Experimental Biology and Medicine最新文献

{"title":"Antibody-mediated immune responses and cardiovascular disease: a Mendelian randomization study.","authors":"Yi Li, Jiuqi Fan, Lirong Wu","doi":"10.3389/ebm.2026.10945","DOIUrl":"10.3389/ebm.2026.10945","url":null,"abstract":"<p><p>Cardiovascular diseases represent the leading cause of global mortality and disability, posing a severe threat to human health. Accumulating evidence suggests that antigen-antibody-mediated immune responses may be involved in the pathogenesis of various cardiovascular conditions; however, whether these associations reflect causal relationships has long remained unclear. To address this question, we conducted a bidirectional two-sample Mendelian randomization study leveraging summary-level data from genome-wide association studies. In this analysis, 46 antibody-mediated immune traits were evaluated as exposures, and 11 cardiovascular outcomes, including aortic aneurysm, aortic valve stenosis, atrial fibrillation, coronary artery disease, dilated cardiomyopathy, atrioventricular block, heart failure with reduced ejection fraction, hypertrophic cardiomyopathy, infective endocarditis, myocarditis, and pericarditis, were examined as outcomes. Our results revealed several significant causal associations: genetically predicted higher levels of Epstein-Barr virus EBNA-1 antibodies were associated with increased risks of myocarditis and aortic valve stenosis, while elevated VCA p18 antibody levels were linked to a higher risk of myocarditis. Furthermore, increased antibody levels against BK polyomavirus VP1 were causally associated with greater risks of aortic valve stenosis and dilated cardiomyopathy. In contrast, higher levels of antibodies against varicella-zoster virus glycoproteins and human herpesvirus 6 IE1B were associated with reduced risks of myocarditis and aortic aneurysm, respectively. These findings not only help clarify the causal role of immune-mediated mechanisms in cardiovascular pathogenesis but also provide a theoretical foundation for the future development of immune-targeted strategies for prevention and treatment.</p>","PeriodicalId":12163,"journal":{"name":"Experimental Biology and Medicine","volume":"251 ","pages":"10945"},"PeriodicalIF":3.8,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13201210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148041523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationship between oral diseases and hypertension: a Mendelian randomization study.","authors":"Bofan Qian, Zhiwen Fang","doi":"10.3389/ebm.2026.10922","DOIUrl":"10.3389/ebm.2026.10922","url":null,"abstract":"<p><p>Current evidence supports the potential association between several common oral diseases and hypertension. The aim of the research is to clarify the causal relationship between these oral diseases and hypertension using Mendelian randomization (MR) analysis. Single nucleotide polymorphisms (SNPs) related to five oral traits (periodontitis, bleeding gums, loose teeth, periapical abscess and dental caries) were obtained from GWAS catalog, while those associated with hypertension (essential and secondary) were extracted from the FinnGen database. The SNPs were employed as instrumental variables (IVs) in the MR analysis. Assorted methods were applied, and inverse variance-weighted (IVW) analytical method was prioritized. Sensitivity analyses including MR-PRESSO method, MR Egger intercept test, Cochran's Q test, leave-one-out analysis and MR Steiger test were conducted. Our analysis identified the potential causal relationship between dental caries and essential hypertension. The forward MR analysis demonstrated a significant causal effect of dental caries on essential hypertension (OR = 1.036, 95%CI: 1.012-1.059, <i>P</i> = 0.003). The reverse analysis also indicated a significant causal effect (OR = 1.160, 95%CI: 1.016-1.323, <i>P</i> = 0.028). Additionally, we observed a causal effect of bleeding gums on essential hypertension (OR = 1.145, 95%CI: 1.019-1.288, <i>P</i> = 0.023). These findings support the potential causality between specific oral diseases and essential hypertension.</p>","PeriodicalId":12163,"journal":{"name":"Experimental Biology and Medicine","volume":"251 ","pages":"10922"},"PeriodicalIF":3.8,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13189983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148014247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferroptosis and futile recanalization after mechanical thrombectomy in acute ischemic stroke: mechanisms, risk factors, predictive models and therapeutic interventions.","authors":"Yuexin Wu, Cuiying Zhang, Yangyang Peng, Longlong Liu","doi":"10.3389/ebm.2026.10997","DOIUrl":"10.3389/ebm.2026.10997","url":null,"abstract":"<p><p>Acute ischemic stroke (AIS) remains a leading cause of mortality and long-term disability worldwide. Endovascular mechanical thrombectomy (EVT) has revolutionized stroke treatment by enabling rapid recanalization of occluded cerebral vessels. However, a significant proportion of patients experience futile recanalization, where successful vessel reopening fails to translate into favorable functional outcomes. Emerging evidence highlights ferroptosis, a regulated form of cell death driven by iron-dependent lipid