Evolution, Medicine, and Public Health最新文献_第3页

Life history traits and cancer prevalence in birds 鸟类的生活史特征和癌症发病率

IF 3.7 3区医学

Evolution, Medicine, and Public Health Pub Date : 2024-06-27 DOI: 10.1093/emph/eoae011

Stefania E Kapsetaki, Zachary T Compton, Jordyn Dolan, Valerie Κ Harris, Walker Mellon, Shawn M Rupp, Elizabeth G Duke, Tara M Harrison, Selin Aksoy, Mathieu Giraudeau, Orsolya Vincze, Kevin J McGraw, Athena Aktipis, Marc Tollis, Amy Μ Boddy, Carlo C Maley

{"title":"Life history traits and cancer prevalence in birds","authors":"Stefania E Kapsetaki, Zachary T Compton, Jordyn Dolan, Valerie Κ Harris, Walker Mellon, Shawn M Rupp, Elizabeth G Duke, Tara M Harrison, Selin Aksoy, Mathieu Giraudeau, Orsolya Vincze, Kevin J McGraw, Athena Aktipis, Marc Tollis, Amy Μ Boddy, Carlo C Maley","doi":"10.1093/emph/eoae011","DOIUrl":"https://doi.org/10.1093/emph/eoae011","url":null,"abstract":"Background and objectives Cancer is a disease that affects nearly all multicellular life, including the broad and diverse taxa of Aves. While little is known about the factors that contribute to cancer risk across Aves, life history trade-offs may explain some of this variability in cancer prevalence. We predict birds with high investment in reproduction may have a higher likelihood of developing cancer. In this study, we tested whether life history traits are associated with cancer prevalence in 108 species of birds. Methodology We obtained life history data from published databases and cancer data from5,729 necropsies from 108 species of birds across 24 taxonomic orders from 25 different zoological facilities. We performed phylogenetically-controlled regression analyses between adult body mass, lifespan, incubation length, clutch size, sexually dimorphic traits, and both neoplasia and malignancy prevalence. We also compared the neoplasia and malignancy prevalence of female and male birds. Results Providing support for a life history trade-off between somatic maintenance and reproduction, we found a positive relationship between clutch size and cancer prevalence across Aves. There was no significant association with body mass, lifespan, incubation length, or sexual dimorphism and cancer. Conclusions and implications Life history theory presents an important framework for understanding differences in cancer defenses across various species. These results suggest a trade-off between reproduction and somatic maintenance, where Aves with small clutch sizes get less cancer.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"36 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141502101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 3.3 3区医学

Evolution, Medicine, and Public Health Pub Date : 2024-06-19 eCollection Date: 2024-01-01 DOI: 10.1093/emph/eoae010

Megan F Cole, Paige Barnes, Isabelle G Monroe, Joshua Rukundo, Melissa Emery Thompson, Alexandra G Rosati

{"title":"Age-related physiological dysregulation progresses slowly in semi-free-ranging chimpanzees.","authors":"Megan F Cole, Paige Barnes, Isabelle G Monroe, Joshua Rukundo, Melissa Emery Thompson, Alexandra G Rosati","doi":"10.1093/emph/eoae010","DOIUrl":"10.1093/emph/eoae010","url":null,"abstract":"Background and objectives: Lifestyle has widespread effects on human health and aging. Prior results from chimpanzees (Pan troglodytes), one of humans' closest evolutionary relatives, indicate that these lifestyle effects may also be shared with other species, as semi-free-ranging chimpanzees fed a naturalistic diet show healthier values in several specific health biomarkers, compared with their sedentary, captive counterparts. Here, we examined how lifestyle factors associated with different environments affect rates of physiological aging in closely related chimpanzees.Methodology: We compared physiological dysregulation, an index of biological aging, in semi-free-ranging chimpanzees in an African sanctuary versus captive chimpanzees in US laboratories. If the rate of aging is accelerated by high-calorie diet and sedentism, we predicted greater age-related dysregulation in the laboratory populations. Conversely, if costs of a wild lifestyle accelerate aging, then semi-free-ranging chimpanzees at the sanctuary, whose environment better approximates the wild, should show greater age-related dysregulation. We further tested whether dysregulation differed based on sex or body system, as in humans.Results: We found that semi-free-ranging chimpanzees showed lower overall dysregulation, as well as lower age-related change in dysregulation, than laboratory chimpanzees. Males experienced lower dysregulation than females in both contexts, and the two populations exhibited distinct aging patterns based on body system.Conclusions and implications: Our results support the conclusion that naturalistic living conditions result in healthier aging in chimpanzees. These data provide support for the proposal that lifestyle effects on human health and aging are conserved from deeper into our evolutionary history.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"12 1","pages":"129-142"},"PeriodicalIF":3.3,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Uncontrollable Mortality Risk Hypothesis: Theoretical Foundations and Implications for Public Health 无法控制的死亡风险假说：理论基础和对公共卫生的影响

