a distinct phylogenetic position, suggesting its potential affiliation as a novel Streptomyces species. These results provide a baseline microbial resource discovery from an underexplored Algerian hypersaline environment and highlight promising candidates for future detailed characterization for biotechnological applications.","PeriodicalId":12302,"journal":{"name":"Extremophiles","volume":"29 3","pages":"35"},"PeriodicalIF":2.2,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145344288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Halobacillus as source of natural products and enzyme factories. 盐杆菌作为天然产物和酶工厂的来源。

IF 2.2 3区生物学

Extremophiles Pub Date : 2025-08-23 DOI: 10.1007/s00792-025-01400-7

Andri Frediansyah, Dhea Sandra Fitriany

{"title":"Halobacillus as source of natural products and enzyme factories.","authors":"Andri Frediansyah, Dhea Sandra Fitriany","doi":"10.1007/s00792-025-01400-7","DOIUrl":"10.1007/s00792-025-01400-7","url":null,"abstract":"Halobacillus, renowned for their remarkable metabolic diversity, thrive in saline and high-salt environments, making them a fascinating subject of study. These adaptable organisms are commonly found in extreme habitats, including saline waters, salt mines, salt-rich soils, and high-salinity foods. Their ecological versatility and beneficial properties—such as the synthesis of alkaline enzymes, bioremediation potential, and production of bioactive small molecules—have sparked growing interest. The genome of Halobacillus encodes a vast array of natural products and enzymes, many of which hold significant promise for biotechnological applications. This review explores Halobacillus as a rich source of both natural products and enzymes, offering a comprehensive overview of its taxonomy, comparative genomics, and ecological diversity. We present a detailed analysis of the natural products isolated from Halobacillus, discussing their biosynthesis, bioactivity, mechanisms of action, and the geographical origins of their producers. Additionally, we delve into the production of alkaline enzymes, examining both novel and well-characterized variants, alongside the optimal conditions for their synthesis. The growing availability of public genomic databases for Halobacillus offers an exciting opportunity to unlock the full potential of this genus, paving the way for the discovery of novel natural products with diverse applications.","PeriodicalId":12302,"journal":{"name":"Extremophiles","volume":"29 3","pages":"34"},"PeriodicalIF":2.2,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Actinomycetes from high altitude salt lake Tso-Kar of Ladakh offers bright prospects for antimycobacterial drug discovery especially for drug resistant mycobacteria. 来自拉达克措卡尔高海拔盐湖的放线菌为抗菌药物特别是耐药分枝杆菌的开发提供了广阔的前景。

IF 2.2 3区生物学

Extremophiles Pub Date : 2025-08-01 DOI: 10.1007/s00792-025-01398-y

Ishfaq Ahmad Baba, Zubair Ahmad Wani, Mohamad Mosa Mubarak, Zahoor Ahmad

{"title":"Actinomycetes from high altitude salt lake Tso-Kar of Ladakh offers bright prospects for antimycobacterial drug discovery especially for drug resistant mycobacteria.","authors":"Ishfaq Ahmad Baba, Zubair Ahmad Wani, Mohamad Mosa Mubarak, Zahoor Ahmad","doi":"10.1007/s00792-025-01398-y","DOIUrl":"10.1007/s00792-025-01398-y","url":null,"abstract":"The rise of multidrug-resistant (MDR) strains of Mycobacterium tuberculosis (M. tb) has driven the search for new antimycobacterial agents. Our study focused on isolation and characterization of actinomycetes from the hypersaline Tso-Kar Salt lake in Ladakh, India, to explore their antibacterial potential. We isolated 145 bacterial isolates from various soil, salt and water samples and found 23 actinomycete isolates effective against Mycobacterium smegmatis through cross-streak screening. Molecular identification confirmed that these isolates belonged to 14 genera of actinomycetes. Out of 23 extracts from these isolates, 15 ethyl acetate organic extracts exhibited strong antimycobacterial activities against M. smegmatis, M. tb H37Ra, and M. tb H37Rv, with MIC values between 125 and 31.25 µg/mL. Importantly, all 15 extracts demonstrated bactericidal activities at their respective MICs against M. tb H37Rv. The other 8 extracts displayed comparatively weaker MIC and MBC ranging 500-250 µg/mL and 1000-500 µg/mL respectively. These extracts were equally effective against drug-resistant and drug-susceptible M. tb clinical isolates. Furthermore, they showed broad antibacterial activity against both gram-positive and gram-negative bacteria, with MICs ranging from 500 to 31.25 µg/mL. The GC-MS analysis of the potent extracts revealed that a wide range of compounds including Phenolics, Peptides, Ergot alkaloids and their derivates may have contributed to anti-mycobacterial activity. The genetic diversity and significant antimicrobial properties of these actinomycetes from extreme environments highlight their potential for developing new antituberculosis and general antibiotic agents, particularly against MDR infections.","PeriodicalId":12302,"journal":{"name":"Extremophiles","volume":"29 2","pages":"33"},"PeriodicalIF":2.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural insight into the unique substrate specificity of glutamate dehydrogenase from Saccharolobus solfataricus. 谷氨酸脱氢酶独特底物特异性的结构分析。

