Experimental and clinical psychopharmacology最新文献

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A behavioral economic investigation of the effect of sports wagering on alcohol demand and relations to gambling motives. 体育博彩对酒精需求的影响及其与赌博动机的关系的行为经济学研究。
IF 1.6 3区 医学
Experimental and clinical psychopharmacology Pub Date : 2026-07-20 DOI: 10.1037/pha0000871
Matthew D Andersland, James G Murphy, Meredith K Ginley, James P Whelan
{"title":"A behavioral economic investigation of the effect of sports wagering on alcohol demand and relations to gambling motives.","authors":"Matthew D Andersland, James G Murphy, Meredith K Ginley, James P Whelan","doi":"10.1037/pha0000871","DOIUrl":"10.1037/pha0000871","url":null,"abstract":"<p><p>Sports wagering is associated with alcohol use and alcohol-related harm, and gambling can increase alcohol consumption and drinking urges. However, the effect of sports wagering on alcohol reward value remains unclear. The present study explored the interactive effect of placing a single-event sports wager and social context on alcohol demand (a behavioral economic measure of alcohol reward value) using context-adapted alcohol purchase tasks in a sample of individuals reporting past-month alcohol use and sports wagering (<i>n</i> = 425; <i>M</i><sub>age</sub> = 31.28; 71.29% male). Contrary to hypotheses, there were no differences in alcohol demand between context-adapted alcohol purchase tasks as a function of concurrent sports wagering (<i>p</i><sub>adj</sub> = .876-.924) or social context (<i>p</i><sub>adj</sub> = .170-.667). Exploratory analyses investigated relations between gambling motives and alcohol demand and the relations between various behavioral economic constructs and problem gambling. <i>O</i><sub>max</sub> was associated with an increased likelihood of problem gambling (<i>OR</i> = 1.02, <i>p</i><sub>adj</sub> = .03). <i>O</i><sub>max</sub> and elasticity were associated with financial gambling motives, but less so during concurrent gambling events, with concurrent sports wagering attenuating the relation between elasticity and financial motives (<i>b</i> = 0.34, <i>p</i><sub>adj</sub> = .003). Financial motives for gambling were positively associated with alcohol use broadly, but not with simultaneous drinking while gambling. These findings suggest relations between sports wagering and alcohol demand are complex-highlighting the need for future research into the sports wagering experience, specific sports wagering forms, and alcohol's role in sports culture to better understand the relation between alcohol use and sports wagering. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Individual and spouse alcohol consumption patterns and anxiety: The mediating role of relationship satisfaction. 个人和配偶饮酒模式与焦虑:关系满意度的中介作用。
IF 1.6 3区 医学
Experimental and clinical psychopharmacology Pub Date : 2026-07-06 DOI: 10.1037/pha0000866
Simon D'Aquino, Koen Smit, Benjamin Riordan, Megan Cook, Sarah Callinan
{"title":"Individual and spouse alcohol consumption patterns and anxiety: The mediating role of relationship satisfaction.","authors":"Simon D'Aquino, Koen Smit, Benjamin Riordan, Megan Cook, Sarah Callinan","doi":"10.1037/pha0000866","DOIUrl":"10.1037/pha0000866","url":null,"abstract":"<p><p>Spousal relationships are a key context for alcohol use and psychological well-being. Alcohol consumption may influence mental health through its impact on relationship dynamics. This study examined whether relationship satisfaction mediates the association between alcohol use and anxiety and whether this pathway is moderated by spousal drinking congruence. Participants were spouses from the Household, Income, and Labour Dynamics in Australia Survey between 2005 and 2021. Multilevel structural equation models regressed individual and spouse alcohol consumption frequency and quantity on relationship satisfaction 1-year later, and all variables on anxiety another year later, up to eight times per participant. Moderation was assessed with individual and spouse alcohol consumption pattern interactions. Based on age-based differences in previous research, models were estimated separately for 18-50 (<i>n</i> = 6,483) and 51+ (<i>n</i> = 5,110) year olds. For 18- to 50-year-olds, relationship satisfaction partially mediated the association between individual alcohol quantity and anxiety, with effects dependent on spouse quantity (greater anxiety at low spouse quantity; lower anxiety at high spouse quantity). For those aged 51+, relationship satisfaction fully mediated the association between spouse quantity and anxiety, and partially mediated associations involving individual quantity and frequency, with frequency effects moderated by spouse frequency (greater anxiety at low spouse frequency; lower anxiety at high spouse frequency). Spousal incongruence in alcohol consumption patterns and heavier drinking among older spouses were associated with poorer psychosocial outcomes. Better outcomes were observed where spouses showed congruent heavy and frequent drinking among younger and older couples, respectively. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovations in health behavior research: Current status and strategic future directions. 健康行为研究的创新:现状与未来战略方向。
