European Radiology最新文献

{"title":"Evaluating the diagnostic performance of [¹⁸F]ALF-NOTA-FAPI-04 PET/CT in gastric cancer: a comparative study with [¹⁸F]FDG PET/CT.","authors":"Jinghui Lv, Kai Zheng, Chengzhi Jiang, Jian Yang, Xiang Peng, Hui Ye, Yanyin Zhang","doi":"10.1007/s00330-024-11219-z","DOIUrl":"10.1007/s00330-024-11219-z","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the diagnostic value of [¹⁸F]ALF-NOTA-FAPI-04 positron emission tomography/computed tomography (PET/CT) and ¹⁸F-fluorodeoxyglucose (FDG) PET/CT in gastric cancer.</p><p><strong>Methods: </strong>This single-center retrospective analysis included 65 patients with gastric cancer who received both [¹⁸F]FDG and [¹⁸F]ALF-NOTA-FAPI-04 PET/CT for initial staging or restaging. Histopathological manifestations, typical imaging manifestations, follow-up imaging, and comprehensive clinical assessment were used as reference criteria. The uptakes of [¹⁸F]FDG and [¹⁸F]ALF-NOTA-FAPI-04 PET were compared using the Wilcoxon signed-rank test. McNemar's test was employed to compare the diagnostic performance of the two imaging techniques.</p><p><strong>Results: </strong>A total of 65 patients were included (26 male and 39 female; mean age, 54.03 ± 10.41 years), Among them, 10 were newly diagnosed, 46 underwent radical gastrectomy, and 9 received only chemotherapy prior to the study. Compared with [¹⁸F]FDG PET/CT, [¹⁸F]ALF-NOTA-FAPI-04 PET/CT showed higher sensitivity in primary or recurrent tumors (100% vs. 64.52%, p < 0.001)), lymph node metastases (88.89% vs. 38.89%, p = 0.006), distant metastases (91.18% vs. 50%, p < 0.001). From the semi-quantitative evaluation, the Maximum standardized uptake value (SUVmax) and target-to-background ratio of [¹⁸F]ALF-NOTA-FAPI-04 PET/CT were significantly higher than that of [¹⁸F]FDG PET/CT in primary or recurrent tumors, lymph node metastases, and distant metastases (all p < 0.001).</p><p><strong>Conclusion: </strong>Our study results indicate that [¹⁸F]ALF-NOTA-FAPI-04 PET/CT outperforms [¹⁸F]FDG PET/CT in the detection of primary or recurrent tumors, lymph node metastasis, and distant metastasis in gastric cancer.</p><p><strong>Key points: </strong>Question Early diagnosis and precise staging of gastric cancer are crucial for patient prognosis; however, current imaging techniques still face significant limitations. Findings [¹⁸F]ALF-NOTA-FAPI-04 PET/CT demonstrated significantly higher sensitivity than [¹⁸F]FDG PET/CT in detecting primary or recurrent tumors and metastases in patients with gastric cancer. Clinical relevance [¹⁸F]ALF-NOTA-FAPI-04 PET/CT is an advanced imaging diagnostic technique that significantly enhances the diagnostic accuracy for gastric cancer and its metastatic lesions. This technology provides robust support for clinical decision-making, thereby improving the management of patients with gastric cancer.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"3314-3323"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI-based prediction of microvascular invasion/high tumor grade and adjuvant therapy benefit for solitary HCC ≤ 5 cm: a multicenter cohort study.","authors":"Hanyu Jiang, Binrong Li, Tianying Zheng, Yun Qin, Yuanan Wu, Zhenru Wu, Maxime Ronot, Victoria Chernyak, Kathryn J Fowler, Mustafa R Bashir, Weixia Chen, Yuan-Cheng Wang, Shenghong Ju, Bin Song","doi":"10.1007/s00330-024-11295-1","DOIUrl":"10.1007/s00330-024-11295-1","url":null,"abstract":"<p><strong>Objectives: </strong>To develop and externally validate an MRI-based diagnostic model for microvascular invasion (MVI) or Edmondson-Steiner G3/4 (i.e., high-risk histopathology) in solitary BCLC 0/A hepatocellular carcinoma (HCC) ≤ 5 cm and to assess its performance in predicting adjuvant therapy benefits.</p><p><strong>Materials and methods: </strong>This multicenter retrospective cohort study included 577 consecutive adult patients who underwent contrast-enhanced MRI and subsequent curative resection or ablation for solitary BCLC 0/A HCC ≤ 5 cm (December 2011 to January 2024) from four hospitals. For resection-treated patients, a diagnostic model integrating clinical and 50 semantic MRI features was developed against pathology with logistic regression analyses on the training set (center 1) and externally validated on the testing dataset (centers 2-4), with its utilities in predicting posttreatment recurrence-free survival (RFS) and adjuvant therapy benefit evaluated by Cox regression analyses.