European Radiology最新文献

{"title":"Ovarian-Adnexal Imaging-Reporting and Data System (O-RADS) ultrasound version 2019: a prospective validation and comparison to updated version (v2022) in pathologically confirmed adnexal masses.","authors":"Yassir Edrees Almalki, Mohammad Abd Alkhalik Basha, Mohamad Gamal Nada, Maha Ibrahim Metwally, Yasmin Ibrahim Libda, Noha Yahia Ebaid, Mohamed M A Zaitoun, Nader E M Mahmoud, Amgad M Elsheikh, Mohamed Hesham Saleh Saleh Radwan, Mohamed I Amin, Elshaimaa Mohamed Mohamed, Engy Fathy Tantawy, Sameh Saber, Walid Mosallam, Housseini Mohamed Abdalla, Mohamed Abd El-Aziz Mohamed Farag, Tamer Mahmoud Dawoud, Hamada M Khater, Diaa Bakry Eldib, Jehan Ibrahim Altohamy, Rasha Taha Abouelkheir, Waseem M El Gendy, Sharifa Khalid Alduraibi, Majed Saeed Alshahrani, Safaa A Ibrahim, Ahmed M Radwan, Ahmed Ali Obaya, Ahmed M Abdelkhalik Basha, Ahmed Mohamed El-Maghraby","doi":"10.1007/s00330-024-11235-z","DOIUrl":"10.1007/s00330-024-11235-z","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the diagnostic accuracy and reliability of the Ovarian-Adnexal Reporting and Data System (O-RADS) ultrasound v2019 in classifying adnexal masses (AMs) and compare the old and updated systems (v2022).</p><p><strong>Patients and methods: </strong>This prospective study enrolled 977 consecutive women with suspected AMs from three institutions between January 2022 and December 2023. Ultrasound examinations were performed by three experienced radiologists who categorized AMs according to O-RADS ultrasound v2019. The same radiologists retrospectively reviewed the stored ultrasound images and provided the O-RADS ultrasound v2022 classification. Histopathology was used as the reference standard to calculate the diagnostic accuracy of the O-RADS versions in predicting malignant AMs. Inter-observer agreement (IOA) of the O-RADS scoring results was evaluated using the Fleiss kappa (κ) test.</p><p><strong>Results: </strong>The final analysis included 803 women with 855 AMs (219 (25.6%) malignant and 636 (74.4%) benign). Both O-RADS versions demonstrated good diagnostic accuracy, with area under the curve (AUC) values ranging from 0.906 to 0.923 (v2019) and 0.919 to 0.936 (v2022). The updated v2022 showed a slightly higher accuracy (82.5-86.7% vs. 80.7-85.3%), sensitivity (93.6-95.0% vs. 92.2-94.1%), and specificity (78.1-84.1% vs. 76.1-82.9%) compared to v2019. The IOA for the overall O-RADS classification was perfect for both versions (κ = 0.96-0.97).</p><p><strong>Conclusions: </strong>The O-RADS ultrasound classification system demonstrated good diagnostic accuracy and reliability in predicting malignant AMs, with the updated v2022 showing modest improvements.</p><p><strong>Key points: </strong>Question Accurate classification of adnexal masses is essential for management. Can updated O-RADS ultrasound v2022 improve diagnostic accuracy and reliability compared to v2019 in predicting malignancies? Findings O-RADS ultrasound v2022 demonstrated slightly higher diagnostic accuracy for identifying malignant adnexal masses compared to v2019, reflecting modest improvements in risk stratification and clinical decision-making. Clinical relevance The updated O-RADS ultrasound v2022 provides improved risk stratification for adnexal masses, enhancing diagnostic confidence, supporting more precise clinical decision-making, and improving patient outcomes through timely intervention or tailored management strategies in ovarian cancer care.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"3080-3095"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel hybrid model for predicting tertiary lymphoid structures and targeted immunotherapy outcomes in hepatocellular carcinoma: a multicenter retrospective study.","authors":"Yiman Li, Xiaofeng Li, Xixi Xiao, Jie Cheng, Qingrui Li, Chen Liu, Ping Cai, Wei Chen, Huarong Zhang, Xiaoming Li","doi":"10.1007/s00330-024-11255-9","DOIUrl":"10.1007/s00330-024-11255-9","url":null,"abstract":"<p><strong>Objective: </strong>To develop a novel hybrid model for preoperative prediction of tertiary lymphoid structures (TLSs) of hepatocellular carcinoma (HCC), and to identify patients who may benefit from postoperative targeted immunotherapy.