Evolution, Medicine, and Public Health最新文献_第2页

How market integration impacts human disease ecology. 市场一体化如何影响人类疾病生态。

IF 3.3 3区医学

Evolution, Medicine, and Public Health Pub Date : 2024-09-28 eCollection Date: 2024-01-01 DOI: 10.1093/emph/eoae026

Lev Kolinski, Tyler M Barrett, Randall A Kramer, Charles L Nunn

{"title":"How market integration impacts human disease ecology.","authors":"Lev Kolinski, Tyler M Barrett, Randall A Kramer, Charles L Nunn","doi":"10.1093/emph/eoae026","DOIUrl":"https://doi.org/10.1093/emph/eoae026","url":null,"abstract":"Market integration (MI), or the shift from subsistence to market-based livelihoods, profoundly influences health, yet its impacts on infectious diseases remain underexplored. Here, we synthesize the current understanding of MI and infectious disease to stimulate more research, specifically aiming to leverage concepts and tools from disease ecology and related fields to generate testable hypotheses. Embracing a One Health perspective, we examine both human-to-human and zoonotic transmission pathways in their environmental contexts to assess how MI alters infectious disease exposure and susceptibility in beneficial, detrimental and mixed ways. For human-to-human transmission, we consider how markets expand contact networks in ways that facilitate infectious disease transmission while also increasing access to hygiene products and housing materials that likely reduce infections. For zoonotic transmission, MI influences exposures to pathogens through agricultural intensification and other market-driven processes that may increase or decrease human encounters with disease reservoirs or vectors in their shared environments. We also consider how MI-driven changes in noncommunicable diseases affect immunocompetence and susceptibility to infectious disease. Throughout, we identify statistical, survey and laboratory methods from ecology and the social sciences that will advance interdisciplinary research on MI and infectious disease.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"12 1","pages":"229-241"},"PeriodicalIF":3.3,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenome-wide association study of population-differentiating genetic variants around gene ACSL1. 围绕基因 ACSL1 的人群差异遗传变异的全表型关联研究。

IF 3.3 3区医学

Evolution, Medicine, and Public Health Pub Date : 2024-09-20 eCollection Date: 2024-01-01 DOI: 10.1093/emph/eoae024

Shuang Yang, Houjian Cai, Kaixiong Ye

{"title":"Phenome-wide association study of population-differentiating genetic variants around gene ACSL1.","authors":"Shuang Yang, Houjian Cai, Kaixiong Ye","doi":"10.1093/emph/eoae024","DOIUrl":"10.1093/emph/eoae024","url":null,"abstract":"Background and objectives: Demographic dynamics and natural selection during human evolution shaped the present-day patterns of genetic variations, and geographically varying genetic factors contribute to different disease prevalences across human populations. This study aims to evaluate the presence of positive selection on the gene encoding long-chain fatty acyl-CoA synthetase 1 (ACSL1) and the phenotypic impacts of population-differentiating genetic variants around this gene.Methodology: Three types of statistical tests for positive selection, based on site frequency spectrum, extended haplotype homozygosity and population differentiation, were applied to the whole-genome sequencing data from the 1000 Genomes Project. A phenome-wide association study of ACSL1 was performed with published genome-wide association studies (GWAS) and transcriptome-wide association studies, including phenome-wide studies in biobanks.Results: Genetic variants associated with ACSL1 expression in various tissues exhibit geographically varying allele frequencies. Three types of statistical tests consistently supported the presence of positive selection on the coding and regulatory regions of ACSL1 in African, European, South Asian and East Asian populations. A phenome-wide association study of ACSL1 revealed associations with type 2 diabetes, blood glucose, age at menopause, mean platelet volume and mean reticulocyte volume. The top allele associated with lower diabetes risk has the highest frequency in European populations, whereas the top allele associated with later menopause has the highest frequency in African populations.Conclusions and implications: Positive selection on ACSL1 resulted in geographically varying genetic variants, which may contribute to differential phenotypes across human populations, including type 2 diabetes and age at menopause.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"12 1","pages":"178-190"},"PeriodicalIF":3.3,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11462608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142389196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new perspective on tumor progression: Evolution via selection for function. 肿瘤进展的新视角：通过功能选择进行进化。

IF 3.3 3区医学

Evolution, Medicine, and Public Health Pub Date : 2024-09-19 eCollection Date: 2024-01-01 DOI: 10.1093/emph/eoae021

