European RadiologyPub Date : 2025-10-01Epub Date: 2025-04-11DOI: 10.1007/s00330-025-11558-5
Wenlong Song, Yang Xu, Jun Zhou, Jiayi Yu, Xiaojing He, Caiming Jiang, Dajing Guo
{"title":"Predicting postresection outcomes in solitary small hepatocellular carcinoma via pretreatment MR imaging features: subgroup analysis according to alpha-fetoprotein expression.","authors":"Wenlong Song, Yang Xu, Jun Zhou, Jiayi Yu, Xiaojing He, Caiming Jiang, Dajing Guo","doi":"10.1007/s00330-025-11558-5","DOIUrl":"10.1007/s00330-025-11558-5","url":null,"abstract":"<p><strong>Objectives: </strong>To develop models including MRI features for predicting recurrence-free survival (RFS) in patients with solitary small hepatocellular carcinoma (SHCC) following curative resection according to alpha-fetoprotein (AFP) expression and for achieving risk stratification.</p><p><strong>Materials and methods: </strong>A total of 201 solitary SHCC patients diagnosed pathologically who underwent MRI were enrolled retrospectively and divided into AFP-negative (n = 85) and AFP-positive (n = 116) SHCC groups. Clinicopathological factors, imaging features, and geometric parameters associated with RFS were determined by univariate and multivariate Cox analyses. Two prognostic models predicting postresection RFS were developed by multivariate Cox proportional hazard model, and their discriminatory ability was evaluated by the concordance index (C-index) and conducted internal validation. Kaplan‒Meier analysis with RFS as the endpoint was used to assess model performance.</p><p><strong>Results: </strong>The predictors of RFS in AFP-negative SHCC included mosaic architecture, portal-venous phase tumor-to-right erector spinae muscle signal intensity ratio, and sphericity, whereas those in AFP-positive SHCC were liver cirrhosis, tumor growth subtype, and asphericity. The C-indexes of the models in predicting RFS in AFP-negative and AFP-positive SHCC were 0.700 and 0.717, respectively. The risk probability calculated with the models stratified the two patient subgroups into two risk groups with significantly different survival outcomes (p < 0.001).</p><p><strong>Conclusion: </strong>Our two prognostic models may assist physicians in stratifying risk and monitoring relapses in patients with AFP-negative or AFP-positive solitary SHCCs.</p><p><strong>Key points: </strong>Question This study explored the predictors of the postresection outcomes of patients with small hepatocellular carcinoma according to the level of alpha-fetoprotein expression. Findings Pretreatment MRI and geometric features can serve as prognostic markers for predicting postoperative recurrence-free survival of small hepatocellular carcinoma with different alpha-fetoprotein expression. Clinical relevance Our models guide clinicians in administering appropriate therapeutic decisions and implementing proper postoperative monitoring regimens in different alpha-fetoprotein expression small hepatocellular carcinoma patients.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"6527-6540"},"PeriodicalIF":4.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European RadiologyPub Date : 2025-10-01Epub Date: 2025-04-16DOI: 10.1007/s00330-025-11575-4
Dejun She, Yalan Yan, Junhuan Hong, Dongmei Jiang, Hao Jiang, Ying Zou, Xiance Zhao, Dairong Cao
{"title":"The value of MR neurography in assessing lesions of the thoracic dorsal root ganglia in patients with zoster-associated pain.","authors":"Dejun She, Yalan Yan, Junhuan Hong, Dongmei Jiang, Hao Jiang, Ying Zou, Xiance Zhao, Dairong Cao","doi":"10.1007/s00330-025-11575-4","DOIUrl":"10.1007/s00330-025-11575-4","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the imaging characteristics of the thoracic dorsal root ganglia (DRG) in patients with zoster-associated pain (ZAP) using magnetic resonance neurography (MRN) and its correlation with disease stages and serological marker.</p><p><strong>Methods: </strong>Twenty-six consecutive ZAP patients with different disease stages (acute herpes neuralgia, subacute herpes neuralgia, and postherpetic neuralgia) and thirteen healthy subjects were scanned on a 3-T MR scanner for thoracic DRG visualization. The T<sub>1</sub>-T<sub>12</sub> DRG for each ZAP patient were divided into three groups (prominent affected segment, rash distribution segment, and non-rash distribution segment). The volume and T2 signal intensity (SI) of thoracic DRG were measured and compared. The visual analog scale (VAS) and serological data were also recorded.