重新思考癌症进化：从基因突变到肿瘤逆转的复杂信息系统。

IF 3.3 3区医学 Q2 EVOLUTIONARY BIOLOGY

Evolution, Medicine, and Public Health Pub Date : 2024-12-13 eCollection Date: 2025-01-01 DOI:10.1093/emph/eoae032

Mesut Tez

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引用次数: 0

摘要

癌症研究历来关注体细胞突变理论，将癌症视为基因突变的结果。然而，这种观点在解释肿瘤逆转和癌症异质性等现象时存在局限性。本文介绍了另一种方法：将癌症视为由其微环境形成的复杂信息处理系统。通过整合肿瘤逆转的历史数据和对进化动力学的见解，我提出了癌症生物学的重构。这种过程导向的观点强调了细胞可塑性和适应性行为的作用，为治疗发展提供了新的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Rethinking cancer evolution: from genetic mutations to complex information systems in tumor reversion.

Cancer research has historically focused on the somatic mutation theory, viewing cancer as a consequence of genetic mutations. However, this perspective has limitations in explaining phenomena like tumor reversion and cancer heterogeneity. This paper introduces an alternative approach: viewing cancer as a complex information-processing system shaped by its microenvironment. By integrating historical data on tumor reversion and insights into evolutionary dynamics, I propose a reframing of cancer biology. This process-oriented perspective highlights the role of cellular plasticity and adaptive behaviors, offering new pathways for therapeutic development.

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来源期刊

Evolution, Medicine, and Public Health Environmental Science-Health, Toxicology and Mutagenesis

CiteScore

5.40

自引率

2.70%

发文量

审稿时长

8 weeks

期刊介绍： About the Journal Founded by Stephen Stearns in 2013, Evolution, Medicine, and Public Health is an open access journal that publishes original, rigorous applications of evolutionary science to issues in medicine and public health. It aims to connect evolutionary biology with the health sciences to produce insights that may reduce suffering and save lives. Because evolutionary biology is a basic science that reaches across many disciplines, this journal is open to contributions on a broad range of topics.