FEBS Open Bio最新文献_第4页

Report on the 2nd MObility for Vesicle research in Europe (MOVE) symposium-2024. 第二届欧洲囊泡研究移动性（MOVE）研讨会报告-2024。

IF 2.3 4区生物学

FEBS Open Bio Pub Date : 2025-08-29 DOI: 10.1002/2211-5463.70112

Dorival Mendes Rodrigues-Junior, Michaela Kocholata, Marilena E Lekka, Olga Janouskova, Moran Yadid, Maja Kosanovic

{"title":"Report on the 2nd MObility for Vesicle research in Europe (MOVE) symposium-2024.","authors":"Dorival Mendes Rodrigues-Junior, Michaela Kocholata, Marilena E Lekka, Olga Janouskova, Moran Yadid, Maja Kosanovic","doi":"10.1002/2211-5463.70112","DOIUrl":"https://doi.org/10.1002/2211-5463.70112","url":null,"abstract":"The 2nd MObility for Vesicle research in Europe (MOVE) Symposium, held in Belgrade-Serbia, from October 8 to 11, 2024, showcased the dynamic and interdisciplinary nature of extracellular vesicles (EVs) research in Europe. Organized by eight National EV Societies under the MOVE initiative, the event gathered over 280 attendees from 28 countries, promoting collaboration and scientific exchange. The symposium featured eight keynote lectures, 48 oral and 126 poster presentations, and sessions dedicated to EV-related tools and industry innovations. The scientific program was structured around seven core themes: EV biogenesis and signal transmission, roles of EVs in health and disease, EV-based biomarkers, interspecies communication, novel EV preparation and analysis techniques, therapeutic and regenerative applications, and the manufacturing of native and engineered EV products. Supported by 18 sponsors and the Ministry of science, technological development and innovation of the Republic of Serbia, the symposium also highlighted the MOVE Fellowship Program and offered rich networking opportunities. This landmark event reinforced MOVE's promising mission to promote excellence, mobility, and resource sharing in EV research across Europe.","PeriodicalId":12187,"journal":{"name":"FEBS Open Bio","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural and functional characterization of chitinase from carnivorous plant Drosera adelae. 几丁质酶的结构与功能研究。

IF 2.3 4区生物学

FEBS Open Bio Pub Date : 2025-08-28 DOI: 10.1002/2211-5463.70110

Kazunari Yoneda, Yuki Naruse, Yusaku Suizu, Tomohiro Araki, Yoshikazu Hoshi, Haruhiko Sakuraba, Junji Hayashi, Toshihisa Ohshima

{"title":"Structural and functional characterization of chitinase from carnivorous plant Drosera adelae.","authors":"Kazunari Yoneda, Yuki Naruse, Yusaku Suizu, Tomohiro Araki, Yoshikazu Hoshi, Haruhiko Sakuraba, Junji Hayashi, Toshihisa Ohshima","doi":"10.1002/2211-5463.70110","DOIUrl":"https://doi.org/10.1002/2211-5463.70110","url":null,"abstract":"A class I chitinase from the carnivorous sundew plant Drosera adelae was successfully expressed in the methylotrophic yeast Pichia pastoris and efficiently purified using a chitin affinity column. Enzymatic activity assays revealed that the enzyme showed a specific activity of 235.3 ± 10.2 U·mg-1. Crystallization of wild-type and E167Q catalytic mutant chitinases yielded needle-like microcrystals. X-ray diffraction experiments were performed, and high-resolution datasets were obtained at 1.73 Å and 1.57 Å, respectively. Structural analysis of diffraction data revealed that only the catalytic domain could be resolved in both crystal forms. Using AutoDock Vina, we performed docking simulations of two (GlcNAc)4 molecules at eight subsites (+4 to -4) of the catalytic domain of D. adelae chitinase to investigate their binding energies and conformations. Further, the structure of the chitin-binding domain (hevein domain), which could not be resolved by X-ray crystallography, was predicted using alphafold2. Based on this model, the binding conformation and binding energy of (GlcNAc)3 were analyzed using similar methods. In D. adelae chitinase, a characteristic tyrosine cluster consisting of Tyr174, Tyr199, and Tyr201 formed a unique structural feature that enabled recognition of the (GlcNAc)4 substrate. The hevein domain structures further indicated that the tyrosine cluster (Tyr41, Tyr43, Tyr50) in D. adelae chitinase may be involved in hydrogen bonding and CH/π interactions with (GlcNAc)3.","PeriodicalId":12187,"journal":{"name":"FEBS Open Bio","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach. 急性阑尾炎中阑尾生态位的微生物特征：一种新的采样方法。

