Hunain Shiwani, João Augusto, Constantin-Cristian Topriceanu, Adam Ioannou, Stefania Rosmini, Viviana Maestrini, Rebecca Hughes, Kristopher Knott, Anish Bhuva, Benjamin Dowsing, Jessica Artico, Iain Pierce, Thomas Treibel, James Howard, Charlotte Manisty, Peter Kellman, Rebecca Kozor, Richard Steeds, Gabriella Captur, Saidi Mohiddin, Luis Lopes, Marianna Fontana, James Moon, Rhodri Davies
{"title":"Prevalence and determinants of asymmetric septal hypertrophy (ASH) in diseases of left ventricular hypertrophy (LVH).","authors":"Hunain Shiwani, João Augusto, Constantin-Cristian Topriceanu, Adam Ioannou, Stefania Rosmini, Viviana Maestrini, Rebecca Hughes, Kristopher Knott, Anish Bhuva, Benjamin Dowsing, Jessica Artico, Iain Pierce, Thomas Treibel, James Howard, Charlotte Manisty, Peter Kellman, Rebecca Kozor, Richard Steeds, Gabriella Captur, Saidi Mohiddin, Luis Lopes, Marianna Fontana, James Moon, Rhodri Davies","doi":"10.1093/ehjci/jeag203","DOIUrl":"10.1093/ehjci/jeag203","url":null,"abstract":"<p><strong>Aims: </strong>To determine the prevalence of asymmetric septal hypertrophy (ASH) across health and in diseases associated with left ventricular hypertrophy (LVH), including hypertrophic cardiomyopathy (HCM).</p><p><strong>Methods and results: </strong>We analysed two complementary datasets. First, a large UK Biobank healthy reference cohort (n = 4020) was used to model demographic determinants of septal-to-lateral wall thickness ratio (SLR) and to provide the reference group for age-, sex-, and body surface area-adjusted comparisons. Second, a multi-cohort clinical CMR dataset included 1655 subjects comprising local healthy volunteers, athletes, patients with hypertension, aortic stenosis, Fabry disease, amyloid light chain (AL) amyloidosis, amyloid transthyretin (ATTR) amyloidosis, and HCM. LVH was defined by maximum wall thickness (MWT) ≥15 mm and asymmetry defined as SLR≥1.3. Left ventricular morphology was classified as normal, asymmetric remodelling (SLR≥1.3; MWT<15 mm), symmetric hypertrophy (SLR<1.3; MWT≥15 mm) or ASH (SLR≥1.3; MWT≥15 mm). ASH was highly prevalent in HCM (61%) but was also observed in ATTR amyloidosis (37%), AS (26%), and AL amyloidosis (23%). In the healthy reference cohort, a higher septal-to-lateral ratio was independently associated with older age, female sex, and larger body surface area (P < 0.001). After adjustment for these demographic factors, only HCM retained a clinically meaningful excess in septal asymmetry (ΔSLR = +0.27; P < 0.001). In contrast, the apparent asymmetry in non-HCM cohorts was partly explained by demographic variation. After adjustment, only HCM showed a clinically meaningful excess in SLR, whereas other disease cohorts showed either no material difference or small negative differences relative to healthy controls.</p><p><strong>Conclusion: </strong>ASH is a common but non-specific finding in diseases associated with LVH. Septal asymmetry increases with age and body-size and is more pronounced in women. After adjusting for age, sex, and body-size, disproportionate septal asymmetry was most characteristic of HCM.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1860-1869"},"PeriodicalIF":6.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel J Lim, Malak Hoballah, Ashkan Abdollahi, Robyn L McClelland, Wendy Post, Theo Pezel, Steven Shea, David Bluemke, Bharath Ambale-Venkatesh, Joao A C Lima
