肥胖对儿童哮喘和成年期影响的临床医生指南。

IF 2.9 3区 医学 Q2 RESPIRATORY SYSTEM
Mahmoud Abu Zahra,Jeffrey Pessin,Deepa Rastogi
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引用次数: 0

摘要

导言肥胖是影响全球人类最常见的慢性疾病之一,会影响包括呼吸系统在内的多个器官系统,导致哮喘的发病和高负担。在这篇综述中,我们讨论了儿童和成人的疾病负担,强调了这两个年龄段与肥胖相关的哮喘的症状和肺功能缺陷之间的重叠,然后讨论了三种不同机制对疾病负担的潜在作用,即机械性脂肪负荷、免疫扰动和代谢扰动。我们还讨论了干预措施,包括减肥药物干预(如饮食调整)、抗生素和抗炎疗法,以及手术干预对减轻肥胖相关性哮喘负担的作用。研究其潜在机制的时机已经成熟,重点是确定新的治疗靶点,并考虑重新使用对其他肥胖介导的并发症(如胰岛素抵抗、血脂异常和全身炎症)有效的药物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A clinician's guide to effects of obesity on childhood asthma and into adulthood.
INTRODUCTION Obesity, one of the most common chronic conditions affecting the human race globally, affects several organ systems, including the respiratory system, where it contributes to onset and high burden of asthma. Childhood onset of obesity-related asthma is associated with high persistent morbidity into adulthood. AREAS COVERED In this review, we discuss the disease burden in children and adults to highlight the overlap between symptoms and pulmonary function deficits associated with obesity-related asthma in both age ranges, and then discuss the potential role of three distinct mechanisms, that of mechanical fat load, immune perturbations, and of metabolic perturbations on the disease burden. We also discuss interventions, including medical interventions for weight loss such as diet modification, that of antibiotics and anti-inflammatory therapies, as well as that of surgical intervention on amelioration of burden of obesity-related asthma. EXPERT OPINION With increase in obesity-related asthma due to increasing burden of obesity, it is evident that it is a disease entity distinct from asthma among lean individuals. The time is ripe to investigate the underlying mechanisms, focusing on identifying novel therapeutic targets as well as consideration to repurpose medications effective for other obesity-mediated complications, such as insulin resistance, dyslipidemia and systemic inflammation.
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来源期刊
CiteScore
6.80
自引率
2.60%
发文量
90
期刊介绍: Coverage will include the following key areas: - Prospects for new and emerging therapeutics - Epidemiology of disease - Preventive strategies - All aspects of COPD, from patient self-management to systemic effects of the disease and comorbidities - Improved diagnostic methods, including imaging techniques, biomarkers and physiological tests. - Advances in the treatment of respiratory infections and drug resistance issues - Occupational and environmental factors - Progress in smoking intervention and cessation methods - Disease and treatment issues for defined populations, such as children and the elderly - Respiratory intensive and critical care - Updates on the status and advances of specific disease areas, including asthma, HIV/AIDS-related disease, cystic fibrosis, COPD and sleep-disordered breathing morbidity
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