Evidence Based Mental Health最新文献

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COVID-19 vaccines, hesitancy and mental health. COVID-19疫苗、犹豫和心理健康。
IF 6.6 2区 医学
Evidence Based Mental Health Pub Date : 2021-05-01 Epub Date: 2021-04-13 DOI: 10.1136/ebmental-2021-300266
Katharine Smith, Sinéad Lambe, Daniel Freeman, Andrea Cipriani
{"title":"COVID-19 vaccines, hesitancy and mental health.","authors":"Katharine Smith, Sinéad Lambe, Daniel Freeman, Andrea Cipriani","doi":"10.1136/ebmental-2021-300266","DOIUrl":"10.1136/ebmental-2021-300266","url":null,"abstract":"","PeriodicalId":12233,"journal":{"name":"Evidence Based Mental Health","volume":"24 2","pages":"47-48"},"PeriodicalIF":6.6,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10212221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Introducing artificial intelligence in acute psychiatric inpatient care: qualitative study of its use to conduct nursing observations. 更正:将人工智能引入急性精神病住院护理:定性研究其用于护理观察。
IF 5.2 2区 医学
Evidence Based Mental Health Pub Date : 2021-05-01 DOI: 10.1136/ebmental-2019-300136corr1
{"title":"Correction: <i>Introducing artificial intelligence in acute psychiatric inpatient care: qualitative study of its use to conduct nursing observations</i>.","authors":"","doi":"10.1136/ebmental-2019-300136corr1","DOIUrl":"https://doi.org/10.1136/ebmental-2019-300136corr1","url":null,"abstract":"","PeriodicalId":12233,"journal":{"name":"Evidence Based Mental Health","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728650/pdf/ebmental-2019-300136corr1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38913604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Common infections, mental health problems and healthcare use in people with inflammatory bowel disease: a cohort study protocol. 炎症性肠病患者的常见感染、心理健康问题和医疗保健使用:一项队列研究方案
IF 5.2 2区 医学
Evidence Based Mental Health Pub Date : 2021-05-01 Epub Date: 2020-09-17 DOI: 10.1136/ebmental-2020-300167
Peter Irving, Kevin Barrett, Daniel Tang, Monica Nijher, Simon de Lusignan
{"title":"Common infections, mental health problems and healthcare use in people with inflammatory bowel disease: a cohort study protocol.","authors":"Peter Irving,&nbsp;Kevin Barrett,&nbsp;Daniel Tang,&nbsp;Monica Nijher,&nbsp;Simon de Lusignan","doi":"10.1136/ebmental-2020-300167","DOIUrl":"https://doi.org/10.1136/ebmental-2020-300167","url":null,"abstract":"<p><strong>Introduction: </strong>People with inflammatory bowel disease (IBD) are at increased risk of pneumonia and herpes zoster, yet other common infection types have not been explored. Anxiety and depression are more prevalent in IBD; however, the impact of these conditions on primary care healthcare use in IBD is not known.</p><p><strong>Methods and analysis: </strong>We will perform two retrospective studies using a large English population-based primary care cohort to compare the following outcomes in people with IBD and matched controls: incident infections (Study 1) and prevalent mental health problems and healthcare use, overall and in those with and without mental health problems (Study 2). All adults registered with general practices contributing to Royal College of General Practitioners Research and Surveillance Centre database between 1 January 2014 and 1 January 2019 are eligible. Infection outcomes comprise the incidence of common infections (upper respiratory tract infections, pneumonia, acute bronchitis, influenza and influenza-like illnesses, skin infections, herpes simplex and herpes zoster infections, genital infections, urinary tract infections and gastrointestinal infections) and any viral infection. Mental health and healthcare use outcomes are: prevalence of depressive episodes; anxiety episodes; recurrent depression; rates of primary care and emergency secondary care visits; primary-care issued sick notes (reflecting time off work). Analyses will be adjusted for sociodemographic factors recorded in the primary care record.</p><p><strong>Discussion: </strong>These studies will quantify the infection risk in IBD, the excess burden of anxiety and depression in a population-based IBD cohort, and the impact of mental health conditions on healthcare use and time off work. Greater understanding and awareness of infection risk and common mental health issues will benefit people with IBD and healthcare practitioners and will guide policy makers as allocation of resource may be guided by the real-world information produced by these studies.