{"title":"Change in left atrioventricular coupling index predicts incident heart failure with preserved ejection fraction: the multi-ethnic study of atherosclerosis.","authors":"Daniel J Lim, Malak Hoballah, Ashkan Abdollahi, Robyn L McClelland, Wendy Post, Theo Pezel, Steven Shea, David Bluemke, Bharath Ambale-Venkatesh, Joao A C Lima","doi":"10.1093/ehjci/jeag211","DOIUrl":"10.1093/ehjci/jeag211","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1893-1895"},"PeriodicalIF":6.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148839821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Not all asymmetry is equal: asymmetric septal hypertrophy across hypertrophic cardiomyopathy, amyloidosis and beyond.","authors":"Nicola Ciocca, Christoph Gräni","doi":"10.1093/ehjci/jeag214","DOIUrl":"10.1093/ehjci/jeag214","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1870-1872"},"PeriodicalIF":6.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Three caveats to the independent prognostic value of myocardial perfusion reserve in type 2 diabetes.","authors":"Shankar Biswas, Yashasvi Srivastava, Susruth Kumar Bandaru","doi":"10.1093/ehjci/jeag209","DOIUrl":"10.1093/ehjci/jeag209","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1899-1900"},"PeriodicalIF":6.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148724564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mrunalini Dandamudi, Bezalel Hakkeem, Juan Pinilla, Nathalia Schettino Samad, Larissa Araújo de Lucena, Zainab Humayun, Terezia Toni Khairallah, Francesco Stabile
{"title":"Intracardiac vs. transesophageal echocardiography in patients undergoing ablation for atrial fibrillation: a systematic review and meta-analysis.","authors":"Mrunalini Dandamudi, Bezalel Hakkeem, Juan Pinilla, Nathalia Schettino Samad, Larissa Araújo de Lucena, Zainab Humayun, Terezia Toni Khairallah, Francesco Stabile","doi":"10.1093/ehjci/jeag206","DOIUrl":"10.1093/ehjci/jeag206","url":null,"abstract":"<p><strong>Aims: </strong>Intracardiac echocardiography (ICE) is a valuable, real-time imaging tool in structural cardiology and electrophysiology, performed without general anaesthesia. However, its safety compared to transesophageal echocardiography (TEE) remains unclear.</p><p><strong>Objective: </strong>To conduct a meta-analysis evaluating outcomes of catheter ablation for atrial fibrillation (AF) with or without left atrial appendage closure (LAAC) guided by TEE vs. ICE.</p><p><strong>Methods and results: </strong>Databases were searched for studies comparing ICE with TEE guidance during AF ablation ± LAAC. Outcomes were pooled using the inverse-variance (IV) random-effects model in R, with risk ratios (RRs) for dichotomous variables and mean or standardized mean differences (MD or SMD) for continuous variables, and 95% confidence intervals (CIs) reported. We included eight studies involving 7671 patients, of whom 3903 (50.9%) underwent procedures with ICE guidance. There were no significant differences between groups in cardiac tamponade risk (RR 0.86; 95% CI 0.44-1.66; P = 0.39), stroke, or transient ischaemic attack (RR 1.00; 95% CI 0.39-2.55; P = 0.57), and vascular complications (RR 0.80; 95% CI 0.51-1.25; P = 0.37). ICE was associated with lower pre-procedure LAA thrombus detection (RR 0.32; 95% CI 0.11-0.94; P = 0.04), radiation dose (SMD -0.47; 95% CI -0.90 to -0.04; P = 0.03), and fluoroscopy time (-4.25 min; 95% CI -6.01 to -2.49; P < 0.01) but the procedure duration was significantly lower only in combined AF ablation + LAAC (MD -19.56 min; 95% CI -24.15 to -14.97; P < 0.01).</p><p><strong>Conclusion: </strong>This meta-analysis indicates that ICE is a safe, effective, and non-inferior alternative to TEE for patients undergoing AF ablation ± LAAC. However, TEE remains an effective tool for detecting LAA thrombus.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1845-1856"},"PeriodicalIF":6.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}