IF 1.6 3区 医学
Experimental and clinical psychopharmacology Pub Date : 2026-06-01 DOI: 10.1037/pha0000841
Nioud Mulugeta Gebru, Samuel F Acuff
{"title":"Innovations in health behavior research: Current status and strategic future directions.","authors":"Nioud Mulugeta Gebru, Samuel F Acuff","doi":"10.1037/pha0000841","DOIUrl":"10.1037/pha0000841","url":null,"abstract":"<p><p>Given the public health burden associated with health behaviors such as substance use, significant efforts are directed toward developing effective interventions to facilitate health behavior change. As digital technologies continue to advance at accelerating pace and integrate into people's daily lives, researchers have a unique and significant opportunity to leverage these tools to advance theory and practice. Emerging tools, novel intervention targets, and technologies have great potential to improve health behavior change research to unburden individuals and communities impacted by substance use and related behaviors, though much work remains to be done to fully realize this potential. This article examines the current state of the health behavior change research highlighting recent innovations facilitated by digital transformations. Looking ahead, potential challenges and opportunities are discussed, along with a call for health behavior change researchers to become intentional interdisciplinary collaborators and innovation brokers toward the development of effective theory-informed digital tools and to maximize the field's impact on public health outcomes. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":"34 3","pages":"217-223"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13286044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feasibility and acceptability of a trauma-informed and peer-supported digital brief intervention for heavy-drinking emerging adults with interpersonal trauma. 创伤知情和同伴支持的数字简短干预对有人际创伤的重度饮酒新成人的可行性和可接受性。
IF 1.6 3区 医学
Experimental and clinical psychopharmacology Pub Date : 2026-06-01 DOI: 10.1037/pha0000864
Matthew J Woodward, Jenni B Teeters, Caitlin R McGettrick, Lily C Milam, Hanna E Forrest
{"title":"Feasibility and acceptability of a trauma-informed and peer-supported digital brief intervention for heavy-drinking emerging adults with interpersonal trauma.","authors":"Matthew J Woodward, Jenni B Teeters, Caitlin R McGettrick, Lily C Milam, Hanna E Forrest","doi":"10.1037/pha0000864","DOIUrl":"10.1037/pha0000864","url":null,"abstract":"<p><p>Brief interventions (BIs) are generally effective at reducing heavy drinking and mitigating alcohol-related harms. However, some studies suggest that BIs may be less effective for substance-using interpersonal trauma survivors, indicating additional modifications may be needed to improve outcomes for this at-risk demographic. Additionally, given lower engagement and adherence in digital modalities, digital navigators such as peer coaches may help strengthen gains following technology-based BIs. The purpose of the present study was to examine the feasibility and acceptability of a mobile-delivered, trauma-informed BI for undergraduate emerging adults with interpersonal trauma and heavy alcohol use that was augmented with peer coaches. Participants included 52 individuals recruited as part of an ongoing randomized pilot trial. Participants completed a digital BI, peer coaching sessions via synchronous text messages at 1 and 2 months post-BI, and a 3-month follow-up. Completion rates were high, with approximately 80% of the sample completing the peer coaching sessions, and results showed that the majority of participants had positive perceptions of the BI and peer coaching. Findings indicate that BIs supported with peer coaching are feasible and acceptable, although rigorous examinations of their effectiveness relative to existing interventions are needed. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":"34 3","pages":"331-339"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13286039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case report of focused ultrasound neuromodulation of the bilateral nucleus accumbens for methamphetamine use disorder. 双侧伏隔核聚焦超声神经调节治疗甲基苯丙胺使用障碍1例报告。
IF 1.6 3区 医学
Experimental and clinical psychopharmacology Pub Date : 2026-06-01 Epub Date: 2025-09-01 DOI: 10.1037/pha0000793
James J Mahoney, Daisy G Y Thompson-Lake, Manish Ranjan, Jennifer L Marton, Jeffrey S Carpenter, Pierre-François D'Haese, Tasneem Arsiwala, Jacob Suffridge, Daniel L Farmer, Victor S Finomore, Padma Tirumalai, Sally L Hodder, Ali R Rezai