</p><p><strong>Trial registration number: </strong>NCT03836612.</p>","PeriodicalId":12233,"journal":{"name":"Evidence Based Mental Health","volume":" ","pages":"82-87"},"PeriodicalIF":5.2,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/ebmental-2020-300167","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38391284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Vital exhaustion in women with chest pain and no obstructive coronary artery disease: the iPOWER study. 胸痛且无阻塞性冠状动脉疾病的女性生命衰竭:iPOWER研究
IF 5.2 2区 医学
Evidence Based Mental Health Pub Date : 2021-05-01 DOI: 10.1136/ebmental-2020-300175
Daria Frestad Bechsgaard, Ida Gustafsson, Marie Mide Michelsen, Naja Dam Mygind, Adam Pena, Hannah Elena Suhrs, Kira Bove, Jens Dahlgaard Hove, Eva Prescott
{"title":"Vital exhaustion in women with chest pain and no obstructive coronary artery disease: the iPOWER study.","authors":"Daria Frestad Bechsgaard,&nbsp;Ida Gustafsson,&nbsp;Marie Mide Michelsen,&nbsp;Naja Dam Mygind,&nbsp;Adam Pena,&nbsp;Hannah Elena Suhrs,&nbsp;Kira Bove,&nbsp;Jens Dahlgaard Hove,&nbsp;Eva Prescott","doi":"10.1136/ebmental-2020-300175","DOIUrl":"https://doi.org/10.1136/ebmental-2020-300175","url":null,"abstract":"<p><strong>Background: </strong>More than half of women with symptoms suggestive of myocardial ischaemia have no obstructive coronary artery disease (CAD), yet they face a higher risk of cardiovascular mortality and morbidity. Both vital exhaustion (VE) and depression have been linked to adverse cardiovascular prognosis in patients with CAD. We aimed to assess whether symptomatic women with no obstructive CAD are more vitally exhausted compared with asymptomatic women. Furthermore, we investigated the overlap between the constructs of VE and depression.</p><p><strong>Methods: </strong>Prevalence and burden of VE was assessed in symptomatic women with no obstructive CAD (n=1.266) and asymptomatic women (n=2.390). Among symptomatic women, we also assessed chest pain characteristics and symptoms of Hospital Anxiety and Depression Questionnaire.</p><p><strong>Findings: </strong>Median (IQR) VE score was 4 (1-9) and 2 (0-5) in symptomatic and asymptomatic women, respectively (age adjusted, p<0.001). The risk of severe VE was significantly higher in symptomatic women compared with asymptomatic women (OR 3.3, 95% CI 2.5 to 4.4), independent of age and risk factors, and was associated with symptom severity. VE and depression scores were correlated but principal component cluster analysis (PCCA) showed clear distinctiveness between the two constructs.</p><p><strong>Conclusions: </strong>Women with chest pain and no obstructive CAD are more vitally exhausted compared with asymptomatic women. PCCA showed that VE is distinct from depression in symptomatic women.</p><p><strong>Clinical implications: </strong>Mental health screening focusing on depressive symptomatology in women with chest pain presenting with symptoms of mental and physical exhaustion may overlook VE in these patients.</p>","PeriodicalId":12233,"journal":{"name":"Evidence Based Mental Health","volume":"24 2","pages":"49-55"},"PeriodicalIF":5.2,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231582/pdf/ebmental-2020-300175.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10581481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Mind the methods of determining minimal important differences: three critical issues to consider. 注意确定最小重要差异的方法:需要考虑三个关键问题。
IF 5.2 2区 医学
Evidence Based Mental Health Pub Date : 2021-05-01 DOI: 10.1136/ebmental-2020-300164
Tahira Devji, Alonso Carrasco-Labra, Gordon Guyatt