peroxidation, as a critical mechanism contributing to neuronal damage in ischemic stroke, particularly during reperfusion injury. This comprehensive review examines the intricate relationship between ferroptosis and futile recanalization following mechanical thrombectomy. We systematically explore the molecular mechanisms underlying ferroptosis in the context of cerebral ischemia-reperfusion injury, including iron metabolism dysregulation, lipid peroxidation cascades, glutathione depletion, and mitochondrial dysfunction. Multiple factors contribute to futile recanalization, including patient demographics (age, comorbidities), stroke characteristics (severity, infarct volume, collateral status), procedural variables (time to treatment, recanalization quality), and post-procedural complications (hemorrhagic transformation, reperfusion injury). We review current predictive models, including nomograms and machine learning algorithms, that integrate clinical, radiological, and biomarker data to stratify patient risk. Importantly, we discuss potential therapeutic interventions targeting ferroptosis pathways, such as iron chelators, lipophilic antioxidants, and ferroptosis-specific inhibitors. The integration of ferroptosis biomarkers into predictive models may enhance risk stratification and guide personalized treatment strategies. Future research should focus on validating ferroptosis-targeted therapies in clinical trials, developing real-time monitoring techniques, and establishing standardized protocols for neuroprotective interventions during mechanical thrombectomy. A deeper understanding of ferroptosis mechanisms and their contribution to futile recanalization may pave the way for novel therapeutic approaches to improve stroke outcomes.</p>","PeriodicalId":12163,"journal":{"name":"Experimental Biology and Medicine","volume":"251 ","pages":"10997"},"PeriodicalIF":3.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13175941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147962681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sacubitril valsartan combined with bisoprolol reduces doxorubicin-induced cardiotoxicity in rats by attenuating oxidative stress.","authors":"Ping Liu, Hui Yang, Runqi Li, Hui Huang, Min Xu","doi":"10.3389/ebm.2026.10946","DOIUrl":"10.3389/ebm.2026.10946","url":null,"abstract":"<p><p>Doxorubicin-induced cardiotoxicity remains a leading cause of mortality among cancer patients, with oxidative stress serving as a central pathogenic mechanism. This study investigated whether combination therapy with sacubitril valsartan and bisoprolol attenuates doxorubicin-induced cardiotoxicity through modulation of oxidative stress pathways. Sixty male Sprague-Dawley rats were randomized into five groups: control, doxorubicin (DOX), bisoprolol (1.0 mg/kg/d), sacubitril valsartan (30 mg/kg/d), and combination therapy. All groups except control received intraperitoneal DOX (2.5 mg/kg weekly for 5 weeks). Cardiac function was assessed by echocardiography, myocardial injury by histopathology and enzyme levels (CK-MB, cTnI, BNP), and oxidative stress by ROS fluorescence, MDA, and SOD. Protein expression of Nrf2, HO-1, and Keap1 was analyzed by Western blot. DOX administration significantly impaired cardiac function, induced myocardial structural damage, elevated cardiac enzymes and oxidative stress markers, and downregulated Nrf2 pathway proteins compared to controls (all P < 0.05). All treatment groups significantly attenuated these abnormalities versus DOX (all P < 0.05), with combination therapy demonstrating superior cardioprotection evidenced by greatest improvement in LVEF (68.74 ± 6.87% vs. 50.26 ± 6.11%, P < 0.05), lowest cardiac enzyme levels, and most robust restoration of Nrf2 pathway expression. These findings demonstrate that sacubitril valsartan combined with bisoprolol effectively reduces doxorubicin-induced cardiotoxicity in rats by activating Nrf2-mediated antioxidant responses, providing experimental evidence for a potentially synergistic prophylactic strategy.</p>","PeriodicalId":12163,"journal":{"name":"Experimental Biology and Medicine","volume":"251 ","pages":"10946"},"PeriodicalIF":3.8,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13160683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147927871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Training the next-generation of biomedical scientists through artificial intelligence-driven education and research in pharmacology and pharmaceutical sciences.","authors":"Santosh Kumar, Ritu Karwasra, Weinan Zhou, Jayaraman Seetharaman, Bhupesh Singla","doi":"10.3389/ebm.2026.10988","DOIUrl":"10.3389/ebm.2026.10988","url":null,"abstract":"<p><p>Artificial intelligence (AI)-driven graduate education and research in pharmacology and pharmaceutical sciences (AIPPS) aims to address the rapidly-growing role of AI and machine learning (ML) applications in biomedical sciences. This review provides perspectives on why and how the next-generation of biomedical scientists equip themselves with skills necessary to integrate AI and ML tools into their current fields of study, particularly pharmacology and pharmaceutical sciences. The AI-enabled approaches discussed in this article highlight opportunities for improving competitiveness in an evolving scientific