Expert Review of Respiratory Medicine最新文献

Non-invasive respiratory support in elderly hospitalized patients. 老年住院病人的无创呼吸支持。

IF 3.9 3区医学

Expert Review of Respiratory Medicine Pub Date : 2024-09-19 DOI: 10.1080/17476348.2024.2404696

Silvia Coppola,Dejan Radovanovic,Tommaso Pozzi,Fiammetta Danzo,Cosmo Rocco,Giada Lazzaroni,Pierachille Santus,Davide Chiumello

{"title":"Non-invasive respiratory support in elderly hospitalized patients.","authors":"Silvia Coppola,Dejan Radovanovic,Tommaso Pozzi,Fiammetta Danzo,Cosmo Rocco,Giada Lazzaroni,Pierachille Santus,Davide Chiumello","doi":"10.1080/17476348.2024.2404696","DOIUrl":"https://doi.org/10.1080/17476348.2024.2404696","url":null,"abstract":"INTRODUCTIONThe proportion of elderly people among hospitalized patients is rapidly growing. Between 7% to 25% of ICU patients are aged 85 and over and noninvasive respiratory support is often offered to avoid the risks of invasive mechanical ventilation or in patients with a 'do-not-intubate' order. However, while noninvasive respiratory support has been extensively studied in the general population, there is limited data available on its efficacy in elderly patients with ARF.AREAS COVEREDPubMed/Medline, Web of Science, Scopus and Embase online databases were searched for studies that assessed clinical efficacy of high flow nasal cannula, continuous positive airway pressure and noninvasive ventilation in patients ≥ 65 years old with acute de novo ARF, showing that short to mid-term benefits provided by noninvasive respiratory support in elderly patients in terms of reduction of mechanical ventilation risk and mortality are similar to younger patients, if adjusted for the severity of comorbidities and respiratory failure.EXPERT OPINIONNoninvasive support strategies can represent an effective opportunity in elderly patients with ARF, especially in patients too frail to undergo endotracheal intubation and in whom received or decided for a 'do not intubate' order. Indeed, noninvasive support has a different impact, depending on the setting.","PeriodicalId":12103,"journal":{"name":"Expert Review of Respiratory Medicine","volume":"19 1","pages":"1-16"},"PeriodicalIF":3.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142252226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overcoming challenges of managing chronic obstructive pulmonary disease in low- and middle-income countries 克服中低收入国家在管理慢性阻塞性肺病方面的挑战

IF 3.9 3区医学

Expert Review of Respiratory Medicine Pub Date : 2024-09-16 DOI: 10.1080/17476348.2024.2398639

Patricia Alupo, Joseph Baluku, Felix Bongomin, Trishul Siddharthan, Winceslaus Katagira, Ahmed Ddungu, John R. Hurst, Job F. M. van Boven, William Worodria, Bruce J. Kirenga

引用次数: 0

Understanding the impact of breathing pattern disorders in difficult-to-treat asthma 了解呼吸模式紊乱对难治性哮喘的影响

IF 3.9 3区医学

Expert Review of Respiratory Medicine Pub Date : 2024-09-16 DOI: 10.1080/17476348.2024.2404673

J. J. Hudson-Colby, Adam Lewis, Judit Varkonyi-Sepp, Ben Ainsworth, Anna Freeman, Anneliese Day, Ratko Djukanovic, Liuyu Wei, Hans Michael Haitchi, Ramesh J. Kurukulaaratchy

引用次数: 0

Omics research in lymphangioleiomyomatosis: status and challenges. 淋巴管瘤病的 Omics 研究：现状与挑战。

IF 3.9 3区医学

Expert Review of Respiratory Medicine Pub Date : 2024-09-11 DOI: 10.1080/17476348.2024.2403498

Xinhe Zhang,Song Liu,Luning Yang,Chongsheng Cheng,Hanghang Wang,Danjing Hu,Xiaoxin Zhang,Miaoyan Zhang,Yaping Liu,Xinlun Tian,Hongbing Zhang,Kai-Feng Xu