Frédéric Thomas, James DeGregori, Andriy Marusyk, Antoine M Dujon, Beata Ujvari, Jean-Pascal Capp, Robert Gatenby, Aurora M Nedelcu

{"title":"A new perspective on tumor progression: Evolution via selection for function.","authors":"Frédéric Thomas, James DeGregori, Andriy Marusyk, Antoine M Dujon, Beata Ujvari, Jean-Pascal Capp, Robert Gatenby, Aurora M Nedelcu","doi":"10.1093/emph/eoae021","DOIUrl":"10.1093/emph/eoae021","url":null,"abstract":"Tumorigenesis is commonly attributed to Darwinian processes involving natural selection among cells and groups of cells. However, progressing tumors are those that also achieve an appropriate group phenotypic composition (GPC). Yet, the selective processes acting on tumor GPCs are distinct from that associated with classical Darwinian evolution (i.e. natural selection based on differential reproductive success) as tumors are not genuine evolutionary individuals and do not exhibit heritable variation in fitness. This complex evolutionary scenario is analogous to the recently proposed concept of 'selection for function' invoked for the evolution of both living and non-living systems. Therefore, we argue that it is inaccurate to assert that Darwinian processes alone account for all the aspects characterizing tumorigenesis and cancer progression; rather, by producing the genetic and phenotypic diversity required for creating novel GPCs, these processes fuel the evolutionary success of tumors that is dependent on selection for function at the tumor level.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"12 1","pages":"172-177"},"PeriodicalIF":3.3,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11448472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142374004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Birth and household exposures are associated with changes to skin bacterial communities during infancy 出生和家庭接触与婴儿期皮肤细菌群落的变化有关

IF 3.7 3区医学

Evolution, Medicine, and Public Health Pub Date : 2024-09-17 DOI: 10.1093/emph/eoae023

Melissa B Manus, Maria Luisa Savo Sardaro, Omolola Dada, Maya Davis, Melissa R Romoff, Stephanie G Torello, Esther Ubadigbo, Rebecca C Wu, Maria Gloria Dominguez-Bello, Melissa K Melby, Emily S Miller, Katherine R Amato

{"title":"Birth and household exposures are associated with changes to skin bacterial communities during infancy","authors":"Melissa B Manus, Maria Luisa Savo Sardaro, Omolola Dada, Maya Davis, Melissa R Romoff, Stephanie G Torello, Esther Ubadigbo, Rebecca C Wu, Maria Gloria Dominguez-Bello, Melissa K Melby, Emily S Miller, Katherine R Amato","doi":"10.1093/emph/eoae023","DOIUrl":"https://doi.org/10.1093/emph/eoae023","url":null,"abstract":"Microbial exposures during infancy shape the development of the microbiome, the collection of microbes living in and on the body, which in turn directs immune system training. Newborns acquire a substantial quantity of microbes during birth and throughout infancy via exposure to microbes in the physical and social environment. Alterations to early life microbial environments may give rise to mismatches, where environmental, cultural, and behavioral changes that outpace the body’s adaptive responses can lead to adverse health outcomes, particularly those related to microbiome development and immune system regulation. This study explored the development of the skin microbiome among infants born in Chicago, USA. We collected skin swab microbiome samples from 22 mother-infant dyads during the first 48 hours of life and again at six weeks postpartum. Mothers provided information about social environments and hygiene behaviors that may impact infants’ microbial exposures. Analysis of 16S rRNA bacterial gene sequencing data revealed correlations between infant skin bacterial abundance shortly after birth and factors such as antibiotic exposure and receiving a bath in the hospital. The composition of the infant microbiome at six weeks of age was associated with interactions with caregivers and infant feeding practices. We also found shifts in maternal skin microbiomes that may reflect increased hygiene practices in the hospital. Our data suggest that factors related to the birth and household environment can impact the development of infant skin microbiomes and point to practices that may produce mismatches for the infant microbiome and immune system.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"42 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142255459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low haemoglobin in arduous seasons is associated with reduced chance of ovulation among women living in the Bolivian altiplano 艰苦季节血红蛋白低与玻利维亚高原妇女排卵机会减少有关

IF 3.7 3区医学

Evolution, Medicine, and Public Health Pub Date : 2024-09-11 DOI: 10.1093/emph/eoae022

