European Surgical Research最新文献

{"title":"Pig models in translational surgery.","authors":"Rebecca Goutchtat, Axelle Béguier, Nathalie Kasal-Hoc, Pierre Guerreschi, Pierre Fayoux, Lisa Rancan, François Pattou, Thomas Hubert","doi":"10.1159/000546168","DOIUrl":"https://doi.org/10.1159/000546168","url":null,"abstract":"<p><p>Large mammals are required for surgical research since the small size of rodents does not allow the translation of the procedures to those of humans. The pig has a particularly high translational value due to its similar overall anatomy and physiology, thus used as a first choice in many fields of surgical research. In cardiovascular procedures, it contributed to stents development, coronary bypass grafting improvement and heart valve xenotransplantation. A particular focus will be done in the future to improve the models and consequently the reliability of the preclinical findings. In digestive surgery, the utility of pigs has been diverse, with the development of meshes for abdominal defects repair or improvement of surgical procedures aiming at compensate functional defects. A particular utilization has been made in liver regeneration and transplantation procedures, for which the future perspectives are wide, and in metabolic surgery research for metabolic diseases interventional therapy. In endocrine surgery, the use of the pig has mainly consisted in the development of pancreas and islets transplantation for type 1 diabetes therapy, whereas the research on the other glands is less represented. Osteoarticular and neurosurgery are fields where the use of the pig is increasing: for ethical reasons instead of non-human primate models in neurosurgery but also because the rapid growth of this species allows to test the biomechanical properties of orthopedic devices in context of skeletal growth. More generally, the pig has a particular present and future involvement for testing new surgical equipment or bioengineering solutions, developing new minimally invasive approaches and robotic surgery training, regardless of the field. Finally, pig-to-human organ xenotransplantation represents a major translational surgery challenge. If the research has reached a milestone with some living patients grafted with heart or kidney from pigs with multiple genetic modifications, additional findings are required to demonstrate the safety and the long-term benefit and to extend it to other organs like the liver. In summary, the pig model has led to many advances in surgical research, with future prospects focusing primarily on xenotransplantation. However, the use of the pig in biomedical research will have to deal with growing societal ethical expectations.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Utilisation, Application, and Quality of Videos of Clinical Interventions in Peer-Reviewed Literature: A Scoping Review.","authors":"Henry Douglas Robb, Michael G Fadel, Bibek Das, Laith Omar Khalaf Alghazawi, Olivia Ariarasa, Aksaan Arif, Ayda Alizadeh, Zohaib Arain, Matyas Fehervari, Hutan Ashrafian","doi":"10.1159/000545224","DOIUrl":"10.1159/000545224","url":null,"abstract":"<p><strong>Background: </strong>Videos of clinical interventions (VoCIs) demonstrating surgical and interventional procedures have become a mainstay in clinical practice and peer-reviewed academic literature. Despite the widespread availability of VoCI in the literature, there remain no established guidelines regarding the reporting of VoCI. We undertook a scoping review to investigate the current utilisation, application, and quality in VoCI reporting.</p><p><strong>Summary: </strong>A comprehensive literature search of Medline, Embase, Emcare, and CINAHL databases was performed to retrieve articles presenting VoCI, from January 2020 to December 2023. A customised data extraction tool assessed video characteristics (e.g., case presentation, outcomes), utility (e.g., target audience, reproducibility of procedure), and quality (subjective and objective). A total of 624 VoCIs were included (mean length 06:06), with over 62 h of VoCI reviewed. The most common VoCI perspectives were endoscopic (n = 153; 25%) and laparoscopic (n = 140; 22%). The clinical background and outcomes were described in 480 (76.9%) and 403 cases (64.6%), respectively, with disclosures (n = 23; 3.8%) rarely presented. VoCI primarily targeted trainees (n = 547; 87.7%) with most videos providing technical guidance (n = 394; 63.1%). In total, 248 videos (40%) were rated as medium or low quality on subjective assessment.</p><p><strong>Key messages: </strong>There are significant heterogeneity and notably poor-quality control in VoCI reporting in peer-reviewed literature resulting in the omission of critical procedural steps and suboptimal visual quality. VoCI reporting guidelines are therefore urgently required to provide a set of minimum items that should be reported by clinicians when uploading VoCI.