Birte Ohm, Kenji Fukushima, Pascal Paschenda, Zoltan Czigany, Jens Bertram, Thomas Kraus, Fabian Kiessling, Yonson Ku, Takumi Fukumoto, René H Tolba
{"title":"Dialyzers Outperform Activated Charcoal Filters for Extracorporeal Cisplatin Removal in an Isolated Perfused Porcine Liver Model.","authors":"Birte Ohm, Kenji Fukushima, Pascal Paschenda, Zoltan Czigany, Jens Bertram, Thomas Kraus, Fabian Kiessling, Yonson Ku, Takumi Fukumoto, René H Tolba","doi":"10.1159/esr/actag006","DOIUrl":"https://doi.org/10.1159/esr/actag006","url":null,"abstract":"<p><strong>Introduction: </strong>Percutaneous isolated hepatic perfusion enables regional delivery of high-dose chemotherapy while limiting systemic exposure through extracorporeal drug removal. In current clinical practice, this is achieved by the use of activated charcoal-based filtration systems, which are limited by finite adsorption capacity and non-selective binding. Hemodialysis filters may provide a membrane-based alternative for extracorporeal drug elimination. This study compared the efficacy of both systems for cisplatin removal.</p><p><strong>Methods: </strong>An isolated perfused porcine liver model was used. Livers were randomized into charcoal filtration, hemodialysis filtration, or control groups (n=5 per group). Cisplatin was administered into the hepatic circulation, and drug removal was performed according to group allocation. Cisplatin concentrations, liver injury markers, bile production, and blood cell counts were assessed.</p><p><strong>Results: </strong>Hemodialysis filters achieved significantly greater cisplatin clearance compared with activated charcoal filters, with sustained differences over time. Liver injury markers and bile production did not differ between groups. Blood cell counts revealed no relevant treatment effects.</p><p><strong>Conclusion: </strong>Hemodialysis filters improve cisplatin removal without affecting liver injury markers or blood cell counts in this experimental model.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":"1"},"PeriodicalIF":2.5,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Haotian Xie, Zhenghua Cai, Qi Li, Jun Chen, Ying Li, Jingjing Ji, Yudong Qiu
{"title":"A non-invasive artificial intelligence model to predict the severity of intrapancreatic perineural invasion.","authors":"Haotian Xie, Zhenghua Cai, Qi Li, Jun Chen, Ying Li, Jingjing Ji, Yudong Qiu","doi":"10.1159/esr/actag002","DOIUrl":"https://doi.org/10.1159/esr/actag002","url":null,"abstract":"<p><strong>Introduction: </strong>Intrapancreatic perineural invasion (IPNI) was a poor prognostic factor in pancreatic ductal adenocarcinoma (PDAC), but few studies quantified the severity of IPNI. Additionally, there was an absence of non-invasive tool to predicted IPNI.</p><p><strong>Methods: </strong>Patients who underwent radical pancreatectomy betweem 2018 and 2022 were enrolled. Severity of IPNI was assessed via binary classification, numeration, and neural invasion (NI) severity score. Cox regression analysis was performed to clarify the relationship between IPNI and prognosis. Clinical data, artificial intelligence (AI) , and radiomics were used to develop predictive models, evaluated by receiver operating characteristics (ROC) curve and decision curve analysis (DCA). Kaplan-Meier analysis confirmed the model's clinical utility.</p><p><strong>Results: </strong>A total of 192 patients were enrolled and rate of IPNI was 93.8%. Cox regression analysis and ROC curve indicated NI severity score>10.5 was responsible for poor prognosis (p<0.05). Further analysis indicated the AI model had better performance in predicting NI severity score>10.5 in both training set (clinical model AUC=0.66, AI model AUC=0.85, radiomics model AUC=0.81) and validation set (clinical model AUC=0.74, AI model AUC=0.84, radiomics model AUC=0.73). According to the predictive results of AI model, patient with NI severity score>10.5 had decreased recurrence free survival(RFS) and overall survival(OS) in training set (RFS 12months vs. 24 months, p=0.002; OS 24 months vs. 35 months, p=0.024) and validation set (RFS 8 months vs. 16 months, p=0.03; OS 25 months vs. 36 months, p=0.04).</p><p><strong>Conclusions: </strong>NI severity score >10.5 predicted poor PDAC prognosis, and AI was an useful tool to predict it.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":"1"},"PeriodicalIF":2.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chen Cao, Fanqin Wei, Jie Deng, Liping Chai, Zhangfeng Wang