</p><p><strong>Methods: </strong>Retrospective data were gathered from 332 patients with HCC who underwent surgical resection and gadoxetate disodium (Gd-EOB-DTPA) enhanced MRI at two tertiary hospitals (training cohort, n = 205; internal validation cohort, n = 90; and external validation cohort, n = 37) between March 2020 and January 2023. Radiomic features were extracted from Gd-EOB-DTPA-enhanced MRI sequences. These signatures were integrated with clinical-radiologic (CR) factors into a hybrid model and nomogram for clinical application. The performance of the model was assessed using the area under the curve (AUC) and 95% confidence intervals (CI).</p><p><strong>Results: </strong>The hybrid model outperformed the radiomics and CR models in the training cohort (AUC = 0.860 [95% CI: 0.805, 0.904], 0.784 [95% CI: 0.721, 0.838], and 0.809 [95% CI: 0.748, 0.860]). The hybrid model showed optimal performance, with AUCs of 0.823 (95% CI: 0.728, 0.895) and 0.875 (95% CI: 0.725, 0.960) in the internal and external validation cohorts, respectively. The calibration curve demonstrated that the nomogram had good diagnostic ability, and decision curve analysis indicated good clinical utility across all cohorts. Importantly, patients with a predicted high risk of TLSs from the hybrid model gained a survival benefit from targeted immunotherapy.</p><p><strong>Conclusion: </strong>The hybrid model showed satisfactory performance in predicting intra-tumoral TLS positivity and targeted immunotherapy benefit in patients with HCC, potentially assisting clinicians in selecting precise individualized therapies.</p><p><strong>Key points: </strong>Question How can accurate preoperative risk stratification of tertiary lymphoid structures positivity HCC be achieved to support targeted immunotherapy decision-making? Findings A hybrid model combining radiomics model and clinical-radiological model may be a reliable marker for predicting tertiary lymphoid structures positivity HCC. Clinical relevance Using this hybrid model may be useful in predicting tertiary lymphoid structures and screening candidate patients for targeted immunotherapy based on multiparametric MRI, which has potential clinical value in guiding clinical decision-making and improving patient outcomes.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"3206-3222"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A predictive model for cerebellar mutism syndrome based on lesion map in children with medulloblastoma.","authors":"Wei Yang, Sikang Ren, Yiming Li, Yingjie Cai, Xiaojiao Peng, Hailang Sun, Jiashu Chen, Xinyi Chai, Hong Zhang, Kaiyi Zhu, Wenping Ma, Yongji Tian, Ming Ge","doi":"10.1007/s00330-024-11264-8","DOIUrl":"10.1007/s00330-024-11264-8","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to establish a voxel-based map to predict the occurrence of cerebellar mutism syndrome (CMS) and investigate the relationship between CMS and motor dysfunction.</p><p><strong>Method: </strong>This multicenter study cohort included 224 patients diagnosed with medulloblastoma at Beijing Children's Hospital (n = 88) and Beijing Tiantan Hospital (n = 136). The dataset was randomly divided into training (n = 95), test (n = 41), and validation (n = 88) datasets. Voxel-based lesion-symptom mapping (VLSM) was used to identify the corresponding tumoral voxels for CMS and motor dysfunction. A prediction model was constructed based on the VLSM results.</p><p><strong>Results: </strong>The two cohorts showed significant differences in hydrocephalus (58.0 vs. 32.4%, p < 0.001), paraventricular edema (83.0 vs. 59.6%, p < 0.001), and presurgical ventricular-peritoneal shunt placement (53.7 vs. 10.2%, p < 0.001). The CMS group had a significantly higher rate of hydrocephalus than the non-CMS group (54.6 vs. 33.1%; p = 0.002). VLSM revealed that the left inferior cerebellar peduncle (32.26%), right dentate gyrus (24.23%), and right X lobule (21.79%) were the most impaired structures associated with CMS. CMS-related areas overlapped with motor planning and verbal fluency regions, while areas associated with motor dysfunction overlapped with motor planning. The prediction model achieved areas under the curve of 0.733, and 0.702 for the testing and external validation datasets, respectively.</p><p><strong>Conclusions: </strong>VLSM-based models are used to predict CMS occurrence prior to surgery. CMS was related to motor planning and verbal fluency regions of the cerebellum. Motor dysfunction was associated with CMS functionally.