</p><p><strong>Results: </strong>The volume ratio of prominent affected thoracic DRG in ZAP patients was larger than that in non-rash distribution segment of ZAP patients and that in the healthy group, respectively (both p < 0.05). The volume ratio of affected DRG in the acute herpes neuralgia and subacute herpes neuralgia group was both higher than that in the postherpetic neuralgia group (both p < 0.05). For T2 SI, no differences were found among three disease stages. The ESR index was the only parameter associated with volume ratio of prominent affected DRG segment (r = 0.48, p = 0.01).</p><p><strong>Conclusion: </strong>MRN is able to visualize and identify morphological changes of thoracic DRG of ZAP patients. The imaging characteristics of affected thoracic DRG exhibit differences across different disease stages, which was associated with ESR index in ZAP patients.</p><p><strong>Key points: </strong>Question Magnetic resonance neurography is able to detect the abnormal imaging features of dorsal root ganglia (DRG) in zoster-associated pain patients. Findings Magnetic resonance neurography (MRN) demonstrates a difference in the volume ratio of affected DRG among three disease stages in zoster-associated pain (ZAP) patients. Clinical relevance Combining serological parameter with observed thoracic DRG volume changes on MRN may serve as a viable predictor for ZAP development.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"6207-6216"},"PeriodicalIF":4.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of antiplatelet therapy on reducing stroke risk in patients with moyamoya disease: the role of postcontrast MR vessel wall imaging.","authors":"Mingming Lu, Hongtao Zhang, Shitong Liu, Yuan Liu, Baobao Li, Fangbin Hao, Peng Peng, Fugeng Sheng, Xihai Zhao, Fei Yuan, Cong Han, Jianming Cai","doi":"10.1007/s00330-025-11562-9","DOIUrl":"10.1007/s00330-025-11562-9","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the role of vessel wall enhancement in the efficacy of antiplatelet therapy (APT) on reducing the stroke risk in patients with Moyamoya disease (MMD) based on postcontrast MR vessel wall imaging.</p><p><strong>Methods: </strong>Consecutive patients with MMD underwent postcontrast MR vessel wall imaging and were divided into APT and non-APT groups according to the prescribed antiplatelet agents. Kaplan-Meier survival and Cox regression analyses were performed to determine the association between APT and stroke risk of patients with MMD, and subgroup analysis was performed to determine the role of vessel wall enhancement in reducing stroke risk after APT.</p><p><strong>Results: </strong>A total of 1262 patients (mean age: 42.6 ± 11.1 years) were finally included for analysis. Compared with patients without APT, those with APT were older (p = 0.023) and had a higher incidence of hypertension (p = 0.015), and with advanced Suzuki stage (≥ IV) (p < 0.001). During an average follow-up of 37.9 months, patients without APT had a marginally greater incidence of cerebrovascular events (12.9% vs. 9.7%; HR p = 0.069) than those who underwent APT before and after propensity score matching. The subgroup analyses revealed that vessel wall enhancement had a significant interaction effect on the association between APT and stroke outcomes, and APT could significantly reduce stroke risk in MMD patients with vessel wall enhancement (HR = 0.43; 95% CI: 0.23-0.79, interaction p = 0.038).</p><p><strong>Conclusion: </strong>APT may significantly reduce stroke risk in patients with MMD with vessel wall enhancement.</p><p><strong>Key points: </strong>Question The effect of antiplatelet therapy (APT) varies in patients with moyamoya disease (MMD). Findings APT may significantly reduce stroke risk for MMD patients with vessel wall enhancement. Clinical relevance Post-contrast high-resolution MRI may help identify MMD patients who would mostly benefit from APT; APT should be highly recommended in MMD patients with vessel wall enhancement.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"5911-5921"},"PeriodicalIF":4.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European RadiologyPub Date : 2025-10-01Epub Date: 2025-04-13DOI: 10.1007/s00330-025-11567-4
Lin Zhu, Qian Li, Oyunbileg von Stackelberg, Simon M F Triphan, Jürgen Biederer, Oliver Weinheimer, Monika Eichinger, Claus F Vogelmeier, Rudolf A Jörres, Hans-Ulrich Kauczor, Claus P Heußel, Bertram J Jobst, Hong Yu, Mark O Wielpütz