Rose Stevens, Alexandra Alvergne, Virginia J Vitzthum

{"title":"Low haemoglobin in arduous seasons is associated with reduced chance of ovulation among women living in the Bolivian altiplano","authors":"Rose Stevens, Alexandra Alvergne, Virginia J Vitzthum","doi":"10.1093/emph/eoae022","DOIUrl":"https://doi.org/10.1093/emph/eoae022","url":null,"abstract":"Background and objectives Female reproductive function flexibly responds to ecological variation in energy availability, but the roles of other ecologically limited resources, such as iron, remain poorly understood. This analysis investigates whether haemoglobin associates with investment in reproductive function in a rural natural fertility population living in the Bolivian altiplano. Methodology We conducted a cross-sectional secondary analysis of prospectively collected biomarker and sociodemographic data, comprising 152 menstrual cycles from 96 non-contracepting women living at 3800m altitude. Multivariable multilevel models were used to investigate (1) whether haemoglobin concentration is associated with ecological variation in subsistence strategy and seasonal conditions, and (2) whether haemoglobin concentration is associated with the occurrence of ovulation and/or the concentration of luteal progesterone, two biomarkers of current investment in reproduction. Results Haemoglobin concentrations were lower in arduous seasons among those women more dependent on traditional agropastoral subsistence strategies (β = -0.42, 95% CI: -0.80 to -0.04, p = 0.032). During more arduous seasons, a 1 standard deviation increase in haemoglobin was associated with an over 3-fold increase in the odds of ovulation after adjusting for body fat, breastfeeding status, and age (adjusted odds ratio = 3.27, 95% CI: 1.10 to 9.27, p = 0.033). Conclusions and implications When conditions are relatively harsh and may be expected to improve, low haemoglobin levels are associated with lower current investment in reproduction and reduced fecundity. These results support the role of iron, independent of energy stores, as a limiting resource in modulating reproductive trade-offs.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"16 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142255460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Guillain-Barré syndrome. 格林-巴利综合征

IF 3.3 3区医学

Evolution, Medicine, and Public Health Pub Date : 2024-08-28 eCollection Date: 2024-01-01 DOI: 10.1093/emph/eoae020

Nicholas Shedd, Peter Woods, Damon Hoad

引用次数: 0

Diagnostic testing and the evolution of detection avoidance by pathogens 诊断检测和病原体逃避检测的演变

IF 3.7 3区医学

Evolution, Medicine, and Public Health Pub Date : 2024-08-27 DOI: 10.1093/emph/eoae018

Jason Wood, Ben Ashby

{"title":"Diagnostic testing and the evolution of detection avoidance by pathogens","authors":"Jason Wood, Ben Ashby","doi":"10.1093/emph/eoae018","DOIUrl":"https://doi.org/10.1093/emph/eoae018","url":null,"abstract":"Diagnostic testing is a key tool in the fight against many infectious diseases. The emergence of pathogen variants that are able to avoid detection by diagnostic testing therefore represents a key challenge for public health. In recent years, variants for multiple pathogens have emerged which escape diagnostic testing, including mutations in Plasmodium falciparum (malaria), Chlamydia trachomatis (chlamydia) and SARS-CoV-2 (COVID-19). However, little is currently known about when and the extent to which diagnostic test escape will evolve. Here we use a mathematical model to explore how the frequency of diagnostic testing, combined with variation in compliance and efficacy of isolating, together drive the evolution of detection avoidance. We derive key thresholds under which a testing regime will (i) select for diagnostic test avoidance, or (ii) drive the pathogen extinct. Crucially, we show that imperfect compliance with diagnostic testing regimes can have marked effects on selection for detection avoidance, and consequently, for disease control. Yet somewhat counterintuitively, we find that an intermediate level of testing can select for the highest level of detection avoidance. Our results, combined with evidence from various pathogens, demonstrate that the evolution of diagnostic testing avoidance should be carefully considered when designing diagnostic testing regimes.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"165 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Elephant and the Spandrel 大象和壁画

IF 3.7 3区医学

Evolution, Medicine, and Public Health Pub Date : 2024-08-26 DOI: 10.1093/emph/eoae019