</p><p><strong>Key points: </strong>Question Cerebellar mutism syndrome (CMS) is a severe postoperative complication of medulloblastoma for which the specific responsible anatomical correlates remain unclear. Findings We identified areas associated with CMS in Voxel-based Lesion-Symptom Mapping (VLSM), which were used to establish the CMS predicting model. Clinical relevance VLSM analysis helps develop a reliable predictive model for CMS and explore its association with motor dysfunction, The establishment of this model will facilitate the prediction of CMS in clinical practice.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"3294-3304"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of radiation exposure from dual- and single-energy CT imaging protocols resulting in equivalent contrast-to-noise ratio of lesions for adults and children: a phantom study.","authors":"Nikos Ntoufas, Maria Raissaki, John Damilakis, Kostas Perisinakis","doi":"10.1007/s00330-024-11273-7","DOIUrl":"10.1007/s00330-024-11273-7","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the radiation exposure from single-energy CT (SECT) against rapid kV-switching dual-energy CT (DECT) imaging in both adults and children when resulting image data offer equivalent lesion identification power.</p><p><strong>Materials and methods: </strong>Lesions in an adult and a 10-year-old-child body phantom were imitated using iodine solutions of different concentrations. Phantoms were subjected to several SECT and DECT thoracic and abdominal scans using a rapid kV-switching DECT scanner. The contrast-to-noise ratio (CNR) of each lesion was measured on resulting SECT images and virtual monoenergetic images (VMI) available from DECT. The SECT scans that resulted in CNR values similar to the maximum CNR observed in VMIs derived from corresponding DECT scans were identified. SECT and DECT scans with equivalent lesion-discriminating power were compared regarding the associated radiation dose burden. Doses to the lung, breast, and esophagus from thoracic imaging and doses to the liver, kidneys, and stomach from abdominal imaging were determined through Monte Carlo simulations of SECT and DECT exposures.</p><p><strong>Results: </strong>Compared to SECT imaging of the adult body phantom, organ doses from DECT were found to be 5-11% lower in thoracic imaging and 44-45% lower in abdominal imaging. Compared to SECT imaging of the 10-year-old body phantom, organ doses from DECT were found to be 2.8-3.4 times higher in thoracic imaging and 1.5-1.6 times higher in abdominal imaging.</p><p><strong>Conclusion: </strong>The use of rapid kV-switching DECT instead of SECT imaging may be associated with a similar or lower dose burden in adults but a noticeably higher dose burden in children.</p><p><strong>Key points: </strong>Question How does the radiation exposure from single-energy and dual-energy CT imaging compare when both techniques provide equivalent lesion identification power? Findings Rapid kV-switching dual-energy CT compared to single-energy CT may result in a similar or lower radiation dose in adults, but higher radiation dose in children. Clinical relevance Rapid kV-switching dual-energy CT imaging in children should be preferred over single-energy CT imaging only in cases where the additional information provided is crucial for an effective diagnosis.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"3528-3537"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contrast-enhanced mammography vs MRI: Which breast imaging modality leads in lesion detection?","authors":"Yoav Amitai","doi":"10.1007/s00330-024-11306-1","DOIUrl":"10.1007/s00330-024-11306-1","url":null,"abstract":"","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"3068-3069"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carotid artery intima-media thickness values in obese or overweight children: a meta-analysis.","authors":"Jean-Baptiste Moretti, Alexandre Korban, Émilie Alchourron, Sylvie Gervais, Ramy El Jalbout","doi":"10.1007/s00330-024-11284-4","DOIUrl":"10.1007/s00330-024-11284-4","url":null,"abstract":"<p><strong>Objective: </strong>Carotid artery intima-media thickness (IMT) is a non-invasive ultrasound marker of early atherosclerosis. This systematic review and meta-analysis aim to report the published differences in IMT values in children living with overweight or obesity compared to controls with normal weight.