IF 3.7 3区医学

Evolution, Medicine, and Public Health Pub Date : 2024-05-09 DOI: 10.1093/emph/eoae009

Richard D Brown, Gillian V Pepper

引用次数: 0

Senolytics and cell senescence: historical and evolutionary perspectives. 衰老素与细胞衰老：历史与进化的视角。

IF 3.7 3区医学

Evolution, Medicine, and Public Health Pub Date : 2024-05-03 eCollection Date: 2024-01-01 DOI: 10.1093/emph/eoae007

Caleb E Finch

引用次数: 0

A multi-million-year natural experiment: comparative genomics on a massive scale and its implications for human health 数百万年的自然实验：大规模比较基因组学及其对人类健康的影响

IF 3.7 3区医学

Evolution, Medicine, and Public Health Pub Date : 2024-04-02 DOI: 10.1093/emph/eoae006

Iker Rivas-González, Jenny Tung

引用次数: 0

Introduction to the Special Issue, Evolutionary and Biopsychosocial Perspectives on Sickness Communication 特刊《疾病沟通的进化与生物心理社会视角》导言

IF 3.7 3区医学

Evolution, Medicine, and Public Health Pub Date : 2024-03-25 DOI: 10.1093/emph/eoae005

Eric C Shattuck, Chloe C Boyle

引用次数: 0

Could care giving have altered the evolution of human immune strategies? 护理会改变人类免疫策略的进化吗？

IF 3.7 3区医学

Evolution, Medicine, and Public Health Pub Date : 2024-01-25 DOI: 10.1093/emph/eoae004

Bethany L P Gilbert, Sharon E Kessler

{"title":"Could care giving have altered the evolution of human immune strategies?","authors":"Bethany L P Gilbert, Sharon E Kessler","doi":"10.1093/emph/eoae004","DOIUrl":"https://doi.org/10.1093/emph/eoae004","url":null,"abstract":"Absract Life history theory indicates that individuals/species with a slow pace of life invest more in acquired than innate immunity. Factors that decrease pace of life and predict greater investment in acquired immunity include increased nutritional resources, increased pathogen exposure and decreased risk of extrinsic mortality. Common care behaviours given to sick individuals produce exactly these effects: provisioning increases nutritional resources; hygiene assistance increases disease exposure of carers; and protection can reduce the risk of extrinsic mortality to sick individuals. This, study, therefore, investigated under what conditions care giving behaviours might impact immune strategy and pace of life. The study employed an agent-based model approach which simulated populations with varying levels of care giving, disease mortality, disease transmissibility, and extrinsic mortality, enabling measurements of how the immune strategy and age structure of the populations changed over evolutionary time. We used multiple regressions to examine the effects of these variables on immune strategy and the age structure of the population. The findings supported our predictions in that care selected for an acquired immunity. However, pace of life did not slow as expected. Instead, the population shifted to a faster, but also more cost intensive reproductive strategy in which care improved child survival by subsidizing the development of acquired immune responses.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"85 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139584271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolutionary and Empirical Perspectives on ‘Demand’ Breastfeeding: the Baby in the Driver’s Seat or the Back Seat? 从进化和经验角度看 "按需 "母乳喂养：婴儿坐在驾驶座还是后座？

IF 3.7 3区医学

Evolution, Medicine, and Public Health Pub Date : 2024-01-19 DOI: 10.1093/emph/eoae003

David P Tracer

{"title":"Evolutionary and Empirical Perspectives on ‘Demand’ Breastfeeding: the Baby in the Driver’s Seat or the Back Seat?","authors":"David P Tracer","doi":"10.1093/emph/eoae003","DOIUrl":"https://doi.org/10.1093/emph/eoae003","url":null,"abstract":"Background/Objectives The concept of “demand” breastfeeding is central in public health. A key feature of the concept is that the infant is the locus of control in the breastfeeding process; when the breast is demanded by the infant, it is given the opportunity to feed. This study questions this notion of the infant as the locus of control in demand breastfeeding for empirical and theoretical reasons. From an evolutionary perspective, infants are expected to seek maximal investment and, against this backdrop of maximal investment-seeking, parents decide how much investment to put into offspring. Methodology Focal follows were conducted among 113 mother-infant dyads in Papua New Guinea. During these follows, response times and types of responses including breastfeeding to offspring fussing and crying were recorded. Results Infants were breastfed an average of 3.6 times/hour for just over 2 minutes/feed. Fussing and crying were responded to quickly, with most response times under 1 minute. When the mother responded, she breastfed the child approximately 52% of the time. The other 48% of the time, mothers responded to infants with other forms of pacification. Mothers were significantly less likely to respond to infants by breastfeeding if the child had been breastfed within the past 59-76 minutes. Conclusion/Implications As predicted by evolutionary parental investment theory, infants make frequent demands on their parents for investment, but mothers are ultimately the locus of control in the investment process. The mother decides whether and how frequently to breastfeed her offspring against this backdrop of near-continuous investment demands.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"21 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139510457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reconsidering the developmental origins of adult disease paradigm: the ‘metabolic coordination of childbirth’ hypothesis 重新审视成人疾病的发育起源范式："分娩代谢协调 "假说