Zachary T Compton, J Arvid Ågren, Andriy Marusyk, Aurora M Nedelcu

{"title":"The Elephant and the Spandrel","authors":"Zachary T Compton, J Arvid Ågren, Andriy Marusyk, Aurora M Nedelcu","doi":"10.1093/emph/eoae019","DOIUrl":"https://doi.org/10.1093/emph/eoae019","url":null,"abstract":"Comparative oncology has made great strides in identifying patterns of cancer prevalence and risk across the tree of life. Such studies have often centered on elucidating the evolution of cancer suppression mechanisms, especially in large and/or long-lived animals such as elephants, in which cancer risk is assumed to exert a strong selective pressure. There is a worry, however, that we are overinterpreting these conclusions, as the deep evolutionary origins of these mechanisms and their involvement in cancer-unrelated functions suggest that the preeminent functions of the identified mechanisms may be unrelated to cancer. Instead, cancer suppression may be an evolutionary byproduct, or “spandrel”, of selection acting on development and somatic maintenance. Here, we highlight the importance of development and somatic maintenance as the underlying axis of natural selection. We argue that by shifting the focus of study from cancer suppression to development and somatic maintenance as the ultimate cause, we can gain a deeper understanding of the evolutionary pressures that shaped the mechanisms responsible for the observed variation in cancer prevalence across species.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"3 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coping with extreme heat: current exposure and implications for the future 应对极端高温：当前面临的问题及对未来的影响

IF 3.7 3区医学

Evolution, Medicine, and Public Health Pub Date : 2024-08-22 DOI: 10.1093/emph/eoae015

Chrles A Weitz

{"title":"Coping with extreme heat: current exposure and implications for the future","authors":"Chrles A Weitz","doi":"10.1093/emph/eoae015","DOIUrl":"https://doi.org/10.1093/emph/eoae015","url":null,"abstract":"A preview of how effective behavioral, biological, and technological responses might be in the future, when outdoor conditions will be at least 2oC hotter than current levels, is available today from studies of individuals already living in extreme heat These studies indicate that people commonly experience heat conditions that are substantially different from those recorded outdoors at fixed weather stations. In areas where high temperatures are common – particularly those in the hot and humid tropics – several studies report that indoor temperatures in low-income housing can be significantly hotter than those outdoors. A case study indicates that daily indoor heat indexes in almost all the 123 slum dwellings monitored in Kolkata during a summer were above 41oC (106oF) for at least an hour. Economic constraints make it unlikely that technological fixes, such as air conditioners, will remedy conditions like these – now or in the future. People without access to air conditioning will have to rely on behavioral adjustments and/or biological/physiological acclimatization. One important unknown is whether individuals who have lived their entire lives in hot environments without air conditioning possess natural levels of acclimatization greater than those indicated by controlled laboratory studies. Answering questions about the future will require more studies of individual experienced heat conditions, more information on indoor versus outdoor heat conditions, and a greater understanding of the behavioral and biological adjustments made by people living today in extremely hot conditions.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"62 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142225712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commemorating the monkey bars, catalyst of debate at the intersection of human evolutionary biology and public health 纪念猴栏，人类进化生物学与公共卫生交汇处的辩论催化剂

IF 3.7 3区医学

Evolution, Medicine, and Public Health Pub Date : 2024-08-19 DOI: 10.1093/emph/eoae017

Luke D Fannin, Zaneta M Thayer, Nathaniel J Dominy

{"title":"Commemorating the monkey bars, catalyst of debate at the intersection of human evolutionary biology and public health","authors":"Luke D Fannin, Zaneta M Thayer, Nathaniel J Dominy","doi":"10.1093/emph/eoae017","DOIUrl":"https://doi.org/10.1093/emph/eoae017","url":null,"abstract":"Play is an essential part of childhood, and growing attention has focused on the potential health benefits of “risky” or “thrill-seeking” play. Such play behavior is readily observed on any playground, where it can sometimes lead to injuries––most often from fall impacts––that require medical attention. Monkey bars account for ~7% of childhood arm fractures in the United States, an alarming statistic that raises difficult questions over its costs and benefits. Many authors view monkey bars as a public health hazard, but it is plausible that our childhood impulse toward thrill-seeking play is a result of selective pressures throughout our primate evolutionary history. Indeed, emerging evidence suggests that the developmental benefits of thrill-seeking play extend into adulthood, outweighing the occasional costs of injury. Disparate and consequential, these dueling perspectives have fueled debate among health professionals and policymakers, but with little attention to the work of biological anthropologists. Here we call attention to the hominin fossil record and play behaviors of non-human primates, providing a novel perspective that bolsters arguments for the adaptive significance of thrill-seeking play. The moment for such a review is timely, for it commemorates the centennial anniversaries of two playground icons: the jungle gym and monkey bars.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"30 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142225713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0