{"title":"Mind the methods of determining minimal important differences: three critical issues to consider.","authors":"Tahira Devji,&nbsp;Alonso Carrasco-Labra,&nbsp;Gordon Guyatt","doi":"10.1136/ebmental-2020-300164","DOIUrl":"https://doi.org/10.1136/ebmental-2020-300164","url":null,"abstract":"<p><strong>Objective: </strong>Clinical trialists, meta-analysts and clinical guideline developers are increasingly using minimal important differences (MIDs) to enhance the interpretability of patient-reported outcome measures (PROMs). Here, we elucidate three critical issues of which MID users should be aware. Improved understanding of MID concepts and awareness of common pitfalls in methodology and reporting will better inform the application of MIDs in clinical research and decision-making.</p><p><strong>Methods: </strong>We conducted a systematic review to inform the development of an inventory of anchor-based MID estimates for PROMs. We searched four electronic databases to identify primary studies empirically calculating an anchor-based MID estimate for any PROM in adolescent or adult populations across all clinical areas. Our findings are based on information from 338 studies reporting 3389 MIDs for 358 PROMs published between 1989 and 2015.</p><p><strong>Results: </strong>We identified three key issues in the MID literature that demand attention. (1) The profusion of terms representing the MID concept adds unnecessary complexity to users' task in identifying relevant MIDs, requiring meticulous inspection of methodology to ensure estimates offered truly reflect the MID. (2) A multitude of diverse methods for MID estimation that will yield different estimates exist, and whether there are superior options remains unresolved. (3) There are serious issues of incomplete presentation and reporting of key aspects of the design, methodology and results of studies providing anchor-based MIDs, which threatens the optimal use of these estimates for interpretation of intervention effects on PROMs.</p><p><strong>Conclusions: </strong>Although the MID represents a powerful tool for enhancing the interpretability of PROMs, realising its full value will require improved understanding and reporting of its measurement fundamentals.</p>","PeriodicalId":12233,"journal":{"name":"Evidence Based Mental Health","volume":"24 2","pages":"77-81"},"PeriodicalIF":5.2,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/ebmental-2020-300164","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10213674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Classification of psychotherapy interventions for people with schizophrenia: development of the Nottingham Classification of Psychotherapies. 精神分裂症患者心理治疗干预的分类:诺丁汉心理治疗分类的发展。
IF 5.2 2区 医学
Evidence Based Mental Health Pub Date : 2021-05-01 DOI: 10.1136/ebmental-2020-300151
Matthew T Roberts, Farhad Shokraneh, Yanli Sun, Maddie Groom, Clive E Adams
{"title":"Classification of psychotherapy interventions for people with schizophrenia: development of the Nottingham Classification of Psychotherapies.","authors":"Matthew T Roberts,&nbsp;Farhad Shokraneh,&nbsp;Yanli Sun,&nbsp;Maddie Groom,&nbsp;Clive E Adams","doi":"10.1136/ebmental-2020-300151","DOIUrl":"https://doi.org/10.1136/ebmental-2020-300151","url":null,"abstract":"<p><strong>Background: </strong>Currently, there is no accepted system for the classification of psychotherapies for application within systematic reviews. The creation of anuncomplicated, understandable and practical classification system is neccessary for conducting reliable systematic reviews.</p><p><strong>Objective: </strong>To devise a system for classification of psychotherapy interventions-for use, initially, in systematic reviews.</p><p><strong>Methods: </strong>Cochrane Schizophrenia's Register used as the source of randomised controlled trial. After being piloted and refined at least twice, finally we applied it to all relevant trials within the register. Basic statistical data already held within the register were extracted and used to calculate the distribution of schizophrenia research by form of psychotherapy.</p><p><strong>Findings: </strong>The final classification system consisted of six definable broad 'boughs' two of which were further subdivided into 'branches'. The taxonomy accommodated all psychotherapy interventions described in the register. Of the initial 1645 intervention categories within the register, after careful recoding, 539 (33%) were psychotherapies (234 coded as 'Thought/Action' (cognitive & behavioural)-1495 studies; 135 'Cognitive Functioning'-652 studies; 113 'Social'-684 studies; 55 'Humanistic'-272 studies; 23 'Psychoanalytic/dynamic'-40 studies; and 63 'Other'-387 studies). For people with schizophrenia, across categories, the average size of psychotherapy trial is small (107) but there are notable and important exceptions.