2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT)最新文献

Development of an AI-based non-invasive Pulse AudioGram monitoring device for arrhythmia screening 心律失常筛查人工智能无创脉搏听图监测装置的研制

2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT) Pub Date : 2017-12-19 DOI: 10.1109/HIC.2017.8227579

Che-Wei Lin, Yung-Cheng Chang, Chou-Ching K. Lin, L. Tsai, Ju-Yi Chen

{"title":"Development of an AI-based non-invasive Pulse AudioGram monitoring device for arrhythmia screening","authors":"Che-Wei Lin, Yung-Cheng Chang, Chou-Ching K. Lin, L. Tsai, Ju-Yi Chen","doi":"10.1109/HIC.2017.8227579","DOIUrl":"https://doi.org/10.1109/HIC.2017.8227579","url":null,"abstract":"An artificial intelligence-based (AI-based) noninvasive Pulse AudioGram (PAG) monitoring device with arrhythmia screening algorithm has been developed in this research study. The PAG monitoring device consists of four components, including an audiogram sensor, an analog-digital converter, a microprocessor, and a data storage unit. The main function of the proposed AI-based non-invasive PAG is to measure the audio signal in radial artery generated by hemodynamics. Hemodynamics under arrhythmia and sinus rhythm (SR) conditions might exhibit different patterns as the heart rhythm becomes irregular under arrhythmia condition. PAG signals of SR and other arrhythmia symptoms such as atrial fibrillation (AF), aortic regurgitation (AR), and congestive heart failure (CHF) were collected during this research. In the experiment results, the proposed method can achieve accuracy of 99.29% when discriminating SR and AF; the proposed method can achieve accuracy of 98.92% when discriminating SR, AF, AR, and CHF. In this study, we have successfully developed an AI-based non-invasive PAG monitoring device for arrhythmia screening, and have plan to use it in on large-scale screening for arrhythmia in the near future.","PeriodicalId":120815,"journal":{"name":"2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT)","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126361736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Label-free detection of lactoferrin and beta-2-microglobuin in contrived tear film using a low-cost electrical biosensor chip 利用低成本电生物传感器芯片对人造泪膜中的乳铁蛋白和β -2微球蛋白进行无标记检测

2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT) Pub Date : 2017-12-19 DOI: 10.1109/HIC.2017.8227587

Muhammad S. Khan, K. Dighe, Zhen Wang, E. Daza, A. Schwartz-Duval, Conor P. Rowley, Isaac A. Calvillo, Dr. Santoshi Misra, Leanne T. Labriola, D. Pan

{"title":"Label-free detection of lactoferrin and beta-2-microglobuin in contrived tear film using a low-cost electrical biosensor chip","authors":"Muhammad S. Khan, K. Dighe, Zhen Wang, E. Daza, A. Schwartz-Duval, Conor P. Rowley, Isaac A. Calvillo, Dr. Santoshi Misra, Leanne T. Labriola, D. Pan","doi":"10.1109/HIC.2017.8227587","DOIUrl":"https://doi.org/10.1109/HIC.2017.8227587","url":null,"abstract":"In this paper, we present a biosensor chip to study two important biomarkers, lactoferrin (LCF) and beta-2-microglubin (B2M) present in our tear fluid. LCF and B2M have direct relevance with dry eye syndrome and diabetic retinopathy in patients respectively. We have developed a multi-layer paper-based biosensor chip connected with handheld printed circuit board (PCB) to monitor the effectiveness of B2M and LCF in contrived tear film (TF) with a wide range of detection (RoD) from 0.001 to 1ng/mL (R2=0.9886) and 1 to 10mg/mL (R2=0.9554) respectively. Multilayer biosensor is composed of graphene nanoplatelet and diblock-co-polymer coated on a filter paper followed by deposition of micro-Au electrodes. Anti-LCF and anti-B2M antibodies were immobilized via 3,3'-dithiodipropionic acid di(N-hydroxysuccinimide ester (DTSP) as a self-assembled monolayer (SAM) on Au. In addition to electrical measurements in real-time setup, Raman spectral analysis and SEM were utilized to characterize the sensor surface before and after testing the relevant proteins. We anticipate that the fabricated sensor chip has promising application to study dry-eye-disease (DED) and diabetes in Point-of-care (POC) setting.","PeriodicalId":120815,"journal":{"name":"2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT)","volume":"117 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123732751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Highly sensitive fluorescence-based lateral flow platform for point-of-care detection of biomarkers in plasma 高度敏感的基于荧光的横向流动平台，用于即时检测血浆中的生物标志物

2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT) Pub Date : 2017-11-01 DOI: 10.1109/HIC.2017.8227631

