Expert Review of Respiratory Medicine最新文献_第2页

Association between depression and COPD: results from the NHANES 2013–2018 and a bidirectional Mendelian randomization analysis 抑郁症与慢性阻塞性肺病之间的关系：2013-2018 年 NHANES 和双向孟德尔随机分析的结果

IF 3.9 3区医学

Expert Review of Respiratory Medicine Pub Date : 2023-12-12 DOI: 10.1080/17476348.2023.2282022

Bi Ran, Yutian Zhang, Yanqiu Wu, Fuqiang Wen

引用次数: 0

High risks adverse events associated with usage of aspirin in chronic obstructive pulmonary disease 与慢性阻塞性肺病患者服用阿司匹林相关的高风险不良事件

IF 3.9 3区医学

Expert Review of Respiratory Medicine Pub Date : 2023-12-12 DOI: 10.1080/17476348.2023.2294927

Xiaohua Li, Bin Dai, Qingbing Han, Yanqiu Wu, Bi Ran, Tao Wang, Fuqiang Wen, Jun Chen

引用次数: 0

Effects of cardiorespiratory rehabilitation program on submaximal exercise in patients with long-COVID-19 conditions: a systematic review of randomized controlled trials and recommendations for future studies 心肺康复计划对长 COVID-19 病症患者亚极限运动的影响：随机对照试验的系统回顾及对未来研究的建议

IF 3.9 3区医学

Expert Review of Respiratory Medicine Pub Date : 2023-12-08 DOI: 10.1080/17476348.2023.2293226

Amine Ghram, Imed Latiri, Jabeur Methnani, Amine Souissi, Wafa Benzarti, Emna Toulgui, Helmi Ben Saad

引用次数: 0

Pharmacotherapy and immunotherapy of allergic rhinitis induced by house dust mite, grass, and birch pollen allergens: a meta-analysis of randomized clinical trials. 屋尘螨、草和桦树花粉过敏原诱导的过敏性鼻炎的药物治疗和免疫治疗：一项随机临床试验的荟萃分析。

IF 3.9 3区医学

Expert Review of Respiratory Medicine Pub Date : 2023-07-01 Epub Date: 2023-07-28 DOI: 10.1080/17476348.2023.2241364

Monika Marko, Rafał Pawliczak

{"title":"Pharmacotherapy and immunotherapy of allergic rhinitis induced by house dust mite, grass, and birch pollen allergens: a meta-analysis of randomized clinical trials.","authors":"Monika Marko, Rafał Pawliczak","doi":"10.1080/17476348.2023.2241364","DOIUrl":"10.1080/17476348.2023.2241364","url":null,"abstract":"Background: The aim of this study was to assess the efficacy and safety of oral antihistamines (AHs), intranasal antihistamines (INAH) intranasal glucocorticosteroids (INCS), subcutaneous immunotherapy (SCIT), and sublingual immunotherapy (SLIT) in the management of allergic rhinitis (AR). The authors focused on the division into selected AR's triggers: house dust mites (HDMs), grass pollen, and birch pollen.Methods: For each drug and allergen class, a meta-analysis of the efficacy and adverse events (AEs) was performed. The obtained results were presented as a therapeutic index (TIX-Score).Results: Twenty-seven randomized clinical trials (RCTs) were included. The best total efficacy was observed for: HDMs for INCS and grass pollen for combination of INCS with INAH in a single device and for INAH. Considering the data that was obtained for birch pollen, SLIT showed statistically significant total efficacy. Summation scores for efficacy and AEs showed highest TIX-Score for combination of INCS and INAH in a single device in grass pollen.Conclusions: Treatment methods selected for this review may serve as an effective and safe treatment in reducing perennial and seasonal AR's symptoms. However, due to high heterogeneity probably associated with potential confounders existence in control in some cases, results should be interpreted with caution.","PeriodicalId":12103,"journal":{"name":"Expert Review of Respiratory Medicine","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10490487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic and prognostic value of Ang-2 in ARDS: a systemic review and meta-analysis. Ang-2在ARDS中的诊断和预后价值：一项系统综述和荟萃分析。

IF 3.9 3区医学

Expert Review of Respiratory Medicine Pub Date : 2023-07-01 Epub Date: 2023-07-04 DOI: 10.1080/17476348.2023.2230883

