European Surgical Research最新文献

{"title":"Pheochromocytoma and Extraadrenal Paraganglioma: Case Report and Review of the Laparoscopic Approach","authors":"Saul Eduardo Torres Arano, Bryan Armando Morales Eslava, Manuel Guadalupe Torres Gonzalez, Carolina Flores Castro, Federico Lopez Rosales","doi":"10.33425/2689-1093.1046","DOIUrl":"https://doi.org/10.33425/2689-1093.1046","url":null,"abstract":"The reported percentage of catecholamine-producing tumors is around 80-85% in pheochromocytomas and 15- 20% in paragangliomas. The case of a 34-year-old female patient with a clinical, imaging and histopathological diagnosis of pheochromocytoma with paraganglioma with successful laparoscopic surgical resolution with a retroperitoneal approach is described. The cardinal symptom is uncontrolled hypertension despite medical management with multiple antihypertensives. The initial diagnostic approach is with the measurement of metanephrines in plasma and urine, if this is not conclusive, the clonidine test can be performed. With a positive laboratory result, an imaging study should be performed for localization and finally surgical resolution with a preference for the laparoscopic approach, with less risk of post-surgical complications.","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"28 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76070928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Value of the Crowd-Sourced Assessment of Technical Skills (C-SATS) Platform in Surgical Procedures: A Systematic Review of Evidence","authors":"Tommaselli Giovanni A, Sehat Alvand J, Ricketts Crystal D, Ć. W., Grange Philippe","doi":"10.33425/2689-1093.1047","DOIUrl":"https://doi.org/10.33425/2689-1093.1047","url":null,"abstract":"Background: Crowd-Sourced Assessment of Technical Skills (C-SATS) is a surgical data management and learning platform that leverages the knowledge of large expert surgeon and lay groups to assess the technique and technical skills of surgeons in a highly efficient manner. The aim of this systematic review was to summarize published literature on the performance of C-SATS as compared to expert evaluations and assess its use as a training and validation tool in minimally invasive surgery (MIS). Methods: A comprehensive literature search was performed per PRISMA guidelines using the Medline, Embase, and Google Scholar databases on published studies that evaluated the use of C-SATS following MIS, such as laparoscopic or robotic-assisted surgery. Results: A total of 21 reports were included in the review. Twelve studies comparing crowd-sourcing evaluations against expert opinion indicated overall excellent or good correlation with Global Operative Assessment of Laparoscopic Skills (GOALS), Global Evaluative Assessment of Robotic Skills (GEARS), and Robotic Objective Structured Assessment of Technical Skills (R-OSATS) scores, with correlation coefficients (Pearson or Spearman) ranging from 0.69 to 0.95 and reliability index (Cronbach’s alpha) from 0.63 to 0.93 across different specialties and surgical approaches. When using C-SATS to assess performance and validation, assessments positively correlated with traditional methods of time and error-based scoring and global rating scale. Conclusions: Based on the current published literature, the C-SATS platform has been shown to efficiently provide crowd-sourced evaluations that correlate favorably with expert evaluation across a range of surgical specialties and approaches. Use of crowdsourcing has uniformly yielded accurate evaluations of surgeons’ technical skills in a markedly shorter time than expert reviews. C-SATS may be a cost-effective complement or alternative to traditional models of evaluating surgical proficiency. Future studies are needed to determine whether the use of C-SATS will lead to improved surgical performance and patient outcomes.","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"59 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74054177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of FOXO3 on neuronal ferroptosis after intracerebral hemorrhage via modulating NOX4 transcription.","authors":"Zhongzong Qin, Gang Zhu, Honghai Luo, Yifan Deng","doi":"10.1159/000527617","DOIUrl":"10.1159/000527617","url":null,"abstract":"<p><strong>Introduction: </strong>Intracerebral hemorrhage (ICH) is known to trigger neuronal ferroptosis while forkhead box O3 (FOXO3) is implicated in ICH. This study aimed to determine the specific effect of FOXO3 on neuronal ferroptosis after ICH.