{"title":"High-resolution deep learning reconstruction for coronary CTA: compared efficacy of stenosis evaluation with other methods at in vitro and in vivo studies.","authors":"Takahiro Matsuyama, Hiroyuki Nagata, Yoshiyuki Ozawa, Yuya Ito, Hirona Kimata, Kenji Fujii, Naruomi Akino, Takahiro Ueda, Masahiko Nomura, Takeshi Yoshikawa, Daisuke Takenaka, Hideki Kawai, Masayoshi Sarai, Hideo Izawa, Yoshiharu Ohno","doi":"10.1007/s00330-025-11376-9","DOIUrl":"https://doi.org/10.1007/s00330-025-11376-9","url":null,"abstract":"<p><strong>Objective: </strong>To directly compare coronary arterial stenosis evaluations by hybrid-type iterative reconstruction (IR), model-based IR (MBIR), deep learning reconstruction (DLR), and high-resolution deep learning reconstruction (HR-DLR) on coronary computed tomography angiography (CCTA) in both in vitro and in vivo studies.</p><p><strong>Materials and methods: </strong>For the in vitro study, a total of three-vessel tube phantoms with diameters of 3 mm, 4 mm, and 5 mm and with simulated non-calcified stepped stenosis plaques with degrees of 0%, 25%, 50%, and 75% stenosis were scanned with area-detector CT (ADCT) and ultra-high-resolution CT (UHR-CT). Then, ADCT data were reconstructed using all methods, although UHR-CT data were reconstructed with hybrid-type IR, MBIR, and DLR. For the in vivo study, patients who had undergone CCTA at ADCT were retrospectively selected, and each CCTA data set was reconstructed with all methods. To compare the image noise and measurement accuracy at each of the stenosis levels, image noise, and inner diameter were evaluated and statistically compared. To determine the effect of HR-DLR on CAD-RADS evaluation accuracy, the accuracy of CAD-RADS categorization of all CCTAs was compared by using McNemar's test.</p><p><strong>Results: </strong>The image noise of HR-DLR was significantly lower than that of others on ADCT and UHR-CT (p < 0.0001). At a 50% and 75% stenosis level for each phantom, hybrid-type IR showed a significantly larger mean difference on ADCT than did others (p < 0.05). At in vivo study, 31 patients were included. Accuracy on HR-DLR was significantly higher than that on hybrid-type IR, MBIR, or DLR (p < 0.0001).</p><p><strong>Conclusion: </strong>HR-DLR is potentially superior for coronary arterial stenosis evaluations to hybrid-type IR, MBIR, or DLR shown on CCTA.</p><p><strong>Key points: </strong>Question How do coronary arterial stenosis evaluations by hybrid-type IR, MBIR, DLR, and HR-DLR compare to coronary CT angiography? Findings HR-DLR showed significantly lower image noise and more accurate coronary artery disease reporting and data system (CAD-RADS) evaluation than others. Clinical relevance HR-DLR is potentially superior to other reconstruction methods for coronary arterial stenosis evaluations, as demonstrated by coronary CT angiography results on ADCT and as shown in both in vitro and in vivo studies.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Steve Connor, Alexander Christoforou, Philip Touska, Soraya Robinson, Nancy J Fischbein, Pim de Graaf, Anne R J Péporté, Jussi Hirvonen, Darka Hadnadjev Šimonji, Gloria J Guzmán Pérez-Carrillo, Xin Cynthia Wu, Christine Glastonbury, Kristine M Mosier, Ashok Srinivasan
{"title":"An international survey of diffusion and perfusion magnetic resonance imaging implementation in the head and neck.","authors":"Steve Connor, Alexander Christoforou, Philip Touska, Soraya Robinson, Nancy J Fischbein, Pim de Graaf, Anne R J Péporté, Jussi Hirvonen, Darka Hadnadjev Šimonji, Gloria J Guzmán Pérez-Carrillo, Xin Cynthia Wu, Christine Glastonbury, Kristine M Mosier, Ashok Srinivasan","doi":"10.1007/s00330-025-11370-1","DOIUrl":"https://doi.org/10.1007/s00330-025-11370-1","url":null,"abstract":"<p><strong>Objective: </strong>The goal of this international survey was to understand how diffusion (DWI) and perfusion imaging (PWI) are being applied to clinical head and neck imaging.</p><p><strong>Methods and materials: </strong>An online questionnaire focusing on acquisition, clinical indications, analysis, and reporting of qualitative DWI (QlDWI), quantitative DWI (QnDWI) and dynamic contrast-enhanced PWI (DCE-PWI) in the head and neck was circulated to members of the American Society of Head and Neck Radiology (ASHNR) and European Society of Head and Neck Radiology (ESHNR) over a 3-month period. Descriptive statistics and group comparisons were calculated with SPSS® v27.