</p><p><strong>Results: </strong>Serum α-fetoprotein > 100 ng/mL (odds ratio (OR), 1.94; p = 0.006), non-simple nodular growth subtype (OR, 1.69; p = 0.03), and the VICT2 trait (OR, 4.49; p < 0.001) were included in the MVI or high-grade (MHG) trait, with testing set AUC, sensitivity, and specificity of 0.832, 74.0%, and 82.5%, respectively. In the multivariable Cox analysis, the MHG-positive status was associated with worse RFS (resection testing set HR, 3.55, p = 0.02; ablation HR, 3.45, p < 0.001), and adjuvant therapy was associated with improved RFS only for the MHG-positive patients (resection HR, 0.39, p < 0.001; ablation HR, 0.30, p = 0.005).</p><p><strong>Conclusion: </strong>The MHG trait effectively predicted high-risk histopathology, RFS and adjuvant therapy benefit among patients receiving curative resection or ablation for solitary BCLC 0/A HCC ≤ 5 cm.</p><p><strong>Key points: </strong>Question Despite being associated with increased recurrence and potential benefit from adjuvancy in HCC, microvascular invasion or Edmondson-Steiner grade 3/4 are hardly assessable noninvasively. Findings We developed and externally validated an MRI-based model for predicting high-risk histopathology, post-resection/ablation recurrence-free survival, and adjuvant therapy benefit in solitary HCC ≤ 5 cm. Clinical relevance Among patients receiving curative-intent resection or ablation for solitary HCC ≤ 5 cm, noninvasive identification of high-risk histopathology (MVI or high-grade) using our proposed MRI model may help improve individualized prognostication and patient selection for adjuvant therapies.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"3223-3237"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of aortic arch involvement in ascending thoracic aortic aneurysm by three-dimensional growth mapping using CT-angiography.","authors":"Nicasius S Tjahjadi, Carlos Alberto Campello Jorge, Prabhvir Singh Marway, Heather A Knauer, Constantijn Hazenberg, Joost van Herwaarden, C Alberto Figueroa, Himanshu J Patel, Nicholas S Burris","doi":"10.1007/s00330-024-11239-9","DOIUrl":"10.1007/s00330-024-11239-9","url":null,"abstract":"<p><strong>Purpose: </strong>We investigated pre-surgical arch growth by vascular deformation mapping (VDM) and examined how well proximal arch diameter indicates arch involvement by the primary ascending aneurysm.</p><p><strong>Methods and materials: </strong>A total of 123 patients who underwent elective repair of ascending thoracic aortic aneurysm (aTAA) with or without concomitant arch repair and had 2 or more pre-operative computed tomography angiography (CTA) studies with a minimum interval of > 22 months were included. We compared growth at the proximal arch measured by three-dimensional VDM analysis with standard diameter measurements in overall, dilated (≥ 40 mm), and non-dilated (< 40 mm) arch subgroups.</p><p><strong>Results: </strong>Concurrent (hemi)arch replacement was performed in 30% of patients. In 59% of patients, VDM growth and arch diameter assessments were concordant VDM growth rate was higher in the dilated arch group (0.46 mm/year vs 0.26 mm/year, p = 0.007), however, pre-operative proximal arch diameter was similar in growth and non-growing arches among patients without arch dilation (36.2 mm vs 35.9 mm). Among non-dilated arches, 26% demonstrated significant growth by VDM but not by standard diameter measurements. Arch growth assessments by VDM and standard diameter measurements agreed with 73%; discrepancies up to 6 mm were observed. Within the post-operative subgroup, 12 (55%) patients demonstrated growth (> 0.3 mm/year) of the native aortic arch, with most (7/12, 59%) having non-dilated arches on pre-operative CT.</p><p><strong>Conclusion: </strong>Reliable assessment of arch involvement in aTAA by diameter thresholds is limited. VDM analysis allows for a more comprehensive analysis of arch growth and involvement by the ascending aneurysm, which may be useful to advance patient-specific surgical planning.</p><p><strong>Key points: </strong>Question Can VDM measured proximal aortic arch diameter indicate proximal arch involvement by a primary ascending aneurysm? Findings Discrepancies between arch dilation status by conventional diameter thresholds and VDM exist; over half of patients with dilated proximal arches demonstrated no growth by VDM pre-operatively. Clinical relevance Arch involvement is common in ascending aortic aneurysms, though the degree of growth is not accurately assessed pre-operatively by standard measurements. VDM is an emerging technique that provides a three-dimensional assessment of arch growth and may inform patient-specific repair strategies.