Long-term adiposity in early adulthood affects coronary artery calcification incidence in midlife: a 25-year longitudinal study.

IF 6.6 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

European Heart Journal - Cardiovascular Imaging Pub Date : 2025-08-15 DOI:10.1093/ehjci/jeaf236

Shunyi Li, Haobin Zhou, Wenyan Li, Liusheng Wang, Qiming Zhao, Jun Chen, Song Lin, Shichao Li, Sijie Jiang, Weijing Feng, Qianqin Li, Dingli Xu, Qingchun Zeng

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引用次数: 0

Abstract

Aims: The study aimed to evaluate longitudinal adiposity exposure, assessed by body roundness index (BRI), from young adulthood and its association with the risk of coronary artery calcification (CAC) incidence in midlife.

Methods: We included 2102 participants from the CARDIA study with available BRI measurements at eight follow-up visits over 25 years. Cardiac computed tomography at year 25 exam was used to assess the presence of CAC (CAC > 0). The cumulative BRI (cBRI) was calculated as the mean of BRI between consecutive visits multiplied by the number of years. Logistic regression models and restricted cubic spline (RCS) analyses were assessed the relationship between cBRI and the risk of CAC incidence.

Results: A total of 598 participants developed CAC, over the 25-year follow-up period. Higher cBRI was associated with an increased risk of CAC incidence. Participants were divided into four quartiles based on cBRI. In model 3, the odds ratio (OR) for CAC was 2.52(95%CI, 1.82 - 3.49) in the top quartile of cBRI. RCS analyses suggested linear-shaped relationship between cBRI and the risk of CAC incidence. Furthermore, multivariable Cox regression showed that individuals in the higher cBRI had a higher risk of all-cause mortality (1.009; 95% CI, 1.003-1.016).

Conclusions: Greater cBRI from early adulthood was associated with an elevated risk of CAC incidence in mid-life. These findings uncover potential evidence to support that BRI may be a useful marker for identifying individuals at high risk of CAC.

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成年早期长期肥胖影响中年冠状动脉钙化发生率：一项25年的纵向研究。

目的：该研究旨在评估纵向肥胖暴露，通过身体圆度指数（BRI）来评估，从青年期开始，及其与中年冠状动脉钙化（CAC）发病率的关系。方法：我们纳入了来自CARDIA研究的2102名参与者，在25年的8次随访中获得了可用的BRI测量值。25岁时的心脏计算机断层扫描用于评估CAC的存在（CAC >）。累积BRI （cBRI）计算为连续访问之间BRI的平均值乘以年数。Logistic回归模型和限制性三次样条（RCS）分析评估了cBRI与CAC发病风险之间的关系。结果：在25年的随访期间，共有598名参与者患上了CAC。较高的cBRI与CAC发病率增加相关。参与者根据cBRI分为四个四分位数。在模型3中，在cBRI的前四分位数中，CAC的优势比（OR）为2.52（95%CI, 1.82 - 3.49）。RCS分析显示cBRI与CAC发病率呈线性关系。此外，多变量Cox回归显示，cBRI高的个体有更高的全因死亡风险(1.009；95% ci, 1.003-1.016)。结论：成年早期较高的cBRI与中年CAC发病率升高相关。这些发现揭示了潜在的证据，支持BRI可能是识别CAC高风险个体的有用标记。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Heart Journal - Cardiovascular Imaging CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

11.60

自引率

9.70%

发文量

708

审稿时长

4-8 weeks

期刊介绍： European Heart Journal – Cardiovascular Imaging is a monthly international peer reviewed journal dealing with Cardiovascular Imaging. It is an official publication of the European Association of Cardiovascular Imaging, a branch of the European Society of Cardiology. The journal aims to publish the highest quality material, both scientific and clinical from all areas of cardiovascular imaging including echocardiography, magnetic resonance, computed tomography, nuclear and invasive imaging. A range of article types will be considered, including original research, reviews, editorials, image focus, letters and recommendation papers from relevant groups of the European Society of Cardiology. In addition it provides a forum for the exchange of information on all aspects of cardiovascular imaging.