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":"18-31"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advocacy for Adequate Translational Surgery in Large Mammals.","authors":"Thomas Hubert","doi":"10.1159/000546174","DOIUrl":"10.1159/000546174","url":null,"abstract":"","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":"46-48"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonhuman Primate Models in Translational Surgery.","authors":"Jaco Bakker, Tim Buchholz, Melissa Ann de la Garza, Tommaso Virgilio, Thomas Hubert","doi":"10.1159/000545834","DOIUrl":"10.1159/000545834","url":null,"abstract":"<p><strong>Background: </strong>Nonhuman primates (NHPs) play a unique role in translational science by bridging the gap between basic and clinical investigations and are often seen as a last step before clinical application. They are widely utilized in biomedical research due to their anatomical and physiological similarities to humans. Examples of commonly used species include the genera Macaca (macaques), Papio (baboons), Aotus (owl monkeys), Callithrix (marmosets), Saimiri (squirrel monkeys), and Chlorocebus (vervet monkeys).</p><p><strong>Summary: </strong>NHP models have played an instrumental role in the development of surgical techniques, each being balanced with a unique set of advantages and shortcomings. With the appropriate selection of species and anatomy, animal models can be used to provide insight into the pathophysiology of diseases, to confirm the feasibility of new surgery technologies, to assess the potential efficacy of new surgical techniques for specific clinical outcomes, and to establish reasonable safety of new techniques for specified clinical use. Robotics have augmented surgical precision for microinjections and a brain-spine robotic interface used in gait restoration, illustrating the translational potential of NHP models in human neurological research. Recent studies highlight protocols for procedures such as tubectomy and spinal cord access with minimal postoperative risk, expanding surgical possibilities.</p><p><strong>Key messages: </strong>This review provides an overview of the recent advancements made in surgery in NHP models and the translation of these techniques to the clinical setting. Surgical refinements not only enhance animal welfare but also improve the quality of experimental outcomes. The integration of robotics, imaging, and personalized approaches signifies a transformative shift in NHP surgical models, encouraging collaboration among veterinary and research staff for continuous progress.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":"32-38"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Appendicolith as a Sign of Complicated Appendicitis: A Myth or Reality? A Retrospective Study.","authors":"Ceith Nikkolo, Mariliis Muuli, Ülle Kirsimägi, Urmas Lepner","doi":"10.1159/000543683","DOIUrl":"10.1159/000543683","url":null,"abstract":"<p><strong>Introduction: </strong>Appendicolith can be incidentally detected on abdominal computer tomography (CT) without any signs of appendicitis. However, it has also been found to be a risk factor for failure of nonoperative management in acute appendicitis. The present retrospective study aimed to evaluate whether appendicolith predicts complicated appendicitis in patients with any appendicitis.</p><p><strong>Methods: </strong>A retrospective chart review was conducted for patients undergoing appendectomy from January 2016 to December 2018. Appendicolith was considered to be present when it was described in a CT scan.</p><p><strong>Results: </strong>Of the 267 patients, appendicolith was found in 120 cases, while there were no in 147 cases in preoperative CT scans. In the case of complicated appendicitis (gangrenous or gangrenous perforated appendicitis), appendicolith was visible in CT scans in 57.7% of the patients. Of the patients with uncomplicated appendicitis, 38.3% had appendicolith in CT scan (p = 0.002). In univariate logistic regression analysis, based on the finding of the histological specimen, appendicolith was associated with complicated appendicitis (OR: 2.12; 95% CI: 1.28-3.51; p = 0.004). When adjusting for sex, age group (age ≤50 vs. >50 years), and duration of symptoms (≤24 vs. >24 h), the odds ratio was 3.52 (95% CI: 1.88-6.58; p < 0.001).</p><p><strong>Conclusion: </strong>Our study found that appendicolith can be considered an independent risk factor for complicated appendicitis. Therefore, in the presence of appendicolith, surgical treatment should probably be preferred over nonsurgical treatment in acute appendicitis.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the C-REX LapAid and Circular Stapled Colorectal Anastomoses in an Experimental Model.","authors":"Dadi Thor Vilhjalmsson, Anders Grönberg, Ingvar Syk, Henrik Tobias Thorlacius","doi":"10.1159/000543069","DOIUrl":"10.1159/000543069","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The rate of colorectal anastomotic leakage has remained unchanged for the last decades. The limitations of current anastomotic methods have generated an interest in alternative anastomotic techniques, such as compression anastomosis. The aim of this experimental study was to evaluate the early mechanical strength in left colonic anastomoses, comparing C-REX LapAid and circular stapled anastomotic methods.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 48 pigs underwent open sigmoid resection with end-to-end colorectal anastomoses 15 cm above the anal verge, where 21 anastomoses were constructed with traditional circular staplers and 27 with the C-REX LapAid device. Bursting pressure was measured at different time intervals postoperatively through an attached anal plug while the upper limit of the bowel segment was closed with a bowel clamp. Early histological changes were assessed 6-24 h after the anastomotic formation with vascular CD31 and collagen Masson Trichrom staining.