Qianglin Zeng, Gui Huang, Shanna Li, Fuqiang Wen

{"title":"Diagnostic and prognostic value of Ang-2 in ARDS: a systemic review and meta-analysis.","authors":"Qianglin Zeng, Gui Huang, Shanna Li, Fuqiang Wen","doi":"10.1080/17476348.2023.2230883","DOIUrl":"10.1080/17476348.2023.2230883","url":null,"abstract":"Background: To investigate the diagnostic and prognostic value of angiopoietin-2 (Ang-2) for acute respiratory distress syndrome (ARDS).Methods: Seven databases (4 English and 3 Chinese databases) were searched, the quality was evaluated by QUADAS-2 and GRADE profile. The bivariate model was employed to combine area under the curve (AUC), pooled sensitivity (pSEN) and pooled specificity (pSPE), the Fagan's nomogram was employed for evaluating clinical utility. This study was registered in PROSPERO (NO.CRD42022371488).Results: 18 eligible studies comprising 27 datasets (12 diagnostic and 15 prognostic datasets) were included for meta-analysis. For diagnostic analysis, Ang-2 yielded an AUC of 0.82, with a pSEN of 0.78 and a pSPE of 0.74; in clinical utility analysis, a pretest probability of 50% regulated the post probability positive (PPP) of 75% and the post probability negative (PPN) of 23%. In prognostic analysis, Ang-2 yielded an AUC of 0.83, with a pSEN of 0.69, a pSPE of 0.81, and good clinical utility (a pretest probability of 50% regulated the PPP of 79% and the PPN of 28%). Heterogeneity existed in both diagnostic and prognostic analysis.Conclusions: Ang-2 demonstrates promising diagnostic and prognostic capabilities as a noninvasive circulating biomarker for ARDS, especially in the Chinese population. It is advisable to dynamically monitor Ang-2 in critically ill patients both suspected and with confirmed ARDS.","PeriodicalId":12103,"journal":{"name":"Expert Review of Respiratory Medicine","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10471827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

How can we improve our use of allergen immunotherapy as a treatment option for asthma and severe asthma? 我们如何改进过敏原免疫疗法作为哮喘和严重哮喘治疗选择的使用？

IF 3.9 3区医学

Expert Review of Respiratory Medicine Pub Date : 2023-07-01 Epub Date: 2023-08-29 DOI: 10.1080/17476348.2023.2251403

Désirée Larenas-Linnemann, Blanca María Morfin Maciel

{"title":"How can we improve our use of allergen immunotherapy as a treatment option for asthma and severe asthma?","authors":"Désirée Larenas-Linnemann, Blanca María Morfin Maciel","doi":"10.1080/17476348.2023.2251403","DOIUrl":"10.1080/17476348.2023.2251403","url":null,"abstract":"Introduction: In patients suffering from allergic asthma, especially in the pediatric age-group, allergen immunotherapy (AIT) could be of benefit and has the potential of long-term disease modification.Areas covered: We reviewed the evidence for a beneficial effect of AIT in allergic asthma. A correct selection of the possible candidates for AIT is crucial. We define the comprehensive allergic asthma diagnosis: confirming asthma, confirming allergic sensitization and having symptoms on exposure to the relevant allergens.We analyze why the first trials on AIT for asthma were contradictory; we consider the results of systematic reviews and discuss the high degree of heterogeneity often found in meta-analysis. We assess recent, double-blind, placebo-controlled trials in sublingual AIT that provide robust evidence for a reduction in acute asthma exacerbations and a decrease in the use of inhaled corticosteroids. Further, we demonstrate how real-world trials and large pharmacy data-based analyses confirm these findings for SLIT and SCIT. Finally, we explore the option of AIT in severe asthma patients, once well-controlled on biologic therapy.Expert opinion: Clear indications for AIT in asthma guidelines would benefit allergic asthmatics. AIT is a therapeutic option in appropriately selected asthmatics. Three years treatment has the potential for long-term tolerance, with persisting benefits years after discontinuation.","PeriodicalId":12103,"journal":{"name":"Expert Review of Respiratory Medicine","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10296385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interstitial lung abnormality in COPD is associated with higher prevalence of antinuclear antibody. COPD患者肺间质异常与抗核抗体的高患病率有关。

IF 3.9 3区医学

Expert Review of Respiratory Medicine Pub Date : 2023-07-01 Epub Date: 2023-09-12 DOI: 10.1080/17476348.2023.2257135