{"title":"The Application of Platysma Myocutaneous Flap in Tracheostomy after Total Laryngectomy: A Novel Surgical Technique.","authors":"Chen Cao, Fanqin Wei, Jie Deng, Liping Chai, Zhangfeng Wang","doi":"10.1159/000550547","DOIUrl":"10.1159/000550547","url":null,"abstract":"<p><strong>Introduction: </strong>Here we presented a new surgical technique for tracheostomy using the platysma myocutaneous flap after total laryngectomy and analyzed its results and follow-up data.</p><p><strong>Methods: </strong>In this innovative technique, longitudinal incisions are made on the posterior tracheal wall with a platysma myocutaneous flap for tracheostomy. The outcomes and analyses of 168 patients who underwent tracheostomy (from December 2006 to June 2021) were recorded.</p><p><strong>Results: </strong>The incidence of post-tracheostomy tracheal stenosis was 2.38%, which is much lower than that of conventional surgery. Stoma size was not affected by body mass index, smoking, alcohol consumption, diabetes, and number of resected tracheal cartilage rings (p > 0.05). Patients who underwent this surgery had reduced psychological problems and increased physical appearance satisfaction.</p><p><strong>Conclusion: </strong>This technique is easily reproducible and suitable for patients with lower incidence of tracheal stenosis and higher satisfaction.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":"92-98"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13221170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah Bouari, Yitian Fang, Jacqueline van de Wetering, Vincent E de Meijer, Robert A Pol, Stefan P Berger, Wojciech G Polak, Hans Blokzijl, Aiko P J de Vries, Minneke J Coenraad, Hwai-Ding Lam, Dorottya K de Vries, Robert J Porte, Caroline M den Hoed, Jan N M IJzermans, Robert C Minnee
{"title":"Simultaneous Liver-Kidney Transplantation versus Liver Transplantation in End-Stage Liver Disease Patients with Kidney Dysfunction.","authors":"Sarah Bouari, Yitian Fang, Jacqueline van de Wetering, Vincent E de Meijer, Robert A Pol, Stefan P Berger, Wojciech G Polak, Hans Blokzijl, Aiko P J de Vries, Minneke J Coenraad, Hwai-Ding Lam, Dorottya K de Vries, Robert J Porte, Caroline M den Hoed, Jan N M IJzermans, Robert C Minnee","doi":"10.1159/000550008","DOIUrl":"10.1159/000550008","url":null,"abstract":"<p><strong>Introduction: </strong>The role of simultaneous liver-kidney transplantation (SLKT) in end-stage liver disease patients with varying kidney dysfunction remains unclear. This study aims to compare clinical outcomes of SLKT recipients with those undergoing liver transplant alone (LTA) with comparable kidney dysfunction.</p><p><strong>Methods: </strong>This retrospective cohort study included the SLKT cohort (n = 52) from the Dutch Organ Transplantation Registration and the LTA cohort (n = 829) from Erasmus Medical Center between 2000 and 2020. Patients were stratified by pretransplant renal function (chronic kidney disease [CKD] stages 3b-5) and pretransplant renal replacement therapy (RRT) status. Patient and graft survival, and renal function were compared across renal function strata.</p><p><strong>Results: </strong>Across CKD stages 3b and 4, there was no statistically significant difference in overall survival rates (p = 0.59 and p = 0.23, respectively). For patients with CKD stage 5 or RRT, patient survival rates at 1, 3, and 5 years posttransplant were significantly lower in the LTA group (60.3%, 51.7%, and 51.7%, respectively) compared to the SLKT group (90.0%, 90.0%, and 80.8%, p = 0.048). Death-censored liver graft survival rates at 1, 3, and 5 years were also significantly lower in the LTA group (59.8%, 49.9%, and 49.9%) versus SLKT group (86.4%, 86.4%, and 77.0%, p = 0.048). Cox proportional hazards model confirmed the association between SLKT and improved patient survival (HR 0.31, 95% CI: 0.10-0.98, p = 0.046).</p><p><strong>Conclusion: </strong>For patients with CKD stage 5 or those on pretransplant RRT, SLKT was associated with better survival outcomes compared to LTA. Primary etiology of liver disease and severity of kidney dysfunction should be considered when determining SLKT eligibility. Due to the limited group size, these findings should be interpreted with caution and further validated.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":"46-55"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12845520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Georges Pfister, Julien Venant, Laurent Mathieu, Jean-Marc Collombet, Marjorie Durand