IF 2.2 3区生物学

Extremophiles Pub Date : 2025-07-24 DOI: 10.1007/s00792-025-01395-1

Itsuki Okabe, Masashi Hirano, Taketo Ohmori, Minako Segawa, Kazunari Yoneda, Toshihisa Ohshima, Haruhiko Sakuraba

{"title":"Structural insight into the unique substrate specificity of glutamate dehydrogenase from Saccharolobus solfataricus.","authors":"Itsuki Okabe, Masashi Hirano, Taketo Ohmori, Minako Segawa, Kazunari Yoneda, Toshihisa Ohshima, Haruhiko Sakuraba","doi":"10.1007/s00792-025-01395-1","DOIUrl":"10.1007/s00792-025-01395-1","url":null,"abstract":"The gene (SSO1457) encoding a L-glutamate dehydrogenase (GDH) homolog from the thermoacidophilic archaeon Saccharolobus solfataricus P2 was overexpressed in Escherichia coli. At a substrate concentration of 50 mM, the enzyme (SSO1457) produced exhibited much higher specific activity toward L-norvaline than L-glutamate at temperatures between 55 and 75°C, whereas the enzyme showed higher activity for L-glutamate than L-norvaline at 85°C. The crystal structures of both NAD+/2-oxovalerate-bound and NAD+/2-oxoglutarate-bound SSO1457 were determined. Comparison of the two structures showed that the positioning of the substrate molecules and the surrounding residues is nearly identical in the two complexes. In the 2-oxoglutarate-bound structure, the C5-carboxylate group of 2-oxoglutarate is hydrogen-bonded with the side chains of Lys72, Arg188, and Ser351, as observed in other GDHs. By contrast, in the 2-oxovalerate-bound structure, the C01, C02, and C03 atoms of 2-oxovalerate are anchored via hydrophobic interactions to the side chains of Met93 and Val348. Site-directed mutagenesis shows that the side chain of Met93 mainly mediates the reactivity of SSO1457 towards L-norvaline and contributes to high specific activities for L-norvaline.","PeriodicalId":12302,"journal":{"name":"Extremophiles","volume":"29 2","pages":"32"},"PeriodicalIF":2.2,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Idiomarina aminovorans sp. nov., a halophilic bacterium isolated from the Llamara salt pan in the Atacama Desert of northern Chile. Idiomarina aminovorans sp. nov.，一种从智利北部阿塔卡马沙漠的Llamara盐田分离出来的嗜盐细菌。

IF 2.6 3区生物学

Extremophiles Pub Date : 2025-07-21 DOI: 10.1007/s00792-025-01399-x

Christian Hintersatz, Luis Antonio Rojas, Sean Ting-Shyang Wei, Sabine Kutschke, Angela Thewes, Falk Lehmann, Rohan Jain, Katrin Pollmann

{"title":"Idiomarina aminovorans sp. nov., a halophilic bacterium isolated from the Llamara salt pan in the Atacama Desert of northern Chile.","authors":"Christian Hintersatz, Luis Antonio Rojas, Sean Ting-Shyang Wei, Sabine Kutschke, Angela Thewes, Falk Lehmann, Rohan Jain, Katrin Pollmann","doi":"10.1007/s00792-025-01399-x","DOIUrl":"10.1007/s00792-025-01399-x","url":null,"abstract":"The Atacama Desert, one of the most extreme environments on our planet, harbors a plethora of unique microbial communities adapted to the harsh conditions of the habitat. In this study, strain ATCH4T, a novel Gram-stain-negative, curved rod-shaped bacterium, was isolated from the Llamara salt pan, located in the Atacama Desert in the north of Chile. ATCH4T was capable of growth within a range of 3-12% (w/v) NaCl, 4-40 °C, and pH 6-9. Comparative 16S rRNA analysis placed the strain within the genus Idiomarina, with its closest related type species being I. loihiensis, I. ramblicola, and I. abyssalis. Genomic analysis revealed the presence of several genes linked to halophilicity as well as unique metabolic pathways, including the ability to synthesize C5 and C10-C20 isoprenoids, which may contribute to the isolate's survival in hypersaline conditions. The observed isoprenoid biosynthesis pathways suggest potential applications in various biotechnological fields, including the production of biofuels, pharmaceuticals, and other valuable chemicals. Levels of DNA-DNA relatedness, average nucleotide identity, and several phenotypic and chemotaxonomic markers clearly indicate that strain ATCH4T represents a novel species of the genus Idiomarina, for which the designation Idiomarina aminovorans sp. nov. (type strain ATCH4T = DSM 114475 = LMG 32710) is proposed.","PeriodicalId":12302,"journal":{"name":"Extremophiles","volume":"29 2","pages":"31"},"PeriodicalIF":2.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An ice inhabiting bdelloid rotifer from North America. 一种产于北美的冰栖蛭形轮虫。