</p><p><strong>Methods: </strong>The ICH mouse model was established through the injection of bacterial collagenase type IV and the cell model was established in Hemin-induced HT-22 cells. Subsequently, neurological functions, brain water content, and histopathological changes in mice were assessed. HT-22 cell activity was examined via cell counting kit-8 (CCK-8) method, and the levels of FOXO3, NADPH oxidase 4 (NOX4), and glutathione peroxidase 4 (GPX4) in brain tissues and HT-22 cells were measured. Fe2+ concentration and the levels of reactive oxygen species (ROS), malondialdehyde (MDA), and glutathione (GSH) in the tissues and cells were examined. The binding relationship between FOXO3 and the NOX4 promoter region was determined via chromatin-immunoprecipitation (Ch-IP). Rescue experiments were designed to probe the role of NOX4 in the regulation of FOXO3 on neuronal ferroptosis.</p><p><strong>Results: </strong>FOXO3 was highly-expressed in ICH models while silencing FOXO3 alleviated brain damage, edema, and inflammatory infiltration in ICH mice. Meanwhile, silencing FOXO3 enhanced cell activity, diminished ROS and MDA activities and Fe2+ concentration, and elevated GSH and GPX4 levels in the tissues or cells. FOXO3 could bind to the NOX4 promoter and upregulate NOX4 transcription. NOX4 overexpression partially neutralized the repressive role of silencing FOXO3 in neuronal ferroptosis.</p><p><strong>Conclusion: </strong>Silencing FOXO3 attenuated ICH-induced neuronal ferroptosis via down-regulating NOX4 transcription levels, thus ameliorating post-ICH brain damage.</p>","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40475964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front & Back Matter","authors":"","doi":"10.1159/000526881","DOIUrl":"https://doi.org/10.1159/000526881","url":null,"abstract":"","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42272862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Bromelain on Noradrenaline Release During Anxiety-Like Behaviour Following Intra-Medial Forebrain Bundle 6-OHDA Injection in Rat Model of Parkinsonism","authors":"T. Adu, O. Adu, M. Mabandla","doi":"10.33425/2689-1093.1043","DOIUrl":"https://doi.org/10.33425/2689-1093.1043","url":null,"abstract":"Introduction: Parkinson’s disease (PD) is characterized by emotional dysfunction which is a typical manifestation of non-motor symptoms. Non-motor symptoms may occur simultaneously with motor impairment in PD. Anxiety is a comorbidity in PD. This study therefore addresses the question of whether prior/post 6-OHDA lesion treatment with bromelain can show an effect on the behavioural signs of parkinsonism and damage to the CNS noradrenergic system in experimental rats. Methods: Open field and despair swim tests were used to assess certain psychomotor functions and emotional reactivity in the neurotoxin injected rats. The level of noradrenaline in certain regions of the brain as well as in the blood was further analyzed by enzyme linked immunosorbent assay. Findings: The results showed that unilateral injection of the neurotoxin into the rats’ medial forebrain bundle caused a decrease in the rearing time and a corresponding increase in the time spent grooming. There was a further indication that 6-OHDA injection resulted in the reduction of noradrenaline in the systemic environment. Also, the duration of immobility was increased by 6-OHDA injection but not statistically significant. Pretreatment with bromelain caused a change in the grooming behaviour not consistent with noradrenaline level. Conclusion: This finding suggests that bromelain treatment interferes with the regulation of mood and emotion during the early phase of parkinsonism in the 6-OHDA rat model of PD which was accompanied by changes in noradrenaline level.","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"14 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85194800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Management of Hepatocellular Carcinoma at the Kara Teaching Hospital (Togo)","authors":"Ossouvi Tamegnon, EL-HADJI Yakoubou, Rafiou, Adabra Komlan, Bouglouga Oumboma, Kanassoua Kokou, Kassegne Irokoura, D. David","doi":"10.33425/2689-1093.1041","DOIUrl":"https://doi.org/10.33425/2689-1093.1041","url":null,"abstract":"Objective: To describe the epidemiological, diagnostic, therapeutic and evolutionary aspects of hepatocellular carcinoma at CHU Kara. Method: This is a retrospective study conducted over a period of 3 years in the Department of General Surgery and Hepato-Gastroenterology of CHU-Kara (Togo). Were included in our study all patients, aged over 15 years old hospitalized for hepatocellular carcinoma. Results: We recorded 98 cases out of 7237 hospitalized patients, i.e. a frequency of 1.4%. The patients were consisted of 65 men and 33 women with a sex ratio (F/M) of 0.5. The average age was 49 years old. Clinically, painful hepatomegaly was found in all cases; abdominal pain in all cases, poor general condition in 86 patients; collateral venous circulation in 3 cases. Alpha-fetoprotein (AFP) was above 400 ng/ml in all patients. Abdominal imaging revealed diffuse liver involvement in 85 patients (86.7%), a localized nodular appearance in 13 cases (13.3%).All these patients had received symptomatic treatment combining analgesics and antispasmodics. The mortality rate