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;All animals recovered uneventfully after the surgical procedure. The circular stapled anastomoses exhibited a median bursting pressure of 36 mbar (28-64) at 1 h, 45 mbar (43-69) at 6 h, and 145 mbar (85-185) 12 h after surgery. In comparison, the C-REX LapAid anastomoses demonstrated a median bursting pressure of 195 mbar (180-240) at 1 h, 192 mbar (180-220) at 6 h, and 180 mbar (160-180) 12 h after surgery, representing a 2-5-fold higher median bursting pressure in the early anastomotic healing phase. Early microscopic architecture showed little evidence of vascular and collagen formation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The novel C-REX LapAid device demonstrated significantly higher bursting pressure values in the early phase of the anastomotic healing process compared to the circular stapled method. A clinical study to further verify the benefits of C-REX LapAid is warranted.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The rate of colorectal anastomotic leakage has remained unchanged for the last decades. The limitations of current anastomotic methods have generated an interest in alternative anastomotic techniques, such as compression anastomosis. The aim of this experimental study was to evaluate the early mechanical strength in left colonic anastomoses, comparing C-REX LapAid and circular stapled anastomotic methods.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 48 pigs underwent open sigmoid resection with end-to-end colorectal anastomoses 15 cm above the anal verge, where 21 anastomoses were constructed with traditional circular staplers and 27 with the C-REX LapAid device. Bursting pressure was measured at different time intervals postoperatively through an attached anal plug while the upper limit of the bowel segment was closed with a bowel clamp. Early histological changes were assessed 6-24 h after the anastomotic formation with vascular CD31 and collagen Masson Trichrom staining.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/str","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":"9-17"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sheep Models in Translational Surgery.","authors":"Bertrand Lussier, Luc Behr, Nicolas Borenstein, Irena Brants, Charles Garabedian, Louise Ghesquiere, Kevin Le Duc, Dyuti Sharma, Laurent Storme, Gwenola Touzot-Jourde, Jeff White, Thomas Hubert","doi":"10.1159/000546157","DOIUrl":"10.1159/000546157","url":null,"abstract":"<p><strong>Background: </strong>The selection of an animal model is tedious. One must consider several factors; one of these, of utmost importance, is the translational value of the animal model. The sheep, as a translational surgical model, possesses a multiple of advantages that makes it one of the preferred models in several research domains.</p><p><strong>Summary: </strong>Sheep are the state-of-the-art test models for cardiovascular research and safety studies required for approval of cardiovascular implantable devices; the sheep's heart size, cardiac muscle, heart valves, and the mechanical, haemodynamic, and coagulation parameters are very similar to humans. Furthermore, the pregnant sheep/lamb are robust models for studying neonatal adaptation and placental physiology due to its physiological similarities with humans. Its placental structure supports efficient gas exchange, resembling human oxygen transfer mechanisms. The ovine model is mainly used in studies of adaptation at birth, foetal physiology during labour, and congenital diaphragmatic hernia. The sheep model is also used in several orthopaedic preclinical models, mainly in the study of critical bone defects, cancellous bone healing, osteomyelitis, and joint replacement surgeries. It is also a preferred model of bone healing in osteoporosis. Moreover, the sheep has gained popularity as a model of osteoarthritis (OA); it is a validated model of surgically induced OA. Several therapeutic modalities can be evaluated using validated outcome measures such as, kinetics, kinematics, imaging, repeated arthroscopic grading, synovial fluid analysis, and biomarkers. The ovine model, because of its size, is the closest to humans for the evaluation of spinal surgery techniques, devices, and spinal fusion biological enhancers/cancellous graft replacement. Finally, we will outline the different specificities of sheep analgesia and anaesthesia. Challenges encountered in ruminant anaesthesia are mainly in relation with their digestive physiology that creates a high risk of regurgitation during anaesthesia and a hindrance of diaphragm/respiratory movements due to rumen repletion and meteorism. Fasting regimen and management of recovery should encompass strategies that limit the starving sensation and allow for reduced social isolation. Clarification of the interactions between scientific objectives and anaesthesia-analgesia protocols prevents conflicts between the ethics and the purpose of the experiment while allowing for development of model-specific anaesthesia and pain management protocols.</p><p><strong>Key messages: </strong>The sheep has become a popular model because of its size, availability, robustness, cost, and ease of handling. Furthermore, as a preclinical model, the same validated objective outcome measures used to measure success in humans can apply to sheep.