</p><p><strong>Conclusion: </strong>We reported a practical method for categorising psychotherapy interventions in evaluative studies with applications beyond schizophrenia. A move towards consensus on the classification and reporting of psychotherapies is needed.</p><p><strong>Clinical implications: </strong>This classification can aid clinicians, clinical practice guideline developers, and evidence synthesis experts to recognise and compare the interventions from same or different classes.</p>","PeriodicalId":12233,"journal":{"name":"Evidence Based Mental Health","volume":"24 2","pages":"62-69"},"PeriodicalIF":5.2,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231480/pdf/ebmental-2020-300151.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10269430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Prevalence of bipolar disorder in multiple sclerosis: a systematic review and meta-analysis. 双相情感障碍在多发性硬化症中的患病率:一项系统综述和荟萃分析。
IF 6.6 2区 医学
Evidence Based Mental Health Pub Date : 2021-05-01 Epub Date: 2020-12-16 DOI: 10.1136/ebmental-2020-300207
Boney Joseph, Aiswarya L Nandakumar, Ahmed T Ahmed, Neethu Gopal, M Hassan Murad, Mark A Frye, W Oliver Tobin, Balwinder Singh
{"title":"Prevalence of bipolar disorder in multiple sclerosis: a systematic review and meta-analysis.","authors":"Boney Joseph, Aiswarya L Nandakumar, Ahmed T Ahmed, Neethu Gopal, M Hassan Murad, Mark A Frye, W Oliver Tobin, Balwinder Singh","doi":"10.1136/ebmental-2020-300207","DOIUrl":"10.1136/ebmental-2020-300207","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis (MS) is a chronic disabling, demyelinating disease of the central nervous system and is often associated with psychiatric comorbidities. Some studies suggest increased prevalence of bipolar disorder (BD) in MS.</p><p><strong>Objective: </strong>To conduct a systematic review and meta-analysis assessing the prevalence of BD in adults with MS.</p><p><strong>Methods: </strong>We registered this review with PROSPERO and searched electronic databases (Ovid MEDLINE, Central, Embase, PsycINFO and Scopus) for eligible studies from earliest inception to October 2020. Prevalence data of BD in adult patients with MS were extracted. Meta-analysis was conducted using random-effects model.</p><p><strong>Findings: </strong>Of the 802 articles that were screened, 23 studies enrolling a total of 68 796 patients were included in the systematic review and meta-analysis. The pooled prevalence rate of BD in patients with MS was 2.95% (95% CI 2.12% to 4.09%) with higher prevalence in the Americas versus Europe. The lifetime prevalence of BD was 8.4% in patients with MS. Subgroup analysis showed a higher prevalence of BD in MS in females (7.03%) than in males (5.64%), which did not reach statistical significance (p=0.53).</p><p><strong>Conclusions: </strong>This meta-analysis suggests a high lifetime prevalence of BD in patients with MS. Patients with MS should be routinely screened for BD. Further assessment of bipolar comorbidity in MS through prospective studies may help in developing effective management strategies and may improve treatment outcomes in patients with MS.</p>","PeriodicalId":12233,"journal":{"name":"Evidence Based Mental Health","volume":"24 2","pages":"88-94"},"PeriodicalIF":6.6,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231514/pdf/ebmental-2020-300207.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10565570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Linking the Mini-Mental State Examination, the Alzheimer's Disease Assessment Scale-Cognitive Subscale and the Severe Impairment Battery: evidence from individual participant data from five randomised clinical trials of donepezil. 连接迷你精神状态检查,阿尔茨海默病评估量表-认知亚量表和严重损伤电池:来自多奈哌齐五项随机临床试验的个体参与者数据的证据。
IF 5.2 2区 医学
Evidence Based Mental Health Pub Date : 2021-05-01 DOI: 10.1136/ebmental-2020-300184
Stephen Z Levine, Kazufumi Yoshida, Yair Goldberg, Myrto Samara, Andrea Cipriani, Orestis Efthimiou, Takeshi Iwatsubo, Stefan Leucht, Toshi A Furukawa