{"title":"Two-Stage Fixation in a Rat Model of the Induced Membrane: A Novel Surgical Technique.","authors":"Georges Pfister, Julien Venant, Laurent Mathieu, Jean-Marc Collombet, Marjorie Durand","doi":"10.1159/000551080","DOIUrl":"10.1159/000551080","url":null,"abstract":"<p><strong>Introduction: </strong>In the context of high-energy trauma or ballistic injury, wound healing is often compromised by underlying structural damage such as bone loss, infection, or instability. The induced membrane technique (IMT), a two-stage approach for segmental bone defects, is frequently used in the management of chronic infected wounds. Although a change in osteosynthesis is routinely performed between stages in clinical settings, no preclinical animal model has reproduced this key surgical step. We present a novel surgical technique in rats combining a reinforced polymethylmethacrylate (PMMA) spacer with a Kirschner wire during the first stage, followed by plate osteosynthesis during the second stage. This represents the first reported animal model of IMT that integrates a staged change in fixation.</p><p><strong>Methods: </strong>Eleven Sprague Dawley rats underwent a 5-mm femoral bone defect creation stabilized with an intramedullary Kirschner wire and a PMMA spacer (stage one). Four weeks later, the spacer and wire were removed, and internal fixation was achieved using a locking plate system, after grafting the defect with cancellous bone (stage two). Clinical monitoring, radiographic imaging, and postmortem micro-CT analysis at 10 weeks post-second surgery assessed model feasibility and bone regeneration.</p><p><strong>Results: </strong>All animals survived and maintained satisfactory weight and clinical status throughout the protocol. The mean bone volume of the newly mineralized bone into the defect was 64.05 ± 36.62 mm3.</p><p><strong>Conclusion: </strong>This is the first reproducible animal model of IMT incorporating a staged change in osteosynthesis, closely mimicking clinical management of chronic bone wounds. The technique offers a robust preclinical platform for studying the influence of fixation methods on membrane properties and bone healing. It is particularly relevant for translational research in wound-associated bone defects and infection control.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":"117-121"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148381980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rafael Llombart-Blanco, María Benlloch, Gonzalo Mariscal, Pablo Vera, Egor Polevoi, Ali Dway, Carlos Barrios, Rafael Llombart-Ais
{"title":"Brachial Plexus Blockage versus General Anesthesia for Upper Extremity Surgery: A Systematic Review and Meta-Analysis.","authors":"Rafael Llombart-Blanco, María Benlloch, Gonzalo Mariscal, Pablo Vera, Egor Polevoi, Ali Dway, Carlos Barrios, Rafael Llombart-Ais","doi":"10.1159/000550121","DOIUrl":"10.1159/000550121","url":null,"abstract":"<p><strong>Introduction: </strong>This meta-analysis investigated differences in rebound pain and opioid consumption when using brachial plexus blockade (BPB) versus general anesthesia (GA) for upper limb surgery.</p><p><strong>Methods: </strong>Four databases were searched. Odds ratios (OR), mean differences (MD), and standard mean differences (SMD) with 95% confidence intervals (CIs) were calculated. Outcomes included were pain, opioid consumption, adverse events, and discharge time. The risk of bias was assessed.</p><p><strong>Results: </strong>Nine clinical trials involving 487 patients were included. BPB resulted in significantly lower pain scores within 2 h postoperatively (MD -4.57, 95% CI -5.76 to 3.38; participants = 263; studies = 5; I2 = 0%; p < 0.00001) but not from 6 to 24 h. Opioid consumption (mg) was lower in the BPB group in the first 24 h (SMD -0.85, 95% CI -1.41 to -0.29; participants = 188; studies = 3; I2 = 67%; p < 0.003). BPB was associated with fewer postoperative nausea/vomiting events (OR 0.19, 95% CI 0.10-0.33; participants = 326; studies = 6; I2 = 45%; p < 0.00001) and shorter hospital stay (SMD -1.20, 95% CI -1.73 to -0.66; participants = 213; studies = 4; I2 = 69%; p < 0.0001). There was no difference in the number of patients not requiring opioids from 24 to 48 h.