{"title":"Longitudinal MRI in comparison to low-dose CT for follow-up of incidental pulmonary nodules in patients with COPD-a nationwide multicenter trial.","authors":"Lin Zhu, Qian Li, Oyunbileg von Stackelberg, Simon M F Triphan, Jürgen Biederer, Oliver Weinheimer, Monika Eichinger, Claus F Vogelmeier, Rudolf A Jörres, Hans-Ulrich Kauczor, Claus P Heußel, Bertram J Jobst, Hong Yu, Mark O Wielpütz","doi":"10.1007/s00330-025-11567-4","DOIUrl":"10.1007/s00330-025-11567-4","url":null,"abstract":"<p><strong>Purpose: </strong>This multicenter trial was conducted to evaluate MRI for the longitudinal management of incidental pulmonary nodules in heavy smokers.</p><p><strong>Materials and methods: </strong>239 participants (63.9 ± 8.4 years, 43-82 years) at risk of or with COPD GOLDI-IV from 16 centers prospectively underwent two rounds of same-day low-dose computed tomography (LDCT1&2) and MRI1&2 at an interval of three years in the nationwide COSYCONET trial. All exams were independently assessed for incidental pulmonary nodules in a standardized fashion by two blinded readers, incl. axis measurements and Lung-RADS categorization, with consensual LDCT results serving as the standard of reference. A change in diameter ≥ 2 mm was rated as progress. 11 patients underwent surgery for suspicious nodules after the first round.</p><p><strong>Results: </strong>Two hundred twenty-four of two hundred forty nodules (93.3%) persisted from LDCT1 to LDCT2, with a sensitivity of MRI2 of 82.8% and 81.5% for readers 1 and 2, respectively. Agreement in Lung-RADS categories between LDCT2 and MRI2 was substantial in per-nodule (κ = 0.62-0.70) and excellent in a per-patient (κ = 0.86-0.88) approach for both readers, respectively. Concordance between LDCT2 and MRI2 for growth was excellent to almost perfect (κ = 0.88-1.0). The accuracy of LDCT1 and MRI1 for lung cancer was 87.5%. Lung-RADS ≥ 3 category on MRI1 had higher accuracy for predicting progress (23.1% and 21.4%, respectively) than LDCT1 (15.8%).</p><p><strong>Conclusion: </strong>Compared to LDCT, MRI shows similar capabilities for the longitudinal evaluation of incidental nodules in heavy smokers. Decision-making for nodule management guided by Lung-RADS seems feasible based on longitudinal MRI.</p><p><strong>Key points: </strong>Question Can MRI serve as an alternative to low-dose CT (LDCT) for the longitudinal management of pulmonary nodules in heavy smokers, addressing concerns over radiation exposure? Findings MRI demonstrated substantial agreement with LDCT in detecting nodule growth, accurately categorizing Lung-RADS, and comparable accuracy in identifying malignancy over a three-year follow-up. Clinical relevance Longitudinal MRI demonstrates high consistency with LDCT in assessing the growth of incidental pulmonary nodules and categorizing per-patient Lung-RADS, offering a reliable, radiation-free alternative for monitoring and early malignancy detection in high-risk populations.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"6336-6349"},"PeriodicalIF":4.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European RadiologyPub Date : 2025-10-01Epub Date: 2025-04-11DOI: 10.1007/s00330-025-11564-7
Yassine N Azma, Nada Boci, Katarzyna Abramowicz, Luca Russo, Matthew R Orton, Nina Tunariu, Dow-Mu Koh, Geoffrey Charles-Edwards, David J Collins, Jessica M Winfield
{"title":"Influence of imaging method on fat fraction estimation for assessing bone marrow in metastatic prostate cancer.","authors":"Yassine N Azma, Nada Boci, Katarzyna Abramowicz, Luca Russo, Matthew R Orton, Nina Tunariu, Dow-Mu Koh, Geoffrey Charles-Edwards, David J Collins, Jessica M Winfield","doi":"10.1007/s00330-025-11564-7","DOIUrl":"10.1007/s00330-025-11564-7","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the accuracy of fat fraction estimation with clinically available Dixon sequences in normal-appearing marrow and bone metastases in the pelvis of metastatic prostate cancer patients.</p><p><strong>Methods: </strong>A prospective single-centre study was conducted with metastatic prostate cancer patients and healthy volunteers. Linearity and bias of fat fraction estimates from clinically available Dixon sequences were assessed against a 6-point PDw gradient echo (q-Dixon) sequence measuring the reference standard proton density fat fraction. Lesion fat fraction estimates were cross-compared using the Friedman test. Repeatability in volunteers was evaluated with Bland-Altman plots. Sensitivity of fat fraction estimates using TSE-Dixon sequences to specific absorption rate (SAR) related modifications were evaluated with correlation plots.</p><p><strong>Results: </strong>Thirty-three patients were recruited for this study. Significant (p < 0.05) absolute bias (12.4%) was demonstrated in the T1-weighted (T1w) Dixon measurements against the q-Dixon. Significant differences (p < 0.05) between fat fraction estimates provided by the T1w Dixon and PDw Dixon sequences were observed in 13 active and 6 treated lesions. Repeatability coefficients for fat fraction estimates ranged from 5.9 to 9.0% in the pelvic tissues of healthy volunteers. Reduction of slice number with repetition time for SAR had the greatest effect, reaching a maximum difference in fat fraction of 14.7% from the q-Dixon for the T2w-TSE Dixon in bone marrow.