European Heart Journal - Cardiovascular Imaging最新文献

{"title":"Cardiovascular magnetic resonance abnormalities in an infantile-onset Pompe disease.","authors":"Yaoji Zhu, Xiaoliang Liu, Lei Hu, Yingkun Guo, Lingyi Wen","doi":"10.1093/ehjci/jeaf006","DOIUrl":"10.1093/ehjci/jeaf006","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"935"},"PeriodicalIF":6.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of ascending aortic morphology: cross-sectional deep learning-based analysis on 25 073 non-contrast-enhanced NAKO MRI studies.","authors":"Louisa Fay, Tobias Hepp, Moritz T Winkelmann, Annette Peters, Margit Heier, Thoralf Niendorf, Tobias Pischon, Beate Endemann, Jeanette Schulz-Menger, Lilian Krist, Matthias B Schulze, Rafael Mikolajczyk, Andreas Wienke, Nadia Obi, Bernard C Silenou, Berit Lange, Hans-Ulrich Kauczor, Wolfgang Lieb, Hansjörg Baurecht, Michael Leitzmann, Kira Trares, Hermann Brenner, Karin B Michels, Stefanie Jaskulski, Henry Völzke, Konstantin Nikolaou, Christopher L Schlett, Fabian Bamberg, Mario Lescan, Bin Yang, Thomas Küstner, Sergios Gatidis","doi":"10.1093/ehjci/jeaf081","DOIUrl":"10.1093/ehjci/jeaf081","url":null,"abstract":"<p><strong>Aims: </strong>Understanding determinants of thoracic aortic morphology is crucial for precise diagnostics and therapeutic approaches. This study aimed to automatically characterize ascending aortic morphology based on 3D non-contrast-enhanced magnetic resonance angiography (NC-MRA) data from the epidemiological cross-sectional German National Cohort (NAKO) and to investigate possible determinants of mid-ascending aortic diameter (mid-AAoD).</p><p><strong>Methods and results: </strong>Deep learning (DL) automatically segmented the thoracic aorta and ascending aortic length, volume, and diameter was extracted from 25 073 NC-MRAs. Statistical analyses investigated relationships between mid-AAoD and demographic factors, hypertension, diabetes, alcohol, and tobacco consumption. Males exhibited significantly larger mid-AAoD than females (M: 35.5 ± 4.8 mm, F: 33.3 ± 4.5 mm). Age and body surface area (BSA) were positively correlated with mid-AAoD (age: male: r²=0.20, P < 0.001, female: r²=0.16, P < 0.001; BSA: male: r²=0.08, P < 0.001, female: r²=0.05, P < 0.001). Hypertensive and diabetic subjects showed higher mid-AAoD (ΔHypertension=2.9±0.5 mm; ΔDiabetes=1.5±0.6 mm). Hypertension was linked to higher mid-AAoD regardless of age and BSA, while diabetes and mid-AAoD were uncorrelated across age-stratified subgroups. Daily alcohol consumption (male: 37.4 ± 5.1 mm, female: 35.0 ± 4.8 mm) and smoking history exceeding 16.5 pack-years (male: 36.6 ± 5.0 mm, female: 33.9 ± 4.3 mm) exhibited the highest mid-AAoD. Causal analysis (Peter-Clark algorithm) suggested that age, BSA, hypertension, and alcohol consumption are possibly causally related to mid-AAoD, while diabetes and smoking are likely spuriously correlated.</p><p><strong>Conclusion: </strong>This study demonstrates the potential of DL and causal analysis for understanding ascending aortic morphology. By disentangling observed correlations using causal analysis, this approach identifies possible causal determinants, such as age, BSA, hypertension, and alcohol consumption. These findings can inform targeted diagnostics and preventive strategies, supporting clinical decision-making for cardiovascular health.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"895-907"},"PeriodicalIF":6.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The right horse for the race in the finite element analysis simulations to predict mitral valve regurgitation following transcatheter edge-to-edge mitral valve repair.","authors":"Francesco Nappi, Cristiano Spadaccio","doi":"10.1093/ehjci/jeaf068","DOIUrl":"10.1093/ehjci/jeaf068","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"931-932"},"PeriodicalIF":6.