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"3508-3518"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninvasive identification of proliferative hepatocellular carcinoma on multiphase dynamic CT: quantitative and LI-RADS lexicon-based evaluation.","authors":"Wanli Zhang, Nan Li, Jiamin Li, Yue Zhao, Yi Long, Chutong He, Chuanxian Zhang, Bo Li, Yandong Zhao, Shengsheng Lai, Wenshuang Ding, Mingyong Gao, Lilian Tan, Xinhua Wei, Ruimeng Yang, Xinqing Jiang","doi":"10.1007/s00330-024-11247-9","DOIUrl":"10.1007/s00330-024-11247-9","url":null,"abstract":"<p><strong>Objective: </strong>To identify proliferative hepatocellular carcinoma (HCC) preoperatively using quantitative measurements combined with the updated standard 2021 LI-RADS universal lexicon-based qualitative features on multiphase dynamic CT (MDCT).</p><p><strong>Methods: </strong>We retrospectively analyzed 273 patients (102 proliferative HCCs) who underwent preoperative MDCT with surgically confirmed HCC in two medical centers. Imaging features were evaluated according to the updated 2021 LI-RADS universal lexicon, and quantitative measurements were analyzed. All MDCT findings and clinical factors were compared. Four predictive models (clinical, CT quantitative-clinical, CT qualitative-clinical, and combinational models) were developed and validated in an external cohort for identifying proliferative HCC. ROC analysis was used to assess model performances. All models were tested in a subgroup of patients with a single lesion ≤ 5 cm (n = 124).</p><p><strong>Results: </strong>Both the CT quantitative-clinical and CT qualitative-clinical models effectively identified proliferative HCC in the training and external validation cohorts (all AUCs > 0.79). The combinational model, integrating one clinical (AFP ≥ 200 ng/mL), three qualitative (rim arterial phase hyperenhancement (APHE), non-smooth tumor margin, and incomplete or absent capsule), and one quantitative feature (standardized tumor-to-aorta density ratio in portal venous phase ≤ (- 0.13), showed significant improvement in the training cohort (AUC 0.871) and comparable performance in the validation cohort (AUC 0.870). Additionally, AFP ≥ 200 ng/mL and Rim APHE were significantly associated with HCC recurrence (p < 0.05).</p><p><strong>Conclusions: </strong>The combinational model, integrating clinical, CT quantitative, and qualitative features, shows potential for the noninvasively preoperative prediction of proliferative HCC. Further validation is needed to establish its broader clinical utility.</p><p><strong>Key points: </strong>Question Preoperative identification of proliferative HCC could influence patient treatment and prognosis, yet there is no CT-based universally applicable model to identify this subtype. Findings The updated standard 2021 LI-RADS universal lexicon-based features, in combination with quantitative MDCT measurements, could aid in the noninvasive detection of proliferative HCC. Clinical relevance The updated standard 2021 LI-RADS universal lexicon-based CT qualitative features and quantitative measurements may aid in identifying proliferative HCC and tumor recurrence, offering potential guidance for personalized treatment. Further studies are required to assess their generalizability to different clinical scenarios.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"3460-3475"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PSMA PET/CT in staging recurrent prostate cancer: a viewfinder, not a compass.","authors":"Matteo Bauckneht, Riccardo Laudicella, Francesco Lanfranchi, Chiara Ciccarese","doi":"10.1007/s00330-024-11297-z","DOIUrl":"10.1007/s00330-024-11297-z","url":null,"abstract":"","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"3131-3133"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Super-delayed-phase imaging on gadoxetic acid-enhanced MRI: do we need it? Are there other alternatives for improving liver parenchymal enhancement?","authors":"Sarah Poetter-Lang, Ulrike Attenberger, Ahmed Ba-Ssalamah","doi":"10.1007/s00330-024-11298-y","DOIUrl":"10.1007/s00330-024-11298-y","url":null,"abstract":"","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"3192-3194"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ESR Essentials: gadolinium-wise MRI-practice recommendations by the European Society for Magnetic Resonance in Medicine and Biology.","authors":"Carlo C Quattrocchi, Àlex Rovira, Aart J van der Molen, Carlo A Mallio","doi":"10.1007/s00330-024-11214-4","DOIUrl":"10.1007/s00330-024-11214-4","url":null,"abstract":"<p><p>The Gadolinium Research and Education Committee (GREC) is a working group of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB), established in 2016. The aim of the committee is to monitor scientific evidence for a continuous quality and safety improvement of enhanced MRI using gadolinium-based contrast agents (GBCAs), and