{"title":"Alterations in left atrial and left ventricular coupling in mixed aortic valve disease.","authors":"Maala Sooriyakanthan, Fraser J Graham, Natalie Ho, Howard Leong-Poi, Wendy Tsang","doi":"10.1093/ehjci/jeae199","DOIUrl":"10.1093/ehjci/jeae199","url":null,"abstract":"<p><strong>Aims: </strong>To characterize left atrial (LA) and left ventricular (LV) function and atrioventricular (AV) coupling in patients with moderate mixed aortic valve disease (MMAVD) against those with isolated moderate or severe aortic valve disease and controls.</p><p><strong>Methods and results: </strong>Retrospective LA and LV peak longitudinal strain (LS) analysis were performed on 260 patients [46 MMAVD, 81 moderate aortic stenosis (AS), 50 severe AS, 48 moderate aortic regurgitation (AR), and 35 severe AR] and 66 controls. Peak LV and LA LS and AV coupling, assessed by combined peak LA and LV strain, was compared between the groups. Analysis of variance and two-sided t-tests were used, and a P-value of <0.01 was considered significant. LV strain was significantly lower in those with MMAVD compared with controls and those with moderate or severe isolated AR but comparable to those with moderate or severe AS (-17.1 ± 1.1% MMAVD vs. -17.7 ± 1.5% moderate AS, P = 0.02, vs. -17.0 ± 1.5% severe AS, P = 0.74). AV coupling was significantly lower in those with MMAVD compared with controls and those with moderate AS or AR but comparable to those with severe AS or AR (47.1 ± 6.8% MMAVD vs. 45.1 ± 5.6% severe AS, P = 0.13, vs. 50.4 ± 9% severe AR, P = 0.07).</p><p><strong>Conclusion: </strong>Impairments in AV coupling are comparable for patients with MMAVD and those with severe isolated AS or AR. Impairments in LV GLS in MMAVD mirror those found in severe AS. These findings suggest that haemodynamic consequences and adverse remodelling are similar for patients with MMAVD and isolated severe disease.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1652-1660"},"PeriodicalIF":6.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Could the reduced tricuspid annulus plane systolic excursion and right ventricular pulmonary artery be considered the most powerful independent predictors of cardiac mortality?","authors":"Hadi Raeisi Shahraki","doi":"10.1093/ehjci/jeae207","DOIUrl":"10.1093/ehjci/jeae207","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"e322"},"PeriodicalIF":6.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Torcuato Garrido-Arroquia Jurado, José Antonio Fernández-Sánchez, Miguel Morales-García, José Manuel Oyonarte-Ramírez
{"title":"Primary cardiac angiosarcoma: an extremely rare cause of chest discomfort.","authors":"Torcuato Garrido-Arroquia Jurado, José Antonio Fernández-Sánchez, Miguel Morales-García, José Manuel Oyonarte-Ramírez","doi":"10.1093/ehjci/jeae206","DOIUrl":"10.1093/ehjci/jeae206","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"e324"},"PeriodicalIF":6.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction to: Value of dynamic computed tomography myocardial perfusion in CAD: a systematic review and meta-analysis.","authors":"","doi":"10.1093/ehjci/jeae202","DOIUrl":"10.1093/ehjci/jeae202","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"e312-e320"},"PeriodicalIF":6.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elizabeth Curtis, Léo Lemarchand, K Charlotte Lee, Elena Galli, Guillaume L'Official, Vincent Auffret, Guillaume Leurent, Emmanuel Oger, Erwan Donal
{"title":"Right atrial and right ventricular strain: prognostic value depends on the severity of tricuspid regurgitation.","authors":"Elizabeth Curtis, Léo Lemarchand, K Charlotte Lee, Elena Galli, Guillaume L'Official, Vincent Auffret, Guillaume Leurent, Emmanuel Oger, Erwan Donal","doi":"10.1093/ehjci/jeae182","DOIUrl":"10.1093/ehjci/jeae182","url":null,"abstract":"<p><strong>Aims: </strong>Assessing right heart function is challenging, particularly when significant tricuspid regurgitation (TR) is present. Amongst available echocardiographic techniques for assessment, literatures suggest that strain imaging may be more reliable and less susceptible to loading conditions. Thus, we aimed to assess the validity of right atrial (RA) and right ventricular (RV) strain relative to conventional metrics as well as their utility in predicting patient outcomes in TR.