Meilin Zhu, U. Obahiagbon, K. Anderson, J. Christen

{"title":"Highly sensitive fluorescence-based lateral flow platform for point-of-care detection of biomarkers in plasma","authors":"Meilin Zhu, U. Obahiagbon, K. Anderson, J. Christen","doi":"10.1109/HIC.2017.8227631","DOIUrl":"https://doi.org/10.1109/HIC.2017.8227631","url":null,"abstract":"Point-of-Care (PoC) diagnostic devices, such as lateral flow tests, are often used in low and middle-income countries (LMIC) for low-cost disease detection. Most commercial lateral flow tests use colorimetric detection on a nitrocellulose substrate. In this paper, we present a multistep, fluorescence-based assay detection system, which can detect antibodies in plasma to recombinant protein. Fluorescence-based detection allows us to achieve higher sensitivity, while a nitrocellulose substrate enables fluid handling, high protein immobilization, rapid detection time, and affordability. As a proof-of-concept for detection of disease-specific biomarkers in plasma, we demonstrate the detection of antibodies in plasma to Epstein-Barr nuclear antigen-1 (EBNA-1) recombinant protein and to human papillomavirus (HPV) 16 E7 recombinant protein. We show that our detection system is able to detect EBNA-1-specific antibodies at a 1:10,000 plasma dilution and HPV 16 E7-specific antibodies at a 1:5,000 plasma dilution, indicating high sensitivity. This platform is a low-cost device that can detect fluorescence from labeled biomarkers on a lateral flow assay. Ultimately, we aim to adapt this system to detect HPV 16 and 18 biomarkers for cervical cancer screening in LMICs.","PeriodicalId":120815,"journal":{"name":"2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126971171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

A low-cost, mass-producible point-of-care platform for diagnosing hemoglobin disorders 用于诊断血红蛋白疾病的低成本、可批量生产的即时护理平台

2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT) Pub Date : 2017-11-01 DOI: 10.1109/HIC.2017.8227610

M. N. Hasan, A. Fraiwan, J. Little, U. Gurkan

引用次数: 6

Smartphone-based gait assessment to infer Parkinson's disease severity using crowdsourced data 基于智能手机的步态评估，利用众包数据推断帕金森病的严重程度

2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT) Pub Date : 2017-11-01 DOI: 10.1109/HIC.2017.8227621

Hamza Abujrida, E. Agu, K. Pahlavan

引用次数: 15

Simultaneous glucose sensing and bioenergy harnessing 同时葡萄糖传感和生物能源利用

2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT) Pub Date : 2017-11-01 DOI: 10.1109/HIC.2017.8227589

Tanmay Kulkarni, G. Slaughter

{"title":"Simultaneous glucose sensing and bioenergy harnessing","authors":"Tanmay Kulkarni, G. Slaughter","doi":"10.1109/HIC.2017.8227589","DOIUrl":"https://doi.org/10.1109/HIC.2017.8227589","url":null,"abstract":"We describe herein the construction of a glucose biosensor system that senses glucose without the use of potentiostat and harness usable electrical energy from glucose to power a digital electronic device simultaneously. This system is powered by a single enzymatic glucose biofuel cell comprising a highly dense mesh network of multi-walled carbon nanotubes and enzymes that results in the immobilization and direct electrical connection of the enzymes. The bioanode is functionalized with pyroloquinoline quinone glucose dehydrogenase, while the biocathode is functionalized with bilirubin oxidase. The glucose biofuel cell assembly and its performance were investigated under physiological conditions (pH 7.4 and 37 °C) at which a maximum open circuit voltage of 548.2 mV, short circuit current density of 7.19 mA/cm2 and peak power density of 1.475 mA/cm2 were obtained in 20 mM glucose. The nominal electrical power generated from the single glucose biofuel cell (∼ 548 mV) was amplified to 3.2 V using a two stage electrical power amplification circuit and a capacitive element functioning as a glucose transducer. The self-powered glucose biosensor exhibited a linear dynamic range of 1 mM–45 mM and a high sensitivity of 92.51 Hz/cm2.mM when simultaneously sensing glucose and powering a glucometer. Additionally, the system demonstrated excellent operational stability over a 53-day period.","PeriodicalId":120815,"journal":{"name":"2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT)","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134325917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Clinical evaluation of a portable pocket colposcope for cervical cancer screening in the United States, Perú, and Tanzania 美国、Perú和坦桑尼亚用于宫颈癌筛查的便携式口袋阴道镜的临床评价

2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT) Pub Date : 2017-11-01 DOI: 10.1109/HIC.2017.8227598