landscape, that includes academia, pharmaceutical and biotech industries and regulatory science. Furthermore, this review discusses how graduate education and research can be enhanced through training in AI-driven disease prediction, molecular target identification drug design and discovery, drug repurposing and pharmacometric modelling. The knowledge outlined here may help graduate students and early career researchers navigate the challenges associated with applying AI-based methodologies in fundamental research, product and process development, service delivery, and regulatory policy and ethics. Overall, the insights provided in the review aim to support the development of skilled forward-thinking biomedical and pharmaceutical scientists capable of leveraging AI technologies in modern research environments.</p>","PeriodicalId":12163,"journal":{"name":"Experimental Biology and Medicine","volume":"251 ","pages":"10988"},"PeriodicalIF":3.8,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13143847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated ApoC3 levels in cerebrospinal fluid predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage.","authors":"Bin Tong, Junjie Wang, Jiarui Chen, Qia Zhang, Zhouhan Xu, Kaichuang Yang, Xiaomin Chen","doi":"10.3389/ebm.2026.10827","DOIUrl":"10.3389/ebm.2026.10827","url":null,"abstract":"<p><p>Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating condition associated with approximately 30% mortality and 20% severe disability among survivors. Delayed cerebral ischemia due to cerebral vasospasm and hydrocephalus significantly contribute to poor neurological outcomes. Currently, reliable biomarkers for early prediction of these complications remain lacking. In this study, 63 patients with a mean age of 59.7 ± 11.53 years were enrolled. Functional outcomes were assessed by the modified Rankin Scale (mRS). Cerebrospinal fluid (CSF) samples were obtained through lumbar drainage (LD) or external ventricular drainage (EVD) and analyzed by ELISA. The predictive value of biomarkers was evaluated using receiver operating characteristic (ROC) curve analysis. Elevated Apolipoprotein C-III (ApoC3) levels in CSF of aSAH patients were observed. Furthermore, increased ApoC3 concentrations were significantly associated with poor prognosis and an elevated risk of severe complications. At an optimal cutoff value of 4,463 ng/mL, patients with high ApoC3 levels exhibited significantly worse 3-month functional outcomes and a higher incidence of delayed cerebral ischemia and hydrocephalus. Monitoring ApoC3 levels in CSF may be beneficial for predicting complications such as delayed cerebral ischemia and hydrocephalus in patients with aSAH.</p>","PeriodicalId":12163,"journal":{"name":"Experimental Biology and Medicine","volume":"251 ","pages":"10827"},"PeriodicalIF":3.8,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13132793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CAR T cell engineering approaches to minimise toxicities.","authors":"Elizabeth Hogben, Anna Schurich, Charlotte Graham","doi":"10.3389/ebm.2026.11021","DOIUrl":"10.3389/ebm.2026.11021","url":null,"abstract":"<p><p>For the treatment of many forms of cancer, cell- and gene-based therapies are showing promise in both pre-clinical data and clinical trials. In particular, CAR T cell therapies, of which there are now 7 FDA-approved products, have shown ground-breaking results in haematological cancers such as multiple myeloma and B cell malignancies. Recent research is also attempting to develop effective CAR T cell therapies for solid tumours, with varying success. One of the key challenges faced by CAR T cell therapy is balancing strong cytotoxic activity for an effective treatment with preventing severe and potentially lethal toxicities, such as Cytokine Release Syndrome and Immune Effector Cell-Associated Neurotoxicity Syndrome. This mini review discusses some of the potential solutions that scientists have devised to overcome toxicities and improve existing CAR T cell therapies.</p>","PeriodicalId":12163,"journal":{"name":"Experimental Biology and Medicine","volume":"251 ","pages":"11021"},"PeriodicalIF":3.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphatic pumping technique in mice alters blood parameters and metastatic melanoma in an age-dependent manner.","authors":"Christopher Walsh, Matthew Kirstein, Elise Wagner, Emily Scott, Jerome Walsh, Shashank Reddy, Nathan Hoggard, Arshad Ahmad, Reetobrata Basu, Sam Mathes, Yanrong Qian, John J Kopchick","doi":"10.3389/ebm.2026.10850","DOIUrl":"10.3389/ebm.2026.10850","url":null,"abstract":"<p><p>Therapeutic touch applied to primary tumors can increase metastasis. The goal of this project was to determine whether touch applied to metastatic tumors also increases metastasis. We evaluated touch on a mouse model of experimental metastasis using a manual treatment called Lymphatic Pumping Technique (LPT), which increases lymphatic fluid flow and is contraindicated in patients with cancer. The LPT, or a sham treatment, was administered for 5 minutes while the mice were anesthetized with vaporized isoflurane. Young adult (3 months old) and aged (20-24 months old) mice received daily sham or LPT treatments for 7 days prior to the injection of 200k B16F10-luc2 mouse melanoma