</p><p><strong>Methods and results: </strong>We studied 262 consecutive patients (mean age 74 ± 11.2 years, 53% male) who underwent same-day echocardiography and right heart catheterization between 2018 and 2023. We compared right heart strain to traditional metrics of RV function and subsequently correlated RA and RV strain to heart failure (HF)-related death or hospitalization, whichever came first. Over a mean follow-up of 34 ± 15 months, there were 103 deaths and HF hospitalizations. Both RA strain and RV strain were correlated with echocardiographic and invasive measures of right heart function. Across all patients, preserved RA strain was associated with lower risk of adverse outcomes [hazard ratio (HR) 0.763, 95% confidence interval (CI) 0.618-0.943]. Similarly, preserved RV strain was correlated with better outcomes, although this was only statistically significant in patients without severe TR or pulmonary hypertension (HR 2.450, 95% CI 1.244-4.825). Moreover, abnormal ratios of RV strain to pulmonary pressures and RV size were significantly correlated with adverse outcomes (P < 0.05 each).</p><p><strong>Conclusion: </strong>RA and RV strain are independently correlated with echocardiographic and invasive measures of cardiac function. Moreover, preserved RA and RV strain is likely associated with better clinical outcomes.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1734-1742"},"PeriodicalIF":6.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francesco Natale, Francesco Loffredo, Maurizio Cappelli Bigazzi, Paolo Golino, Giovanni Cimmino
{"title":"Acquired mild aortic regurgitation following left main stent implantation.","authors":"Francesco Natale, Francesco Loffredo, Maurizio Cappelli Bigazzi, Paolo Golino, Giovanni Cimmino","doi":"10.1093/ehjci/jeae302","DOIUrl":"https://doi.org/10.1093/ehjci/jeae302","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Vancraeynest, Anne-Catherine Pouleur, Christophe de Meester, Agnès Pasquet, Bernhard Gerber, Hector Michelena, Giovanni Benfari, Benjamin Essayagh, Christophe Tribouilloy, Dan Rusinaru, Francesco Grigioni, Andrea Barbieri, Francesca Bursi, Jean-François Avierinos, Federico Guerra, Elena Biagini, Khung Keong Yeo, See Hooi Ewe, Alex Pui-Wai Lee, Jean-Louis J Vanoverschelde, Maurice Enriquez-Sarano
{"title":"Survival loss linked to guideline-based indications for degenerative mitral regurgitation surgery.","authors":"David Vancraeynest, Anne-Catherine Pouleur, Christophe de Meester, Agnès Pasquet, Bernhard Gerber, Hector Michelena, Giovanni Benfari, Benjamin Essayagh, Christophe Tribouilloy, Dan Rusinaru, Francesco Grigioni, Andrea Barbieri, Francesca Bursi, Jean-François Avierinos, Federico Guerra, Elena Biagini, Khung Keong Yeo, See Hooi Ewe, Alex Pui-Wai Lee, Jean-Louis J Vanoverschelde, Maurice Enriquez-Sarano","doi":"10.1093/ehjci/jeae176","DOIUrl":"10.1093/ehjci/jeae176","url":null,"abstract":"<p><strong>Aims: </strong>Operating on patients with severe degenerative mitral regurgitation (DMR) is based on ACC/AHA or ESC/EACTS guidelines. Doubts persist on best surgical indications and their potential association with postoperative survival loss. We sought to investigate whether guideline-based indications lead to late postoperative survival loss in DMR patients.</p><p><strong>Methods and results: </strong>We analysed outcome of 2833 patients from the Mitral Regurgitation International Database registry undergoing surgical correction of DMR. Patients were stratified by surgical indications: Class I trigger (symptoms, left ventricular end-systolic diameter ≥ 40 mm, or left ventricular ejection fraction < 60%, n = 1677), isolated Class IIa trigger [atrial fibrillation (AF), pulmonary hypertension (PH), or left atrial diameter ≥ 55 mm, n = 568], or no trigger (n = 588). Postoperative survival was compared after matching for clinical differences. Restricted mean survival time (RMST) was analysed. During a median 8.5-year follow-up, 603 deaths occurred. Long-term postoperative survival was lower with Class I trigger than in Class IIa trigger and no trigger (71.4 ± 1.9, 84.3 ± 2.3, and 88.9 ± 1.9% at 10 years, P < 0.001). Having at least one Class I criterion led to excess mortality (P < 0.001), while several Class I criteria conferred additional death risk [hazard ratio (HR): 1.53, 95% confidence interval (CI): 1.42-1.66]. Isolated Class IIa triggers conferred an excess mortality risk vs. those without (HR: 1.46, 95% CI: 1.00-2.13, P = 0.05). Among these patients, isolated PH led to decreased postoperative survival vs. those without (83.7 ± 2.8% vs. 89.3 ± 1.6%, P = 0.011), with the same pattern observed for AF (81.8 ± 5.0% vs. 88.3 ± 1.5%, P = 0.023). According to RMST analysis, compare to those operated on without triggers, operating on Class I trigger patients led to 9.4-month survival loss (P < 0.001) and operating on isolated Class IIa trigger patients displayed 4.9-month survival loss (P = 0.001) after 10 years.