IF 2.3 4区生物学

FEBS Open Bio Pub Date : 2025-08-22 DOI: 10.1002/2211-5463.70105

Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang

{"title":"Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach.","authors":"Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang","doi":"10.1002/2211-5463.70105","DOIUrl":"https://doi.org/10.1002/2211-5463.70105","url":null,"abstract":"Relatively little is known about the microbial variations within the human appendix niche. To overcome this knowledge gap, we employed endoscopic retrograde appendicitis treatment (ERAT) technology to collect microbial samples from the appendix lumen, followed by shotgun metagenomic sequencing on participants with acute appendicitis without antibiotic treatment. Compared to the cecum and terminal ileum, the appendix had a higher abundance at the genus level of Sphingobium, Leptotrichia and Oribacterium, as well as a significant increase in species-level abundance of oral bacteria, including Streptococcus sanguinis, Streptococcus australis, Streptococcus sp. A12, Leptotrichia sp. oral taxon 215, Veillonella dispar, Veillonella infantium and Oribacterium sinus. Pearson correlation analysis showed that bacterial species abundant in the appendix, such as Acinetobacter johnsonii, Sphingobium yanoikuyae and Agrobacterium tumefaciens, had negative correlations with the top five most abundant Gene Ontology (GO) categories (molecular function, biological process and cellular component). Conversely, species underrepresented in the appendix, including Mogibacterium diversum, Streptococcus sanguinis, Megasphaera micronuciformis and Actinomyces graevenitzii, had significant positive correlations with these GO categories. Our results show that ERAT technology can be used to improve sampling and microbiome profiling in the appendix. Furthermore, this in-depth microbial characterization could inform clinicians during antibiotic prescription. However, further large sample size studies are required to validate these results.","PeriodicalId":12187,"journal":{"name":"FEBS Open Bio","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptional regulation of neuropeptide receptors underlies context-dependent adaptation in Drosophila melanogaster. 神经肽受体的转录调控是黑腹果蝇环境依赖适应的基础。

IF 2.3 4区生物学

FEBS Open Bio Pub Date : 2025-08-21 DOI: 10.1002/2211-5463.70107

SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim

{"title":"Transcriptional regulation of neuropeptide receptors underlies context-dependent adaptation in Drosophila melanogaster.","authors":"SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim","doi":"10.1002/2211-5463.70107","DOIUrl":"https://doi.org/10.1002/2211-5463.70107","url":null,"abstract":"Neuropeptides (NPs) and their receptors (NPRs) play critical roles in modulating physiological processes and behaviors across species. While the transcriptional regulation of NP genes has been extensively studied, how NPRs contribute to context-dependent behavioral plasticity remains poorly understood. Here, we investigate the genomic features and expression patterns of NPRs in Drosophila melanogaster, leveraging comparative genomics, single-cell RNA sequencing (scRNA-seq), transcription factor (TF) network analysis, and empirical validation to uncover the regulatory mechanisms that involve NPRs and play roles in context-dependent adaptation. We demonstrate that NPR genes exhibit more complex cis-regulatory landscapes, with greater numbers of enhancers compared to NP genes. Also, NPRs are regulated via a broader network of TFs, particularly in response to environmental and physiological cues such as temperature shifts. Through analysis of scRNA-seq data and qRT-PCR, we show that the expression level of NPRs is dynamically modulated in a context-dependent manner, while NP levels remain relatively stable. This \"NPR-biased\" gene regulation is evident across diverse combinations of NP-NPR pairs, with a distinct pattern of TF control in the head and body of D. melanogaster. Furthermore, the expression level of NPR genes increases during aging of the fly, suggesting a key role in aging and developmental processes. Our findings highlight the importance of NPR transcriptional control in shaping neuropeptidergic signaling and adaptive behaviors.","PeriodicalId":12187,"journal":{"name":"FEBS Open Bio","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context-dependent tumour suppression and oncogenicity. 杜氏肌营养不良基因参与癌症的统一模型：环境依赖性肿瘤抑制和致癌性。

