Mónica Dias, Sofia Fernandes, Catarina Vieira, Miguel Álvares Pereira
{"title":"Twice the spice: a unique association of hypertrophic cardiomyopathy and pericardial agenesis.","authors":"Mónica Dias, Sofia Fernandes, Catarina Vieira, Miguel Álvares Pereira","doi":"10.1093/ehjci/jeaf159","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf159","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anca Balinisteanu, Jürgen Duchenne, Alexis Puvrez, Laurine Wouters, Stéphanie Bézy, Ahmed Youssef, Lennert Minten, Youri Bekhuis, Leen Van Langenhoven, Konstantina Papangelopoulou, Aleksandra Cieplucha, Irene Cattapan, Paulo Tostes, Jan Bogaert, Dragos Vinereanu, James D Thomas, Luigi Badano, Jens-Uwe Voigt
{"title":"Vendor Differences in 2D-Speckle Tracking Global Longitudinal Strain: An Update on a Ten-Year Standardization Effort.","authors":"Anca Balinisteanu, Jürgen Duchenne, Alexis Puvrez, Laurine Wouters, Stéphanie Bézy, Ahmed Youssef, Lennert Minten, Youri Bekhuis, Leen Van Langenhoven, Konstantina Papangelopoulou, Aleksandra Cieplucha, Irene Cattapan, Paulo Tostes, Jan Bogaert, Dragos Vinereanu, James D Thomas, Luigi Badano, Jens-Uwe Voigt","doi":"10.1093/ehjci/jeaf155","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf155","url":null,"abstract":"<p><strong>Aims: </strong>To assess the inter-vendor differences in global longitudinal strain measurements and determine a potential improvement compared to the situation 10 years ago.</p><p><strong>Methods and results: </strong>372 echocardiographic exams were performed in 62 subjects (50 male, age 56 ± 17) with LV ejection fraction ranging from 30% to 68%, using ultrasound systems from six manufacturers: GE, Philips, Canon, Siemens, Fujifilm and Esaote. Each subject was scanned consecutively on all machines by the same assigned sonographer, with two image sets per subject to assess test-retest setting reproducibility. Average peak systolic global strain from the three apical views (GLSAV) was measured on three vendor-specific (Canon, Siemens and Fujifilm) and six vendor-agnostic (GE, Philips, US2.AI, Caas Qardia, Medis and Epsilon) software solutions (SWS). Endocardial and mid-/full-wall GLS were measured and compared to the mean GLS of contemporary semi-automated clinical software: GE, Philips, Canon, Fujifilm, and Caas Qardia.Endocardial and mid-/full-wall GLS measurements from contemporary semi-automated clinical software showed minimal inter-vendor differences, with an average maximum bias of 0.6% strain units. There was a remaining inter-vendor bias with and among some other vendors.The average minimal detectable change with contemporary semi-automated clinical software was 2.5 and 2.4 strain% for endocardial and mid-/full-wall GLS, resp. These values were higher for and among some other vendors.Test-retest variability of GLS measurements was good and similar to that of LV ejection fraction (6.6% vs. 6.5%, p > .05), indicating consistent results across repeated scans.</p><p><strong>Conclusion: </strong>In this controlled study setting, GLS measurements from companies that provide contemporary semi-automated clinical software have become more consistent, compared to ten years ago. Mid-/full-wall strain was now available in all but one software.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pok-Tin Tang, Jonathan Raby, Jessica Gunn, Andrew J M Lewis
{"title":"Regression of late gadolinium enhancement in a case of eosinophilic granulomatous polyangiitis with cardiac involvement.","authors":"Pok-Tin Tang, Jonathan Raby, Jessica Gunn, Andrew J M Lewis","doi":"10.1093/ehjci/jeaf163","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf163","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jürgen Duchenne, Simon Calle, Ivan Stankovic, Alexis Puvrez, Gabor Voros, John M Aalen, Camilla K Larsen, Einar Hopp, Otto A Smiseth, Elena Galli, Erwan Donal, Martin Penicka, Daniël Devos, Marc De Buyzere, Jan De Pooter, Frank Timmermans, Jens-Uwe Voigt
