European Surgical Research最新文献

{"title":"Effects of Bromelain on Noradrenaline Release During Anxiety-Like Behaviour Following Intra-Medial Forebrain Bundle 6-OHDA Injection in Rat Model of Parkinsonism","authors":"T. Adu, O. Adu, M. Mabandla","doi":"10.33425/2689-1093.1043","DOIUrl":"https://doi.org/10.33425/2689-1093.1043","url":null,"abstract":"Introduction: Parkinson’s disease (PD) is characterized by emotional dysfunction which is a typical manifestation of non-motor symptoms. Non-motor symptoms may occur simultaneously with motor impairment in PD. Anxiety is a comorbidity in PD. This study therefore addresses the question of whether prior/post 6-OHDA lesion treatment with bromelain can show an effect on the behavioural signs of parkinsonism and damage to the CNS noradrenergic system in experimental rats. Methods: Open field and despair swim tests were used to assess certain psychomotor functions and emotional reactivity in the neurotoxin injected rats. The level of noradrenaline in certain regions of the brain as well as in the blood was further analyzed by enzyme linked immunosorbent assay. Findings: The results showed that unilateral injection of the neurotoxin into the rats’ medial forebrain bundle caused a decrease in the rearing time and a corresponding increase in the time spent grooming. There was a further indication that 6-OHDA injection resulted in the reduction of noradrenaline in the systemic environment. Also, the duration of immobility was increased by 6-OHDA injection but not statistically significant. Pretreatment with bromelain caused a change in the grooming behaviour not consistent with noradrenaline level. Conclusion: This finding suggests that bromelain treatment interferes with the regulation of mood and emotion during the early phase of parkinsonism in the 6-OHDA rat model of PD which was accompanied by changes in noradrenaline level.","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"14 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85194800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Management of Hepatocellular Carcinoma at the Kara Teaching Hospital (Togo)","authors":"Ossouvi Tamegnon, EL-HADJI Yakoubou, Rafiou, Adabra Komlan, Bouglouga Oumboma, Kanassoua Kokou, Kassegne Irokoura, D. David","doi":"10.33425/2689-1093.1041","DOIUrl":"https://doi.org/10.33425/2689-1093.1041","url":null,"abstract":"Objective: To describe the epidemiological, diagnostic, therapeutic and evolutionary aspects of hepatocellular carcinoma at CHU Kara. Method: This is a retrospective study conducted over a period of 3 years in the Department of General Surgery and Hepato-Gastroenterology of CHU-Kara (Togo). Were included in our study all patients, aged over 15 years old hospitalized for hepatocellular carcinoma. Results: We recorded 98 cases out of 7237 hospitalized patients, i.e. a frequency of 1.4%. The patients were consisted of 65 men and 33 women with a sex ratio (F/M) of 0.5. The average age was 49 years old. Clinically, painful hepatomegaly was found in all cases; abdominal pain in all cases, poor general condition in 86 patients; collateral venous circulation in 3 cases. Alpha-fetoprotein (AFP) was above 400 ng/ml in all patients. Abdominal imaging revealed diffuse liver involvement in 85 patients (86.7%), a localized nodular appearance in 13 cases (13.3%).All these patients had received symptomatic treatment combining analgesics and antispasmodics. The mortality rate was 97.9% within 12 months. Conclusion: Hepatocellular carcinoma remains a serious condition and its diagnosis is often difficult. It poses a real problem of care in our developing countries.","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"07 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86016644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Diffuse Large B-Cell Lymphoma of the Colon with Spontaneous Perforation: A Case Report","authors":"Mehdi Hammemi, M. Hajri, S. Omrani, W. Ferjaoui, D. Bacha, B. Rached, Hafedh Mestir","doi":"10.33425/2689-1093.1042","DOIUrl":"https://doi.org/10.33425/2689-1093.1042","url":null,"abstract":"We report a rare case of primary lymphoma of the colon with spontaneous perforation in A 54-year-old woman.","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"126 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77727873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Pudendal Thigh Flap In The Creation of A Neovagina and Restoration of Utero-Neovaginal Continuity – A Case Report","authors":"K. Ogundipe, Elizabeth Evelyn Enoch","doi":"10.33425/2689-1093.1040","DOIUrl":"https://doi.org/10.33425/2689-1093.1040","url":null,"abstract":"The pudendal thigh flap is a sensate flap based on the posterior labial artery, which has shown great versatility in the reconstruction of genital anomalies as well as genital oncologic reconstruction. This report showcases the creation of a neovagina with the restoration of uterovaginal continuity in a 12-year-old