Yujia Liu, Yanwen Jiang, Yongchang Sun

{"title":"Interstitial lung abnormality in COPD is associated with higher prevalence of antinuclear antibody.","authors":"Yujia Liu, Yanwen Jiang, Yongchang Sun","doi":"10.1080/17476348.2023.2257135","DOIUrl":"10.1080/17476348.2023.2257135","url":null,"abstract":"Object: To investigate whether the prevalence of positive ANA was increased in COPD with interstitial lung abnormality (ILA).Methods: Patients with COPD from 1 September, 2019 to 31 August, 2022 were consecutively enrolled in this cross-sectional study. The characteristics, PFTs, visual assessment of ILA and emphysema on chest CT, and tests for ANA and CRP were recorded for analysis.Results: In the study period, 100 patients with COPD were enrolled, with 90 (90.0%) males, aging 69.4 ± 8.3 years. ILA was present in 42% (n = 42) of the patients, with subpleural non-fibrotic ILA being the most common pattern. In patients with ILA, the prevalence of positive ANA was higher (45.2%) as compared to those without ILA (13.3%); between whom the difference in DLCO was also significant. In patients with positive ANA, the scores of ILA were higher, while FEV1, DLCO, DLCO % predicted, FVC, total lung capacity (TLC), and TLC % predicted were significantly lower, as compared to those with negative ANA.Conclusion: The presence of ILA in patients with COPD was associated with a higher prevalence of positive ANA. Patients with positive ANA tended to have lower FEV1, DLCO and lung volume.","PeriodicalId":12103,"journal":{"name":"Expert Review of Respiratory Medicine","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10653396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Up-to-date guidance towards improving medication adherence in patients with chronic obstructive pulmonary disease. 改善慢性阻塞性肺病患者药物依从性的最新指南。

IF 2.9 3区医学

Expert Review of Respiratory Medicine Pub Date : 2023-07-01 Epub Date: 2023-07-28 DOI: 10.1080/17476348.2023.2239708

Meredith A Case, Michelle N Eakin

{"title":"Up-to-date guidance towards improving medication adherence in patients with chronic obstructive pulmonary disease.","authors":"Meredith A Case, Michelle N Eakin","doi":"10.1080/17476348.2023.2239708","DOIUrl":"10.1080/17476348.2023.2239708","url":null,"abstract":"Introduction: Despite efficacious treatment for chronic obstructive pulmonary disease (COPD), medication adherence remains quite poor, with most estimates based on electronic monitoring devices ranging from 20-30%. This degree of nonadherence represents a significant missed opportunity to realize the benefits of treatment of this disease.Areas covered: In this article, we review research on the prevalence of nonadherence among patients with COPD, the association of nonadherence with health outcomes, barriers to adherence in this patient population, and potential interventions.Expert opinion: Integrating research into practice involves assessing patients' adherence, identifying modifiable barriers to adherence, open discussion of these barriers with patients, and tailored interventions to address them. These interventions may include treatment of previously unrecognized comorbid disease, providing educational or behavioral interventions, optimizing prescribing strategies, use of adherence aids, or addressing cost and other access barriers. Electronic inhaler monitors are promising interventions for both monitoring and improving adherence. However, remaining concerns about integration into patient care, data management, cost, acceptability, and ethical and privacy issues must be overcome prior to their implementation in clinical practice.","PeriodicalId":12103,"journal":{"name":"Expert Review of Respiratory Medicine","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10108356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pneumothorax, pneumomediastinum, and subcutaneous emphysema in hospitalized COVID-19 patients: incidence, clinical characteristics, and outcomes. 新冠肺炎住院患者的胸腔、纵隔气肿和皮下气肿：发病率、临床特征和结果。

IF 3.9 3区医学

Expert Review of Respiratory Medicine Pub Date : 2023-07-01 Epub Date: 2023-09-11 DOI: 10.1080/17476348.2023.2254689

Aleksandra Murawska Baptista, Jorge Sinclair De Frías, Trisha Singh, Ananya Vasudhar, Jacob Guzzino, Waheed Khalili, Aysun Tekin, Vikas Bansal, Rahul Kashyap, William J Joyce, Patricia A Lewis, Devang Sanghavi, Tatjana Gavrancic, Pablo Moreno Franco

