EXCLI Journal最新文献_第2页

Phyto-derived interferons: a promising frontier in antiviral therapy development.

IF 3.8 3区生物学

EXCLI Journal Pub Date : 2025-02-24 eCollection Date: 2025-01-01 DOI: 10.17179/excli2024-7998

Baskar Venkidasamy, Ashok Kumar Balaraman, Muthu Thiruvengadam

引用次数: 0

Breast cancer preclinical models: a vital resource for comprehending disease mechanisms and therapeutic development. 乳腺癌临床前模型：了解疾病机理和开发疗法的重要资源。

IF 3.8 3区生物学

EXCLI Journal Pub Date : 2025-02-19 eCollection Date: 2025-01-01 DOI: 10.17179/excli2024-7973

Ravneet Kaur, Anuradha Sharma, Nalaka Wijekoon

{"title":"Breast cancer preclinical models: a vital resource for comprehending disease mechanisms and therapeutic development.","authors":"Ravneet Kaur, Anuradha Sharma, Nalaka Wijekoon","doi":"10.17179/excli2024-7973","DOIUrl":"10.17179/excli2024-7973","url":null,"abstract":"A significant obstacle in translating innovative breast cancer treatments from bench to bed side is demonstrating efficacy in preclinical settings prior to clinical trials, as the heterogeneity of breast cancer can be challenging to replicate in the laboratory. A significant number of potential medicines have not progressed to clinical trials because preclinical models inadequately replicate the complexities of the varied tumor microenvironment. Consequently, the variety of breast cancer models is extensive, and the selection of a model frequently depends on the specific inquiry presented. This review aims to present an overview of the existing breast cancer models, highlighting their advantages, limitations, and challenges in the context of innovative drug discovery, thereby offering insights that may be advantageous to future translational studies. Conventional monolayer cultures are critical for elucidating the different breast cancer types and their behavior, have limitations in adequately replicating tumor environments. The 3D models such as patient-derived xenografts, cell-derived xenografts and genetically engineered models offer better insights by maintaining tumor microenvironments and cellular heterogeneity. Results can be further enhanced when compared with breast epithelial cells, a negative control to determine early stages by investigating differences between healthy and cancerous mammary cells. While cell lines such as MCF-7, MDA-MB-231 etc are useful in vitro models, they exhibit genetic variations that may affect drug responses over time. Additionally, animal models, particularly rodents, are instrumental in breast cancer research due to their biological resemblances to humans and the relative ease of genetic modification, however, witness a low occurrence of tumors. This review thus concludes that different preclinical models have their associated benefits and pitfalls. Therefore, specific preclinical models can be created by altering the gene expression at the genetic level or could be selected as per specific experimental needs which will enable successful translation of preclinical findings into clinical trials can be possible. See also the graphical abstract(Fig. 1).","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"267-285"},"PeriodicalIF":3.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms underpinning the effect of exercise on the non-alcoholic fatty liver disease: review.

IF 3.8 3区生物学

EXCLI Journal Pub Date : 2025-02-11 eCollection Date: 2025-01-01 DOI: 10.17179/excli2024-7718

Mohamed Bekheit, Blessed Kamera, Laura Colacino, Anne Dropmann, Mirela Delibegovic, Fatema Almadhoob, Nemany Hanafy, Giovanna Bermano, Seddik Hammad

{"title":"Mechanisms underpinning the effect of exercise on the non-alcoholic fatty liver disease: review.","authors":"Mohamed Bekheit, Blessed Kamera, Laura Colacino, Anne Dropmann, Mirela Delibegovic, Fatema Almadhoob, Nemany Hanafy, Giovanna Bermano, Seddik Hammad","doi":"10.17179/excli2024-7718","DOIUrl":"10.17179/excli2024-7718","url":null,"abstract":"Non-alcoholic Fatty Liver Disease (NAFLD) - whose terminology was recently replaced by metabolic liver disease (MAFLD) - is an accumulation of triglycerides in the liver of >5 % of its weight. Epidemiological studies indicated an association between NAFLD and reduced physical activity. In addition, exercise has been shown to improve NAFLD independently of weight loss. In this paper, we aim to systematically review molecular changes in sedentary experimental NAFLD models vs. those subjected to exercise. We utilized the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist and standard review techniques. Studies were considered for inclusion if they addressed the primary question: the mechanisms by which exercise influenced NAFLD. This review summarized experimental evidence of improvements in NAFLD with exercise in the absence of weight loss. The pathways involved appeared to have AMPK as a common denominator. See also the graphical abstract(Fig. 1).","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"238-266"},"PeriodicalIF":3.8,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reasons for using electronic cigarettes among young adults aged 18 - 30: a systematic review.