{"title":"Strain-based staging as a unifying concept in cardiac resynchronization therapy.","authors":"Jürgen Duchenne, Simon Calle, Ivan Stankovic, Alexis Puvrez, Gabor Voros, John M Aalen, Camilla K Larsen, Einar Hopp, Otto A Smiseth, Elena Galli, Erwan Donal, Martin Penicka, Daniël Devos, Marc De Buyzere, Jan De Pooter, Frank Timmermans, Jens-Uwe Voigt","doi":"10.1093/ehjci/jeaf162","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf162","url":null,"abstract":"<p><strong>Aims: </strong>Left bundle branch block (LBBB) septal strain patterns are associated with left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT). However, their prognostic value and impact in patients undergoing CRT, as well as in CRT-eligible patients receiving conservative treatment remains underexplored. This study aimed to validate the prognostic significance of LBBB strain patterns and elucidate the mechanisms underlying CRT response by evaluating their interaction with myocardial scar and clinical outcomes.</p><p><strong>Methods and results: </strong>In this multicenter study, 267 CRT patients underwent pre-implantation speckle-tracking strain analysis, with 155 also undergoing cardiac magnetic resonance imaging. CRT-treated patients were compared to 116 CRT-eligible conservatively treated patients. LBBB septal strain curves were categorized into five stages (LBBB-0 to LBBB-4). Endpoints included all-cause mortality, heart transplantation, and volumetric response in CRT recipients.CRT outcomes showed a stepwise improvement across LBBB stages in volumetric response (p<0.001) and survival (log-rank p=0.002). Myocardial scar, present in 52% of CRT patients, inversely correlated with LBBB stages (p=0.003). After multivariable adjustment, LBBB stages independently predicted volumetric response (OR 2.30, p<0.001) and survival (HR 0.64, p=0.038), while scar burden did not. Survival benefits were greater in CRT-treated patients than in conservatively treated patients, ranging from HR 1.42 (p=0.436) in LBBB-0 to HR 16.49 (p<0.001) in LBBB-4.</p><p><strong>Conclusions: </strong>LBBB strain stages independently predict CRT outcomes, with lower stages associated with attenuated benefits, possibly due to higher scar burden. This classification provides a framework for understanding LBBB pathophysiology and CRT response.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Conor J Kane, Vidhu Anand, Ratnasari Padang, Jwan A Naser, Kyla M Lara-Breitinger, Jared G Bird, Jeremy J Thaden, Vuyisile T Nkomo, Garvan C Kane, Cristina Pislaru, Christopher G Scott, Sorin V Pislaru
{"title":"Right ventricular-pulmonary artery coupling in patients with tricuspid valve regurgitation: Use of echo-derived pulmonary artery effective elastance.","authors":"Conor J Kane, Vidhu Anand, Ratnasari Padang, Jwan A Naser, Kyla M Lara-Breitinger, Jared G Bird, Jeremy J Thaden, Vuyisile T Nkomo, Garvan C Kane, Cristina Pislaru, Christopher G Scott, Sorin V Pislaru","doi":"10.1093/ehjci/jeaf161","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf161","url":null,"abstract":"<p><strong>Aims: </strong>Tricuspid valve regurgitation (TR) is common and associated with increased mortality. The interaction between the pulmonary artery (PA) circulation and the right ventricle (RV) and association with outcomes is incompletely understood. The effective PA elastance (PA Ea) is a composite measure of RV afterload that refers to the pulmonary vascular load that the RV must overcome to eject blood. Whether PA Ea discriminates mortality risk in unselected patients with significant TR is unknown.</p><p><strong>Methods and results: </strong>In consecutive patients with ≥ moderate TR, we compared all-cause mortality at five years based on the PA Ea (defined as the RV systolic pressure/stroke volume as measured by transthoracic echocardiography). In a total of 12,682 patients, the median PA Ea was 0.7 mmHg/mL (IQR 0.5, 0.9). Increasing levels of PA Ea were associated with heart failure, liver and kidney disease and clinical markers of risk such as the TRIO score. Increasing levels of PA Ea were associated with larger RVs, worse RV systolic function, higher NT-pro BNP levels, and greater degrees of right heart failure. After adjusting for age and sex, PA Ea was associated with higher risk of death (HR 1.55 per 0.5 mmHg/mL change of PA EA; 95% confidence intervals 1.51-1.60); p<.0001). In multivariable modeling incorporating available clinical variables, PA Ea was independently predictive of outcome compared to other indexes of RV-PA coupling.