</p><p><strong>Results: </strong>There were 294 unique respondents (17.6% response rate) from 256 institutions (182 ESHNR, 74 ASHNR). DWI was routinely acquired for some head and neck indications at 95.7% of the respondents' institutions, with 92.5% of radiologists interpreting QlDWI but only 36.7% analysing QnDWI. QlDWI was most frequently applied to primary mucosal masses or the middle ear, whilst QnDWI was routinely used to distinguish tumour histologies, and primary or recurrent carcinoma. DCE-PWI was routinely acquired at 53.6% of institutions and used by 40.8% of respondents, however, there was no clinical scenario in which it was routinely applied by most users. DCE-PWI analysis methods varied, with time-intensity curve classifications being the most frequently reported. Lack of standardisation was identified as a key reason for not implementing QnDWI, whilst numerous factors prevented the adoption of DCE-PWI.</p><p><strong>Conclusion: </strong>There is widespread routine interpretation of QlDWI by head and neck radiologists, but there is considerable variation in the application and analysis of head and neck QnDWI and DCE-PWI.</p><p><strong>Key points: </strong>Question How are diffusion (DWI) and dynamic contrast-enhanced perfusion imaging (DCE-PWI) being utilised by head and neck radiologists across a wide range of practices? Findings An international survey demonstrated widespread routine interpretation of qualitative DWI but variable application and analysis of quantitative DWI and DCE-PWI with numerous barriers to implementation. Clinical relevance The survey results will aid discussion on how to standardise and optimally disseminate these MRI techniques in day-to-day practice. More focused education and resource allocation may be required to accelerate the adoption of quantitative DWI and DCE-PWI.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adeline Degremont, Valérie Lindecker-Cournil, Catherine Bisquay, Valérie Ertel-Pau, Pierre Gabach, Sophie Lecocq Teixeira, Jean-Baptiste Pialat, Pierre-Alain Jachiet, Louis Boyer, Marie Faruch-Bilfeld
{"title":"Lower extremity MRI: are their requests always appropriate in France?","authors":"Adeline Degremont, Valérie Lindecker-Cournil, Catherine Bisquay, Valérie Ertel-Pau, Pierre Gabach, Sophie Lecocq Teixeira, Jean-Baptiste Pialat, Pierre-Alain Jachiet, Louis Boyer, Marie Faruch-Bilfeld","doi":"10.1007/s00330-025-11402-w","DOIUrl":"https://doi.org/10.1007/s00330-025-11402-w","url":null,"abstract":"<p><strong>Objectives: </strong>The primary aim is to assess current lower extremity MRI requests' relevance with a secondary focus on the knee.</p><p><strong>Materials and methods: </strong>Using data from the National Health Data System (SNDS), we conducted an observational study of adults (18+) who underwent lower extremity MRI between July 1 and December 31, 2021. This study included analyzing medical consultations and imaging procedures (particularly X-rays) in the 6 months before and after the index MRI, as well as medical procedures and hospitalizations related to knee procedures within 6 months post-MRI.</p><p><strong>Results: </strong>During the study period, 779,721 adults underwent lower extremity MRI, marking a 76% increase compared to a previous study conducted in 2012. General practitioners requested MRI in 70.5% of cases, often as the primary imaging modality. Notably, 52.1% of patients had not undergone lower extremity X-rays in the 6 months preceding MRI, and 13% underwent at least two MRI examinations within a year. Focusing on the knee, most patients (80%) did not undergo any outpatient medical procedure or hospitalization involving the knee within the 6 months post MRI.</p><p><strong>Conclusion: </strong>In France, lower extremity MRI, particularly knee MRI, is frequently used as a first-line imaging procedure, unlike what is recommended.</p><p><strong>Key points: </strong>Question How often are requests for lower extremity MRI examinations appropriate? Findings Lower extremity MRI is often performed as a first-line imaging procedure, even though it is not recommended. Clinical relevance The study findings underscore the importance of disseminating guidelines regarding lower extremity MRI appropriateness to increase its availability for appropriate purposes, thereby improving patient care.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European RadiologyPub Date : 2025-02-01Epub Date: 2024-08-12DOI: 10.1007/s00330-024-11015-9
Minerva Becker, Boris Brkljacic