girl who had vaginal atresia. She presented with concealed menstruation and cyclical abdominal pain and had a creation of a neovagina with utero-vaginal continuity using a bilateral pudendal thigh fascio-cutaneous flap. Post-operatively, she attained normal menstrual flow and a sensate neovagina with a satisfactory vaginal canal depth. Partial wound dehiscence of the flap donor site was managed with dressing and healing by secondary intention. Even in new centres, the pudendal thigh flap remains a versatile flap for managing vaginal atresia.","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"49 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84346816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Information in YouTube Videos on Penis Enlargement Surgery","authors":"Perçin Karakol, Tuncay Taş","doi":"10.33425/2689-1093.1039","DOIUrl":"https://doi.org/10.33425/2689-1093.1039","url":null,"abstract":"Background: An increasing number of patients and their aesthetic curiosity are causing the online questioning of penis enlargement surgery (PES). Although there is a wealth of healthcare information about PES on the internet, the quality of PES-related information on YouTube, the most visited online video streaming service, has not fully known. It is aimed to evaluate the quality of information about PES in YouTube videos. Materials and Methods: In January 2021, we cross-sectionally performed YouTube search using the keywords \"penis enlargement surgery\", \"penis lengthening surgery\", or \"penis thickening surgery\". We sorted the videos as reliability in terms of containing scientifically proven information by 1 urologist and 1 plastic surgeon. Irrelevant, non-Turkish, and silent videos were not included. Video demographics were analyzed based on the quality and source of the video. A 5-point global quality scale, a 5-point reliability (DISCERN) tool, kappa statistic, the intraclass correlation coefficient, and descriptive statistics in the form of proportions and percentages were used. Results: A total of one-hundred PES videos published on YouTube between 2015-2021 were searched. Thirty-nine of these videos were removed due to duplicate, irrelevant, lack of sound or misleading information. Deceptive videos had a significantly higher number of likes than useful videos. On the other hand, useful videos had significantly more views than misleading videos. Useful videos had a higher DISCERN score compared to misleading videos. The fact that the uploader was sourced by professionals and doctors working at universities significantly contributed to the usefulness of the videos. Conclusion: As searching for information about PES on YouTube, patients are exposed to low-quality and confusing videos. Complexity in the number of views and likes could make accessing the informative PES video difficult. It may be recommended that patients prefer PES videos created by professionals.","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"38 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88468050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front & Back Matter","authors":"","doi":"10.1159/000525322","DOIUrl":"https://doi.org/10.1159/000525322","url":null,"abstract":"","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"4750 3 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65301517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"139th Congress of the German Society of Surgery (DGCH)","authors":"","doi":"10.1159/000523908","DOIUrl":"https://doi.org/10.1159/000523908","url":null,"abstract":"","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"63 1","pages":"I - II"},"PeriodicalIF":1.6,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44094649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"139th Congress of the German Society of Surgery (DGCH)","authors":"F. Hansen, A. Mittelstädt, Anne Jacobsen, M. Podolska, Dina Kouhestani, Izabela J. Swierzy, Lotta Roßdeutsch, M. Brunner, C. Krautz, R. Gruetzmann, Alan Bénard, G. Weber, Guanxi Wang, Franziska Langner, R. Jackstadt, F. Greten, C. Geppert, C. Günther, M. Waldner, M. Stürzl, E. Naschberger","doi":"10.1159/000523882","DOIUrl":"https://doi.org/10.1159/000523882","url":null,"abstract":"Background: Barrett’s esophagus (BE), the result of chronic exposure of esophageal mucosa to acid exposure, predisposes to the development of esophageal adenocarcinoma (EAC). While the incidence of EAC is rapidly increasing, its prognosis remains poor, with a five-year survival rate of 20%. For advanced cancer stages, chemotherapy together with surgery is considered to be the standard in therapy. Consequently, the discovery of new molecular targets for an efficient characterization of EAC patients is necessary. CKAP4 has been attributed to be increased in various cancer entities and has a role in tumorigenesis. However, its role in EAC development and progression is widely unknown. Materials and Methods: In a Barrett’s esophagus, in