Alexandra Fábián, Andrea Ferencz, Karima Addetia, Janka Hatvani, Bálint Magyar, Ádám Szijártó, Juan I Cotella, Bálint K Lakatos, Márton Tokodi, Martin Gruca, Federico M Asch, Béla Merkely, Jeremy Slivnick, Denisa Muraru, Luigi P Badano, Victor Mor-Avi, Roberto M Lang, Attila Kovács
{"title":"Decoding Right Ventricular Geometry: Novel 3D Echocardiography-Derived Global Shape Analysis Across Health and Disease States.","authors":"Alexandra Fábián, Andrea Ferencz, Karima Addetia, Janka Hatvani, Bálint Magyar, Ádám Szijártó, Juan I Cotella, Bálint K Lakatos, Márton Tokodi, Martin Gruca, Federico M Asch, Béla Merkely, Jeremy Slivnick, Denisa Muraru, Luigi P Badano, Victor Mor-Avi, Roberto M Lang, Attila Kovács","doi":"10.1093/ehjci/jeaf287","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf287","url":null,"abstract":"<p><strong>Aims: </strong>While pre-defined reference shapes have been used to assess morphological changes in the left ventricle, standardized methods for evaluating right ventricular (RV) remodeling are lacking. This study aimed to develop and test a new 3D echocardiography (3DE)-based method for quantifying RV shape in a large cohort of healthy individuals and across various disease states.</p><p><strong>Methods and results: </strong>3DE-derived RV mesh models were reconstructed in 1043 healthy subjects from the World Alliance of Societies of Echocardiography (WASE) study and in 581 patients with severe aortic stenosis (AS), heart failure with reduced ejection fraction (HFrEF), post-heart transplantation (HTX), severe primary mitral regurgitation (MR), atrial secondary tricuspid regurgitation (A-STR), tetralogy of Fallot (TOF) and pulmonary hypertension (PH). To assess global RV shape, hemi-sphericity volume ratio (HSVR) and hemi-conicity angle (HCA) were calculated, where a higher HSVR and a more acute HCA reflect more spherical and conical shapes, respectively. In the WASE population, females had more spherical RVs, whereas males had more conical RVs (p=0.028). Considering age, younger females had more conical RVs, while older individuals in both sexes showed spherical remodeling (p<0.05). Comparing disease groups with WASE controls, MR, HFrEF, and A-STR patients had more spherical RVs compared to controls (both p<0.001), while PH and TOF patients showed conical remodeling (both p<0.001). In A-STR, a more conical remodeling was associated with adverse clinical outcomes.</p><p><strong>Conclusion: </strong>The proposed 3DE method comprehensively characterizes RV geometry, demonstrating demographic variation in healthy individuals and disease-specific alterations in patients, with important prognostic implications.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexandra S Buta, Luigi P Badano, Marco Penso, Michele Tomaselli, Yuka Kawada, Noela D Radu, Alexandra Clement, Paolo Springhetti, Samantha Fisicaro, Francesca Heilbron, Giorgia Benzoni, Cinzia Pece, Francesco Damiani, Federico Franciosi, Bogdan A Popescu, Denisa Muraru
{"title":"Refining tricuspid regurgitation severity assessment with new corrected proximal isovelocity surface area threshold values.","authors":"Alexandra S Buta, Luigi P Badano, Marco Penso, Michele Tomaselli, Yuka Kawada, Noela D Radu, Alexandra Clement, Paolo Springhetti, Samantha Fisicaro, Francesca Heilbron, Giorgia Benzoni, Cinzia Pece, Francesco Damiani, Federico Franciosi, Bogdan A Popescu, Denisa Muraru","doi":"10.1093/ehjci/jeaf288","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf288","url":null,"abstract":"<p><strong>Aims: </strong>Research has shown that the corrected proximal isovelocity surface area (PISA) method yields larger values for regurgitant volume (RegVol) and effective regurgitant orifice area (EROA) than conventional PISA method. However, it remains unclear whether new threshold values are needed for the corrected PISA method to effectively categorize the severity of secondary tricuspid regurgitation (STR). This study sought to identify threshold values for EROA and RegVol measured by the corrected PISA method for a three-grade classification of STR severity.</p><p><strong>Methods and results: </strong>We used three-dimensional echocardiography to determine the volumetric regurgitant fraction (RegFr), calculated as the difference between the right (RV) and left ventricular (LV) stroke volumes (SV) divided by the RVSV. A total of 213 patients (78±10 years; 64% women) with isolated STR were enrolled. Based on RegFr, we classified STR severity into mild (RegFr< 16%), moderate (RegFr 16-49%), and severe (RegFr> 49%) grades. EROA and RegVol were measured using conventional (EROACONV, RegVolCONV) and corrected (EROACORR, RegVolCORR) PISA methods.The threshold values for identifying patients with mild, moderate, and severe STR were <0.22 cm², 0.22-0.46 cm², and >0.46 cm² for EROACORR, respectively; and <18 mL, 18-42 mL, and >42 mL for RegVolCORR, respectively. The accuracy of these new threshold values in predicting STR severity based on RegFr was 99% for EROACORR and 94% for RegVolCORR. These accuracies were significantly higher than those of EROACONV (90%, p<0.001) and RegVolCONV (41%, p<0.001).</p><p><strong>Conclusion: </strong>New threshold values for the corrected PISA method must be considered to improve the classification of STR severity.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giovanni Benfari, Corrado Fiore, Nicolas Merke, Mani A Vannan