{"title":"The future of academic radiology in Europe: challenges and opportunities.","authors":"Minerva Becker, Boris Brkljacic","doi":"10.1007/s00330-024-11015-9","DOIUrl":"10.1007/s00330-024-11015-9","url":null,"abstract":"","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"559-561"},"PeriodicalIF":4.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Contrast-enhanced US versus US-guided biopsy for abdominal and pelvic neoplasm in paediatric patients: a propensity score matching study.","authors":"Ming Liu, Yingxin Liu, Wenying Zhou, Fushun Pan, Meixi Chen, Xiaoyan Xie, Luyao Zhou","doi":"10.1007/s00330-024-11018-6","DOIUrl":"10.1007/s00330-024-11018-6","url":null,"abstract":"<p><strong>Objective: </strong>To compare the diagnostic performance of CEUS-guided biopsy (CEUS-GB) and ultrasound-guided biopsy (US-GB) in evaluating abdominal and pelvic (abdominopelvic) neoplasms in paediatric patients.</p><p><strong>Methods: </strong>Patients aged < 18 years with abdominopelvic tumours who underwent either CEUS-GB or US-GB between April 2005 and May 2022 were retrospectively evaluated. Tumours diagnosed as malignancies by pathology were considered true-positive findings. Benign lesions were identified by pathology or clinical follow-up of at least 6 months. The diagnostic performance of the two groups was compared using propensity score matching (PSM). Complications were also analysed.</p><p><strong>Results: </strong>The present study included 764 paediatric patients (437 boys; median age, 24 months; interquartile range, 10-60 months); 151 were in the CEUS-GB group, and 613 were in the US-GB group. The sample adequacy rate was 100% (151 of 151) for the CEUS-GB group, which was greater than the 97.4% (597 of 613) for the US-GB group (p < 0.001). The overall diagnostic accuracy of the CEUS-GB group and US-GB group was 98.7% (149 of 151) versus 97.3% (581 of 597) in the total cohort (p = 0.551) and 98.7% (149 of 151) versus 92.7% (140 of 151) in the PSM cohort (p = 0.020). Two patients (0.3%) in the US-GB group experienced complications (Common Terminology Criteria for Adverse Events (CTCAE), grade 1-2) correlated with the biopsy. No adverse reactions occurred in the CEUS-GB group.</p><p><strong>Conclusion: </strong>CEUS-GB of abdominopelvic tumours in paediatric patients is an effective and safe procedure with greater diagnostic accuracy than US-GB, especially for tumours with necrotic areas.</p><p><strong>Clinical relevance statement: </strong>Contrast-enhanced US-guided biopsy of solid abdominal and pelvic tumours in paediatric patients is an effective and safe procedure with greater diagnostic accuracy than US-guided biopsy, especially for tumours with necrotic areas.</p><p><strong>Key points: </strong>Contrast-enhanced ultrasound (CEUS) may be superior to conventional ultrasound at guiding biopsy of abdominopelvic masses in paediatric patients. CEUS-guided core needle biopsy of abdominopelvic masses in children was safe and resulted in a diagnostic yield of 98.7%. CEUS guidance should be considered in this population when colour Doppler US is unable to determine a biopsy site.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"1001-1011"},"PeriodicalIF":4.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European RadiologyPub Date : 2025-02-01Epub Date: 2024-10-25DOI: 10.1007/s00330-024-11100-z
Sabri Selcuk Atamanalp
{"title":"Letter to the Editor: \"Sigmoid volvulus-can CT features predict outcomes and recurrence?\"","authors":"Sabri Selcuk Atamanalp","doi":"10.1007/s00330-024-11100-z","DOIUrl":"10.1007/s00330-024-11100-z","url":null,"abstract":"","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"906-907"},"PeriodicalIF":4.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European RadiologyPub Date : 2025-02-01Epub Date: 2024-10-28DOI: 10.1007/s00330-024-11101-y
Brian M Moloney, Christine E Mc Carthy, Rajesh Bhayana, Satheesh Krishna
{"title":"CT features in sigmoid volvulus: validating predictors of outcomes and recurrence.","authors":"Brian M Moloney, Christine E Mc Carthy, Rajesh Bhayana, Satheesh Krishna","doi":"10.1007/s00330-024-11101-y","DOIUrl":"10.1007/s00330-024-11101-y","url":null,"abstract":"","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"908-909"},"PeriodicalIF":4.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Amide proton transfer-weighted MRI for assessing rectal adenocarcinoma T-staging and perineural invasion: a prospective study.","authors":"Caixia Zhang, Jianyou Chen, Yifan Liu, Yinrui Yang, Yongzhou Xu, Ruimin You, Yanli Li, Lizhu Liu, Ling Yang, Huaxiu Li, Guanshun Wang, Wenliang Li, Zhenhui Li","doi":"10.1007/s00330-024-11000-2","DOIUrl":"10.1007/s00330-024-11000-2","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the value of the pre-operative amide proton transfer-weighted (APTw) MRI to assess the prognostic factors in rectal adenocarcinoma (RA).