vitro cell culture model of BE and EAC, CKAP4 expression levels were verified with qPCR and western blot. In OE33 and OE19 cells a knockdown of CKAP4-expression was done by siRNA for 48h and 72h. In siCKAP4 transfected cells FACS (apoptosis), western blot analysis, colony forming assays, spheroid formation and proliferation assays were performed. Using western blot, the impact of CKAP4-knockdown on the phosphorylation of Akt, MAP-Kinase, GSK3ß and ß-Catenin investigated. Furthermore, Ki67- and p21-mRNA-expression was analyzed in siCKAP4 cells using qPCR. Results: CKAP4 was present in all cell lines of the Barrett’s sequence (squamous epithelium, metaplasia, dysplasia CKAP4 OE19 OE33 Background: Adhesion molecules play a crucial role in tumor growth and metastasis. Histone deacetylase (HDAC) are responsible for epigenetic modifications even in cancer cells. Whether the inhibition of HDACs has an effect in the metastasis and intercellular Background: The HLA-genotype of a person defines the repertoire of peptides that can be presented to T cells. We aimed to determine if HLA-I homozygosity could translate in a smaller repertoire of tumour neoantigens potentially predisposing such individuals with a disadvantage to fight a nascent tumour. Materials and Methods: High-resolution HLA-genotyping combined with cancer EGA and nonsynonymous called used to predict high and moderate affinity binders the Epitope Data Base” and gene were performed Results: Frequency of HLA homozygosity in EGA patients Abstracts our Background: Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with one of the lowest 5-year survival rates of all solid tumors. The determination of prognostic factors with PDAC is essential for predicting the outcomes and for identifying appropriate treatment strategies. Lymph node 8a is located above the pancreas head and was shown to have prognostic value for predicting severity in PDAC patients. The characteristic feature of lymph node 8a is the presence of abundant leucocytes representing both lymphoid and myeloid lineages. One major cellular compart-ment of lymph nodes are CD20+ B cells, which have been shown to be involved in the tumorigenesis of solid tumors. In this study, we sought to phenotype B","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"63 1","pages":"1 - 21"},"PeriodicalIF":1.6,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46516380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front & Back Matter","authors":"Xiaoling Zhang Shanghai, D. Gouma, J. Habermann, M. Heger, J. Kalff","doi":"10.1159/000523934","DOIUrl":"https://doi.org/10.1159/000523934","url":null,"abstract":"","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41834245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potentials of CCL21 and CBS as Therapeutic Approaches for Breast Cancer.","authors":"Jing Peng,&nbsp;Danhua Zhang","doi":"10.1159/000521671","DOIUrl":"https://doi.org/10.1159/000521671","url":null,"abstract":"<p><strong>Objective: </strong>The present research set out to ascertain the roles of CC chemokine ligand 21 (CCL21) and cystathionine beta-synthase (CBS) in breast cancer (BC) cell biological behaviors and the relationship of CCL21 and CBS expression with the clinicopathological features of patients with BC.</p><p><strong>Methods: </strong>Immunohistochemistry of CCL21 or CBS was performed in 18 intraductal cancer tissues, 124 invasive BC tissues, 50 paraneoplastic tissues, 50 lobular hyperplasia tissues, and 30 normal breast tissues. For cell experiments, two human BC cell lines (MDA-MB-231 and MCF-7) and a human breast epithelial cell line (MCF-10A) were utilized to detect the expression of CCL21 and CBS. After loss- and gain-of-function assays for CCL21 or CBS, the expression of CBS and CCL21 was measured by quantitative real-time polymerase chain reaction and western blot. Additionally, BC cell proliferation was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and 5-ethynyl-2'-deoxyuridine staining, and BC cell migration was determined by scratch test and Transwell assay.</p><p><strong>Results: </strong>In the clinical data, the positive rate of CCL21 or CBS was significantly higher in invasive BC tissues than in intraductal BC tissues, lobular hyperplasia tissues, paraneoplastic tissues, and normal breast tissues (p < 0.05 or p < 0.01). CBS or CCL21 expression shared close association with the clinicopathological characteristics and the poor prognosis of BC patients. In cell experiments, overexpression of CCL21 or CBS enhanced the proliferative and migratory abilities of BC cells.</p><p><strong>Conclusion: </strong>CCL21 and CBS promoted BC cell migration and proliferation. CCL21 or CBS expression was strongly related to the poor prognosis of BC patients.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"63 4","pages":"211-223"},"PeriodicalIF":1.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9133334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}