</p><p><strong>Methods: </strong>This review was conducted according to PRISMA guidelines, including only cohorts with normal controls. Inclusion criteria were IMT measured using B-mode or radiofrequency (RF) techniques and based on the four consensuses: American Heart Association, Association for European Pediatric Cardiology, Mannheim Consensus, and American Society of Echocardiography. We used the body mass index based on the World Health Organization growth standard definitions of obesity in children. Relevant articles were extracted from PubMed, Cochrane Library, Embase, and Web of Science searched from inception to February 2024. A meta-analysis was done by a biostatistician using the R-software version 4.0.2.</p><p><strong>Results: </strong>We obtained 15 B-mode-based and two RF echo-tracking-based IMT measurement studies. IMT is significantly increased in children living with obesity. The mean IMT was 0.041 mm, 95% confidence interval (CI): 0.052; 0.031 higher in children with overweight/obesity, using the B-mode technique, and 0.045 mm, 95% CI: 0.062; 0.029 higher in children with overweight/obesity using RF technique.</p><p><strong>Conclusion: </strong>This meta-analysis shows that IMT is significantly increased in children with obesity compared to normal-weight children according to both techniques.</p><p><strong>Key points: </strong>Question IMT measured according to known consensuses is significantly increased in children living with obesity. Findings Mean IMT was 0.041 mm higher in children living with obesity using the B-mode technique and 0.045 mm using the RF technique. Clinical relevance There are different techniques to measure IMT in children. This meta-analysis, using cohorts of children living with obesity compared to normal weight controls, shows a significantly increased IMT in children living with obesity.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"3305-3313"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could MR elastography be a way to make violent contact sports safer?","authors":"Tzu-Chao Chuang, Yu-Hsiu Lee, Hsiao-Wen Chung","doi":"10.1007/s00330-025-11531-2","DOIUrl":"10.1007/s00330-025-11531-2","url":null,"abstract":"","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"3610-3612"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ESR Bridges: imaging and treatment in brain tumours-a multidisciplinary view.","authors":"Marion Smits, Niels Verburg, Martin J van den Bent","doi":"10.1007/s00330-024-11279-1","DOIUrl":"10.1007/s00330-024-11279-1","url":null,"abstract":"","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"3382-3384"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-guided high-intensity focused ultrasound for symptomatic uterine fibroids: clinical outcome of two European centers.","authors":"Sara Dohmen, Florian Recker, Yoana Ivanova, Holger M Strunk, Tolga Tonguc, Olga Ramig, Marcus Thudium, Judith M Stader, Rupert Conrad, Markus Essler, Eva-Katharina Egger, Alexander Mustea, Grigor A Gortchev, Dobromir Dimitrov, Milka Marinova","doi":"10.1007/s00330-024-11230-4","DOIUrl":"10.1007/s00330-024-11230-4","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study is to assess the clinical outcome and mid-term efficacy of ultrasound-guided high-intensity focused ultrasound (USgHIFU) as a treatment for symptomatic uterine fibroids at two major European HIFU centers.</p><p><strong>Materials and methods: </strong>This bi-center longitudinal clinical study involved the treatment of 100 patients with symptomatic uterine fibroids using USgHIFU (n = 59 in Germany, n = 41 in Bulgaria). Clinical outcomes were evaluated at 6 weeks, 6 months, and 1 year follow-up utilizing the uterine fibroid symptoms-quality of life questionnaire for fibroid-related symptoms and health-related quality of life as well as MRI imaging for determining the fibroid volume.