COVID-19 vaccination, all-cause mortality, and hospitalization for cancer: 30-month cohort study in an Italian province.

IF 4.9 3区 生物学 Q1 BIOLOGY
EXCLI Journal Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI:10.17179/excli2025-8400
Cecilia Acuti Martellucci, Angelo Capodici, Graziella Soldato, Matteo Fiore, Enrico Zauli, Roberto Carota, Marco De Benedictis, Graziano Di Marco, Rossano Di Luzio, Maria Elena Flacco, Lamberto Manzoli
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Abstract

Anecdotal reports suggested an association between SARS-CoV-2 vaccination and some cancers, but no formal assessment has been published. This population-wide cohort analysis was aimed at evaluating the risk of all-cause death and cancer hospitalization by SARS-CoV-2 immunization status. Using National Health System official data, the entire population of the Pescara province, Italy was followed from June 2021 (six months after the first vaccination) to December 2023. Cox models were adjusted for age, gender, previous SARS-CoV-2 infection, and selected comorbidities. Of the 296,015 residents aged ≥11 years, 16.6% were unvaccinated, 83.3% received ≥1 dose, and 62.2% ≥3 doses. Compared with the unvaccinated, those receiving ≥1 dose showed a significantly lower likelihood of all-cause death, and a slightly higher likelihood of hospitalization for cancer (HR: 1.23; 95% CI: 1.11-1.37). The latter association was significant only among the subjects with no previous SARS-CoV-2 infection, and was reversed when the minimum time between vaccination and cancer hospitalization was set to 12 months. The subjects who received SARS-CoV-2 vaccination showed a substantial reduction in all-cause mortality, and a risk of cancer hospitalization that varied by infection status, cancer site, and the minimum lag-time after vaccination. Given that it was not possible to quantify the potential impact of the healthy vaccinee bias and unmeasured confounders, these findings are inevitably preliminary. See also the graphical abstract(Fig. 1).

Abstract Image

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COVID-19疫苗接种、全因死亡率和癌症住院:意大利某省30个月队列研究
坊间报道显示,SARS-CoV-2疫苗接种与某些癌症之间存在关联,但尚未发表正式评估。这项全人群队列分析旨在评估SARS-CoV-2免疫状况导致的全因死亡和癌症住院的风险。利用国家卫生系统官方数据,从2021年6月(首次接种疫苗后6个月)至2023年12月对意大利佩斯卡拉省的全部人口进行了跟踪。Cox模型根据年龄、性别、既往SARS-CoV-2感染和选定的合并症进行调整。在296015名年龄≥11岁的居民中,16.6%未接种疫苗,83.3%接种了≥1剂,62.2%接种了≥3剂。与未接种疫苗的患者相比,接种≥1剂疫苗的患者全因死亡的可能性显著降低,因癌症住院的可能性略高(HR: 1.23; 95% CI: 1.11-1.37)。后一种相关性仅在以前没有感染过SARS-CoV-2的受试者中显着,当疫苗接种和癌症住院之间的最短时间设定为12个月时,这种相关性被逆转。接种SARS-CoV-2疫苗的受试者显示全因死亡率大幅降低,癌症住院风险因感染状况、癌症部位和接种疫苗后的最小滞后时间而异。鉴于不可能量化健康疫苗接种者偏见和未测量混杂因素的潜在影响,这些发现不可避免地是初步的。另见图解摘要(图1)。1).
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来源期刊
EXCLI Journal
EXCLI Journal BIOLOGY-
CiteScore
8.00
自引率
2.20%
发文量
65
审稿时长
6-12 weeks
期刊介绍: EXCLI Journal publishes original research reports, authoritative reviews and case reports of experimental and clinical sciences. The journal is particularly keen to keep a broad view of science and technology, and therefore welcomes papers which bridge disciplines and may not suit the narrow specialism of other journals. Although the general emphasis is on biological sciences, studies from the following fields are explicitly encouraged (alphabetical order): aging research, behavioral sciences, biochemistry, cell biology, chemistry including analytical chemistry, clinical and preclinical studies, drug development, environmental health, ergonomics, forensic medicine, genetics, hepatology and gastroenterology, immunology, neurosciences, occupational medicine, oncology and cancer research, pharmacology, proteomics, psychiatric research, psychology, systems biology, toxicology
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