COPD患者肺间质异常与抗核抗体的高患病率有关。

IF 2.9 3区医学 Q2 RESPIRATORY SYSTEM

Expert Review of Respiratory Medicine Pub Date : 2023-07-01 Epub Date: 2023-09-12 DOI:10.1080/17476348.2023.2257135

Yujia Liu, Yanwen Jiang, Yongchang Sun

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引用次数: 0

摘要

目的：探讨ANA阳性在COPD伴间质性肺异常（ILA）患者中的患病率是否增加。方法：将2019年9月1日至2022年8月31日的COPD患者连续纳入本横断面研究。记录特征、PFTs、胸部CT对ILA和肺气肿的视觉评估以及ANA和CRP的测试以进行分析。结果：在研究期间，100名COPD患者入选，其中90名（90.0%）男性，年龄69.4岁 ± 8.3 年。ILA存在于42%（n = 其中胸膜下非纤维化ILA是最常见的模式。在ILA患者中，ANA阳性的患病率（45.2%）高于无ILA患者（13.3%）；DLCO差异也有显著性。与ANA阴性患者相比，ANA阳性患者的ILA评分较高，而FEV1、DLCO、DLCO%预测值、FVC、总肺活量（TLC）和TLC%预测值显著较低。结论：COPD患者ILA的存在与ANA阳性率较高有关。ANA阳性患者的FEV1、DLCO和肺容量往往较低。

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Interstitial lung abnormality in COPD is associated with higher prevalence of antinuclear antibody.

Object: To investigate whether the prevalence of positive ANA was increased in COPD with interstitial lung abnormality (ILA).

Methods: Patients with COPD from 1 September, 2019 to 31 August, 2022 were consecutively enrolled in this cross-sectional study. The characteristics, PFTs, visual assessment of ILA and emphysema on chest CT, and tests for ANA and CRP were recorded for analysis.

Results: In the study period, 100 patients with COPD were enrolled, with 90 (90.0%) males, aging 69.4 ± 8.3 years. ILA was present in 42% (n = 42) of the patients, with subpleural non-fibrotic ILA being the most common pattern. In patients with ILA, the prevalence of positive ANA was higher (45.2%) as compared to those without ILA (13.3%); between whom the difference in D_LCO was also significant. In patients with positive ANA, the scores of ILA were higher, while FEV₁, D_LCO, D_LCO % predicted, FVC, total lung capacity (TLC), and TLC % predicted were significantly lower, as compared to those with negative ANA.

Conclusion: The presence of ILA in patients with COPD was associated with a higher prevalence of positive ANA. Patients with positive ANA tended to have lower FEV₁, D_LCO and lung volume.

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来源期刊

Expert Review of Respiratory Medicine RESPIRATORY SYSTEM-

CiteScore

6.80

自引率

2.60%

发文量

期刊介绍： Coverage will include the following key areas: - Prospects for new and emerging therapeutics - Epidemiology of disease - Preventive strategies - All aspects of COPD, from patient self-management to systemic effects of the disease and comorbidities - Improved diagnostic methods, including imaging techniques, biomarkers and physiological tests. - Advances in the treatment of respiratory infections and drug resistance issues - Occupational and environmental factors - Progress in smoking intervention and cessation methods - Disease and treatment issues for defined populations, such as children and the elderly - Respiratory intensive and critical care - Updates on the status and advances of specific disease areas, including asthma, HIV/AIDS-related disease, cystic fibrosis, COPD and sleep-disordered breathing morbidity