IF 3.7 3区医学

Evolution, Medicine, and Public Health Pub Date : 2024-01-17 DOI: 10.1093/emph/eoae002

Jonathan C K Wells, Gernot Desoye, David A Leon

{"title":"Reconsidering the developmental origins of adult disease paradigm: the ‘metabolic coordination of childbirth’ hypothesis","authors":"Jonathan C K Wells, Gernot Desoye, David A Leon","doi":"10.1093/emph/eoae002","DOIUrl":"https://doi.org/10.1093/emph/eoae002","url":null,"abstract":"In uncomplicated pregnancies, birthweight is inversely associated with adult non-communicable disease (NCD) risk. One proposed mechanism is maternal malnutrition during pregnancy. Another explanation is that shared genes link birthweight with NCDs. Both hypotheses are supported, but evolutionary perspectives address only the environmental pathway. We propose that genetic and environmental associations of birthweight with NCD risk reflect coordinated regulatory systems between mother and fetus, that evolved to reduce risks of obstructed labour. First, the fetus must tailor its growth to maternal metabolic signals, as it cannot predict the size of the birth canal from its own genome. Second, we predict that maternal alleles that promote placental nutrient supply have been selected to constrain fetal growth and gestation length when fetally expressed. Conversely, maternal alleles that increase birth canal size have been selected to promote fetal growth and gestation when fetally expressed. Evidence supports these hypotheses. These regulatory mechanisms may have undergone powerful selection as hominin neonates evolved larger size and encephalisation, since every mother is at risk of gestating a baby excessive for her pelvis. Our perspective can explain the inverse association of birthweight with NCD risk across most of the birthweight range: any constraint of birthweight, through plastic or genetic mechanisms, may reduce the capacity for homeostasis and increase NCD susceptibility. However, maternal obesity and diabetes can overwhelm this coordination system, challenging vaginal delivery while increasing offspring NCD risk. We argue that selection on viable vaginal delivery played an over-arching role in shaping the association of birthweight with NCD risk.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"52 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139506144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Host-gut microbiota interactions during pregnancy 孕期宿主与肠道微生物群的相互作用

IF 3.7 3区医学

Evolution, Medicine, and Public Health Pub Date : 2024-01-06 DOI: 10.1093/emph/eoae001

Katherine R Amato, Priyanka Pradhan, Elizabeth K Mallott, Wesley Shirola, Amy Lu

{"title":"Host-gut microbiota interactions during pregnancy","authors":"Katherine R Amato, Priyanka Pradhan, Elizabeth K Mallott, Wesley Shirola, Amy Lu","doi":"10.1093/emph/eoae001","DOIUrl":"https://doi.org/10.1093/emph/eoae001","url":null,"abstract":"Mammalian pregnancy is characterized by a well-known suite of physiological changes that support fetal growth and development, thereby positively affecting both maternal and offspring fitness. However, mothers also experience trade-offs between current and future maternal reproductive success, and maternal responses to these trade-offs can result in mother-offspring fitness conflicts. Knowledge of the mechanisms through which these trade-offs operate, as well as the contexts in which they operate, is critical for understanding the evolution of reproduction. Historically, hormonal changes during pregnancy have been thought to play a pivotal role in these conflicts since they directly and indirectly influence maternal metabolism, immunity, fetal growth, and other aspects of offspring development. However, recent research suggests the gut microbiota may also play an important role. Here, we create a foundation for exploring this role by constructing a mechanistic model linking changes in maternal hormones, immunity, and metabolism during pregnancy to changes in the gut microbiota. We posit that marked changes in hormones alter maternal gut microbiome composition and function both directly and indirectly via impacts on the immune system. The gut microbiota then feeds back to influence maternal immunity and metabolism. We posit that these dynamics are likely to be involved in mediating maternal and offspring fitness as well as trade-offs in different aspects of maternal and offspring health and fitness during pregnancy. We also predict that the interactions we describe are likely to vary across populations in response to maternal environments. Moving forward, empirical studies that combine microbial functional data and maternal physiological data with health and fitness outcomes for both mothers and infants will allow us to test the evolutionary and fitness implications of the gestational microbiota, enriching our understanding of the ecology and evolution of reproductive physiology.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"80 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139375627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0