Jenna L. Mueller, Christopher T Lam, M. Kellish, Jenna Peters, M. Asiedu, Marlee S. Krieger, Jennifer E. Gallagher, A. Erkanli, Ernesto J Ortiz, Lisa C. Muasher, Peyton Taylor, B. Mchome, O. Oneko, Gino Venegas, John W Schmitt, N. Ramanujam

{"title":"Clinical evaluation of a portable pocket colposcope for cervical cancer screening in the United States, Perú, and Tanzania","authors":"Jenna L. Mueller, Christopher T Lam, M. Kellish, Jenna Peters, M. Asiedu, Marlee S. Krieger, Jennifer E. Gallagher, A. Erkanli, Ernesto J Ortiz, Lisa C. Muasher, Peyton Taylor, B. Mchome, O. Oneko, Gino Venegas, John W Schmitt, N. Ramanujam","doi":"10.1109/HIC.2017.8227598","DOIUrl":"https://doi.org/10.1109/HIC.2017.8227598","url":null,"abstract":"Cervical cancer is the second leading cause of cancer related deaths for women worldwide, despite being both preventable and treatable if detected early enough. The burden of disease persists in part due to a lack of access to early diagnostics and the fact that a significant proportion of women do not return for follow-up care. To address this need, we developed a low-cost, portable Pocket colposcope that can be used in remote settings for cervical cancer screening and prevention. We evaluated whether the Pocket colposcope performs comparably to the standard-of-care colposcope in Durham, North Carolina, Lima, Perú, and Moshi, Tanzania. Concordant image pairs obtained from this device and the current standard imaging was sent to physician experts from high, middle, and low-income countries. They were blinded as to diagnosis, device, and peer response. Each image was critically evaluated for quality and presumptive findings and compared. Corresponding pathology was obtained for each patient. Physician interpretation agreed 76.8% of the time between the Pocket colposcope and standard-of-care colposcope. Physician interpretation agreed with pathology 59.4% and 63.0% for the Pocket and standard-of-care colposcopes, respectively. The primary outcome of this study was to show reasonable concordance between the Pocket colposcope and state of the art imaging in terms of individual examiners, pathologic diagnosis, and image quality. In all areas the Pocket colposcope showed comparable results to country-specific standard-of-care screening.","PeriodicalId":120815,"journal":{"name":"2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT)","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124267811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Cluster analysis framework for novel acoustic catheter stethoscope 新型导管听诊器的聚类分析框架

2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT) Pub Date : 2017-11-01 DOI: 10.1109/HIC.2017.8227575

P. C. Adithya, S. Pandey, R. Sankar, S. Hart, W. Moreno

引用次数: 1

Design of a multi-sensor IoT-enabled assistive device for discrete and deployable gait monitoring 设计一种支持多传感器物联网的辅助设备，用于离散和可部署的步态监测

2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT) Pub Date : 2017-11-01 DOI: 10.1109/HIC.2017.8227623

S. Gill, Jason Hearn, Graeme Powell, E. Scheme

{"title":"Design of a multi-sensor IoT-enabled assistive device for discrete and deployable gait monitoring","authors":"S. Gill, Jason Hearn, Graeme Powell, E. Scheme","doi":"10.1109/HIC.2017.8227623","DOIUrl":"https://doi.org/10.1109/HIC.2017.8227623","url":null,"abstract":"The increasing stress on the global healthcare system driven by the rise of chronic disease and an aging population is necessitating an emphasis on proactive health monitoring and self-management. Potential exists in the wave of emerging wearable devices and the internet of things (IoT) to support a movement towards the decentralization of healthcare. In particular, mobility impairments caused by injury or chronic disease are a major source of concern in the aging population. Individuals with mobility impairments often rely on assistive devices, such as canes or walkers to increase safety and stability. Given the prevalence of assistive devices among these users, instrumenting and connecting assistive technologies could be an effective means of unobtrusive activity monitoring. In this work we present an affordable hybrid sensorized cane, capable of measuring loading, mobility and stability information. The proposed system, which is nearly indistinguishable from a traditional cane, collects these data and then wirelessly transmits them to a mobile device for cloud storage and analysis. A multi-sensor fusion algorithm was used to segment valid gait cycles and identify various temporal gait events. Based on preliminary results, it is believed that the proposed system will be able to identify a variety of gait perturbations, potentially offering future applications in early diagnosis and the management of chronic conditions.","PeriodicalId":120815,"journal":{"name":"2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT)","volume":"153 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127274985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Structural topology optimization for generative design of personalized aneurysm implants: Design, additive manufacturing, and experimental validation 个性化动脉瘤植入物生成设计的结构拓扑优化:设计、增材制造和实验验证

2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT) Pub Date : 2017-11-01 DOI: 10.1109/HIC.2017.8227572

Long Jiang, Shikui Chen, C. Sadasivan, X. Jiao

引用次数: 15