was 97.9% within 12 months. Conclusion: Hepatocellular carcinoma remains a serious condition and its diagnosis is often difficult. It poses a real problem of care in our developing countries.","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"07 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86016644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Diffuse Large B-Cell Lymphoma of the Colon with Spontaneous Perforation: A Case Report","authors":"Mehdi Hammemi, M. Hajri, S. Omrani, W. Ferjaoui, D. Bacha, B. Rached, Hafedh Mestir","doi":"10.33425/2689-1093.1042","DOIUrl":"https://doi.org/10.33425/2689-1093.1042","url":null,"abstract":"We report a rare case of primary lymphoma of the colon with spontaneous perforation in A 54-year-old woman.","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"126 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77727873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Pudendal Thigh Flap In The Creation of A Neovagina and Restoration of Utero-Neovaginal Continuity – A Case Report","authors":"K. Ogundipe, Elizabeth Evelyn Enoch","doi":"10.33425/2689-1093.1040","DOIUrl":"https://doi.org/10.33425/2689-1093.1040","url":null,"abstract":"The pudendal thigh flap is a sensate flap based on the posterior labial artery, which has shown great versatility in the reconstruction of genital anomalies as well as genital oncologic reconstruction. This report showcases the creation of a neovagina with the restoration of uterovaginal continuity in a 12-year-old girl who had vaginal atresia. She presented with concealed menstruation and cyclical abdominal pain and had a creation of a neovagina with utero-vaginal continuity using a bilateral pudendal thigh fascio-cutaneous flap. Post-operatively, she attained normal menstrual flow and a sensate neovagina with a satisfactory vaginal canal depth. Partial wound dehiscence of the flap donor site was managed with dressing and healing by secondary intention. Even in new centres, the pudendal thigh flap remains a versatile flap for managing vaginal atresia.","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"49 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84346816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Information in YouTube Videos on Penis Enlargement Surgery","authors":"Perçin Karakol, Tuncay Taş","doi":"10.33425/2689-1093.1039","DOIUrl":"https://doi.org/10.33425/2689-1093.1039","url":null,"abstract":"Background: An increasing number of patients and their aesthetic curiosity are causing the online questioning of penis enlargement surgery (PES). Although there is a wealth of healthcare information about PES on the internet, the quality of PES-related information on YouTube, the most visited online video streaming service, has not fully known. It is aimed to evaluate the quality of information about PES in YouTube videos. Materials and Methods: In January 2021, we cross-sectionally performed YouTube search using the keywords \"penis enlargement surgery\", \"penis lengthening surgery\", or \"penis thickening surgery\". We sorted the videos as reliability in terms of containing scientifically proven information by 1 urologist and 1 plastic surgeon. Irrelevant, non-Turkish, and silent videos were not included. Video demographics were analyzed based on the quality and source of the video. A 5-point global quality scale, a 5-point reliability (DISCERN) tool, kappa statistic, the intraclass correlation coefficient, and descriptive statistics in the form of proportions and percentages were used. Results: A total of one-hundred PES videos published on YouTube between 2015-2021 were searched. Thirty-nine of these videos were removed due to duplicate, irrelevant, lack of sound or misleading information. Deceptive videos had a significantly higher number of likes than useful videos. On the other hand, useful videos had significantly more views than misleading videos. Useful videos had a higher DISCERN score compared to misleading videos. The fact that the uploader was sourced by professionals and doctors working at universities significantly contributed to the usefulness of the videos. Conclusion: As searching for information about PES on YouTube, patients are exposed to low-quality and confusing videos. Complexity in the number of views and likes could make accessing the informative PES video difficult. It may be recommended that patients prefer PES videos created by professionals.","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"38 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88468050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front & Back Matter","authors":"","doi":"10.1159/000525322","DOIUrl":"https://doi.org/10.1159/000525322","url":null,"abstract":"","PeriodicalId":12222,"journal":{"name":"European Surgical Research","volume":"4750 3 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"65301517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}