EXCLI Journal最新文献

{"title":"Reasons for using electronic cigarettes among young adults aged 18 - 30: a systematic review.","authors":"Shérazade Kinouani, Faustine Roux, Bastien Questel, Maëlys Abraham, Christophe Tzourio","doi":"10.17179/excli2024-8085","DOIUrl":"10.17179/excli2024-8085","url":null,"abstract":"<p><p>The use of psychoactive products by young adults is usually described as part of their exploratory identity development. This behavior is facilitated by social and structural contexts where these substances are perceived as legal and easily accessible. While the motivations for initiating and continuing the use of tobacco and alcohol are well-documented, the same cannot be said for e-cigarettes. The primary objective of this systematic review was to describe the reasons for initiation and continuation of e-cigarette use among adults aged 18 to 30. A secondary objective was to categorize these reasons into intrinsic (i.e., personal motivations) and extrinsic factors (i.e., sociocultural or structural influences). Searches were conducted in MEDLINE, Scopus, SocINDEX full text, PsycArticles, PsycInfo, Psychology and Behavioral Sciences Collection, Cochrane Library and gray literature. Studies involving humans, published in English or French up to June 2024 were eligible for inclusion. After removing 594 duplicates, 1,123 articles were screened by title and abstract, with 37 articles published between 2015 and 2024 ultimately included in the review. These comprised 21 cross-sectional studies, eight qualitative studies, six cross-sectional analyses of cohort data, one cohort study and one mixed methods study. The appeal of e-liquid flavors emerged as one of the most frequently reported extrinsic factors driving both initiation and continuation of e-cigarette use. Other reasons varied across intrinsic and extrinsic domains: smoking cessation was a commonly cited intrinsic motivation, often reported alongside other factors. Structural extrinsic factors such as regulatory policies appeared to be less recognized by young adults, suggesting a gap in awareness or compliance to such regulations. These findings indicate the need for further research to better understand young adults' perceptions of and interactions with regulatory measures concerning e-cigarette and tobacco use.</p>","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"204-237"},"PeriodicalIF":3.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting cGAS-STING signaling: a potential therapeutic approach for the management of Huntington's disease.","authors":"Vishal Kumar, Puneet Kumar","doi":"10.17179/excli2024-8060","DOIUrl":"10.17179/excli2024-8060","url":null,"abstract":"","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"201-203"},"PeriodicalIF":3.8,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies to mitigate emergency department overcrowding: enhancing healthcare efficiency and patient care.","authors":"Mahmoudreza Peyravi, Mohammad Ebrahimi, Marziyeh Hamyali Ainvand","doi":"10.17179/excli2024-8044","DOIUrl":"10.17179/excli2024-8044","url":null,"abstract":"","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"198-200"},"PeriodicalIF":3.8,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dioxins do not only bind to AHR but also team up with EGFR at the cell-surface: a novel mode of action of toxicological relevance?","authors":"Natalie C Sondermann, Christoph F A Vogel, Thomas Haarmann-Stemmann","doi":"10.17179/excli2024-8038","DOIUrl":"10.17179/excli2024-8038","url":null,"abstract":"<p><p>Dioxins and dioxin-like compounds (DLCs) are highly toxic organic pollutants whose production and use are prohibited by international law. Despite this, these biopersistent and lipophilic chemicals are prevalent in the environment and accumulate in the food chain, posing significant health risks to consumers even at low exposure levels. Acute dioxin intoxication can cause chloracne, while chronic exposure has been associated with a wide range of adverse health effects, including carcinogenicity, reproductive and developmental disorders, immunotoxicity, and endocrine disruption. In the mid-1970s, scientists identified a transcription factor known as the aryl hydrocarbon receptor (AHR), which becomes activated upon binding of dioxins. AHR orchestrates numerous adaptive and maladaptive stress responses and is believed to mediate most, if not all, of the toxic effects triggered by dioxins and DLCs. Recent studies have provided mounting evidence that dioxins and dioxin-like polychlorinated biphenyls can inhibit growth factor-induced activation of the epidermal growth factor receptor (EGFR) by directly binding to its extracellular domain. This interaction prevents the activation of EGFR by polypeptide growth factors and downstream signal transduction. In this article, we explain this newly identified mechanism of action for dioxins and DLCs in detail and discuss its potential toxicological relevance by using two examples, i.e. breast cancer development and placental toxicity. Finally, we briefly refer to other environmental chemicals of global concern that, based on first published data, may act <i>via</i> the same mode of action. See also the graphical abstract(Fig. 1).