{"title":"Omics research in lymphangioleiomyomatosis: status and challenges.","authors":"Xinhe Zhang,Song Liu,Luning Yang,Chongsheng Cheng,Hanghang Wang,Danjing Hu,Xiaoxin Zhang,Miaoyan Zhang,Yaping Liu,Xinlun Tian,Hongbing Zhang,Kai-Feng Xu","doi":"10.1080/17476348.2024.2403498","DOIUrl":"https://doi.org/10.1080/17476348.2024.2403498","url":null,"abstract":"INTRODUCTIONLymphangioleiomyomatosis (LAM) is a rare and progressive disorder that usually arises in the lung and almost exclusively affects women of childbearing age. In recent years, a number of molecules have been shown to be differentially expressed between patients with LAM and healthy control individuals, and some of these molecules, in addition to vascular endothelial growth factor D (VEGF-D), have the potential to be novel biomarkers.AREAS COVEREDThis review summarizes the recent advances in omics research, including genomics, transcriptomics, proteomics, and metabolomics, in LAM biomarker discovery. It also retrieves the literature on LAM biomarkers studied by omics techniques in the last ten years using PubMed and other retrieval tools.EXPERT OPINIONFurther research on expanded sample sizes can be conducted to construct specific models to study the role of these molecules in the pathogenesis of LAM and clarify the underlying mechanisms involved. In the future, in terms of technology, the combination of various omics methods is expected to result in novel biomarker discovery.","PeriodicalId":12103,"journal":{"name":"Expert Review of Respiratory Medicine","volume":"60 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A clinician's guide to effects of obesity on childhood asthma and into adulthood. 肥胖对儿童哮喘和成年期影响的临床医生指南。

IF 3.9 3区医学

Expert Review of Respiratory Medicine Pub Date : 2024-09-11 DOI: 10.1080/17476348.2024.2403500

Mahmoud Abu Zahra,Jeffrey Pessin,Deepa Rastogi

{"title":"A clinician's guide to effects of obesity on childhood asthma and into adulthood.","authors":"Mahmoud Abu Zahra,Jeffrey Pessin,Deepa Rastogi","doi":"10.1080/17476348.2024.2403500","DOIUrl":"https://doi.org/10.1080/17476348.2024.2403500","url":null,"abstract":"INTRODUCTIONObesity, one of the most common chronic conditions affecting the human race globally, affects several organ systems, including the respiratory system, where it contributes to onset and high burden of asthma. Childhood onset of obesity-related asthma is associated with high persistent morbidity into adulthood.AREAS COVEREDIn this review, we discuss the disease burden in children and adults to highlight the overlap between symptoms and pulmonary function deficits associated with obesity-related asthma in both age ranges, and then discuss the potential role of three distinct mechanisms, that of mechanical fat load, immune perturbations, and of metabolic perturbations on the disease burden. We also discuss interventions, including medical interventions for weight loss such as diet modification, that of antibiotics and anti-inflammatory therapies, as well as that of surgical intervention on amelioration of burden of obesity-related asthma.EXPERT OPINIONWith increase in obesity-related asthma due to increasing burden of obesity, it is evident that it is a disease entity distinct from asthma among lean individuals. The time is ripe to investigate the underlying mechanisms, focusing on identifying novel therapeutic targets as well as consideration to repurpose medications effective for other obesity-mediated complications, such as insulin resistance, dyslipidemia and systemic inflammation.","PeriodicalId":12103,"journal":{"name":"Expert Review of Respiratory Medicine","volume":"446 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142225015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thoracic ultrasound in guiding management of respiratory disease 胸腔超声在呼吸系统疾病治疗中的指导作用

IF 3.9 3区医学

Expert Review of Respiratory Medicine Pub Date : 2024-08-03 DOI: 10.1080/17476348.2024.2387785

Maged Hassan, Sally Griffiths, Ben Probyn, Ahmed S Sadaka, Abdelfattah A Touman, Gareth Trevelyan, David Breen, Cyrus Daneshvar

引用次数: 0

Relationship between obstructive sleep apnea and pulmonary hypertension: past, present and future 阻塞性睡眠呼吸暂停与肺动脉高压之间的关系：过去、现在和未来

IF 3.9 3区医学

Expert Review of Respiratory Medicine Pub Date : 2024-04-22 DOI: 10.1080/17476348.2024.2345684

Jyotirmayee Lenka, Raymond Foley, Mark Metersky, Adrian Salmon

引用次数: 0

Why don’t anti-inflammatories work in cystic fibrosis? 为什么消炎药对囊性纤维化无效？

IF 3.9 3区医学

Expert Review of Respiratory Medicine Pub Date : 2024-02-22 DOI: 10.1080/17476348.2024.2323189

Michelle Casey, Nicholas J Simmonds

引用次数: 0

Mild asthma is not mild: Risk factors and predictive biomarkers for severe acute exacerbations and progression in mild asthma 轻度哮喘并不轻：轻度哮喘严重急性加重和恶化的风险因素和预测性生物标志物

IF 3.9 3区医学

Expert Review of Respiratory Medicine Pub Date : 2024-02-05 DOI: 10.1080/17476348.2024.2314535

Lingling Wang, Ling zhou, Pengdou Zheng, Zhenyu Mao, Huiguo Liu

引用次数: 0

Indications and evidence for domiciliary noninvasive ventilation 家用无创通气的适应症和证据

IF 3.9 3区医学

Expert Review of Respiratory Medicine Pub Date : 2023-12-19 DOI: 10.1080/17476348.2023.2295941

Anita Saigal, Amar J Shah, Swapna Mandal

引用次数: 0