</p><p><strong>Conclusions: </strong>BPB provided superior pain control at 2 h postoperatively and was associated with reduced opioid use, fewer adverse events, and shorter discharge time. No significant differences in pain scores were observed at 6-24 h or beyond 24 h, likely due to block wear-off. Despite this limitation, BPB still offered perioperative advantages over GA.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":"66-76"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145809912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum.","authors":"","doi":"10.1159/000551130","DOIUrl":"10.1159/000551130","url":null,"abstract":"<p><p>The article \"Desensitization Strategies in Immunized Heart Transplant Recipients\" [Eur Surg Res. 2026;67:1-9; https://doi.org/10.1159/000549669] by Goerler et al. was published with the wrong open access license. The correct license of the article is CC-BY.The original article has been updated.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"67 1","pages":"78"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147480140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Umit Akin Dere, Fatma Altintas, Baris Albuz, Nazli Çil, Pelin Kuzucu, Esin Avci, Hande Senol, Ahmet Koluman, Mehmet Erdal Coskun
{"title":"Efficacy of Platelet-Rich Plasma and Polyvinyl Alcohol Wound Dressing in Open Wound Healing: First Results from an Experimental Rat Model.","authors":"Umit Akin Dere, Fatma Altintas, Baris Albuz, Nazli Çil, Pelin Kuzucu, Esin Avci, Hande Senol, Ahmet Koluman, Mehmet Erdal Coskun","doi":"10.1159/000550016","DOIUrl":"10.1159/000550016","url":null,"abstract":"<p><strong>Introduction: </strong>Wound healing is a complex biological process involving hemostasis, inflammation, proliferation, and tissue remodeling. Despite promising results with platelet-rich plasma (PRP) and synthetic scaffolds used separately, their combined in vivo effects remain insufficiently investigated. This experimental study presents the first results on a composite wound dressing integrating PRP, rich in growth factors, with electrospun polyvinyl alcohol (PVA) nanofibers, a biocompatible and stable polymer.</p><p><strong>Methods: </strong>Full-thickness skin defects (1 × 1 cm2) were created in 21 adult female Sprague-Dawley rats and divided into three groups: control, PVA, and PRP/PVA. Wound healing was assessed histologically and biochemically on days 7 and 14, including fibroblast growth factor-2 (FGF-2) measurement.</p><p><strong>Results: </strong>The PRP/PVA group showed enhanced epithelialization and angiogenesis compared to other groups (p < 0.05), along with higher FGF-2 levels.</p><p><strong>Conclusion: </strong>The relatively small sample size, absence of a PRP-only group, and short observation period limit the generalizability of these findings. Within these constraints, the results indicate a potential synergistic role of PRP and PVA scaffolds in promoting wound repair, supporting further studies with larger cohorts and standardized PRP preparation before clinical translation.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":"56-65"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexander M Bernhardt, Constanze Volgmann, Lennart Bax, Sarah Berger Veith, Markus J Barten, Evaldas Girdauskas
{"title":"Temporary Mechanical Circulatory Support.","authors":"Alexander M Bernhardt, Constanze Volgmann, Lennart Bax, Sarah Berger Veith, Markus J Barten, Evaldas Girdauskas","doi":"10.1159/esr/actag001","DOIUrl":"10.1159/esr/actag001","url":null,"abstract":"<p><strong>Background: </strong>Cardiogenic shock (CS) remains a leading cause of early death in acute cardiac care, with 30-day mortality frequently approaching 40-50% despite advances in revascularization and critical care pathways. Contemporary CS management has progressed through standardized definitions, staging systems, and phenotyping frameworks that support earlier recognition and a more disciplined escalation strategy. However, evidence-based therapies that consistently reduce mortality remain limited, and device-related complications and heterogeneous etiologies continue to constrain outcome gains.