</p><p><strong>Conclusions: </strong>T1w Dixon methods can detect post-treatment changes but remain confounded by relaxation time biases. While all Dixon methods showed good repeatability, careful choice of SAR-related modifications is critical to maintaining accuracy for PD- and T2-weighted TSE sequences.</p><p><strong>Key points: </strong>Question The clinical validity of signal-weighted fat fraction estimates versus proton density fat fraction for characterising metastatic bone lesions has not been fully assessed. Findings T1-weighted Dixon sequences in line with whole-body MRI international guidelines demonstrate significant fat fraction bias, particularly in lesions and muscle. Clinical relevance Fat fraction estimation using T1-weighted Dixon sequences recommended in international guidelines are highly sensitive to relaxation time biases, making underlying physiological changes potentially ambiguous.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"6039-6051"},"PeriodicalIF":4.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European RadiologyPub Date : 2025-10-01Epub Date: 2025-04-16DOI: 10.1007/s00330-025-11544-x
David R van Nederpelt, Zoe C Mendelsohn, Lonneke Bos, Rozemarijn M Mattiesing, Olga Ciccarelli, Jaume Sastre-Garriga, Ferran Prados Carrasco, Joost P A Kuijer, Hugo Vrenken, Joep Killestein, Menno M Schoonheim, Bastiaan Moraal, Tarek Yousry, Giuseppe Pontillo, Àlex Rovira, Eva M M Strijbis, Bas Jasperse, Frederik Barkhof
{"title":"User requirements for quantitative radiological reports in multiple sclerosis.","authors":"David R van Nederpelt, Zoe C Mendelsohn, Lonneke Bos, Rozemarijn M Mattiesing, Olga Ciccarelli, Jaume Sastre-Garriga, Ferran Prados Carrasco, Joost P A Kuijer, Hugo Vrenken, Joep Killestein, Menno M Schoonheim, Bastiaan Moraal, Tarek Yousry, Giuseppe Pontillo, Àlex Rovira, Eva M M Strijbis, Bas Jasperse, Frederik Barkhof","doi":"10.1007/s00330-025-11544-x","DOIUrl":"10.1007/s00330-025-11544-x","url":null,"abstract":"<p><strong>Objectives: </strong>Quantitative radiological reports (QReports) can enhance clinical management of multiple sclerosis (MS) by including quantitative data from MRI scans. However, the lack of consensus on the specific information to include, on and clinicians' preferences, hinders the adoption of these imaging analysis tools. This study aims to facilitate the clinical implementation of QReports by determining clinicians' requirements regarding their use in MS management.</p><p><strong>Materials and methods: </strong>A four-phase Delphi panel approach was employed, involving neurologists and (neuro)radiologists across Europe. Initial interviews with experts helped develop a questionnaire addressing various QReport aspects. This questionnaire underwent refinement based on feedback and was distributed through the MAGNIMS network. A second questionnaire, incorporating additional questions, was circulated following a plenary discussion at the MAGNIMS workshop in Milan in November 2023. Responses from both questionnaire iterations were collected and analyzed, with adjustments made based on participant feedback.</p><p><strong>Results: </strong>The study achieved a 49.6% response rate, involving 78 respondents. Key preferences and barriers to QReport adoption were identified, highlighting the importance of integration into clinical workflows, cost-effectiveness, educational support for interpretation, and validation standards. Strong consensus emerged on including detailed lesion information and specific brain and spinal cord volume measurements. Concerns regarding report generation time, data protection, and reliability were also raised.</p><p><strong>Conclusion: </strong>While QReports show potential for improving MS management, incorporation of the key metrics and addressing the identified barriers related to cost, validation, integration, and clinician education is crucial for practical implementation. These recommendations for developers to refine QReports could enhance their utility and adoption in clinical practice.</p><p><strong>Key points: </strong>Question A lack of consensus on essential features for quantitative magnetic resonance imaging reports limits their integration into multiple sclerosis management. Findings This study identified key preferences, including detailed lesion information, specific brain and spinal cord measurements, and rigorous validation for effective quantitative reports. Clinical relevance This study identified essential features and barriers for implementing quantitative radiological reports in multiple sclerosis management, aiming to enhance clinical workflows, improve disease monitoring, and ultimately provide better, data-driven care for patients through tailored imaging solutions.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"5967-5978"},"PeriodicalIF":4.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European RadiologyPub Date : 2025-10-01Epub Date: 2025-04-11DOI: 10.1007/s00330-025-11526-z