{"title":"A case report of focused ultrasound neuromodulation of the bilateral nucleus accumbens for methamphetamine use disorder.","authors":"James J Mahoney, Daisy G Y Thompson-Lake, Manish Ranjan, Jennifer L Marton, Jeffrey S Carpenter, Pierre-François D'Haese, Tasneem Arsiwala, Jacob Suffridge, Daniel L Farmer, Victor S Finomore, Padma Tirumalai, Sally L Hodder, Ali R Rezai","doi":"10.1037/pha0000793","DOIUrl":"10.1037/pha0000793","url":null,"abstract":"<p><p>Nearly 2 million people had a diagnosis of methamphetamine use disorder (MUD) in 2023 and overdose deaths involving psychostimulants are increasing. Given that there are no currently approved U.S. Food and Drug Administration medications for MUD, novel treatments are needed to complement standard of care behavioral treatments. Neuromodulation using transcranial focused ultrasound (FUS) has the capacity to noninvasively and precisely target subcortical structures, such as the nucleus accumbens, a structure integral to the reward neurocircuitry. Previous findings in individuals with opioid use disorder have demonstrated the potential of FUS in reducing substance craving and use; however, to date, no study has examined the effects of FUS for primary MUD. The objective of the current case study was to evaluate the safety and impact of nucleus accumbens FUS on methamphetamine craving (via a cue-induced craving paradigm) and use (via urine toxicology and self-report) in a man in his mid-20s with primary MUD. The participant received a 20-min session of low-intensity FUS (220 kHz) neuromodulation and completed follow-up visits 1-, 7-, 30-, 60-, and 90-days postprocedure. Results demonstrated that the FUS procedure was safe and well-tolerated. Cue induced craving acutely reduced during the procedure with sustained complete suppression throughout the 90-day follow-up (baseline craving rating was nine out of 10 [where 10 represents maximum craving]; craving at follow-up visits were consistently zero out of 10). Methamphetamine negative urine toxicology was observed during all follow-up visits, contrasting his pre-FUS use patterns of multiple episodes of use per week. While promising, larger, sham-controlled, randomized studies are warranted to determine the potential of FUS for MUD. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":"324-330"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144948159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Behavioral reactivity to ecological momentary assessment of alcohol and sexual assault protective behavioral strategies. 行为反应对酒精和性侵犯保护行为策略的生态瞬时评估。
IF 1.6 3区 医学
Experimental and clinical psychopharmacology Pub Date : 2026-06-01 Epub Date: 2025-10-20 DOI: 10.1037/pha0000807
Elena Kalina, Michael A Russell, G C Rodríguez, Robert F Leeman, Nichole M Scaglione
{"title":"Behavioral reactivity to ecological momentary assessment of alcohol and sexual assault protective behavioral strategies.","authors":"Elena Kalina, Michael A Russell, G C Rodríguez, Robert F Leeman, Nichole M Scaglione","doi":"10.1037/pha0000807","DOIUrl":"10.1037/pha0000807","url":null,"abstract":"<p><p>Ecological momentary assessment (EMA) is increasingly used to examine risk and protective factors associated with alcohol-involved sexual assault (SA). Whereas extant literature demonstrates limited reactivity (i.e., systematic behavior change) to repeated assessment of risk behaviors (e.g., drinking), we know little about the impact of EMA on protective behaviors (i.e., harm reduction strategies). The present study examined between- and within-person reactivity to EMA participation using data from a larger study of alcohol and SA protective behavioral strategy (PBS) use. First-year college women (<i>N</i> = 138) were randomized to a 14-day EMA or a reactivity control condition. Both conditions completed baseline/follow-up measures of drinking behavior, alcohol PBS, and SA PBS. The EMA condition reported alcohol and SA PBS use each morning after drinking. We used 2 × 2 analyses of variance to examine differences in PBS use by condition (EMA vs. control) over time (baseline vs. follow-up); within-person changes in PBS use were probed with multilevel models. We found Significant Condition × Time interactions for both alcohol PBS and SA PBS; the EMA condition increased PBS use relative to the control condition across the first semester of college. Across the 14-day EMA protocol, women marginally increased alcohol PBS use and significantly increased SA PBS use. Participation in a 14-day EMA protocol may lead to changes in PBS use among first-semester college women. Results encourage examination of and controlling for potential reactivity in etiology and intervention studies of PBS use and highlight the potential of momentary interventions to increase PBS use over time. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":"233-242"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12593412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alcohol consumption dynamics and day-to-day experiences of alcohol-related problems: Combining transdermal alcohol concentration sensors and daily self-reports in young adults' natural settings. 酒精消费动态和酒精相关问题的日常体验:结合经皮酒精浓度传感器和年轻人自然环境中的日常自我报告
IF 1.6 3区 医学
Experimental and clinical psychopharmacology Pub Date : 2026-06-01 Epub Date: 2025-12-18 DOI: 10.1037/pha0000819
Michael A Russell, Veronica L Richards, Robert J Turrisi, Yiping Li, Kimberly A Mallett
