{"title":"Intraventricular pressure drops by blood speckle tracking echocardiography: Emerging technology for assessing diastolic function.","authors":"Joao F Fernandes, Pablo Lamata, Otto A Smiseth","doi":"10.1093/ehjci/jeaf169","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf169","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Iria Silva, Alberto Alperi, Antonio Muñoz, Asim Cheema, Luis Nombela, Gabriela Veiga-Fernandez, Edgar Tay, Marina Urena, Lluis Asmarats, María Del Trigo, Yinghao Lim, Lola Gutierrez Alonso, Ander Regueiro, Francisco Campelo-Parada, Vicenç Serra, David Del Val, Henrique Barbosa Ribeiro, Julien Ternacle, Victoria Vilalta, Pablo Vidal, Yassin Belahnech, Fernando Alfonso, Jorge Nuche, Josep Rodes-Cabau, Philippe Pibarot
{"title":"'Incidence and impact of structural valve deterioration following TAVI: a multicenter real-world study'.","authors":"Iria Silva, Alberto Alperi, Antonio Muñoz, Asim Cheema, Luis Nombela, Gabriela Veiga-Fernandez, Edgar Tay, Marina Urena, Lluis Asmarats, María Del Trigo, Yinghao Lim, Lola Gutierrez Alonso, Ander Regueiro, Francisco Campelo-Parada, Vicenç Serra, David Del Val, Henrique Barbosa Ribeiro, Julien Ternacle, Victoria Vilalta, Pablo Vidal, Yassin Belahnech, Fernando Alfonso, Jorge Nuche, Josep Rodes-Cabau, Philippe Pibarot","doi":"10.1093/ehjci/jeaf083","DOIUrl":"10.1093/ehjci/jeaf083","url":null,"abstract":"<p><strong>Aims: </strong>Valve durability becomes a major issue as transcatheter aortic valve implantation (TAVI) is expanding to populations with longer life expectancy. We sought to (i) determine the incidence of structural valve deterioration (SVD), (ii) compare the incidence of SVD between balloon-expandable (BE) and self-expandable (SE) valves, and (iii) analyse the impact of SVD.</p><p><strong>Methods and results: </strong>2040 patients who underwent TAVI (2007-2020) from 9 centres were included. After inverse probability treatment weighting (IPTW), 1848 patients were selected (973 BE and 875 SE). SVD was defined using recent echocardiographic definitions according to VARC-3 criteria: Median follow-up was 4.2 (IQR: 2.5-5.7) years. The estimated incidence of SVD and bioprosthetic valve failure (BVF) at 8 years follow-up for the overall cohort were 13.3% [95% confidence interval (CI) 9.8-18%] and 11.5% (95% CI 8.9-14.8%), respectively. After IPTW and a median follow-up of 4 years, the risk of SVD (5.25% vs. 1.19%; HR 10.25, 95% CI 3.79-27.71, P < 0.001), and all-cause BVF (6.41% vs. 3.2%; HR 2.1, 95% CI 1.27-3.47 P = 0.004), was significantly higher for BE compared with SE recipients. Patients developing SVD had a trend towards a higher incidence of cardiovascular death (P = 0.06), as well as a significantly higher risk of heart failure rehospitalization (P = 0.048). After IPTW, there were no differences between BE and SE recipients in the combined endpoint of cardiovascular death, heart failure rehospitalization and valve reintervention (P = 0.46).</p><p><strong>Conclusion: </strong>In this real-world registry, the incidence of SVD at 8 years after TAVI was relatively low. The risk of SVD was higher among BE compared with SE valve recipients. SVD was associated with an increased risk of heart failure rehospitalization and a trend towards a higher risk of cardiovascular death.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1018-1028"},"PeriodicalIF":6.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bryan Abadie, Yasmine Elghoul, Sakthi Surya Prakash, Besir Besir, Khaled Ziada, Miriam Jacob, Sanjeeb Bhattacharya, Pavan Bhat, Randall C Starling, W H Wilson Tang, Wael Jaber