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of clinical characteristics and prognosis of patients with atrial functional mitral regurgitation exhibiting sinus rhythm and atrial fibrillation.","authors":"Kentaro Minami, Kimi Sato, Tomoko Machino-Ohtsuka, Nobuyuki Kagiyama","doi":"10.1093/ehjci/jeaf061","DOIUrl":"10.1093/ehjci/jeaf061","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"928-930"},"PeriodicalIF":6.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodality imaging of neonatal rhabdomyoma and follow-up under sirolimus treatment.","authors":"Milou Molenaar, Jacobien B Eising, Hildo J Lamb, Roel L F van der Palen","doi":"10.1093/ehjci/jeaf032","DOIUrl":"10.1093/ehjci/jeaf032","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"939"},"PeriodicalIF":6.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"RAC SIGN\": visualization through magnetic resonance imaging.","authors":"Belén Díaz Antón, Raúl Ptaszynski Lanza, Elena Virosta Gil, Leticia Fernández Friera","doi":"10.1093/ehjci/jeaf031","DOIUrl":"10.1093/ehjci/jeaf031","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"938"},"PeriodicalIF":6.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incremental value of multiparametric cardiac magnetic resonance imaging for non-invasive identification of significant acute cardiac allograft rejection: a prospective and biopsy-proven study.","authors":"Pengyu Zhou, Zhixiang Dong, Xiaoying Hu, Shujuan Yang, Jiaxin Wang, Xuan Ma, Yun Tang, Jing Xu, Zhuxin Wei, Xi Jia, Xingrui Chen, Yujie Liu, Xiaorui Xiang, Jie Huang, Shihua Zhao","doi":"10.1093/ehjci/jeaf052","DOIUrl":"10.1093/ehjci/jeaf052","url":null,"abstract":"<p><strong>Aims: </strong>This study aimed to evaluate the association between cardiac magnetic resonance imaging (CMR) multiparameters and significant acute cardiac allograft rejection (SR), and assess the incremental value of CMR multiparameters over conventional serum examinations for identifying SR.</p><p><strong>Methods and results: </strong>Heart transplantation (HTx) recipients with endomyocardial biopsy and healthy controls were prospectively recruited for CMR assessment. CMR feature tracking was performed to evaluate the left ventricular (LV) global strain in all three directions. The last serum examinations including N-terminal pro-brain natriuretic peptide (NT-proBNP) before anti-rejection therapy were recorded. Participants were divided into three groups: control, SR [acute cellular rejection grade ≥ 2R and/or antibody-mediated rejection (AMR) grade ≥ pAMR1], and NSR (non-SR). Finally, 30 controls (43.3 ± 13.6 years, 26 males) and 51 HTx recipients comprising 23 SRs (48.6 ± 12.6 years, 24 males) and 28 NSRs (42.7 ± 14.9 years, 16 males) were enrolled for analysis. Compared with NSRs, SRs showed elevated NT-proBNP (7797.0 ± 7527.6 pg/mL vs. 3334.6 ± 5935.3 pg/mL, P < 0.001), worse LV global longitudinal strain (GLS) (-9.7 ± 3.1% vs. -13.1 ± 2.9%, P < 0.001), and increased native T1 (1384 ± 80.1 ms vs. 1321 ± 69.9 ms, P < 0.001) and T2 values (50.9 ± 2.7 ms vs. 45.7 ± 4.3 ms, P < 0.001). In multivariable analysis, LVGLS (OR = 0.76, 95% CI, 0.59-0.98, P = 0.03) and T2 value (OR = 1.35, 95% CI, 1.10-1.65, P = 0.01) were independently associated with SR after NT-proBNP adjustment. Furthermore, the likelihood ratio test showed LVGLS (P = 0.002) and T2 value (P < 0.001) had incremental value over NT-proBNP for identifying SR.</p><p><strong>Conclusion: </strong>LVGLS and T2 value were independently associated with SR, providing incremental value for non-invasive identification of significant rejection in HTx recipients.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"886-894"},"PeriodicalIF":6.