{"title":"Alcohol consumption dynamics and day-to-day experiences of alcohol-related problems: Combining transdermal alcohol concentration sensors and daily self-reports in young adults' natural settings.","authors":"Michael A Russell, Veronica L Richards, Robert J Turrisi, Yiping Li, Kimberly A Mallett","doi":"10.1037/pha0000819","DOIUrl":"10.1037/pha0000819","url":null,"abstract":"<p><p>Day-level alcohol-related problems (ARPs)-such as craving, difficulty limiting/stopping, tolerance, impairment, and withdrawal-may signal risk for alcohol use disorder in young adults' natural settings. ARPs may relate to how people drink (e.g., intensity, speed, duration), but these consumption dynamics are difficult to assess accurately through self-reports. We tested the association between ARPs and alcohol consumption dynamics in young adults using wearable transdermal alcohol concentration (TAC) sensors and daily diaries. College students (<i>N</i> = 79; 55.7% female, 86.1% White, <i>M</i><sub>age</sub> = 20.1) who frequently engaged in heavy episodic drinking wore TAC sensors and completed daily diaries over four consecutive weekends (89.9% completion rate). ARPs were measured the morning after drinking events. Three consumption dynamics were extracted from TAC data: speed (rise rate), intensity (peak), and duration (rise duration) of drinking. Analyses using unadjusted models showed that young adults reported more ARPs on days with faster rise rates, higher peaks, or longer rise durations compared with their own slower, lower, and shorter days. Adjusted models including all three TAC features showed that faster rise rates and longer rise durations were independently associated with ARPs, but higher peaks were not. These findings provide novel evidence that the speed and duration of drinking-not just the amount-may be key targets for ARP prevention among young adults. These insights would not have emerged without the rich, objective measurement of drinking dynamics offered by TAC sensors. TAC features may help indicate existing alcohol-related impairment, warranting investigation of their prospective links to alcohol use disorder risk. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":"224-232"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12716371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145773996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The utility of bluetooth and smartphone technology to detect peer contact. 利用蓝牙和智能手机技术检测同伴接触。
IF 1.6 3区 医学
Experimental and clinical psychopharmacology Pub Date : 2026-06-01 Epub Date: 2026-02-09 DOI: 10.1037/pha0000827
Nancy P Barnett, Matthew K Meisel, Alexander W Sokolovsky, Shannon R Forkus, Kristina M Jackson
{"title":"The utility of bluetooth and smartphone technology to detect peer contact.","authors":"Nancy P Barnett, Matthew K Meisel, Alexander W Sokolovsky, Shannon R Forkus, Kristina M Jackson","doi":"10.1037/pha0000827","DOIUrl":"10.1037/pha0000827","url":null,"abstract":"<p><p>Adolescents and young adults often engage in risk behaviors in close proximity to peers. Detecting peer presence could identify high-risk contexts, but typically relies on self-report, which is prone to bias. This study evaluated the feasibility, acceptability, functionality, and validity of a smartphone-based passive detection system using Bluetooth beacons to identify real-world peer proximity. Twenty-one young adult participants (38% women) and their peers (<i>N</i> = 55; 40% women) completed a 3-week protocol, during which peers carried a small Bluetooth beacon that was detected by participant smartphones. Participants indicated the presence of peers on beacon signal-contingent ecological momentary assessment reports and three daily random reports. Feasibility of participant recruitment was low, primarily due to Android OS updates requiring app revisions that interrupted recruitment. However, feasibility of peer enrollment was high, occurring rapidly but at a lower-than-expected number. Response latencies to signal-contingent and random reports were similar, indicating good feasibility of the ecological momentary assessment report procedures. Acceptability, reflected in high retention for participants and peers, participant self-report ratings, and good ecological momentary assessment report response rates (76%-79%), was high. Functionality was moderate; problems with the app were reported by almost half of participants, and functionality ratings were lower than for acceptability. For validity, the beacon detection technology identified 61% of participant-reported encounters (true positives), with 5.6% false positives. False negatives (39%) were likely due to peer noncompliance or misreporting. Results support the initial utility of Bluetooth-based passive detection for identifying peer presence in real time, offering potential for use in just-in-time interventions targeting health-risk behaviors. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":"243-252"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13014808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
App-based contingency management to reduce heavy drinking days among smokers receiving varenicline: Feasibility, acceptability, and efficacy indicators from a phase I analog trial. 基于应用程序的应急管理以减少服用伐尼克兰的吸烟者的重度饮酒天数:来自I期模拟试验的可行性、可接受性和疗效指标
IF 1.6 3区 医学
Experimental and clinical psychopharmacology Pub Date : 2026-06-01 DOI: 10.1037/pha0000790