</p><p><strong>Results: </strong>The mean fibroid volume reduction rate was 33.2 ± 22.9%, 51.3 ± 24.2%, and 59.1 ± 28.0% at 6 weeks, 6 months, and 1 year, respectively (each p < 0.001). The mean symptom severity score decreased from 43.9 ± 18.8 at baseline to 35.4 ± 18.2 at 6 weeks, 31.1 ± 20.0 at 6 months, and 23.1 ± 14.0 at 1 year (each p < 0.001). The mean QOL score improved from 56.5 ± 23.4 at baseline to 65.4 ± 22.2 at 6 weeks, 72.5 ± 19.5 at 6 months, and 79.4 ± 15.3 at 1 year (each p < 0.001). No major complications were observed, though two patients experienced temporary sciatic nerve irritation following the procedure. Four patients had pregnancies and deliveries without any complications after USgHIFU therapy.</p><p><strong>Conclusion: </strong>To our knowledge, this is the first longitudinal study conducted in two major European HIFU centers that reveals the clinical efficacy of USgHIFU ablation on symptomatic uterine fibroids. Our results confirm that USgHIFU is a non-invasive approach with a low risk of complications, offering an innovative treatment option for affected women.</p><p><strong>Key points: </strong>Question To evaluate mid-term clinical efficacy and safety of US-guided high-intensity focused ultrasound (HIFU) for treating symptomatic uterine fibroids and patient outcomes across two European centers. Findings US-guided HIFU treatment resulted in significant fibroid volume reduction (up to 59.1% after 1 year) improving symptoms and quality of life with no major complications. Clinical relevance This prospective longitudinal study provides preliminary data assessing mid-term efficacy and clinical outcomes of ultrasound-guided HIFU. It is shown to be a low-risk, non-invasive treatment option for symptomatic uterine fibroids that reduces fibroid size and improves patients' quality of life.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"3638-3648"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of lumbar paraspinal muscles in patients with chronic low back pain and its relationship to pain duration, pain intensity, and quality of life.","authors":"Sihai Liu, Sandra Reitmaier, Lukas Mödl, Daishui Yang, Tianwei Zhang, Luis Becker, Bernhard Hoehl, Lukas Schönnagel, Torsten Diekhoff, Matthias Pumberger, Hendrik Schmidt","doi":"10.1007/s00330-024-11236-y","DOIUrl":"10.1007/s00330-024-11236-y","url":null,"abstract":"<p><strong>Objectives: </strong>To examine the relationship between the quality of paraspinal muscles and pain intensity, duration, and quality of life in patients with chronic low back pain (cLBP).</p><p><strong>Methods: </strong>Between January 2022 and December 2023, 119 individuals with no-back pain (no-BP) and 136 cLBP patients were enrolled. Both groups underwent health surveys and magnetic resonance imaging. Cross-sectional area (CSA), functional cross-sectional area (FCSA), and fat infiltration (FI) of multifidus (MF) and erector spinae (ES) were measured. Data were analyzed using multiple linear and binary logistic regression.</p><p><strong>Results: </strong>Compared to the cLBP group, the no-BP group had smaller CSA influenced by FI of ES at L5/S1 (p = 0.01), higher FCSA of ES (p < 0.01) at L4/L5, and lower FI of ES and MF at L4/L5 and L5/S1 (p < 0.01). CSA, FCSA, and FI showed no significant correlation with cLBP intensity except for the CSA (p = 0.02) and FCSA (p = 0.03) of the L2/3 MF. Pain duration positively correlated with FI at L2/3, L3/4, and L4/5 of MF and ES (p < 0.05) and CSA of the L1/2 MF (p = 0.02). CSA (L3/4, L4/5, and L5/S1) and FCSA (L4/5, L5/S1) of MF correlated positively with SF36 scores (p < 0.05), while ES muscles did not (p > 0.05). FI of MF and ES showed no correlation with SF36 scores.</p><p><strong>Conclusion: </strong>CSA and FI were significantly higher, and FCSA significantly lower in paraspinal muscles of cLBP patients compared to asymptomatic participants. Increased FI correlated with prolonged cLBP duration, indicating FI and FCSA alterations may play a significant role in cLBP development and duration.</p><p><strong>Key points: </strong>Question What is the relationship between paraspinal muscle quality and cLBP, including its intensity, duration, and impact on quality of life? Findings cLBP patients had increased FI and reduced functional muscle area in paraspinal muscles, with FI correlating with prolonged pain duration. Clinical relevance Understanding the changes in lumbar paraspinal muscles provides insight into cLBP progression, guiding personalized interventions to improve pain management and patient quality of life.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"3652-3660"},"PeriodicalIF":4.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}