2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT)最新文献_第6页

Multiplexed detection of infectious diseases with microfluidic loop-mediated isothermal amplification and a smartphone 用微流控环介导的等温扩增和智能手机多路检测传染病

2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT) Pub Date : 2017-11-01 DOI: 10.1109/HIC.2017.8227629

F. Sun, Weili Chen, Hojeong Yu, Akid Omob, Ryan Brisbin, A. Ganguli, V. Vemuri, P. Strzeboński, Guangzhe Cui, K. J. Allen, Smit Desai, Weiran Lin, David M. Nash, D. Hirschberg, Ian Brooks, R. Bashir, B. Cunningham

{"title":"Multiplexed detection of infectious diseases with microfluidic loop-mediated isothermal amplification and a smartphone","authors":"F. Sun, Weili Chen, Hojeong Yu, Akid Omob, Ryan Brisbin, A. Ganguli, V. Vemuri, P. Strzeboński, Guangzhe Cui, K. J. Allen, Smit Desai, Weiran Lin, David M. Nash, D. Hirschberg, Ian Brooks, R. Bashir, B. Cunningham","doi":"10.1109/HIC.2017.8227629","DOIUrl":"https://doi.org/10.1109/HIC.2017.8227629","url":null,"abstract":"New tools are needed to enable rapid detection, identification, and reporting of infectious viral and microbial pathogens in a wide variety of point-of-care applications that impact human and animal health. We report the design, construction, and characterization of a platform for multiplexed analysis of disease-specific DNA sequences that utilizes a smartphone camera as the sensor in conjunction with a handheld instrument that interfaces the phone with a silicon-based microfluidic chip. Utilizing specific nucleic acid sequences for four equine respiratory pathogens as representative examples, we demonstrated the ability of the system to use a single 15-μL droplet of test sample to perform selective positive/negative determination of target sequences, including integrated experimental controls, in approximately 30 minutes. The system achieves detection limits comparable to those obtained by laboratory-based methods and instruments.","PeriodicalId":120815,"journal":{"name":"2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127694822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Automatic clustering-based segmentation and plaque localization in psoriasis digital images 基于聚类的银屑病数字图像自动分割与斑块定位

2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT) Pub Date : 2017-11-01 DOI: 10.1109/HIC.2017.8227597

T. T. Munia, Intisar Rizwan i Haque, A. Aymond, N. Mackinnon, D. Farkas, Minhal Al-Hashim, F. Vasefi, R. Fazel-Rezai

{"title":"Automatic clustering-based segmentation and plaque localization in psoriasis digital images","authors":"T. T. Munia, Intisar Rizwan i Haque, A. Aymond, N. Mackinnon, D. Farkas, Minhal Al-Hashim, F. Vasefi, R. Fazel-Rezai","doi":"10.1109/HIC.2017.8227597","DOIUrl":"https://doi.org/10.1109/HIC.2017.8227597","url":null,"abstract":"Psoriasis is one of the most stressful skin diseases. The accurate assessment and effective management of the disease is one of the contributing factors in reducing the time required for relieving the disease symptoms. As the treatment is unusually subjective, an automatic and efficient computer aided assessment technique is an active area of research. In this study, we developed an automatic psoriasis segmentation and plaque localization system using images captured by a digital camera. Our work differs from other studies by improving the segmentation of lesion regions and using a novel region based color feature extractor for classification of psoriasis plaques from healthy skin areas. The proposed modified k-means clustering based segmentation approach resulted in an accuracy of 93.83% in comparison to the ground truth, which is around 10% more than reported results by others with the same database. Statistical analysis was performed to determine psoriasis biomarkers, and the effectiveness of these biomarkers was validated by developing a machine learning model consisting of support vector machine (SVM) classifier to identify the psoriasis plaques automatically. The classification model predicted the disease plaques with an acceptable accuracy of 86.83% and thus the automated psoriasis segmentation and plaque localization technique developed in this study provide the foundation towards designing an objective assessment system for psoriasis.","PeriodicalId":120815,"journal":{"name":"2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT)","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125074734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A concept of medical expertise pooling by tele sensing and manipulation: Emergency medicine case 利用遥感和操纵技术汇集医疗专业知识的概念:急诊医学案例

