EXCLI Journal最新文献

{"title":"Dioxins do not only bind to AHR but also team up with EGFR at the cell-surface: a novel mode of action of toxicological relevance?","authors":"Natalie C Sondermann, Christoph F A Vogel, Thomas Haarmann-Stemmann","doi":"10.17179/excli2024-8038","DOIUrl":"10.17179/excli2024-8038","url":null,"abstract":"<p><p>Dioxins and dioxin-like compounds (DLCs) are highly toxic organic pollutants whose production and use are prohibited by international law. Despite this, these biopersistent and lipophilic chemicals are prevalent in the environment and accumulate in the food chain, posing significant health risks to consumers even at low exposure levels. Acute dioxin intoxication can cause chloracne, while chronic exposure has been associated with a wide range of adverse health effects, including carcinogenicity, reproductive and developmental disorders, immunotoxicity, and endocrine disruption. In the mid-1970s, scientists identified a transcription factor known as the aryl hydrocarbon receptor (AHR), which becomes activated upon binding of dioxins. AHR orchestrates numerous adaptive and maladaptive stress responses and is believed to mediate most, if not all, of the toxic effects triggered by dioxins and DLCs. Recent studies have provided mounting evidence that dioxins and dioxin-like polychlorinated biphenyls can inhibit growth factor-induced activation of the epidermal growth factor receptor (EGFR) by directly binding to its extracellular domain. This interaction prevents the activation of EGFR by polypeptide growth factors and downstream signal transduction. In this article, we explain this newly identified mechanism of action for dioxins and DLCs in detail and discuss its potential toxicological relevance by using two examples, i.e. breast cancer development and placental toxicity. Finally, we briefly refer to other environmental chemicals of global concern that, based on first published data, may act <i>via</i> the same mode of action. See also the graphical abstract(Fig. 1).</p>","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"184-197"},"PeriodicalIF":3.8,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis C virus care continuum: integrating point of care RNA assay and direct acting antivirals.","authors":"Rabab Fatima","doi":"10.17179/excli2024-7963","DOIUrl":"10.17179/excli2024-7963","url":null,"abstract":"","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"181-183"},"PeriodicalIF":3.8,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination therapy of mitochondria-targeted antioxidants and polyphenols for early intervention in Huntington's disease.","authors":"Anuradha Acharya, Sukriti Vishwas, Sachin Kumar Singh","doi":"10.17179/excli2024-8025","DOIUrl":"10.17179/excli2024-8025","url":null,"abstract":"","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"179-180"},"PeriodicalIF":3.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between leukocytes telomere length and parental consanguineous marriage.","authors":"Fatemeh Zahra Darvishi, Mostafa Saadat","doi":"10.17179/excli2024-7920","DOIUrl":"10.17179/excli2024-7920","url":null,"abstract":"","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"177-178"},"PeriodicalIF":3.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of challenge and threat states on performance outcomes: An updated review and meta-analysis of recent findings.","authors":"Adrian Hase, Maximilian Nietschke, Maciej Kloskowski, Kacper Szymanski, Lee Moore, Jeremy P Jamieson, Maciej Behnke","doi":"10.17179/excli2024-7995","DOIUrl":"https://doi.org/10.17179/excli2024-7995","url":null,"abstract":"<p><p>The biopsychosocial model (BPSM) of challenge and threat provides a framework for understanding stress responses in motivated performance situations, including how stress relates to performance. In this model, experiences of challenge - characterized by evaluations of personal coping resources matching or exceeding situational demands - elicit approach-oriented patterns of physiological responding and tend to facilitate performance, whereas threat - characterized by demands exceeding resources - elicit avoidance-oriented patterns of physiological responding and tend to impair performance. Extant systematic reviews and meta-analyses support the idea that challenge facilitates performance relative to threat (Behnke and Kaczmarek, 2018[8]; Hase et al., 2019[50]). The present systematic review and meta-analysis builds on this evidence base by examining whether conclusions replicate in recent research (post-2017), which is important given seismic cultural shifts tied to a worldwide pandemic, civil unrest, and skyrocketing mental health problems tied to stress. The analysis included 62 studies published between 2017 and 2024 (total <i>N</i> = 7,418 participants). The meta-analytic findings indicate that individuals in a challenge state achieve better performance outcomes than those in a threat state across multiple domains (e.g., education, sport). While effect sizes were small, the risk of bias was generally low. These results reaffirm the utility of the BPSM and emphasize the importance of stress responses in influencing performance outcomes. These data also have the potential to inform future research on this topic by shedding light on expectable effect sizes and highlighting potential influences of publication bias and replicability issues.</p>","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"151-176"},"PeriodicalIF":3.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of N(6)-methyladenosine (m6a) modification in cancer: recent advances and future directions.","authors":"Xiaozhou Xie, Zhen Fang, Haoyu Zhang, Zheng Wang, Jie Li, Yuchen Jia, Liang Shang, Feng Cao, Fei Li","doi":"10.17179/excli2024-7935","DOIUrl":"10.17179/excli2024-7935","url":null,"abstract":"<p><p>N(6)-methyladenosine (m6A) modification is the most abundant and prevalent internal modification in eukaryotic mRNAs. The role of m6A modification in cancer has become a hot research topic in recent years and has been widely explored. m6A modifications have been shown to regulate cancer occurrence and progression by modulating different target molecules. This paper reviews the recent research progress of m6A modifications in cancer and provides an outlook on future research directions, especially the development of molecularly targeted drugs. See also the graphical abstract(Fig. 1).