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":"39-45"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal mucosal perfusion and integrity are maintained in hypotensive brain dead mice.","authors":"Mihai Oltean, Jasmine Bagge, Anna Casselbrant, Andreas Lundgren, Lucas Ferreira da Anunciação, Lucia de Miguel Gomez, Tomas Lorant, Mats Hellström, Michael Olausson","doi":"10.1159/000540020","DOIUrl":"https://doi.org/10.1159/000540020","url":null,"abstract":"<p><p>Brain death (BD) leads to complex hemodynamic and inflammatory alterations which may compromise organ perfusion and induce morphologic and functional damage in various organs. The intestine is particularly sensitive to hypoperfusion and donor hypotension usually precludes intestinal donation. Previous studies reported inflammatory intestinal changes following BD but information on mucosal integrity and perfusion are lacking. BD was induced in mice by inflating an epidural balloon catheter. Controls underwent only anesthesia and tracheostomy. Intestinal perfusion was assessed using laser Doppler flowmetry (LDF). Intestinal injury was assessed after 2h of BD by the Chiu-Park score and morphometry. Intestinal tight junction (TJ) proteins (claudin-1, claudin-3, occludin, tricellulin) as well as inflammatory activation (intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and interleukin-6) were also analysed and compared with a sham group. Although blood pressure decreased in BD mice, intestinal perfusion remained similar between BD and sham mice. Histologically, mucosal injury was absent/minimal and TJs appeared well maintained in both groups. BD may trigger intrinsic, autoregulatory mechanisms to preserve microvascular tissue perfusion and mucosal integrity in spite of mild hypotension.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141456122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rationale and Trial Protocol for a Double-Blinded Randomized Controlled Trial to assess the Impact of a Concomitant Crural Repair during Laparoscopic Sleeve Gastrectomy in Patients with a Lax Gastroesophageal Junction without Frank Hiatal Hernia (REPAIR trial protocol).","authors":"Koy Min Chue, Bin Chet Toh, Lester Wei Lin Ong, Gamage Manisha Kariyawasam, Wai Keong Wong, Chin Hong Lim, Jeremy Tian Hui Tan, Baldwin Po Man Yeung","doi":"10.1159/000538043","DOIUrl":"https://doi.org/10.1159/000538043","url":null,"abstract":"<p><strong>Introduction: </strong>Laparoscopic sleeve gastrectomy (LSG) is associated with postoperative gastroesophageal reflux disease (GERD) and erosive esophagitis (EE). The role of crural repair during LSG is still controversial. The preoperative laxity of the gastroesophageal junction (GEJ), graded by the Hill's classification, is more predictive for postoperative GERD and EE after LSG than the presence of a hiatal hernia seen on endoscopy. Thus, the authors hypothesize that a concomitant crural repair in a specific subgroup of patients with a lax GEJ (Hill's III) may reduce the incidence of postoperative GERD and EE.</p><p><strong>Methods: </strong>A double-blinded, randomized controlled trial of patients with Hill's III GEJ undergoing LSG will be randomized to a concomitant crural repair (experimental) versus LSG alone (control). Primary outcome measures will be presence of EE at 1-year. Secondary outcome measures will include proton pump inhibitor use, postoperative complications, operative time, blood loss, quality of life, GERD and gastrointestinal symptoms.</p><p><strong>Conclusion: </strong>Conflicting crural repair results may be explained by differences in preoperative GEJ laxity. Patients with a frank hiatal hernia and patulous GEJ (Hill's IV) have a very high, while patients with an apposed GEJ (Hill's I, Hill's II) have a low incidence of postoperative GERD and EE respectively. Thus, the authors hypothesize that patients with a lax GEJ without frank hiatal hernia (Hill's III), might benefit from a crural repair. This study results can potentially highlight the clinical importance of preoperative endoscopic evaluation of the GEJ in all patients planned for LSG, to determine which subgroup patients may benefit from a crural repair. (Clinicaltrials.gov: NCT05330910, Registered 15-April-2022).</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139982732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recycling transplanted organs: An exceptional case and literature review.","authors":"Titas Bera, Puneet Sindhwani, Michael Rees, John Rabets, Obinna Ekwenna, Deepak Malhotra, Dinkar Kaw, Shobha Ratnam, Amira Gohara, Dalia Ibrahim, John Fisher, Kunal Yadav","doi":"10.1159/000537821","DOIUrl":"https://doi.org/10.1159/000537821","url":null,"abstract":"<p><strong>Background: </strong>Recycling transplant kidneys, in other words using an allograft which has previously been transplanted in one recipient for transplant in a second recipient, can be a source of opportunity for expanding the pool of available grafts in the United States and beyond.</p><p><strong>Summary: </strong>We describe a case of renal transplantation from a donor who had undergone a kidney transplant 3 years prior and had good graft function at the time of procurement. The recipient underwent transplantation uneventfully and to date has demonstrated excellent graft function. We also include a literature review of reported cases of recycled/retransplanted kidneys.</p><p><strong>Key messages: </strong>-Recycling transplanted kidneys is a largely untapped resource which could help decrease the transplant waitlist. -Utilizing such kidneys does need special considerations in terms of procurement technique, backtable, crossmatch, recipient selection and follow-up.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}