cells into the tail vein, then treated every other day for 21 days. In middle-aged (9-11 months old) mice, we waited 8 days after tumor injection to start treatments and assessed the effect of LPT on immunotherapy efficacy. These mice also received either LPT or sham every other day, along with four doses of 200 µg anti-PD-1 or isotype control antibody. LPT did not increase tumor growth or spread in any of the experiments. Surprisingly, LPT was negatively associated with metastasis in young and middle-aged mice, without enhancing or diminishing the efficacy of immunotherapy. In mice without cancer, LPT rapidly elevated red blood cell, white blood cell, and platelet counts in young, but not middle-aged, animals. Taken together, these findings suggest that therapeutic touch near metastatic tumors does not worsen disease and may confer an age-dependent benefit.</p>","PeriodicalId":12163,"journal":{"name":"Experimental Biology and Medicine","volume":"251 ","pages":"10850"},"PeriodicalIF":3.8,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147689057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards a standardized diabetic prolonged wound healing model in hairless SKH1 mice.","authors":"Elle Koivunotko, Julia Monola, Chris S Pridgeon, Jere Linden, Riina Harjumäki, Emrah Yatkin, Mari Madetoja, Marjo Yliperttula","doi":"10.3389/ebm.2026.10857","DOIUrl":"10.3389/ebm.2026.10857","url":null,"abstract":"<p><p>Chronic wounds, particularly those associated with diabetes, pose a significant clinical challenge due to their impaired healing dynamics and lack of reliable and standardized preclinical models. This pilot study aimed to establish a diabetogenic, immunocompetent, hairless mouse model (SKH1 strain) to simulate prolonged wound healing. Diabetes was induced by streptozotocin administration, followed by the creation of full-thickness dorsal skin wounds. Wounds were treated with either saline or nanofibrillated cellulose hydrogel as a model treatment. Wound healing progression and blood glucose were monitored, and histopathological assessments were performed after a 14-day experiment. In addition, for the first time, the Thermidas thermal imaging system was used in an <i>in vivo</i> mouse model to evaluate skin temperature. Results demonstrated that diabetes induction successfully prolonged wound closure by 5 days compared with the previously described acute wound model in the same strain with the identical protocol without streptozotocin (STZ) induction. Histopathological analyses showed increased macrophage activity (16.2% vs. 2.2% in the treatment groups and 10.2% vs. 0.3% in the control groups) and decreased collagen deposition (12.2% vs. 43.2% in the treatment groups and 17.6% vs. 27.4% in the control groups), suggesting prolonged wound healing. These findings support the use of hairless SKH1 mice as a viable model for studying prolonged diabetic wound healing and evaluating future therapeutic candidates.</p>","PeriodicalId":12163,"journal":{"name":"Experimental Biology and Medicine","volume":"251 ","pages":"10857"},"PeriodicalIF":3.8,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13046712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147622075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetics of epilepsy.","authors":"Kynen Piacentini, Athanasios Gaitatzis, Sulev Kõks","doi":"10.3389/ebm.2026.10933","DOIUrl":"10.3389/ebm.2026.10933","url":null,"abstract":"<p><p>Epilepsy is one of the most common neurological diseases in the world, but it is also complex and difficult to study. There is a significant genetic component to epilepsy and more information is being published frequently. It is difficult to group and summarise all of this information in a way that is beneficial for both researchers and clinicians. The aim of this paper is to create a summary of all currently known epilepsy associated genes in order to aid epilepsy research to better understand the aetiology of the disease. This was achieved through gathering genetic data from three databases: Online Mendelian Inheritance in Man (OMIM), Clincal Genome (ClinGen), and PubMed. Genes were filtered based on specific criteria and were summarised into three tables: Epilepsy genes, Epilepsy associated genes and Predicted epilepsy associated genes. A fourth table was produced to showcase all epilepsy genes that were identified in all three databases. A total of 2,536 genes were identified to have some level of association with epilepsy. A total of 238 genes were classified as Epilepsy genes, 1,317 genes were classified as Epilepsy associated genes and 981 genes were classified as Predicted epilepsy genes. Finally, 86 genes were identified to be epilepsy genes that were found in all three genetic databases and represent the highest confidence in association with epilepsy. The significance of this study involves the ability to give researchers an up-to-date list of genes that have an association to epilepsy and a summary of information about said genes.</p>","PeriodicalId":12163,"journal":{"name":"Experimental Biology and Medicine","volume":"251 ","pages":"10933"},"PeriodicalIF":3.8,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13075117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147689046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}