Interstitial lung abnormality in COPD is associated with higher prevalence of antinuclear antibody.

IF 2.9 3区 医学 Q2 RESPIRATORY SYSTEM
Expert Review of Respiratory Medicine Pub Date : 2023-07-01 Epub Date: 2023-09-12 DOI:10.1080/17476348.2023.2257135
Yujia Liu, Yanwen Jiang, Yongchang Sun
{"title":"Interstitial lung abnormality in COPD is associated with higher prevalence of antinuclear antibody.","authors":"Yujia Liu,&nbsp;Yanwen Jiang,&nbsp;Yongchang Sun","doi":"10.1080/17476348.2023.2257135","DOIUrl":null,"url":null,"abstract":"<p><strong>Object: </strong>To investigate whether the prevalence of positive ANA was increased in COPD with interstitial lung abnormality (ILA).</p><p><strong>Methods: </strong>Patients with COPD from 1 September, 2019 to 31 August, 2022 were consecutively enrolled in this cross-sectional study. The characteristics, PFTs, visual assessment of ILA and emphysema on chest CT, and tests for ANA and CRP were recorded for analysis.</p><p><strong>Results: </strong>In the study period, 100 patients with COPD were enrolled, with 90 (90.0%) males, aging 69.4 ± 8.3 years. ILA was present in 42% (<i>n</i> = 42) of the patients, with subpleural non-fibrotic ILA being the most common pattern. In patients with ILA, the prevalence of positive ANA was higher (45.2%) as compared to those without ILA (13.3%); between whom the difference in D<sub>LCO</sub> was also significant. In patients with positive ANA, the scores of ILA were higher, while FEV<sub>1</sub>, D<sub>LCO</sub>, D<sub>LCO</sub> % predicted, FVC, total lung capacity (TLC), and TLC % predicted were significantly lower, as compared to those with negative ANA.</p><p><strong>Conclusion: </strong>The presence of ILA in patients with COPD was associated with a higher prevalence of positive ANA. Patients with positive ANA tended to have lower FEV<sub>1</sub>, D<sub>LCO</sub> and lung volume.</p>","PeriodicalId":12103,"journal":{"name":"Expert Review of Respiratory Medicine","volume":"17 8","pages":"735-742"},"PeriodicalIF":2.9000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Expert Review of Respiratory Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/17476348.2023.2257135","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/9/12 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0

Abstract

Object: To investigate whether the prevalence of positive ANA was increased in COPD with interstitial lung abnormality (ILA).

Methods: Patients with COPD from 1 September, 2019 to 31 August, 2022 were consecutively enrolled in this cross-sectional study. The characteristics, PFTs, visual assessment of ILA and emphysema on chest CT, and tests for ANA and CRP were recorded for analysis.

Results: In the study period, 100 patients with COPD were enrolled, with 90 (90.0%) males, aging 69.4 ± 8.3 years. ILA was present in 42% (n = 42) of the patients, with subpleural non-fibrotic ILA being the most common pattern. In patients with ILA, the prevalence of positive ANA was higher (45.2%) as compared to those without ILA (13.3%); between whom the difference in DLCO was also significant. In patients with positive ANA, the scores of ILA were higher, while FEV1, DLCO, DLCO % predicted, FVC, total lung capacity (TLC), and TLC % predicted were significantly lower, as compared to those with negative ANA.

Conclusion: The presence of ILA in patients with COPD was associated with a higher prevalence of positive ANA. Patients with positive ANA tended to have lower FEV1, DLCO and lung volume.

COPD患者肺间质异常与抗核抗体的高患病率有关。
目的:探讨ANA阳性在COPD伴间质性肺异常(ILA)患者中的患病率是否增加。方法:将2019年9月1日至2022年8月31日的COPD患者连续纳入本横断面研究。记录特征、PFTs、胸部CT对ILA和肺气肿的视觉评估以及ANA和CRP的测试以进行分析。结果:在研究期间,100名COPD患者入选,其中90名(90.0%)男性,年龄69.4岁 ± 8.3 年。ILA存在于42%(n = 其中胸膜下非纤维化ILA是最常见的模式。在ILA患者中,ANA阳性的患病率(45.2%)高于无ILA患者(13.3%);DLCO差异也有显著性。与ANA阴性患者相比,ANA阳性患者的ILA评分较高,而FEV1、DLCO、DLCO%预测值、FVC、总肺活量(TLC)和TLC%预测值显著较低。结论:COPD患者ILA的存在与ANA阳性率较高有关。ANA阳性患者的FEV1、DLCO和肺容量往往较低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
6.80
自引率
2.60%
发文量
90
期刊介绍: Coverage will include the following key areas: - Prospects for new and emerging therapeutics - Epidemiology of disease - Preventive strategies - All aspects of COPD, from patient self-management to systemic effects of the disease and comorbidities - Improved diagnostic methods, including imaging techniques, biomarkers and physiological tests. - Advances in the treatment of respiratory infections and drug resistance issues - Occupational and environmental factors - Progress in smoking intervention and cessation methods - Disease and treatment issues for defined populations, such as children and the elderly - Respiratory intensive and critical care - Updates on the status and advances of specific disease areas, including asthma, HIV/AIDS-related disease, cystic fibrosis, COPD and sleep-disordered breathing morbidity
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信