IF 3.8 3区生物学

EXCLI Journal Pub Date : 2025-01-31 eCollection Date: 2025-01-01 DOI: 10.17179/excli2024-8085

Shérazade Kinouani, Faustine Roux, Bastien Questel, Maëlys Abraham, Christophe Tzourio

{"title":"Reasons for using electronic cigarettes among young adults aged 18 - 30: a systematic review.","authors":"Shérazade Kinouani, Faustine Roux, Bastien Questel, Maëlys Abraham, Christophe Tzourio","doi":"10.17179/excli2024-8085","DOIUrl":"10.17179/excli2024-8085","url":null,"abstract":"The use of psychoactive products by young adults is usually described as part of their exploratory identity development. This behavior is facilitated by social and structural contexts where these substances are perceived as legal and easily accessible. While the motivations for initiating and continuing the use of tobacco and alcohol are well-documented, the same cannot be said for e-cigarettes. The primary objective of this systematic review was to describe the reasons for initiation and continuation of e-cigarette use among adults aged 18 to 30. A secondary objective was to categorize these reasons into intrinsic (i.e., personal motivations) and extrinsic factors (i.e., sociocultural or structural influences). Searches were conducted in MEDLINE, Scopus, SocINDEX full text, PsycArticles, PsycInfo, Psychology and Behavioral Sciences Collection, Cochrane Library and gray literature. Studies involving humans, published in English or French up to June 2024 were eligible for inclusion. After removing 594 duplicates, 1,123 articles were screened by title and abstract, with 37 articles published between 2015 and 2024 ultimately included in the review. These comprised 21 cross-sectional studies, eight qualitative studies, six cross-sectional analyses of cohort data, one cohort study and one mixed methods study. The appeal of e-liquid flavors emerged as one of the most frequently reported extrinsic factors driving both initiation and continuation of e-cigarette use. Other reasons varied across intrinsic and extrinsic domains: smoking cessation was a commonly cited intrinsic motivation, often reported alongside other factors. Structural extrinsic factors such as regulatory policies appeared to be less recognized by young adults, suggesting a gap in awareness or compliance to such regulations. These findings indicate the need for further research to better understand young adults' perceptions of and interactions with regulatory measures concerning e-cigarette and tobacco use.","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"204-237"},"PeriodicalIF":3.8,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting cGAS-STING signaling: a potential therapeutic approach for the management of Huntington's disease.

IF 3.8 3区生物学

EXCLI Journal Pub Date : 2025-01-24 eCollection Date: 2025-01-01 DOI: 10.17179/excli2024-8060

Vishal Kumar, Puneet Kumar

引用次数: 0

Strategies to mitigate emergency department overcrowding: enhancing healthcare efficiency and patient care.

IF 3.8 3区生物学

EXCLI Journal Pub Date : 2025-01-23 eCollection Date: 2025-01-01 DOI: 10.17179/excli2024-8044

Mahmoudreza Peyravi, Mohammad Ebrahimi, Marziyeh Hamyali Ainvand

引用次数: 0

Dioxins do not only bind to AHR but also team up with EGFR at the cell-surface: a novel mode of action of toxicological relevance?

IF 3.8 3区生物学

EXCLI Journal Pub Date : 2025-01-23 eCollection Date: 2025-01-01 DOI: 10.17179/excli2024-8038

Natalie C Sondermann, Christoph F A Vogel, Thomas Haarmann-Stemmann

{"title":"Dioxins do not only bind to AHR but also team up with EGFR at the cell-surface: a novel mode of action of toxicological relevance?","authors":"Natalie C Sondermann, Christoph F A Vogel, Thomas Haarmann-Stemmann","doi":"10.17179/excli2024-8038","DOIUrl":"10.17179/excli2024-8038","url":null,"abstract":"Dioxins and dioxin-like compounds (DLCs) are highly toxic organic pollutants whose production and use are prohibited by international law. Despite this, these biopersistent and lipophilic chemicals are prevalent in the environment and accumulate in the food chain, posing significant health risks to consumers even at low exposure levels. Acute dioxin intoxication can cause chloracne, while chronic exposure has been associated with a wide range of adverse health effects, including carcinogenicity, reproductive and developmental disorders, immunotoxicity, and endocrine disruption. In the mid-1970s, scientists identified a transcription factor known as the aryl hydrocarbon receptor (AHR), which becomes activated upon binding of dioxins. AHR orchestrates numerous adaptive and maladaptive stress responses and is believed to mediate most, if not all, of the toxic effects triggered by dioxins and DLCs. Recent studies have provided mounting evidence that dioxins and dioxin-like polychlorinated biphenyls can inhibit growth factor-induced activation of the epidermal growth factor receptor (EGFR) by directly binding to its extracellular domain. This interaction prevents the activation of EGFR by polypeptide growth factors and downstream signal transduction. In this article, we explain this newly identified mechanism of action for dioxins and DLCs in detail and discuss its potential toxicological relevance by using two examples, i.e. breast cancer development and placental toxicity. Finally, we briefly refer to other environmental chemicals of global concern that, based on first published data, may act via the same mode of action. See also the graphical abstract(Fig. 1).","PeriodicalId":12247,"journal":{"name":"EXCLI Journal","volume":"24 ","pages":"184-197"},"PeriodicalIF":3.8,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatitis C virus care continuum: integrating point of care RNA assay and direct acting antivirals.

IF 3.8 3区生物学

EXCLI Journal Pub Date : 2025-01-21 eCollection Date: 2025-01-01 DOI: 10.17179/excli2024-7963

Rabab Fatima

引用次数: 0

Combination therapy of mitochondria-targeted antioxidants and polyphenols for early intervention in Huntington's disease.

IF 3.8 3区生物学

EXCLI Journal Pub Date : 2025-01-20 eCollection Date: 2025-01-01 DOI: 10.17179/excli2024-8025

Anuradha Acharya, Sukriti Vishwas, Sachin Kumar Singh

引用次数: 0

Association between leukocytes telomere length and parental consanguineous marriage.