{"title":"Coronary microvascular dysfunction by positron emission tomography and outcomes in patients after cardiac transplantation.","authors":"Bryan Abadie, Yasmine Elghoul, Sakthi Surya Prakash, Besir Besir, Khaled Ziada, Miriam Jacob, Sanjeeb Bhattacharya, Pavan Bhat, Randall C Starling, W H Wilson Tang, Wael Jaber","doi":"10.1093/ehjci/jeaf042","DOIUrl":"10.1093/ehjci/jeaf042","url":null,"abstract":"<p><strong>Aims: </strong>Cardiac allograft vasculopathy (CAV) affects both epicardial and microvascular coronary arteries, however, few studies have characterized microvascular dysfunction in this population. Several prior studies have shown that positron emission tomography/computed tomography (PET/CT) can be used to screen for epicardial CAV, however, the clinical implications of abnormal blood flow in the absence of epicardial CAV are unknown. Our study sought to assess the prognostic implications of microvascular dysfunction and its subtypes, endogen/functional and classical/structural, using PET/CT in cardiac transplant patients without epicardial CAV.</p><p><strong>Methods and results: </strong>Transplant patients with no prior history of CAV and normal myocardial perfusion imaging were included. Patients were then classified by the presence of coronary microvascular dysfunction (CMD) (myocardial flow reserve < 2.0); patients with CMD were further subcategorized into endogen/functional (stress myocardial blood flow ≥ 1.7 mL/min/g) and classical/structural (stress myocardial blood flow < 1.7 mL/min/g). The primary outcomes were all-cause mortality and a composite of all-cause mortality, heart failure hospitalization, acute coronary syndrome, revascularization, and re-transplantation. Three hundred fifty-six patients met the inclusion criteria. CMD was present in 141 (39.6%) patients, of which 112 (31.4%) had endogen/functional CMD and 29 (8.1%) had classical/structural CMD. After multivariable adjustment, endogen/functional CMD was associated with a higher rate of the composite outcome (HR 2.39, 95% CI 1.32-4.29, P = 0.004) and all-cause mortality (HR 2.98, 95% CI 1.34-6.64, P = 0.008). Classical/structural CMD was not associated with the primary composite outcome (HR 0.92, 95% CI 0.27-3.17, P = 0.893) or all-cause mortality (HR 1.22, 95% CI 0.263-5.69, P = 0.797).</p><p><strong>Conclusion: </strong>In cardiac transplant patients with no history of CAV and normal myocardial perfusion, an endogen/functional pattern of CMD is associated with higher rate of adverse events and death. This association was not present in patients with a classical/structural CMD pattern. Incorporating endogen/microvascular dysfunction assessment in PET/CT reporting may identify a higher-risk group hereto now considered low risk.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"957-965"},"PeriodicalIF":6.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rocio Hinojar, Jose Rodriguez Palomares, Rocio Eiros, Manuel Barreiro, Noemi Ramos, Sara Rodriguez Diego, Laura Gutiérrez, Maria José Calero, Alfonso Muriel, Ariana González Gómez, Ana García Martin, Covadonga Fernández-Golfín, Jose Luis Zamorano
{"title":"Unlocking prognostic insights in severe tricuspid regurgitation: impact of right ventricular volumes and function by cardiac magnetic resonance.","authors":"Rocio Hinojar, Jose Rodriguez Palomares, Rocio Eiros, Manuel Barreiro, Noemi Ramos, Sara Rodriguez Diego, Laura Gutiérrez, Maria José Calero, Alfonso Muriel, Ariana González Gómez, Ana García Martin, Covadonga Fernández-Golfín, Jose Luis Zamorano","doi":"10.1093/ehjci/jeaf097","DOIUrl":"10.1093/ehjci/jeaf097","url":null,"abstract":"<p><strong>Aims: </strong>To describe prognostic cut-off values of right ventricular (RV) size and function by cardiac magnetic resonance (CMR) in a multicentre cohort of patients with severe tricuspid regurgitation (TR).