{"title":"Linking the Mini-Mental State Examination, the Alzheimer's Disease Assessment Scale-Cognitive Subscale and the Severe Impairment Battery: evidence from individual participant data from five randomised clinical trials of donepezil.","authors":"Stephen Z Levine,&nbsp;Kazufumi Yoshida,&nbsp;Yair Goldberg,&nbsp;Myrto Samara,&nbsp;Andrea Cipriani,&nbsp;Orestis Efthimiou,&nbsp;Takeshi Iwatsubo,&nbsp;Stefan Leucht,&nbsp;Toshi A Furukawa","doi":"10.1136/ebmental-2020-300184","DOIUrl":"https://doi.org/10.1136/ebmental-2020-300184","url":null,"abstract":"<p><strong>Background: </strong>The Mini-Mental State Examination (MMSE), the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) and the Severe Impairment Battery (SIB) are widely used rating scales to assess cognition in Alzheimer's disease.</p><p><strong>Objective: </strong>To understand the correspondence between these rating scales, we aimed to examine the linkage of MMSE with the ADAS-Cog and SIB total and change scores.</p><p><strong>Methods: </strong>We used individual-level data on participants with Alzheimer's disease (n=2925) from five pivotal clinical trials of donepezil. Data were collected at baseline and scheduled visits for up to 6 months. We used equipercentile linking to identify the correspondence between simultaneous measurements of MMSE with ADAS-Cog, and SIB total and change ratings.</p><p><strong>Findings: </strong>Spearman's correlation coefficients were of strong magnitude between the MMSE total score and the ADAS-Cog (rs from -0.82 to -0.87; p<0.05) and SIB total scores (rs from 0.70 to 0.75; p<0.05). Weaker correlations between the change scores were observed between the MMSE change score and the ADAS-Cog (week 1: r=-0.11, p=0.18; rs thereafter: -0.28 to -0.45; p<0.05) and SIB change scores (rs from 0.31 to 0.44; p<0.05). Linking suggested that the MMSE total scores were sensitive to moderate and severe cognitive impairment levels. Despite weak to moderate correlations for the change scores, moderate change levels linked well, indicating ceiling and floor effects.</p><p><strong>Conclusions: </strong>The current results can be used in meta-analyses, data harmonisation and may contribute to increasing statistical power when pooling data from multiple sources.</p><p><strong>Clinical implications: </strong>The current study results help clinicians to understand these cognitive rating scale scores.</p>","PeriodicalId":12233,"journal":{"name":"Evidence Based Mental Health","volume":"24 2","pages":"56-61"},"PeriodicalIF":5.2,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231617/pdf/ebmental-2020-300184.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10217163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Magnitude and variability of structural brain abnormalities in neuropsychiatric disease: protocol for a network meta-analysis of MRI studies. 神经精神疾病中大脑结构异常的程度和变异性:磁共振成像研究网络荟萃分析协议。
IF 6.6 2区 医学
Evidence Based Mental Health Pub Date : 2021-04-13 DOI: 10.1136/ebmental-2020-300229
Robert McCutcheon, Toby Pillinger, George Welby, Luke Vano, Connor Cummings, Xin Guo, Toni Ann Heron, Orestis Efthimiou, Andrea Cipriani, Oliver Howes
{"title":"Magnitude and variability of structural brain abnormalities in neuropsychiatric disease: protocol for a network meta-analysis of MRI studies.","authors":"Robert McCutcheon, Toby Pillinger, George Welby, Luke Vano, Connor Cummings, Xin Guo, Toni Ann Heron, Orestis Efthimiou, Andrea Cipriani, Oliver Howes","doi":"10.1136/ebmental-2020-300229","DOIUrl":"10.1136/ebmental-2020-300229","url":null,"abstract":"<p><strong>Introduction: </strong>Structural MRI is the most frequently used method to investigate brain volume alterations in neuropsychiatric disease. Previous meta-analyses have typically focused on a single diagnosis, thereby precluding transdiagnostic comparisons.</p><p><strong>Methods and analysis: </strong>We will include all structural MRI studies of adults that report brain volumes for participants from at least two of the following diagnostic groups: healthy controls, schizophrenia, schizoaffective disorder, delusional disorder, psychotic depression, clinical high risk for psychosis, schizotypal personality disorder, psychosis unspecified, bipolar disorder, autism spectrum disorder, major depressive disorder, attention deficit hyperactivity disorder, obsessive compulsive disorder, post-traumatic stress disorder, emotionally unstable personality disorder, 22q11 deletion syndrome, generalised anxiety disorder, social anxiety disorder, panic disorder, mixed anxiety and depression. Network meta-analysis will be used to synthesise eligible studies. The primary analysis will examine standardised mean difference in average volume, a secondary analysis will examine differences in variability of volumes.