{"title":"Endoscopy for endothelialization after left atrial appendage closure by Amplatzer Amulet: in vivo insights from two clinical cases.","authors":"Toshinori Chiba, Yusuke Kondo, Miyo Nakano, Satoko Ryuzaki, Yoshio Kobayashi","doi":"10.1093/ehjci/jeaf133","DOIUrl":"10.1093/ehjci/jeaf133","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1604"},"PeriodicalIF":6.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aniela Petrescu, Marta Cvijic, Laurine Wouters, Ahmed Youssef, Stéphanie Bézy, Marta Orlowska, Ganna Degtiarova, Jürgen Duchenne, Jan Bogaert, Jan D'hooge, Jens-Uwe Voigt
{"title":"Ultrasound shear wave elastography for detection of myocardial fibrosis.","authors":"Aniela Petrescu, Marta Cvijic, Laurine Wouters, Ahmed Youssef, Stéphanie Bézy, Marta Orlowska, Ganna Degtiarova, Jürgen Duchenne, Jan Bogaert, Jan D'hooge, Jens-Uwe Voigt","doi":"10.1093/ehjci/jeaf200","DOIUrl":"10.1093/ehjci/jeaf200","url":null,"abstract":"<p><strong>Aims: </strong>Diffuse interstitial or replacement fibrosis is a common feature of a large variety of cardiomyopathies. These alterations contribute to increased myocardial stiffness (MS). Echocardiographic shear wave (SW) elastography is an emerging approach for measuring MS in vivo. SWs occur after mechanical excitation of the myocardium, e.g. after mitral valve closure, and their propagation velocity is directly related to MS. The objective of this study was to investigate whether SW velocities (SWVs) can distinguish between interstitial and replacement fibrosis.</p><p><strong>Methods and results: </strong>Fifty-two patients [30 heart transplanted patients (52.6 ± 16.0 years, 80% male) and 22 hypertrophic cardiomyopathy patients (54.4 ± 15.6 years, 85% male)] and 37 healthy volunteers (47.2 ± 16.6 years, 76% male) were included. SW elastography was performed using an experimental scanner at 1172 ± 302 frames per second. Patients were classified according to T1 mapping, extracellular volume (ECV) mapping, and late gadolinium enhancement measured by cardiac magnetic resonance into three groups: no fibrosis, interstitial fibrosis (MIF), and replacement fibrosis (MRF). SWVs differed among groups (P < 0.001), with a significant post hoc test between MIF and MRF and subjects without fibrosis (6.5 ± 1.1 m/s and 8.7 ± 1.2 m/s, respectively). Significant correlations were noted between SWVs and ECV values (r = 0.70, P < 0.0001) and native T1 values (r = 0.48, P = 0.0004). SWVs below 6.0 m/s showed the highest accuracy to identify patients without fibrosis [sensitivity 90%, specificity 90%, area under the curve (AUC) = 0.95]. A cut-off of 8.1 m/s could distinguish MRF from MIF (sensitivity 69%, specificity 100%, AUC = 0.92).</p><p><strong>Conclusion: </strong>Natural SWVs can distinguish between normal and pathological myocardium and depend on the fibrosis burden of the myocardium.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1537-1545"},"PeriodicalIF":6.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hossam Lababidi, Maan Malahfji, Mujtaba Saeed, Edward A Graviss, Dipan J Shah, Sherif F Nagueh
{"title":"Relation of left ventricular diastolic function to LV structure and outcomes in patients with aortic regurgitation.","authors":"Hossam Lababidi, Maan Malahfji, Mujtaba Saeed, Edward A Graviss, Dipan J Shah, Sherif F Nagueh","doi":"10.1093/ehjci/jeaf168","DOIUrl":"10.1093/ehjci/jeaf168","url":null,"abstract":"<p><strong>Aims: </strong>This study aimed to investigate the relationship between diastolic dysfunction (DD) and extracellular volume (ECV), scar burden, and myocyte volume in patients with at least moderate aortic regurgitation (AR) by cardiac magnetic resonance (CMR). We also sought to determine the association of DD with mortality in AR patients.