André Q C Miguel, Nicole Akana, Rachel Ryan, Alex Schmidt, Sean Hovland, Brian Stark, Sierra Colletto, Abigail Bowen, Nicole Rodin, Crystal L Smith, Sterling M McPherson
{"title":"App-based contingency management to reduce heavy drinking days among smokers receiving varenicline: Feasibility, acceptability, and efficacy indicators from a phase I analog trial.","authors":"André Q C Miguel, Nicole Akana, Rachel Ryan, Alex Schmidt, Sean Hovland, Brian Stark, Sierra Colletto, Abigail Bowen, Nicole Rodin, Crystal L Smith, Sterling M McPherson","doi":"10.1037/pha0000790","DOIUrl":"10.1037/pha0000790","url":null,"abstract":"<p><p>Tobacco and alcohol coaddiction is highly prevalent and represents a substantial challenge for treatment, as addiction to one of these substances leads to a worse prognosis when treating the other. In this pilot study, we evaluated the feasibility, acceptability, and signals of efficacy when incorporating varenicline (VC) and app-based contingency management (CM) to treat tobacco smoking and alcohol use disorders (AUD), concomitantly. Fourteen participants with an AUD who were seeking smoking cessation treatment were exposed to a within-subject A-B-A experimental design lasting 9 weeks. Participants were provided VC for smoking cessation throughout the study. Participants were also instructed to submit five daily breathalyzer samples using a mobile app. During the experimental phase (B), participants could earn reinforcers totaling $15 per day for submitting all breathalyzer samples with results below 0.08. Submitting all five samples on a given day occurred on 75% of study days, with VC adherence occurring on 74% of study days. Participants were retained for an average of 7.6 weeks and most of them (80%) found the app quick to learn and easy to use. A significant reduction of heavy-drinking days (<i>p</i> < .01) occurred during the B phase, and the number of daily cigarettes smoked significantly declined following each phase change (<i>p</i> < .01). The combination of VC and app-based CM was shown to be feasible and well accepted, with an initial signal of efficacy to reduce heavy-drinking and cigarette smoking. This combined therapeutic may provide a novel approach to treat tobacco smoking and AUD concomitantly. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":"34 3","pages":"271-276"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13286036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Remote alcohol administration: A qualitative study of barriers and facilitators to potential participation. 远程酒精管理:对潜在参与的障碍和促进因素的定性研究。
IF 1.6 3区 医学
Experimental and clinical psychopharmacology Pub Date : 2026-06-01 Epub Date: 2025-12-04 DOI: 10.1037/pha0000810
Abigail P Masterson, Claire Wilhelm, Deepthi S Varma, Drew A Westmoreland, James B Moran, Sarah Chance, Robert F Leeman, Liana S E Hone
{"title":"Remote alcohol administration: A qualitative study of barriers and facilitators to potential participation.","authors":"Abigail P Masterson, Claire Wilhelm, Deepthi S Varma, Drew A Westmoreland, James B Moran, Sarah Chance, Robert F Leeman, Liana S E Hone","doi":"10.1037/pha0000810","DOIUrl":"10.1037/pha0000810","url":null,"abstract":"<p><p>Human laboratory alcohol administration studies are crucial for advancing knowledge of cognitive processes and behaviors that precede alcohol consequences in a controlled environment, improving our understanding of etiology of alcohol problems and ability to develop and test safety and efficacy of interventions. However, conducting lab administration studies is challenging in part due to high participant burden, limiting generalizability of results to individuals who do not typically present for lab studies. Given the advantages of lab administration methods coupled with their challenges, remote alcohol administration was pursued as an alternative to enhance generalizability by removing barriers to participation and reducing participant burden. To establish feasibility and acceptability of this new remote method, we conducted qualitative interviews of 27 individuals (51.8% male; <i>M</i><sub>age</sub> = 21.96) and found that an average of 80% of individuals were willing to potentially participate in remote administration. Several themes emerged concerning participants' willingness and ability to participate, including (1) study location, (2) ease of participation, and (3) wanting to participate with a friend. However, some participants also cited specific barriers to participation, such as (1) living situation not conducive to participation, (2) study safety concerns, and (3) not wanting to participate with a romantic partner. Understanding both facilitators and barriers to potential participation will enable researchers to better design remote studies and enroll individuals not commonly included in current lab administration studies which has important implications for improved generalizability of findings. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":"253-260"},"PeriodicalIF":1.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12707377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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