</p><p><strong>Conclusion: </strong>Waiting for the onset of Class I or isolated Class IIa triggers before operating on DMR patients is associated with postoperative survival loss. These data encourage an early surgical strategy.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1703-1711"},"PeriodicalIF":6.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141598904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bhupendar Tayal, Nadeen N Faza, Duc T Nguyen, Maan Malahfji, Stephen Little, Mujtaba Saeed, Sachin S Goel, Ashrith Guha, Kinan Carlos El-Tallawi, Edward A Graviss, Dipan J Shah
{"title":"Association of secondary mitral regurgitation and right ventricular dysfunction among patients with non-ischaemic cardiomyopathy.","authors":"Bhupendar Tayal, Nadeen N Faza, Duc T Nguyen, Maan Malahfji, Stephen Little, Mujtaba Saeed, Sachin S Goel, Ashrith Guha, Kinan Carlos El-Tallawi, Edward A Graviss, Dipan J Shah","doi":"10.1093/ehjci/jeae134","DOIUrl":"10.1093/ehjci/jeae134","url":null,"abstract":"<p><strong>Aims: </strong>The association between secondary mitral regurgitation (MR) and right ventricular (RV) dysfunction in heart failure patients with non-ischaemic cardiomyopathy (NICM) is unclear. Hence, our objective was to study the association between secondary MR and the occurrence of RV dysfunction among patients with NICM using cardiac magnetic resonance (CMR).</p><p><strong>Methods and results: </strong>Patients with NICM were enrolled in a prospective observational registry between 2008 and 2019. CMR was used to quantify MR severity along with RV function. The RV dysfunction was defined as RV ejection fraction <45%. The outcome of the study was a composite event of all-cause death, heart transplantation, or left ventricular assist device implantation at follow-up. In the study cohort of 241 patients, RV dysfunction (RVEF < 45%) was present in 148 (61%). In comparison with patients without RV dysfunction, those with RV dysfunction had higher median MR volume {23 mL [interquartile range (IQR) 16-31 mL] vs. 18 mL (IQR 12-25 mL), P = 0.002} and MR fraction [33% (IQR 25-43%) vs. 22% (IQR 15-29%), P < 0.001]. Furthermore, secondary MR was independently associated with RV dysfunction: MR volume ≥ 24 mL (OR 3.21, 95% CI 1.26-8.15, P = 0.01) and MR fraction ≥ 30% (OR 5.46, 95% CI 2.23-13.35, P = 0.002). Increasing RVEF (every 1% increase) was independently associated with lower risk of adverse events (HR 0.98; 95% CI 0.95, 1.00; P = 0.047).</p><p><strong>Conclusion: </strong>In patients with NICM, the severity of secondary MR is associated with an increased prevalence of RV dysfunction. The RV dysfunction is not only associated with the severity of LV dysfunction but also with the severity of secondary MR.</p><p><strong>Clinical trial registration: </strong>https://clinicaltrials.gov/ct2/show/NCT04281823.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1627-1635"},"PeriodicalIF":6.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141087337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Steele C Butcher, Kensuke Hirasawa, Maria Chiara Meucci, Jan Stassen, Jurrien H Kuneman, Ana Rita Pereira, Frank van der Kley, Arend de Weger, Philippe J van Rosendael, Nina Ajmone Marsan, David Playford, Victoria Delgado, Jeroen J Bax