</p><p><strong>Discussion: </strong>This network meta-analysis will provide a transdiagnostic integration of structural neuroimaging studies, providing researchers with a valuable summary of a large literature.</p><p><strong>Prospero registration number: </strong>CRD42020221143.</p>","PeriodicalId":12233,"journal":{"name":"Evidence Based Mental Health","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2021-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8311078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9113326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of depression and anxiety in people with inflammatory bowel disease and associated healthcare use: population-based cohort study. 炎症性肠病患者抑郁和焦虑的患病率及相关医疗服务的使用:基于人群的队列研究。
IF 5.2 2区 医学
Evidence Based Mental Health Pub Date : 2021-03-30 DOI: 10.1136/ebmental-2020-300223
Peter Irving, Kevin Barrett, Monica Nijher, Simon de Lusignan
{"title":"Prevalence of depression and anxiety in people with inflammatory bowel disease and associated healthcare use: population-based cohort study.","authors":"Peter Irving, Kevin Barrett, Monica Nijher, Simon de Lusignan","doi":"10.1136/ebmental-2020-300223","DOIUrl":"10.1136/ebmental-2020-300223","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory bowel disease (IBD) has a significant impact on quality of life for many people.</p><p><strong>Objective: </strong>To assess the prevalence of common mental health conditions in IBD and the combined impact of IBD and mental health conditions on healthcare use and time off work.</p><p><strong>Methods: </strong>A UK population-based primary care database (Royal College of General Practitioners Research and Surveillance Centre) was used to identify adults with IBD (n=19 011) (Crohn's disease (CD) or ulcerative colitis (UC)), and matched controls (n=76 044). Prevalences of anxiety, depressive episodes and depressive disorder recorded in primary care were assessed between 2016 and 2018. Outcomes comprised of rates of primary care visits, emergency secondary care visits, certificates for time off work, antidepressant and anxiolytic prescriptions.</p><p><strong>Findings: </strong>Mental health conditions were more common in people with CD than controls: anxiety episodes (3.5% vs 3.0%; p=0.02), depressive episodes (5.7% vs 4.1%; p<0.001) and depressive disorder (17.5% vs 12.9%; p<0.001), and people with UC versus controls: depressive episodes (4.4% vs 3.6%; p<0.001) and depressive disorder (14.2% vs 12.4%; p<0.001). Healthcare utilisation rates were higher in people with IBD than controls (primary care visits incidence rate ratio 1.47 (95% CI 1.43 to 1.51); emergency secondary care visits 1.87 (1.79 to 1.95); fitness for work certificates 1.53 (1.44 to 1.62); antidepressant use 1.22 (1.13 to 1.32); anxiolytic use 1.20 (1.01 to 1.41)). In people with IBD, mental health conditions were associated with additional increases in healthcare use and time off work.</p><p><strong>Conclusion: </strong>Depression and anxiety are more common in people with IBD than matched controls. Healthcare utilisation and prescribing of psychotropic medications are also higher in people with IBD. Mental health conditions in people with IBD are associated with additional healthcare use and time off work.</p><p><strong>Clinical implications: </strong>Evidence-based mental health support programmes, including psychological treatments, are needed for people with IBD.</p>","PeriodicalId":12233,"journal":{"name":"Evidence Based Mental Health","volume":" ","pages":""},"PeriodicalIF":5.2,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9d/80/ebmental-2020-300223.PMC8311072.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10217677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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