</p><p><strong>Methods: </strong>This prospective study ran from January 2022 to September 2023 and consecutively enrolled participants with RA who underwent pre-operative MRI and radical surgery. The APTw signal intensity (SI) values of RA with various tumor (T), node (N) stages, perineural invasion (PNI), and tumor grade were compared by Mann-Whitney U-test or t-test. The receiver operating characteristic curve was used to evaluate the diagnostic performance of the APTw SI values.</p><p><strong>Results: </strong>A total of 51 participants were enrolled (mean age, 58 years ± 10 [standard deviation], 26 men). There were 24 in the T1-T2 stage and 9 with positive PNI. The APTw SI max, 99th, and 95th values were significantly higher in T3-T4 stage tumor than in T1-T2; the median (interquartile range) (M (IQR)) was (4.0% (3.6-4.9%) vs 3.4% (2.9- 4.3%), p = 0.017), (3.7% (3.2-4.1%) vs 3.2% (2.8-3.8%), p = 0.013), and (3.3% (2.8-3.8%) vs 2.9% (2.3-3.5%), p = 0.033), respectively. These indicators also differed significantly between the PNI groups, with the M (IQR) (4.5% (3.6-5.7%) vs 3.7% (3.2-4.2%), p = 0.017), (4.1% (3.4-4.8%) vs 3.3% (3.0-3.9%), p = 0.022), and (3.7% (2.7-4.2%) vs 2.9% (2.6-3.5%), p = 0.045), respectively.</p><p><strong>Conclusion: </strong>Pre-operative APTw MRI has potential value in the assessment of T-staging and PNI determination in RA.</p><p><strong>Clinical relevance statement: </strong>Pre-operative amide proton transfer-weighted MRI provides a quantitative method for noninvasive assessment of T-staging and PNI in RA aiding in precision treatment planning.</p><p><strong>Key points: </strong>The efficacy of APTw MRI in RA needs further investigation. T3-T4 stage and PNI positive APTw signal intensities were higher than T1-T2 and non-PNI, respectively. APTw MRI provides a quantitative method for assessment of T staging and PNI in RA.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"968-978"},"PeriodicalIF":4.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European RadiologyPub Date : 2025-02-01Epub Date: 2024-08-13DOI: 10.1007/s00330-024-10994-z
Gaël Dournes, Ilyes Benlala
{"title":"Breaking new ground in COPD imaging: 3D-PREFUL MRI versus traditional techniques.","authors":"Gaël Dournes, Ilyes Benlala","doi":"10.1007/s00330-024-10994-z","DOIUrl":"10.1007/s00330-024-10994-z","url":null,"abstract":"","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"940-942"},"PeriodicalIF":4.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
European RadiologyPub Date : 2025-02-01Epub Date: 2024-08-13DOI: 10.1007/s00330-024-10999-8
Love Engström Nordin, Karin Åberg, Johan Kihlberg, Titti Owman, Boel Hansson, Isabella M Björkman-Burtscher, Cecilia Petersen, Peter Lundberg
{"title":"ESR Essentials: basic physics of MR safety-practice recommendations by the European Society for Magnetic Resonance in Medicine and Biology.","authors":"Love Engström Nordin, Karin Åberg, Johan Kihlberg, Titti Owman, Boel Hansson, Isabella M Björkman-Burtscher, Cecilia Petersen, Peter Lundberg","doi":"10.1007/s00330-024-10999-8","DOIUrl":"10.1007/s00330-024-10999-8","url":null,"abstract":"<p><strong>Objectives: </strong>The use of magnetic resonance imaging (MRI) is safe from a long-term perspective since there are no known cumulative risks for patients or personnel. However, the technique comes with several acute risks associated with the powerful electromagnetic fields that are necessary to produce medical images. These risks include, among other things, a projectile hazard, loud noise, and the risk of heating. Safe use of MRI requires knowledge about the different hazards related to MRI and organizational structured work including the implementation of routines describing a safe workflow from the referral of a patient to the signed report. In this article, the risks associated with MRI are described along with suggestions for how each risk can be minimized or eliminated.</p><p><strong>Conclusion: </strong>The aim of this article is to provide support for the development of, and compliance with, MRI safety routines, and to work with the technique in a safe way. The scope of this treatise does not cover specific details of implant safety, however, the physical principles described can be applied to the risk assessment of implants.</p><p><strong>Key points: </strong>Establish whether any MR contraindications apply to the patient. Evaluate means to deal with identified risks for both patients and personnel. It is imperative to always perform and document a risk-benefit assessment.</p>","PeriodicalId":12076,"journal":{"name":"European Radiology","volume":" ","pages":"572-579"},"PeriodicalIF":4.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141970876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}