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of cardiovascular multimodality imaging in the evaluation of Anderson-Fabry disease: from early diagnosis to therapy monitoring.","authors":"Matteo Cameli, Maurizio Pieroni, Maria Concetta Pastore, Antonio Brucato, Silvia Castelletti, Lia Crotti, Marc Dweck, Andrea Frustaci, Alessia Gimelli, Karin Klingel, Petr Kuchynka, Johanna Kuusisto, George Lazaros, Giulia Elena Mandoli, Marco Merlo, James Moon, Denisa Muraru, Antonis Pantazis, Angelos G Rigopoulos, Arsen Ristic, Leyla Elif Sade, Mary N Sheppard, Carsten Tschöpe, Steffen E Petersen, Massimo Imazio, Yohann Bohbot, Maja Cikes, Pankaj Garg, Niall Keenan, Aniela Petrescu, Ivan Stankovic, Liliana Szabo, Valtteri Uusitalo","doi":"10.1093/ehjci/jeaf038","DOIUrl":"10.1093/ehjci/jeaf038","url":null,"abstract":"<p><p>Anderson-Fabry disease (AFD) is a rare genetic disease with X-linked transmission characterized by a defect in the enzyme alpha-galactosidase A, which impairs glycosphingolipid metabolism and leads to an excessive storage of globotriaosylceramide (Gb3) within lysosomes. AFD involves renal, cardiac, vascular, and nervous systems and is mainly observed in male patients with onset in childhood, although cardiac manifestation is often shown in adults. AFD cardiomyopathy is caused by the accumulation of Gb3 within myocytes first showed by left ventricular hypertrophy and diastolic dysfunction, leading to restrictive cardiomyopathy and systolic heart failure with biventricular involvement. The diagnosis of AFD cardiomyopathy may be insidious in the first stages and requires accurate differential diagnosis with other cardiomyopathies with hypertrophic phenotype. However, it is fundamental to promptly initiate specific therapies that have shown promising results, particularly for early treatment. A careful integration between clinical evaluation, genetic tests, and cardiac imaging is required to diagnose AFD with cardiac involvement. Basic and advanced echocardiography, cardiac magnetic resonance, and nuclear imaging may offer pivotal information for early diagnosis (Graphical Abstract), and the management of these patients is often limited to centres with high expertise in the field. This clinical consensus statement, developed by experts from the European Society of Cardiology (ESC) Working Group on Myocardial and Pericardial Diseases and the European Association of Cardiovascular Imaging of the ESC, aims to provide practical advice for all clinicians regarding the use of multimodality imaging to simplify the diagnostic evaluation, prognostic stratification, and management of cardiac involvement in AFD.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"814-829"},"PeriodicalIF":6.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scoring system for diagnosing heart failure with preserved ejection fraction based on exercise echocardiography.","authors":"Kazuki Kagami, Tomonari Harada, Naoki Yuasa, Yuta Tani, Fumitaka Murakami, Yuki Saito, Ayami Naito, Takahiro Okuno, Toshimitsu Kato, Noriaki Takama, Naoki Wada, Takeshi Adachi, Hideki Ishii, Masaru Obokata","doi":"10.1093/ehjci/jeaf044","DOIUrl":"10.1093/ehjci/jeaf044","url":null,"abstract":"<p><strong>Aims: </strong>Exercise stress echocardiography (ESE) is often used to identify heart failure with preserved ejection fraction (HFpEF) in patients presenting dyspnoea. However, diagnostic criteria have not been standardized. Here, we sought to develop ESE-based criteria to diagnose HFpEF in dyspnoeic patients.