</p>","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"184-197"},"PeriodicalIF":3.8,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis C virus care continuum: integrating point of care RNA assay and direct acting antivirals.","authors":"Rabab Fatima","doi":"10.17179/excli2024-7963","DOIUrl":"10.17179/excli2024-7963","url":null,"abstract":"","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"181-183"},"PeriodicalIF":3.8,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination therapy of mitochondria-targeted antioxidants and polyphenols for early intervention in Huntington's disease.","authors":"Anuradha Acharya, Sukriti Vishwas, Sachin Kumar Singh","doi":"10.17179/excli2024-8025","DOIUrl":"10.17179/excli2024-8025","url":null,"abstract":"","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"179-180"},"PeriodicalIF":3.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between leukocytes telomere length and parental consanguineous marriage.","authors":"Fatemeh Zahra Darvishi, Mostafa Saadat","doi":"10.17179/excli2024-7920","DOIUrl":"10.17179/excli2024-7920","url":null,"abstract":"","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"177-178"},"PeriodicalIF":3.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of challenge and threat states on performance outcomes: An updated review and meta-analysis of recent findings.","authors":"Adrian Hase, Maximilian Nietschke, Maciej Kloskowski, Kacper Szymanski, Lee Moore, Jeremy P Jamieson, Maciej Behnke","doi":"10.17179/excli2024-7995","DOIUrl":"https://doi.org/10.17179/excli2024-7995","url":null,"abstract":"<p><p>The biopsychosocial model (BPSM) of challenge and threat provides a framework for understanding stress responses in motivated performance situations, including how stress relates to performance. In this model, experiences of challenge - characterized by evaluations of personal coping resources matching or exceeding situational demands - elicit approach-oriented patterns of physiological responding and tend to facilitate performance, whereas threat - characterized by demands exceeding resources - elicit avoidance-oriented patterns of physiological responding and tend to impair performance. Extant systematic reviews and meta-analyses support the idea that challenge facilitates performance relative to threat (Behnke and Kaczmarek, 2018[8]; Hase et al., 2019[50]). The present systematic review and meta-analysis builds on this evidence base by examining whether conclusions replicate in recent research (post-2017), which is important given seismic cultural shifts tied to a worldwide pandemic, civil unrest, and skyrocketing mental health problems tied to stress. The analysis included 62 studies published between 2017 and 2024 (total <i>N</i> = 7,418 participants). The meta-analytic findings indicate that individuals in a challenge state achieve better performance outcomes than those in a threat state across multiple domains (e.g., education, sport). While effect sizes were small, the risk of bias was generally low. These results reaffirm the utility of the BPSM and emphasize the importance of stress responses in influencing performance outcomes. These data also have the potential to inform future research on this topic by shedding light on expectable effect sizes and highlighting potential influences of publication bias and replicability issues.</p>","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"151-176"},"PeriodicalIF":3.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of N(6)-methyladenosine (m6a) modification in cancer: recent advances and future directions.","authors":"Xiaozhou Xie, Zhen Fang, Haoyu Zhang, Zheng Wang, Jie Li, Yuchen Jia, Liang Shang, Feng Cao, Fei Li","doi":"10.17179/excli2024-7935","DOIUrl":"10.17179/excli2024-7935","url":null,"abstract":"<p><p>N(6)-methyladenosine (m6A) modification is the most abundant and prevalent internal modification in eukaryotic mRNAs. The role of m6A modification in cancer has become a hot research topic in recent years and has been widely explored. m6A modifications have been shown to regulate cancer occurrence and progression by modulating different target molecules. This paper reviews the recent research progress of m6A modifications in cancer and provides an outlook on future research directions, especially the development of molecularly targeted drugs. See also the graphical abstract(Fig. 1).</p>","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"113-150"},"PeriodicalIF":3.8,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Competing endogenous RNA networks in ovarian cancer: from bench to bedside.","authors":"Roghaiyeh Derogar, Fatemeh Nejadi Orang, Mahdi Abdoli Shadbad","doi":"10.17179/excli2024-7827","DOIUrl":"10.17179/excli2024-7827","url":null,"abstract":"<p><p>Epithelial ovarian cancer is responsible for the majority of ovarian malignancies, and its highly invasive nature and chemoresistant development have been major obstacles to treating patients with mainstream treatments. In recent decades, the significance of microRNAs (miRNAs), circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and competing endogenous RNAs (ceRNAs) has been highlighted in ovarian cancer development. This hidden language between these RNAs has led to the discovery of enormous regulatory networks in ovarian cancer cells that substantially affect gene expression. Aside from providing ample opportunities for targeted therapies, circRNA- and lncRNA-mediated ceRNA network components provide invaluable biomarkers. The current study provides a comprehensive and up-to-date review of the recent findings on the significance of these ceRNA networks in the hallmarks of ovarian cancer oncogenesis, treatment, diagnosis, and prognosis. Also, it provides the authorship with future perspectives in the era of single-cell RNA sequencing and personalized medicine.</p>","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"86-112"},"PeriodicalIF":3.8,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}