also assess potential alternatives. The scope of the present article is to describe the level of evidence concerning safety beyond the single patient (access to community and environmental impact), justification and optimization of the use of GBCAs beyond dosage (appropriateness and influence on clinical decision making), dose reduction with the use of AI (benefits and pitfalls), the advent of next-generation GBCAs (based on currently available data). CLINICAL RELEVANCE: GBCAs are extensively used in MRI and influence clinical decision-making. Their use to enhance the contrast-to-noise ratio is guided by recommendations from subspecialty societies. These guidelines advocate for GBCA use as an additional tool when necessary, ensuring they are administered at the lowest reasonable dose. KEY POINTS: The choice of GBCAs used in radiology should be based on MRI cost-effectiveness, MRI access to the patient community, and impact on the environment, (evidence level: low). GBCA optimization includes reducing GBCA volume burden and increasing appropriateness by including post-contrast enhancement in MRI protocols, depending on clinical indications, (evidence level: moderate). Next-generation GBCAs show higher kinetic stability and higher T1 relaxivity when compared with standard macrocyclic GBCAs allowing comparable diagnostic accuracy at lower doses, (evidence level: moderate).</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"3347-3353"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of four-dimensional flow MRI for prediction of varices risk in cirrhotic patients.","authors":"Qinqin Hu, Gangjing Li, Dechuan Zhang, Yang Jiang, Lisha Nie, Huiping Yang, Hua Yang","doi":"10.1007/s00330-024-11222-4","DOIUrl":"10.1007/s00330-024-11222-4","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to validate the application of abdominal four-dimensional flow magnetic resonance imaging (MRI) for cirrhotic patients and quantify its effectiveness in assessing the hemodynamic impacts of cirrhosis to evaluate varices.</p><p><strong>Methods: </strong>All consecutive patients who underwent MRIs between September 2022 and June 2023 were enrolled. Groups were divided into varicose, non-varicose, and healthy groups. ANOVA and post hoc LSD-t tests were used for statistical analysis. The correlation between hemodynamic parameters and liver function grade was evaluated using Kendall's correlation coefficient.</p><p><strong>Results: </strong>A total of 80 patients were included (53 cirrhotic, 27 healthy). Significant disparities were found in main portal vein flow (MPV-FR), splenic vein flow (SV-FR), and vessel diameters (MPV-VD, SV-VD) among the groups (p < 0.05). MPV-FR was higher in the varicose group (24.81 ± 8.52) compared to non-varicose (19.52 ± 5.07) and healthy groups (17.26 ± 5.48). The most robust assessment of variceal risk was achieved by combining the flow rates (FRs) and VDs of MPV and SV (AUC 0.83, 95% CI 0.72-0.94).</p><p><strong>Conclusion: </strong>The combined indices of FRs and VDs of MPV and SV effectively predict the occurrence of varicose veins in cirrhotic patients.</p><p><strong>Key points: </strong>Question Non-invasive prediction of variceal risk is essential for the clinical management of advanced chronic cirrhosis, yet existing clinical examinations are inadequate. Findings The effective assessment of variceal risk was achieved by combining the flow rates and vessel diameters of the main portal vein and splenic vein. Clinical relevance Four-dimensional flow MRI can reveal hemodynamic changes in cirrhotic patients and assist in identifying gastroesophageal varices, serving as a marker for varices risk prediction.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"3568-3575"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142727271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fat fraction quantification by MRI predicts diagnosis and prognosis of HBV-related steatohepatitic hepatocellular carcinoma.","authors":"Laizhu Zhang, Xiaoli Mai, Binghua Li, Huan Li, Qi Liu, Yunzheng Li, Yican Zhu, Xiang Jiang, Weihong Wang, Chu Qiao, Jun Chen, Chun Xu, Jun Chen, Decai Yu","doi":"10.1007/s00330-024-11151-2","DOIUrl":"10.1007/s00330-024-11151-2","url":null,"abstract":"<p><strong>Objectives: </strong>This study explored the clinical prognosis and lipidomics of hepatitis B virus steatohepatitic hepatocellular carcinoma (HBV-SHHCC) and aimed to identify a noninvasive and convenient method to diagnose this phenotype and guide treatment using MRI.