{"title":"The Left Ventricle in Aortic Regurgitation: The present is the ever-moving shadow that divides yesterday from tomorrow. In that lies hope - Frank Lloyd Wright.","authors":"Giovanni Benfari, Corrado Fiore, Nicolas Merke, Mani A Vannan","doi":"10.1093/ehjci/jeaf290","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf290","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145228578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mónica Dias, Sofia Fernandes, Catarina Vieira, Miguel Álvares Pereira
{"title":"Twice the spice: a unique association of hypertrophic cardiomyopathy and pericardial agenesis.","authors":"Mónica Dias, Sofia Fernandes, Catarina Vieira, Miguel Álvares Pereira","doi":"10.1093/ehjci/jeaf159","DOIUrl":"10.1093/ehjci/jeaf159","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1690-1691"},"PeriodicalIF":6.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karina Wierzbowska-Drabik, Eszter Dalma Pálinkás, Maria Grazia D'Alfonso, Fabio Mori, Annamaria Del Franco, Jesus Peteiro Vazquez, Federica Re, Milorad Tesic, Ana Djordjevic-Dikic, Attila Pálinkás, Silvia Aguiar Rosa, Maria Angela Losi, Hugo Rodriguez-Zanella, Ines Cruz, Luis Rocha Lopes, Attila Nemes, Adelaide Arruda-Olson, Yi Wang, Lixue Yin, Giovanni L Tripepi, Marlena Broncel, Ylenia Bartolacelli, Mauro Pepi, Scipione Carerj, Quirino Ciampi, Patricia Pellikka, Iacopo Olivotto, Eugenio Picano
{"title":"Hypercontractile phenotype in hypertrophic cardiomyopathy indicates unfavorable hemodynamics, coronary flow and prognosis.","authors":"Karina Wierzbowska-Drabik, Eszter Dalma Pálinkás, Maria Grazia D'Alfonso, Fabio Mori, Annamaria Del Franco, Jesus Peteiro Vazquez, Federica Re, Milorad Tesic, Ana Djordjevic-Dikic, Attila Pálinkás, Silvia Aguiar Rosa, Maria Angela Losi, Hugo Rodriguez-Zanella, Ines Cruz, Luis Rocha Lopes, Attila Nemes, Adelaide Arruda-Olson, Yi Wang, Lixue Yin, Giovanni L Tripepi, Marlena Broncel, Ylenia Bartolacelli, Mauro Pepi, Scipione Carerj, Quirino Ciampi, Patricia Pellikka, Iacopo Olivotto, Eugenio Picano","doi":"10.1093/ehjci/jeaf238","DOIUrl":"10.1093/ehjci/jeaf238","url":null,"abstract":"<p><strong>Aims: </strong>Our aim was to assess the clinical and prognostic significance of the left ventricular (LV) hypercontractile phenotype (HP) in hypertrophic cardiomyopathy (HCM), which until now remains unclear.</p><p><strong>Methods and results: </strong>We enrolled 1533 HCM patients (age 51 ± 15 years, 965 males, 63%) with ejection fraction (EF) ≥ 50%, referred for rest transthoracic echocardiography (TTE) in 27 laboratories from 13 countries. Two-dimensional volumetric TTE assessment included LV outflow tract gradient (LVOTG), LV EF, and LV force (systolic blood pressure + LVOTG/ESV, mmHg/mL). HP was defined as the highest quartile of the force (> 7.32 mmHg/mL). Survival analysis was performed in a subset of 1200 patients with follow-up information. Compared with non-HP patients, HP showed higher heart rate (72 ± 14 vs. 67 ± 14 beats per minute, P < 0.001), lower stroke volume (50 ± 22 vs. 67 ± 22 mL, P < 0.001), larger left atrial volume index (44 ± 16 vs. 40 ± 16 mL/m2, P = 0.011) and higher coronary flow velocity in the mid-distal left anterior descending artery (n = 325, 41 ± 12 vs. 37 ± 14 cm/s, P = 0.021). Force was moderately related to LV EF (r = 0.48, P < 0.001) and weakly to LVOTG (r = 0.36, P < 0.001). During a median follow-up of 87 months (interquartile range 45-143 months), 131 all-cause deaths occurred. At multivariable Cox analysis, a force > 7.32 mmHg (the fourth quartile for analyzed patients) was associated with a hazard ratio of 1.44 (95% Confidence intervals 1.00-2.07) for all-cause death, independently of LVOTG and LV EF.</p><p><strong>Conclusion: </strong>HP in HCM is associated with a disadvantageous systemic, cardiac and coronary hemodynamic profile as well as lower survival in the long-term.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1675-1684"},"PeriodicalIF":6.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inês Conde, Ana Sofia Fernandes, Vitor Hugo Pereira, Catarina Vieira
{"title":"Left ventricular pseudoaneurysm in a high-risk patient: multimodal imaging and surgical repair.","authors":"Inês Conde, Ana Sofia Fernandes, Vitor Hugo Pereira, Catarina Vieira","doi":"10.1093/ehjci/jeaf173","DOIUrl":"10.1093/ehjci/jeaf173","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1697"},"PeriodicalIF":6.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}