{"title":"Prognostic implications and alterations in left atrial deformation following transcatheter aortic valve implantation.","authors":"Steele C Butcher, Kensuke Hirasawa, Maria Chiara Meucci, Jan Stassen, Jurrien H Kuneman, Ana Rita Pereira, Frank van der Kley, Arend de Weger, Philippe J van Rosendael, Nina Ajmone Marsan, David Playford, Victoria Delgado, Jeroen J Bax","doi":"10.1093/ehjci/jeae170","DOIUrl":"10.1093/ehjci/jeae170","url":null,"abstract":"<p><strong>Aims: </strong>To evaluate the prognostic implications of the left atrial reservoir strain-defined diastolic dysfunction (LARS-DD) grade in patients undergoing transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS) and to determine whether post-TAVI LARS was more closely associated with new-onset atrial fibrillation than pre-TAVI LARS.</p><p><strong>Methods and results: </strong>Pre-TAVI LARS-DD was evaluated by speckle-tracking echocardiography and was assigned as Grade 0 to 1 (LARS ≥24%), Grade 2 (LARS 19-24%), and Grade 3 (LARS <19%). Patients were followed up for the primary endpoint of all-cause mortality from the date of TAVI. For the secondary endpoint, patients with pre- and post-TAVI LARS measurements and no history of atrial fibrillation were evaluated for the occurrence of new-onset atrial fibrillation. A total of 601 patients [median age 81 (76-85) years, 53% males] were included. Overall, 169 patients (28%) were LARS-DD Grade 0/1, 96 patients (16%) were LARS-DD Grade 2, and 336 (56%) were LARS-DD Grade 3. Over a median follow-up of 40 (interquartile range 26-58) months, a total of 258 (43%) patients died. In a comprehensive multivariable Cox regression model, the LARS-DD grade was independently associated with all-cause mortality [adjusted hazard ratio (HR) 1.28 per one-grade increase, 95% confidence interval (CI) 1.07-1.53, P = 0.007]. For the secondary endpoint of new-onset atrial fibrillation, a total of 285 patients were evaluated. Post-TAVI LARS (subdistributional HR 1.14 per 1% <20%, 95% CI 1.05-1.23, P = 0.0009), but not pre-TAVI LARS (P = 0.93), was independently associated with new-onset atrial fibrillation.</p><p><strong>Conclusion: </strong>An increased LARS-DD grade was independently associated with long-term post-TAVI survival in patients with severe AS. Post-TAVI LARS was closely related to the occurrence of new-onset atrial fibrillation.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1638-1648"},"PeriodicalIF":6.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dorien Laenens, Pieter van der Bijl, Xavier Galloo, Alessandro C Rossi, Giovanni Tonti, Johan H C Reiber, Gianni Pedrizzetti, Nina Ajmone Marsan, Jeroen J Bax
{"title":"Association between echocardiography-derived haemodynamic force parameters and left ventricular reverse remodelling after cardiac resynchronization therapy.","authors":"Dorien Laenens, Pieter van der Bijl, Xavier Galloo, Alessandro C Rossi, Giovanni Tonti, Johan H C Reiber, Gianni Pedrizzetti, Nina Ajmone Marsan, Jeroen J Bax","doi":"10.1093/ehjci/jeae181","DOIUrl":"10.1093/ehjci/jeae181","url":null,"abstract":"<p><strong>Aims: </strong>Cardiac resynchronization therapy (CRT) may induce left ventricular (LV) reverse remodelling (=LV response) in patients with heart failure. Intraventricular pressure gradients can be quantified using echocardiography-derived haemodynamic forces (HDF). The aim was to evaluate the association between baseline HDF and LV response and to compare the change of HDF after CRT between LV responders and LV non-responders.</p><p><strong>Methods and results: </strong>The following HDF parameters were assessed: (i) apical-basal (AB) strength, (ii) lateral-septal strength, (iii) force vector angle, (iv) systolic AB impulse, (v) systolic force vector angle. LV response was defined as a reduction of LV end-systolic volume ≥ 15% at six months. One hundred ninety-six patients were included [64 ± 11 years, 122 (62%) men], 136 (69%) showed LV response. On multivariable logistic regression analysis, the force vector angle in the complete heart cycle [OR 1.083 (95% CI: 1.018, 1.153), P = 0.012] and the systolic force vector angle [OR 1.089 (95% CI: 1.021, 1.161), P = 0.009], both included in separate models, were independently associated with LV response. Six months after CRT, LV responders had greater AB strength, AB impulse, and higher force vector angles, while LV non-responders only showed improvement in the force vector angle in the complete heart cycle.</p><p><strong>Conclusion: </strong>The orientation of HDF at baseline is associated with LV response to CRT. Six months after CRT, the orientation of HDF improves in LV responders and LV non-responders, while the magnitude of AB HDF only improves in LV responders.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1721-1733"},"PeriodicalIF":6.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}