</p><p><strong>Summary: </strong>Temporary mechanical circulatory support (tMCS) provides rapid hemodynamic stabilization, augments end-organ perfusion, and enables time for revascularization, recovery, durable left ventricular assist device (LVAD) implantation, or transplantation. The major tMCS modalities used in current practice include intra-aortic balloon pump, percutaneous microaxial flow pumps, left atrial-to-arterial bypass devices, and venoarterial extracorporeal membrane oxygenation (VA-ECMO), with dedicated right-sided support strategies for right ventricular failure. Selection should be driven by (i) shock stage and trajectory, (ii) dominant ventricular lesion (LV, RV, or biventricular), (iii) oxygenation need, (iv) anatomical constraints and access options, and (v) intent (bridge to decision, recovery, durable LVAD, or transplant). Randomized evidence supports immediate culprit lesion revascularization for myocardial AMI-CS and suggests benefit from routine microaxial flow pump support in carefully selected AMI-CS patients without major hypoxic brain injury risk, albeit at the cost of higher bleeding and limb ischemia. In contrast, routine early VA-ECMO in infarct-related CS has not demonstrated mortality benefit in randomized trials and is associated with increased complications; therefore, VA-ECMO should be reserved for selected phenotypes, including refractory shock with severe hypoxemia, profound biventricular failure, or circulatory collapse, and should be embedded within an explicit unloading, anticoagulation, limb perfusion, and weaning protocol.</p><p><strong>Key message: </strong>tMCS implantation and management should be based on cardiogenic severity and phenotype.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":"122-127"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148619157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bibek Das, Henry Douglas Robb, Stergios Bobotis, Laith Omar Khalaf Alghazawi, Hutan Ashrafian, Madhava Pai, Matyas Fehervari, Somaiah Aroori, Duncan Spalding
{"title":"Does Treatment of Jaundice Matter before Pancreaticoduodenectomy? Results from an International Multicentre Recurrence after Whipple (RAW) Study.","authors":"Bibek Das, Henry Douglas Robb, Stergios Bobotis, Laith Omar Khalaf Alghazawi, Hutan Ashrafian, Madhava Pai, Matyas Fehervari, Somaiah Aroori, Duncan Spalding","doi":"10.1159/000552543","DOIUrl":"10.1159/000552543","url":null,"abstract":"<p><strong>Introduction: </strong>The management of jaundice before pancreaticoduodenectomy (PD) remains controversial. We aimed to analyse the clinical outcomes of jaundiced patients in a large cohort of PD patients stratified by treatment pathway.</p><p><strong>Methods: </strong>Data were collected from the Recurrence After Whipple's (RAW) study - an international, multicentre, retrospective cohort study of PD patients. Patients that underwent PD with subsequent histology confirmed pancreatic head ductal adenocarcinoma, ampullary adenocarcinoma, and distal cholangiocarcinoma were included in the RAW study. Patients were stratified into three groups by management of preoperative jaundice.</p><p><strong>Results: </strong>Patients (n = 1,172) were classified into three groups: surgery while jaundiced (n = 109), surgery after successful preoperative biliary drainage (PBD) (n = 777), and not jaundiced (n = 286). Jaundice was an independent predictor of poor survival, whether treated (HR 1.45, CI 1.20-1.76) or untreated (HR 1.55, CI 1.16-2.09) pre-operatively. On multivariate analysis, PBD was associated with improved disease-free survival (HR 0.75, CI 0.58-0.97) but not overall survival (HR 0.93, CI 0.72-1.20) relative to the untreated jaundiced population. PBD was associated with a reduced, but statistically nonsignificant, risk of PD-related complications (OR 0.63 CI 0.39-1.02; p = 0.059).</p><p><strong>Conclusion: </strong>We observed a nonsignificant trend towards reduced perioperative complications and improved disease-free survival following PBD prior to PD.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":"107-116"},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13354277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147981288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}