</p><p><strong>Methods: </strong>A total of 433 HBV-infected HCC patients were enrolled in this retrospective study. Survival data were analyzed using Cox regression analyses, and lipidomics was used to study HCC tissue composition. Logistic regression identified an independent predictor for HBV-SHHCC, and receiver-operating characteristic (ROC) analysis verified its discrimination.</p><p><strong>Results: </strong>HBV-SHHCC patients had longer disease-free survival (DFS, p < 0.0001) and overall survival (OS) time (p = 0.00097). Compared with common HCC (cHCC), SHHCC was associated with significantly higher mean triacylglyceride (p = 0.010) and diacylglyceride contents (p = 0.002) in tumor tissues. Fat fraction (FF) was linearly correlated with lipid composition and fatty acid degradation (FAD) subtype, which could help in treatment options for HCC. The univariate and multivariate logistic regression indicated FF (p < 0.001) as an independent predictor for diagnosing this phenotype. ROC analysis confirmed excellent discrimination (area under the curve (AUC), 0.914; sensitivity, 92.3%; specificity, 78.7.0%). After using the optimal cutoff point, the DFS time of patients with SHHCC stratified by FF was significantly higher than that of patients with cHCC.</p><p><strong>Conclusion: </strong>The biological behavior and prognosis of HBV-SHHCC were better than those of other types. FF is a valuable tool for the clinical diagnosis of SHHCC, prognosis prediction, and treatment guidance in patients with HCC.</p><p><strong>Key points: </strong>Question Can the diagnosis of steatohepatitic hepatocellular carcinoma (SHHCC) be made noninvasively? Findings Fat fraction (FF) correlated with lipid composition and could be used to diagnose SHHCC with an AUC of 0.914, sensitivity of 92.3%, and specificity of 78.7%. Clinical relevance MRI-based FF could be used to diagnose HBV-related SHHCC, indicate prognosis, and guide the clinical treatment of patients with HCC.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"3144-3157"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photon-counting detector CT provides superior subsolid nodule characterization compared to same-day energy-integrating detector CT.","authors":"Jinhua Wang, Zhicheng Huang, Zhenchen Zhu, Baiyu Wang, Wei Han, Ge Hu, Zhoumeng Ying, Yang Yu, Yadong Wang, Zhengsong Pan, Daoyun Wang, Yang Song, Haochen Li, Lei Liu, Lan Song, Naixin Liang, Wei Song","doi":"10.1007/s00330-024-11204-6","DOIUrl":"10.1007/s00330-024-11204-6","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the image quality and the performance of photon-counting detector (PCD) CT compared to conventional energy-integrating detector (EID) CT in identifying subsolid nodule (SSN) characteristics.</p><p><strong>Materials and methods: </strong>Participants with SSNs who underwent same-day EID CT and PCD CT between October 2023 and April 2024 were prospectively included. The 1.0 mm EID CT images and, subsequently, 1.0 mm, 0.4 mm, and 0.2 mm PCD CT images were reviewed to assess image noise and subjective image quality on a 5-point Likert scale. SSN characteristics, including lobulation, spiculation, pleural retraction, air cavities, intra-nodular vessel signs, internal vascular changes, and heterogeneous solid components, were evaluated. Additionally, a step-by-step observation and comparison method was used to determine the presence of any additional characteristics.</p><p><strong>Results: </strong>Forty-eight participants (mean age: 56 ± 11 years; 16 males) with 89 SSNs were included. PCD CT significantly reduced radiation dose when using matched scans (1.79 ± 0.39 vs 2.17 ± 0.57 mSv, p < 0.001). Compared to 1.0 mm EID CT, 1.0 mm PCD CT images exhibited significantly lower objective image noise and higher subjective image quality (all p < 0.001). Compared to EID CT, PCD CT demonstrated enhanced visualization of subtle characteristics, except for lobulation, with a 0.4 mm section thickness offering a favorable balance between ultra-high resolution and perceived image quality for radiologists.</p><p><strong>Conclusion: </strong>PCD CT facilitated radiation dose reduction and outperformed conventional EID CT in terms of image quality and visualization of SSN characteristics.</p><p><strong>Key points: </strong>Question PCD CT, featuring ultra-high-resolution mode acquisition and a thinner reconstruction, has not been fully explored for characterizing SSNs. Findings Compared to EID CT, PCD CT was associated with lower objective image noise, higher subjective image quality, and superior SSN characterization. Clinical relevance PCD CT effectively reduced the radiation dose delivered to the patients and enabled more precise SSN characterization.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"2979-2989"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}