IF 2.3 4区生物学

FEBS Open Bio Pub Date : 2025-08-20 DOI: 10.1002/2211-5463.70109

Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony

{"title":"A unified model for Duchenne muscular dystrophy gene involvement in cancer: context-dependent tumour suppression and oncogenicity.","authors":"Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony","doi":"10.1002/2211-5463.70109","DOIUrl":"https://doi.org/10.1002/2211-5463.70109","url":null,"abstract":"Evidence implicates the Duchenne muscular dystrophy gene (DMD) in tumorigenesis, but survival trends are inconsistent. To resolve this, we conducted a comprehensive global analysis of DMD expression and survival outcomes across 33 tumour types using bulk RNA sequencing data from The Cancer Genome Atlas. We examined the impact of total DMD, individual transcript and dystrophin-associated protein complex (DAPC) gene expression levels on overall survival using Kaplan-Meier analysis, Cox proportional hazard modelling and pathway analysis. DMD expression was significantly associated with survival in nine cancers after Bonferroni correction (α = 0.0015), with high expression linked to either improved or worsened outcomes depending on cancer type. The most abundant DMD transcript, Dp71ab, mirrored total DMD trends, distinguishing two tumour groups with opposing survival associations. Hierarchical clustering suggests these divergent effects may be linked to a subset of signalling and adhesion-related DAPC components. Our findings indicate that DMD does not act uniformly as an oncogene or tumour suppressor. Instead, we propose a context-dependent dual model whereby high DMD expression is tumour suppressive in aggressive cancers and oncogenic in less aggressive tumours.","PeriodicalId":12187,"journal":{"name":"FEBS Open Bio","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An optimized protocol to detect high-throughput DNA methylation from custom targeted sequences on 96 samples simultaneously. 一个优化的方案，以检测高通量DNA甲基化自定义的目标序列，同时在96个样品。

IF 2.3 4区生物学

FEBS Open Bio Pub Date : 2025-08-13 DOI: 10.1002/2211-5463.70093

Nathalie Iannuccelli, Sophie Valière, Julien Sarry, Cécile Donnadieu, Julie Demars

{"title":"An optimized protocol to detect high-throughput DNA methylation from custom targeted sequences on 96 samples simultaneously.","authors":"Nathalie Iannuccelli, Sophie Valière, Julien Sarry, Cécile Donnadieu, Julie Demars","doi":"10.1002/2211-5463.70093","DOIUrl":"https://doi.org/10.1002/2211-5463.70093","url":null,"abstract":"Genome methylation represents an important source of regulation of gene expression. To date, custom molecular tools for studying targeted regions of the genome are restricted to several megabases. We developed a protocol to epigenotype differentially methylated CpGs in specific regions of the genome. The protocol describes a targeted methylation library preparation upstream short read sequencing with an Illumina instrument. The protocol includes the New England Biolabs Next Enzymatic Methyl-seq Library Preparation workflow combined with the Twist Bioscience Targeted Methylation Sequencing workflow. The protocol is divided into eight steps: fragmentation, library preparation, enzymatic conversion, indexing, pooling, hybridization, capture, and amplification. Main advantages are (a) a lower amount of DNA (100 and 50 ng) than other technologies, (b) the limitation of DNA degradation using enzymatic conversion instead of chemical bisulfite, (c) the pooling of samples into 8-plex reducing handling time, and (d) the significant reduction of the panel quantity divided by 20 for saving experimental costs. This protocol was carried out on 96 samples simultaneously in a standard molecular biology laboratory, and the multiplexing can be run up to 384 samples for methylation experiments. We developed a high-throughput epigenotyping method as an alternative of methylation arrays. This approach can be adapted to any interesting regions using a custom panel for agronomic species and model organisms.","PeriodicalId":12187,"journal":{"name":"FEBS Open Bio","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144845062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Most autophagic cell death studies lack evidence of causality. 大多数自噬细胞死亡研究缺乏因果关系的证据。

IF 2.3 4区生物学

FEBS Open Bio Pub Date : 2025-08-11 DOI: 10.1002/2211-5463.70101

Ali Burak Özkaya, Yasmin Ghaseminejad

{"title":"Most autophagic cell death studies lack evidence of causality.","authors":"Ali Burak Özkaya, Yasmin Ghaseminejad","doi":"10.1002/2211-5463.70101","DOIUrl":"https://doi.org/10.1002/2211-5463.70101","url":null,"abstract":"Autophagy plays a critical role in maintaining cellular homeostasis and is implicated in various physiological and pathological processes, including cancer, neurodegeneration, and metabolic disorders. Although typically associated with cell survival, autophagy has also been proposed to contribute to cell death, referred to as autophagic cell death (ACD). However, the identification of ACD remains contentious due to inconsistencies in experimental methodologies and terminological misuse. In this study, we systematically evaluated 104 research articles published in 2022 that claimed to demonstrate ACD. Articles were assessed based on established criteria, including evidence for autophagy, evidence for cell death, exclusion of apoptosis, and experimental designs demonstrating causality. Our findings reveal that only 12.5% of the articles fulfilled all ACD criteria, while 37.5% provided only correlation-level evidence. Additionally, 54.81% failed to demonstrate autophagy flux, 32.7% relied on viability loss rather than direct evidence of cell death, and 45.0% of studies utilizing autophagy inhibition failed to demonstrate actual inhibition of autophagy. Inconsistent terminology was also prevalent, with \"autophagy-mediated cell death\" often misclassified as ACD and ACD frequently misused to describe autophagy co-occurring with cell death. These issues highlight a lack of rigor in current practices, with correlation-level evidence, inappropriate experimental designs, and terminological misuse undermining study robustness. To address these challenges, we developed a systematic workflow providing experimental and analytical guidance for classifying evidence for different modes of autophagy. Our analysis underscores the need for greater rigor, standardized approaches, and precise terminology to advance understanding of the interplay between autophagy and cell death.","PeriodicalId":12187,"journal":{"name":"FEBS Open Bio","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Teaching Python with team-based learning: using cloud-based notebooks for interactive coding education. 基于团队学习的Python教学：使用基于云的笔记本进行交互式编码教育。