</p>","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"113-150"},"PeriodicalIF":3.8,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Competing endogenous RNA networks in ovarian cancer: from bench to bedside.","authors":"Roghaiyeh Derogar, Fatemeh Nejadi Orang, Mahdi Abdoli Shadbad","doi":"10.17179/excli2024-7827","DOIUrl":"10.17179/excli2024-7827","url":null,"abstract":"<p><p>Epithelial ovarian cancer is responsible for the majority of ovarian malignancies, and its highly invasive nature and chemoresistant development have been major obstacles to treating patients with mainstream treatments. In recent decades, the significance of microRNAs (miRNAs), circular RNAs (circRNAs), long non-coding RNAs (lncRNAs), and competing endogenous RNAs (ceRNAs) has been highlighted in ovarian cancer development. This hidden language between these RNAs has led to the discovery of enormous regulatory networks in ovarian cancer cells that substantially affect gene expression. Aside from providing ample opportunities for targeted therapies, circRNA- and lncRNA-mediated ceRNA network components provide invaluable biomarkers. The current study provides a comprehensive and up-to-date review of the recent findings on the significance of these ceRNA networks in the hallmarks of ovarian cancer oncogenesis, treatment, diagnosis, and prognosis. Also, it provides the authorship with future perspectives in the era of single-cell RNA sequencing and personalized medicine.</p>","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"86-112"},"PeriodicalIF":3.8,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing psychological states in professional athletes through EEG: sex-based differences.","authors":"Kittichai Tharawadeepimuk, Ampika Nanbancha, Ekarat Onnom","doi":"10.17179/excli2024-7980","DOIUrl":"10.17179/excli2024-7980","url":null,"abstract":"<p><p>The psychological states are essential to maintain a healthy balance and optimize performance, especially in athletes. Sex-related differences in elite athletes are one of the important factors, which are ambiguous. This study aims to explore sex differences in psychological states of 36 professional athletes (12M/24F, 21.6±3.9 y, 166.3±8.9 cm, 56.4±11.3 kg, mean±SD) in the lead-up to a major international competition using objective (quantitative electroencephalogram, QEEG) and subjective measures (Athletic Coping Skills Inventory, ASCI-28). Participants included fifteen gymnasts, eleven swimmers, and ten e-sports players. QEEG measurements were collected during 5 minutes at rest before athletes completed the ASCI-28 scale. Data were obtained during training camp within 3 months before the competition. QEEG data were analyzed using a generalized linear mixed modeling (GLMM) to report the linear predictor of QEEG in brain areas (random) and sex (fixed). A multivariate analysis of variance (MANOVA) was applied to ACSI-28 subscales data to compare sex groups. Female athletes exhibited higher EEG activity in the theta power in the parietal and occipital areas and the beta power in the pre-frontal and temporal areas. Furthermore, significant sex differences were found in the coping with adversity (<i>p</i> =0.038) and goal setting/mental preparation subscales of the ACSI-28. The correlations between the QEEG and questionnaire scores were low to moderate correlations for female athletes, and moderate correlations for male athletes. A significant correlation was observed in both male and female athletes between activity in the temporal region within theta and beta frequency bands (QEEG), and the coping with aversity subscale (questionnaire). These findings provide valuable insights for sports psychologists to design appropriate psychological interventions and for future studies examining the impact of differential psychological interventions for male and female athletes to optimize well-being and performance.</p>","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"1-14"},"PeriodicalIF":3.8,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, biological investigation, and in silico studies of 2-aminothiazole sulfonamide derivatives as potential antioxidants.","authors":"Apilak Worachartcheewan, Ratchanok Pingaew, Veda Prachayasittikul, Setthawut Apiraksattayakul, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul","doi":"10.17179/excli2024-7855","DOIUrl":"10.17179/excli2024-7855","url":null,"abstract":"<p><p>Antioxidant compounds have gained current interest as potential protective agents for several therapeutic applications. Antimicrobial drug resistance and infectious diseases also still be concerning globally health issues. Accordingly, the discovery of new antioxidative and antimicrobial agents is essential for human well-being. Thiazole and sulfonamide are privileged scaffolds in drug discovery due to their various bioactive properties. In this study, a series of 2-aminothiazole sulfonamide derivatives (<b>1</b> <b>-</b> <b>12</b>) were synthesized and investigated for their antioxidant (i.e., DPPH and SOD-mimic) and antimicrobial activities. Among tested compounds, compound <b>8</b> was the most promising one with potent DPPH and SOD (%DPPH = 90.09 %, %SOD = 99.02 %). However, none of these compounds are active antimicrobial agents. Quantitative structure-activity relationship (QSAR) modeling was performed in which the key findings were further used to guide the rational design of additional derivatives. Two antioxidant QSAR models (i.e., DPPH and SOD) were constructed using multiple linear regression (MLR) with good predictive performance. An additional set of structurally modified compounds were designed based on QSAR findings to finally obtain 112 newly designed compounds in which their activities (DPPH and SOD) were predicted. Most of the modified compounds performed better activities than their prototypes. Mass, polarizability, electronegativity, the presence of C-F bond, van der Waals volume, and structural symmetry were revealed as key properties influencing antioxidant activities. In summary, this study demonstrated the combination used of chemical synthesis, experimental assays, and computer-aided drug design for developing novel antioxidants for potential medicinal applications. See also the graphical abstract(Fig. 1).</p>","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"60-81"},"PeriodicalIF":3.8,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brace yourselves, vaccine-preventable diseases are coming! The impact of war on polio and other vaccine-preventable diseases.","authors":"Thalles Guilarducci Costa, Rizia Rocha-Silva, João Victor Rosa de Freitas, Bráulio Evangelista de Lima, Rodrigo Luiz Vancini, Marília Santos Andrade, Claudio Andre Barbosa de Lira","doi":"10.17179/excli2024-8022","DOIUrl":"10.17179/excli2024-8022","url":null,"abstract":"","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"82-85"},"PeriodicalIF":3.8,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}