</p><p><strong>Methods and results: </strong>A total of 81 consecutive patients with dyspnoea who underwent exercise right heart catheterization and ESE were evaluated. Diagnosis of HFpEF was ascertained by directly-measured haemodynamics (61 HFpEF and 20 controls). Logistic regression analysis was applied to develop an ESE-based scoring system to diagnose HFpEF. Multivariable logistic regression analysis identified resting left atrial reservoir strain < 20%, exercise septal E/e' ratio > 13, and increases in ultrasound B-lines as independent predictors of HFpEF. A weighted score was created with these variables (the ESE score) ranging from 0 to 5. The ESE score accurately discriminated HFpEF from controls [area under the curve (AUC) 0.90, P < 0.0001], with a superior diagnostic ability to the ASE/ESCVI criteria (AUC comparison P < 0.0001). The ESE score classified the HFpEF probability into three categories (probabilities: low risk 28%, intermediate risk 59-83%, and high risk 95-99%). In a cohort of 620 dyspnoeic patients, the predictive ability of the derived score was assessed. A higher ESE score was associated with an increased risk of all-cause mortality or worsening HF events even after adjusting for confounders (hazard ratio; 1.17 per 1-point increase, 95% confidence intervals; 1.00-1.37, P = 0.04).</p><p><strong>Conclusion: </strong>The ESE score, which is based on three echocardiographic variables, may be an effective tool for diagnosing HFpEF on exercise echocardiography.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"866-875"},"PeriodicalIF":6.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of exercise stress echocardiography in systemic sclerosis: pathophysiological and prognostic significance of the systemic sclerosis with a heart failure and preserved ejection fraction phenotype.","authors":"Naoki Yuasa, Tomonari Harada, Kazuki Kagami, Hidemi Sorimachi, Yuki Saito, Ayami Naito, Yuta Tani, Toshimitsu Kato, Yukie Endo, Noriaki Takama, Naoki Wada, Sei-Ichiro Motegi, Hideki Ishii, Masaru Obokata","doi":"10.1093/ehjci/jeaf025","DOIUrl":"10.1093/ehjci/jeaf025","url":null,"abstract":"<p><strong>Aims: </strong>Left ventricular (LV) diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF) are common cardiac complications of patients with systemic sclerosis (SSc). Exercise stress echocardiography is often used in symptomatic patients with SSc to detect abnormal increases in pulmonary pressures during exercise, but the pathophysiologic and prognostic significance of exercise stress echocardiography to assess the presence of HFpEF in these patients is unclear.</p><p><strong>Methods and results: </strong>Patients with SSc (n = 140) underwent ergometry exercise stress echocardiography with simultaneous expired gas analysis. The HFA-PEFF score ≥ 5 points was used to diagnose HFpEF. Thirty-five patients met the HFpEF criteria (prevalence 25%). Compared with patients with SSc-non-HFpEF, those with SSc-HFpEF were older and had a higher prevalence of coronary artery disease, more severe LV diastolic dysfunction (by definition), depressed right ventricular systolic function, reduced exercise capacity (lower peak oxygen consumption), and poorer ventilatory efficiency. Exercise right heart catheterization was performed in 25 patients and it confirmed elevated pulmonary capillary wedge pressure during peak exercise in patients with SSc-HFpEF. Participants were followed up to assess the primary composite endpoint: all-cause mortality, HF hospitalization, unplanned hospital visits requiring intravenous diuretics, or oral diuretic intensification. Compared with SSc-non-HFpEF, SSc-HFpEF had a 5.3-fold increased risk of the composite outcomes (hazard ratio 5.29, confidence intervals 2.06-13.5, P = 0.0005).</p><p><strong>Conclusion: </strong>In addition to pulmonary haemodynamics, exercise stress echocardiography may be useful to identify the HFpEF phenotype that has different pathophysiology and clinical outcomes in patients with SSc.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"876-885"},"PeriodicalIF":6.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}