</p><p><strong>Conclusion(s): </strong>In patients with significant TR, higher PA Ea is progressively associated with RV dysfunction, right heart failure, and worse survival. Incorporating PA Ea into the routine echo assessment may help stratify risk.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea Barbieri, Francesca Bursi, Francesca Mantovani, Chiara Pedone, Concetta Zito, Fabrizio Celeste, Giulia Passarini, Alessandro Malagoli, Maria Cristina Turina, Licia Formigaro, Claudia Concilio, Lorenzo Pistelli, Giovanni Benfari, Ylenia Bartolacelli, Quirino Ciampi, Federico Fortuni, Giuseppe Boriani, Francesco Antonini-Canterin, Pompilio Faggiano, Scipione Carerj, Mauro Pepi
{"title":"Resolution of Left Ventricular Thrombus Assessed by Echocardiography: Insights from a Contemporary Multicenter Prospective Registry.","authors":"Andrea Barbieri, Francesca Bursi, Francesca Mantovani, Chiara Pedone, Concetta Zito, Fabrizio Celeste, Giulia Passarini, Alessandro Malagoli, Maria Cristina Turina, Licia Formigaro, Claudia Concilio, Lorenzo Pistelli, Giovanni Benfari, Ylenia Bartolacelli, Quirino Ciampi, Federico Fortuni, Giuseppe Boriani, Francesco Antonini-Canterin, Pompilio Faggiano, Scipione Carerj, Mauro Pepi","doi":"10.1093/ehjci/jeaf156","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf156","url":null,"abstract":"<p><strong>Background: </strong>How to detect and monitor left ventricular thrombus (LVT) remains complex since clinicians can rely only on retrospective, single-center data.</p><p><strong>Objectives: </strong>To characterize the incidence and independent associates of LVT resolution (assessed with echocardiography) and its clinical implications on long-term follow-up in a contemporary cohort of consecutive patients with LVT.</p><p><strong>Methods: </strong>Ten centers were involved in this observational prospective multicenter study. The use of different antithrombotic regimens and ultrasound contrast was left at the discretion of attending physicians. Echocardiographic follow-up was performed on days 16±8, 48±13, and 132±99 days from LVT detection. Resolution was defined as a complete disappearance of LVT on all echocardiographic views at the last available follow-up. Clinical endpoints included all-cause mortality, embolic complications, and bleeding events.</p><p><strong>Results: </strong>From October 2020 to September 2022, 154 consecutive patients with LVT (mean age 67±11 years, 79% men) were enrolled. Different anticoagulant regimens were used, and the median duration of anticoagulation was 6 (3-12) months. LVT resolution was achieved in 68% at a median follow-up of 36 (IQR15-74) days. At baseline assessment, LVT characteristics like smaller LVT area and mobile LVT were independent predictors of LVT resolution. At follow-up echocardiogram, greater LV global and apical mechanical function were independently associated with LVT resolution (OR, 1.04, 95%CI 1.01-1.07, p=0.026 for LVEF and 0.94, 95%CI 0.89-0.99, p=0.025 for apical wall motion score index). During a median follow-up of 1.91 (IQR, 1.32-2.83) years, patients with LVT resolution showed a significantly lower risk of embolic events (adjusted HR, 0.36 95%CI 0.13-0.99, p=0.04) and death (adjusted HR, 0.36 95%CI 0.14-0.95, p=0.03) compared with those without resolution. Moreover, LVT resolution was not associated with bleeding complications.</p><p><strong>Conclusions: </strong>The present longitudinal multicenter registry reveals that LVT persists in nearly one-third of patients after initial detection, even with anticoagulation therapy, and is associated with a poorer prognosis. Additionally, it offers valuable insights into echocardiographic predictors of LVT persistence, which could inform personalized follow-up strategies and treatment approaches.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}