IF 2.6 3区生物学

Extremophiles Pub Date : 2025-07-10 DOI: 10.1007/s00792-025-01390-6

Lydia M Dimattia, Naim Saglam, Ralph Saunders, Daniel H Shain

{"title":"An ice inhabiting bdelloid rotifer from North America.","authors":"Lydia M Dimattia, Naim Saglam, Ralph Saunders, Daniel H Shain","doi":"10.1007/s00792-025-01390-6","DOIUrl":"10.1007/s00792-025-01390-6","url":null,"abstract":"Bdelloid rotifers are major components of zooplankton worldwide and have been reported in glacier ice in both Northern and Southern Hemispheres. Curiously, no reports of psychrophilic bdelloids have surfaced in North America despite exhaustive surveys of other ice-dwelling invertebrates, e.g., glacier ice worms. This distribution gap may be partially explained by a predator-prey relationship between these two animals, but the current study suggests that ice worms and bdelloids can co-inhabit at least some glacial ecosystems over geological time. Here we report the first ice-inhabiting bdelloid rotifer from North America, collected from the northern aspect of Mt. Deception, WA, USA. Nuclear and mitochondrial genotyping identified sister-species relationships within a clade of Nordic ice-dwelling bdelloids, and close evolutionary relationships with Antarctic/New Zealand specimens. Intrapopulation genetic divergences suggest that bdelloids arrived in North America near the onset of the Pleistocene (2.58 myr BP), but their circumpolar dispersal capabilities and robustness (e.g., freeze-thaw tolerance, ability to propagate at elevated temperatures and under extreme laboratory conditions) cannot rule out multiple transoceanic dispersal events throughout the Quaternary.","PeriodicalId":12302,"journal":{"name":"Extremophiles","volume":"29 2","pages":"30"},"PeriodicalIF":2.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12246028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural characteristics and immunomodulatory activity of an exopolysaccharide from Antarctic Pseudoalteromonas sp. LP6-12-2. 南极假互生单胞菌胞外多糖LP6-12-2的结构特征和免疫调节活性。

IF 2.2 3区生物学

Extremophiles Pub Date : 2025-07-08 DOI: 10.1007/s00792-025-01394-2

Dezhi Wang, Han Li, Yu Zhao, Bailin Cong, Pengying Zhang

{"title":"Structural characteristics and immunomodulatory activity of an exopolysaccharide from Antarctic Pseudoalteromonas sp. LP6-12-2.","authors":"Dezhi Wang, Han Li, Yu Zhao, Bailin Cong, Pengying Zhang","doi":"10.1007/s00792-025-01394-2","DOIUrl":"10.1007/s00792-025-01394-2","url":null,"abstract":"Natural polysaccharides from microorganisms have various biological activities. However, those from psychrophiles with immunomodulatory properties have rarely been found. In this study, an immunoactive exopolysaccharide was extracted from Antarctic Pseudoalteromonas sp. LP6-12-2 (EPS1-1), which isolated using DEAE-Sepharose Fast Flow, Sephadex G-75, and Sephadex G-100. EPS1-1, with a molecular weight 23.47 kDa, was composed of mannose, glucose, galactose, glucosamine, and galactosamine in the ratio of 83.1:7.2:4.3:4.2:1.2. Furthermore, EPS1-1 was found to have a main chain composed of α-D-Manp (1→2) and side chains composed of α-D-Manp (1→6) by FT-IR, methylation, and NMR analyses. Besides, through the Congo red test and I2-KI reaction analyses, it was revealed that EPS1-1 lacked triple-helix structure and had more branches. Additionally, EPS1-1 could significantly advance the proliferation, phagocytosis, acid phosphatase activity, and cytokines production of macrophage cells. Data suggested EPS1-1 demonstrated potential as an immunomodulator for functional food or pharmaceutical development.","PeriodicalId":12302,"journal":{"name":"Extremophiles","volume":"29 2","pages":"29"},"PeriodicalIF":2.2,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natranaerobius thermophilus: an anaerobic, polyextremophilic microorganism with unique properties and adaptive mechanisms. 嗜热嗜钠氧菌：一种具有独特性质和适应机制的厌氧、多极端微生物。

IF 2.2 3区生物学

Extremophiles Pub Date : 2025-07-03 DOI: 10.1007/s00792-025-01392-4

Noha M Mesbah

引用次数: 0