</p><p><strong>Methods and results: </strong>The study enrolled patients with at least severe TR (severe, massive, and torrential) assessed by 2D echocardiography undergoing a contemporary CMR study. The primary endpoint was defined as combined endpoint of all-cause mortality or hospitalization for heart failure (HF) events, and the secondary endpoint was defined as cardiovascular mortality. Three hundred fourteen patients with severe TR were included in this study (70 ± 11 years, 67% female, 79% NYHA I or II). During a median follow-up of 35 months (interquartile range: 12-60), 39% of the patients experienced the combined endpoint. After adjusting for clinical and imaging variables, RV end-diastolic volume (RV-EDV) and RV ejection fraction (RVEF) were independently associated with all-cause mortality and HF (adj HR for RV-EDV: 1.015 [1.012-1.019], P < 0.001; adj HR for RVEF: 0.957 [0.938-0.976], P < 0.001). Thresholds of highest risk were defined by RV-EDV > 150 mL/m² and RVEF < 50%, while intermediate risk was defined by RV-EDV between 100 and 150 mL/m² and RVEF between 50% and 60%. Compared with low-risk groups, adjusted threshold for high-risk (adj HR for RV-EDV > 150 mL/m2: 5.42 [3.20-9.16] and for RVEF < 50%: 2.12 [1.21-3.71]) and intermediate-risk (adj HR for RV-EDV 100-150 mL/m2: 1.72 [1.11-2.64] and for RVEF 50-60%: 1.59 [1.04-2.43]) was significantly associated with impaired outcomes.</p><p><strong>Conclusion: </strong>Thresholds of RV volume and function by CMR stratifying low-intermediate and high-risk of cardiovascular events are defined in a multicentre cohort of patients. Compared with low-risk group, high- and, to a lower extent, intermediate-risk groups are independently associated to HF and all-cause mortality.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1007-1017"},"PeriodicalIF":6.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Long-term prognostic value of left and right ventricular systolic function on cardiovascular magnetic resonance imaging in systemic sclerosis.","authors":"Parag Bawaskar, Sanya Chhikara, Yugene Guo, Pal Satyajit Singh Athwal, Chetan Shenoy","doi":"10.1093/ehjci/jeaf086","DOIUrl":"10.1093/ehjci/jeaf086","url":null,"abstract":"<p><strong>Aims: </strong>Systemic sclerosis (SSc) is a rare autoimmune disorder associated with a high risk of cardiovascular diseases. We aimed to determine the long-term prognostic value of left and right ventricular (LV and RV) systolic dysfunction in SSc patients with clinically suspected cardiac disease.</p><p><strong>Methods and results: </strong>We conducted a retrospective cohort study of consecutive adults with SSc who had cardiovascular magnetic resonance (CMR) imaging for suspected cardiac disease. We assessed two CMR measures of LV and RV function, ejection fraction (EF), and feature tracking-derived global longitudinal strain (GLS) and investigated their associations with the long-term incidence of a composite endpoint of death or major adverse cardiac events (MACE). In 151 patients (median age 58 years, 81% women) who had CMR at a median of 3.6 years after diagnosis, the median LVEF was 58.0%, and the median LVGLS was -15.7%. The median RVEF was 57.0%, and the median RVGLS was -16.2%. Over a median follow-up of 4.7 years, 69 patients experienced the composite endpoint of death or MACE. LVGLS was independently associated with the composite endpoint [hazard ratio (HR) 1.08 per 1% worsening; 95% confidence interval (CI) 1.01-1.15; P = 0.018], while LVEF was not. Similarly, RVGLS was independently associated with the composite endpoint (HR 1.08 per 1% worsening; 95% CI 1.01-1.15; P = 0.017), while RVEF was not.</p><p><strong>Conclusion: </strong>In patients with SSc and clinically suspected cardiac disease, worse LVGLS and RVGLS on CMR were independently associated with death or MACE, while LVEF and RVEF were not.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1029-1038"},"PeriodicalIF":6.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"T1 mapping is not ready to replace the use of contrast agents in stress CMR.","authors":"Giovanni Donato Aquaro, Carmelo De Gori","doi":"10.1093/ehjci/jeaf098","DOIUrl":"10.1093/ehjci/jeaf098","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"991-992"},"PeriodicalIF":6.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}