Yuguo Wei, Xinchao Jiang, Mark Hibberd, Alexis Sampedro, Jeannette Rautenbach
{"title":"Estimating the rate of acute adverse reactions to non-ionic low-osmolar contrast media: a systematic review and meta-analysis.","authors":"Yuguo Wei, Xinchao Jiang, Mark Hibberd, Alexis Sampedro, Jeannette Rautenbach","doi":"10.1007/s00330-025-11526-z","DOIUrl":"10.1007/s00330-025-11526-z","url":null,"abstract":"<p><strong>Objectives: </strong>This systematic review and meta-analysis aimed to assess and compare acute adverse reactions (AAR) rates among non-ionic low-osmolar contrast media (LOCM), examining administration routes and severity-specific impact on AAR rates.</p><p><strong>Materials and methods: </strong>A PubMed and Cochrane Library search identified studies published between January 1989 and March 2024. Inclusion criteria focused on studies with > 100 adult patients who received intra-arterial or intravenous LOCM (iobitridol, iohexol, iomeprol, iopamidol, iopromide, and ioversol). Duplicate reports and studies with insufficient information were excluded. Data extraction and quality assessment followed PRISMA guidelines and the Newcastle Ottawa Scale. Statistical analyses were performed using R software, including random effects, meta-regression, and sub-group analysis.</p><p><strong>Results: </strong>After excluding duplicates and non-compliant studies, 32 peer-reviewed articles of initially 6701 identified studies, were included in the final analysis. The pooled overall AAR rate was 0.73%, with ioversol showing the lowest rate (0.34%). From all studies, pooled rates (random effects model) of moderate and severe AARs were 0.10% and 0.014% (p < 0.01), with the lowest rates for iohexol (0.05% and 0.008%, respectively). The highest overall, moderate, and severe AAR rates were seen with iomeprol (1.38%, 0.27%, and 0.040%, respectively). LOCM type (p < 0.0001), study design (p = 0.0001), and injection route (p = 0.034) significantly influenced the overall AAR rate. In contrast, the study center number (p = 0.698), the country where the study was performed (p = 0.808), and the type of reaction (hypersensitivity vs hypersensitivity plus physiological reactions; p = 0.178) did not.</p><p><strong>Conclusion: </strong>AAR rates were low but indicated significant differences between LOCM; iohexol and ioversol demonstrated the overall most favorable safety profiles.</p><p><strong>Key points: </strong>Question Knowledge about AAR is crucial for patient safety, but comprehensive data on the safety profiles of non-ionic LOCM is lacking. Findings Ioversol showed the lowest overall AAR rate; iohexol demonstrated the lowest moderate/severe AAR. Study design, LOCM type, and injection route influenced AAR rates. Clinical relevance This meta-analysis provides evidence for differences in non-ionic LOCM safety profiles, particularly for moderate and severe AARs. These can guide clinicians in selecting contrast agents, aiming to further reduce risks, and improve patient safety in diagnostic imaging.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"6240-6249"},"PeriodicalIF":4.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European RadiologyPub Date : 2025-10-01Epub Date: 2025-04-07DOI: 10.1007/s00330-025-11537-w
Menglong Zhao, Huaili Jiang, Shujie Zhang, Kai Liu, Lei Zhou, Di Wu, Xixi Wen, Junpu Hu, Xuan Wang, Zhuang Liu, Yan Sha, Mengsu Zeng
{"title":"Reply to the Letter to the Editor: \"An unenhanced 3D-FLAIR sequence using long repetition time and constant flip angle to image endolymphatic hydrops\".","authors":"Menglong Zhao, Huaili Jiang, Shujie Zhang, Kai Liu, Lei Zhou, Di Wu, Xixi Wen, Junpu Hu, Xuan Wang, Zhuang Liu, Yan Sha, Mengsu Zeng","doi":"10.1007/s00330-025-11537-w","DOIUrl":"10.1007/s00330-025-11537-w","url":null,"abstract":"","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"6610-6611"},"PeriodicalIF":4.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European RadiologyPub Date : 2025-10-01Epub Date: 2025-04-23DOI: 10.1007/s00330-025-11600-6
Ramiro J Méndez
{"title":"CT evaluation of response in locally advanced gastric cancer. Is it time for a change?","authors":"Ramiro J Méndez","doi":"10.1007/s00330-025-11600-6","DOIUrl":"10.1007/s00330-025-11600-6","url":null,"abstract":"","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"6466-6468"},"PeriodicalIF":4.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}