IF 2.3 4区生物学

FEBS Open Bio Pub Date : 2025-08-11 DOI: 10.1002/2211-5463.70097

Nuno S Osório, Leonardo D Garma

{"title":"Teaching Python with team-based learning: using cloud-based notebooks for interactive coding education.","authors":"Nuno S Osório, Leonardo D Garma","doi":"10.1002/2211-5463.70097","DOIUrl":"https://doi.org/10.1002/2211-5463.70097","url":null,"abstract":"Computer programming and bioinformatics are increasingly essential topics in life sciences research, facilitating the analysis of large and complex 'omics' datasets. However, they remain challenging for students without a background in mathematics or computing. To address challenges in teaching programming within biomedical education, this study integrates team-based learning (TBL) with cloud-hosted interactive Python notebooks, targeting enhanced student engagement, understanding, and collaboration in bioinformatics in two Masters level classes with 28 biomedical students in total. Four interactive notebooks covering Python basics and practical bioinformatics applications-ranging from data manipulation to multi-omics analysis-were developed. Hosted on github and integrated with Google Colaboratory, these notebooks ensured equal access and eliminated technical barriers for students with varied computing setups. During the TBL session, students were highly engaged with the notebooks, which led to a greater interest in Python and increased confidence in using bioinformatics tools. Feedback highlighted the value of TBL and interactive notebooks in enriching the learning experience, while also identifying a need for further development in bioinformatics research skills. Although more validity evidence is needed in future studies, this blended, cloud-based TBL approach effectively made bioinformatics education more accessible and engaging, suggesting its potential for enhancing computational training across life sciences.","PeriodicalId":12187,"journal":{"name":"FEBS Open Bio","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis. 他汀类药物通过KLF4/DPYSL2A轴诱导急性髓系白血病细胞单核细胞分化。

IF 2.3 4区生物学

FEBS Open Bio Pub Date : 2025-08-08 DOI: 10.1002/2211-5463.70104

Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo

{"title":"Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis.","authors":"Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo","doi":"10.1002/2211-5463.70104","DOIUrl":"https://doi.org/10.1002/2211-5463.70104","url":null,"abstract":"Acute myeloid leukemia (AML) is a bone marrow malignancy characterized by arrested early-stage hematopoietic precursor development. Differentiation therapy, which induces terminal differentiation of immature leukemic cells, is less toxic than standard intensive chemotherapy and a promising treatment strategy for AML. Despite the success of all-trans retinoic acid and arsenic trioxide in treating acute promyelocytic leukemia (APL), effective differentiation therapy for non-APL AML has not been established. We previously demonstrated that dihydropyrimidinase-like 2A (DPYSL2A) is crucial for the monocytic differentiation of AML cells. In this study, analysis using the Comparative Toxicogenomics Database identified statins, which are well-known cholesterol-lowering drugs, as potential compounds that upregulate DPYSL2A expression in a Krüppel-like factor 4 (KLF4)-dependent manner. Most of the tested statins promoted the monocytic differentiation of non-APL AML cells, leading to rapid apoptosis. The statin-induced effects were reversed by mevalonate (MVA) supplementation, indicating dependence on MVA pathway inhibition. Furthermore, the inhibition of protein farnesylation, a downstream process of the MVA pathway, mimicked the statin-induced effects, suggesting that farnesylation suppression is essential for statin-induced KLF4/DPYSL2A expression and monocytic differentiation. These findings may help develop more effective differentiation therapies for patients with non-APL AML.","PeriodicalId":12187,"journal":{"name":"FEBS Open Bio","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Menthol-like cooling compounds, including (R)-(-)-carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K. 薄荷醇类冷却化合物，包括(R)-(-)-香芹酮，抑制人类对糖精和乙酰氨基磺酸K的苦味受体。

IF 2.3 4区生物学

FEBS Open Bio Pub Date : 2025-08-06 DOI: 10.1002/2211-5463.70098

Miyuu Saito, Takumi Misaka

引用次数: 0