{"title":"Pneumothorax, pneumomediastinum, and subcutaneous emphysema in hospitalized COVID-19 patients: incidence, clinical characteristics, and outcomes.","authors":"Aleksandra Murawska Baptista, Jorge Sinclair De Frías, Trisha Singh, Ananya Vasudhar, Jacob Guzzino, Waheed Khalili, Aysun Tekin, Vikas Bansal, Rahul Kashyap, William J Joyce, Patricia A Lewis, Devang Sanghavi, Tatjana Gavrancic, Pablo Moreno Franco","doi":"10.1080/17476348.2023.2254689","DOIUrl":"10.1080/17476348.2023.2254689","url":null,"abstract":"Background: Limited data is available on the incidence and outcomes of pneumothorax (PTX), pneumomediastinum (PNM), and subcutaneous emphysema (SCE) in COVID-19 patients. This study aimed to investigate the characteristics of these complications in hospitalized COVID-19 patients.Research design and methods: A retrospective study was conducted, involving adult COVID-19 patients admitted to Mayo Clinic Florida from 03/2020-06/2022. Patients were divided into two groups based on the presence or absence of PTX/PNM/SCE.Results: 1926 hospitalized patients with COVID-19 were included, of which 518 were admitted to the ICU. The incidence of PTX/PNM/SCE was 6.3%. Patients with these complications were more likely to be male, Asian, and unvaccinated. Conversely, they were less likely to have chronic obstructive pulmonary disease. Patients who developed PTX/PNM/SCE after 72 hours of admission were more likely to receive high-dose corticosteroids and for an extended duration. The affected group had an adjusted odds ratio for in-hospital mortality of 13.32 (95%CI, 8.19-21.59) and ICU admission of 9.14 (95%CI, 5.3-12.78) compared to the unaffected group.Conclusion: Although the occurrence of PTX/PNM/SCE in hospitalized COVID-19 patients was rare, it was associated with worse outcomes. Corticosteroids may contribute to the pathogenesis of these complications; however, further studies are needed to investigate this relationship in more detail.","PeriodicalId":12103,"journal":{"name":"Expert Review of Respiratory Medicine","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10305805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe pediatric asthma endotypes: current limits and future perspectives. 严重儿童哮喘内型：当前限制和未来展望。

IF 3.9 3区医学

Expert Review of Respiratory Medicine Pub Date : 2023-07-01 Epub Date: 2023-09-05 DOI: 10.1080/17476348.2023.2254234

Beatrice Andrenacci, Maria De Filippo, Martina Votto, Maria Sole Prevedoni Gorone, Mara De Amici, Stefania La Grutta, Gian Luigi Marseglia, Amelia Licari

{"title":"Severe pediatric asthma endotypes: current limits and future perspectives.","authors":"Beatrice Andrenacci, Maria De Filippo, Martina Votto, Maria Sole Prevedoni Gorone, Mara De Amici, Stefania La Grutta, Gian Luigi Marseglia, Amelia Licari","doi":"10.1080/17476348.2023.2254234","DOIUrl":"10.1080/17476348.2023.2254234","url":null,"abstract":"Introduction: Although rare, pediatric severe therapy-resistant asthma (STRA) is a highly heterogeneous, resource-demanding disease that differs significantly from severe adult asthma and whose pathogenesis is still poorly understood.Areas covered: This review summarizes the latest 10 years of English-written studies defining pediatric STRA endotypes using lung-specific techniques such as bronchoalveolar lavage and endobronchial biopsy. Results of the studies and limits on the field are discussed, together with some future perspectives.Expert opinion: Over the years, it has become increasingly clear that 'one size does not fit all\" in asthma. However, \"Does an extremely tailored size fit more than one?'. Only using multicentric, longitudinal pediatric studies, will we be able to answer. Three issues could be particularly critical for future research. First, to provide, if existing, a distinction between prepuberal STRA and puberal STRA endotypes to understand the transition from pediatric to adult STRA and to design effective, tailored therapies in adolescents, usually suffering from poorer asthma control. Second, design early treatments for pediatric airway remodeling to preserve lifelong good lung function. Finally, to better characterize inflammation before and during biological therapies, to provide clues on whether to stop or change treatments.","PeriodicalId":12103,"journal":{"name":"Expert Review of Respiratory Medicine","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10651900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0