2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT) Pub Date : 2017-11-01 DOI: 10.1109/HIC.2017.8227627

Sakura Sikander, Pradipta Biswas, Pankaj Kulkami, H. Mansy, N. Rahnavard, Sang-Eun Song

引用次数: 4

An antimicrobial light device with clinical utility in the United States and abroad 一种在美国及国外具有临床应用价值的抗菌光装置

2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT) Pub Date : 2017-11-01 DOI: 10.1109/HIC.2017.8227590

R. E. Smith, Ben Smith, Nathan Borgfeld

引用次数: 0

Objective video-based tremor assessment for movement disorders using open-source software 目的利用开源软件对运动障碍的视频震颤进行评估

2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT) Pub Date : 2017-11-01 DOI: 10.1109/HIC.2017.8227617

Shivanthan A. C. Yohanandan, Chathura Perera, Mary Jones, R. Peppard, T. Perera

引用次数: 1

Online and offline anger detection via electromyography analysis 通过肌电图分析在线和离线愤怒检测

2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT) Pub Date : 2017-11-01 DOI: 10.1109/HIC.2017.8227582

D. S. Wickramasuriya, R. Faghih

引用次数: 10

Highly-sensitive detection of Salmonella typhi in human blood using a portable optical system for detection of nucleic acids amplification 用便携式光学系统检测核酸扩增对人血中伤寒沙门菌的高灵敏度检测

2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT) Pub Date : 2017-11-01 DOI: 10.1109/HIC.2017.8227591

First A. Avinash Kaur, Second B. Arti Kapil, Third C. Ravikrishnan Elangovan, Fourth D. Sandeep Jha, Fifth E. Dinesh Kalyanasundaram

{"title":"Highly-sensitive detection of Salmonella typhi in human blood using a portable optical system for detection of nucleic acids amplification","authors":"First A. Avinash Kaur, Second B. Arti Kapil, Third C. Ravikrishnan Elangovan, Fourth D. Sandeep Jha, Fifth E. Dinesh Kalyanasundaram","doi":"10.1109/HIC.2017.8227591","DOIUrl":"https://doi.org/10.1109/HIC.2017.8227591","url":null,"abstract":"Diseases such as enteric fever continues to be major cause of deaths globally, particularly in poor resource settings. Traditional cell viability test using bacterial culture method followed by confirmatory biochemical tests such as motility, triple sugar iron agar (TSI), citrate, urease test, agglutination tests, forms the gold standard method for diagnosis of enteric fever. However, these existing practices are time consuming. Highly sensitive detection of Salmonella typhi (S. typhi) in blood of 50 CFU/mL was achieved using our protocol involving a magnetic nanoparticle based preconcentration, a loop mediated isothermal amplification assay (LAMP) for signal augmentation and signal detection using an in-house designed optical detection system. Primers specific for STY2879 gene were used to amplify the nucleic acid isolated from S. typhi cells. The protocol involves detection of nucleic acid amplification for both pre and four hour post-incubation that confirms (a) cell viability and (b) specificity of S. typhi and (c) quantification of S. typhi. No cross reactivity of the primers were observed against 106 CFU/mL of common pathogenic bacterial species found in blood such as such as E. coli, P. aeruginosa, S. aureus, A baumanni, E. faecalis, S. paratyphi A and K. pneumonia. This detection system shows a promising future in the field of food and medical diagnostics. The instrument can be extended to other pathogens in the future with modification of the primers and minimal modification of the pre-concentration and lysis protocol.","PeriodicalId":120815,"journal":{"name":"2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT)","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125718274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A smart headband for epileptic seizure detection 一种用于癫痫发作检测的智能头带

2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT) Pub Date : 1900-01-01 DOI: 10.1109/HIC.2017.8227624

Shih-Kai Lin, Yu-Shan Lin, Chin-Yew Lin, H. Chiueh

引用次数: 5