</p><p><strong>Methods and results: </strong>Patients with at least moderate AR and who underwent echocardiographic and CMR imaging with a median time of 4 days between the two studies (interquartile range 1-43 days) were included. CMR was used to obtain left ventricular (LV) volumes, ejection fraction and mass, AR severity, scar extent, and ECV. DD was assessed by comprehensive echocardiography. The study included 323 patients. The mean age was 61.9 ± 16.0 and the median follow-up was 3.8 years, during which 86 patients died and 69 were hospitalized for heart failure. LV end-systolic volume, LV mass index, ECV, indexed cellular volume, and scar burden increased with advanced DD (P < 0.01). In multivariable Cox proportional hazard models, Grades II and III DD were independently associated with increased mortality (HR = 1.49, 95% CI = 1.1-1.98, P = 0.009).</p><p><strong>Conclusion: </strong>ECV, scar, and myocyte volume by CMR progressively increase with higher grades of DD by echocardiography, and DD is independently associated with mortality in patients with at least moderate AR.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1560-1569"},"PeriodicalIF":6.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paolo Springhetti, Philippe Pibarot, Denisa Muraru
{"title":"\"Double Trouble\": When Mixed Moderate Aortic Valve Disease Turns Out in a Severe Clinical Issue.","authors":"Paolo Springhetti, Philippe Pibarot, Denisa Muraru","doi":"10.1093/ehjci/jeaf255","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf255","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Osama Soliman, Elfatih A Hasabo, Niels van Royen, Ignacio J Amat-Santos, Martin Hudec, Matjaz Bunc, Alexander IJsselmuiden, Peep Laanmets, Daniel Unic, Bela Merkely, Renicus S Hermanides, Mohamed Mouden, Vlasis Ninios, Marcin Protasiewicz, Benno J W M Rensing, Pedro L Martin, Fausto Feres, Manuel De Sousa Almeida, Eric van Belle, Axel Linke, Alfonso Ielasi, Matteo Montorfano, Mark Webster, Konstantinos Toutouzas, Emmanuel Teiger, Francesco Bedogni, Michiel Voskuil, Dolores Mesa Rubio, Oskar Angerås, Won-Keun Kim, Jürgen Rothe, Ivica Kristić, Vicente Peral, Ben J L Van den Branden, Ashokkumar Thakkar, Udita Chandra, Dina Neiroukh, Cagri Ayhan, Mahmoud Y Nosir, Magdi S Yacoub, Sanaa Ali, Mohamad Altamimi, Hesham Elzomor, Patrick W Serruys, Andreas Baumbach
{"title":"Comparative 30-day Echocardiographic Outcomes of Myval versus Sapien and Evolut THVs: Insights from LANDMARK Trial.","authors":"Osama Soliman, Elfatih A Hasabo, Niels van Royen, Ignacio J Amat-Santos, Martin Hudec, Matjaz Bunc, Alexander IJsselmuiden, Peep Laanmets, Daniel Unic, Bela Merkely, Renicus S Hermanides, Mohamed Mouden, Vlasis Ninios, Marcin Protasiewicz, Benno J W M Rensing, Pedro L Martin, Fausto Feres, Manuel De Sousa Almeida, Eric van Belle, Axel Linke, Alfonso Ielasi, Matteo Montorfano, Mark Webster, Konstantinos Toutouzas, Emmanuel Teiger, Francesco Bedogni, Michiel Voskuil, Dolores Mesa Rubio, Oskar Angerås, Won-Keun Kim, Jürgen Rothe, Ivica Kristić, Vicente Peral, Ben J L Van den Branden, Ashokkumar Thakkar, Udita Chandra, Dina Neiroukh, Cagri Ayhan, Mahmoud Y Nosir, Magdi S Yacoub, Sanaa Ali, Mohamad Altamimi, Hesham Elzomor, Patrick W Serruys, Andreas Baumbach","doi":"10.1093/ehjci/jeaf245","DOIUrl":"10.1093/ehjci/jeaf245","url":null,"abstract":"<p><strong>Introduction: </strong>Several factors, including device design, annulus size, and sizing strategies, influence transcatheter heart valve (THV) hemodynamic outcomes in patients with aortic stenosis(AS). This substudy evaluates early (30-day) echocardiographic outcomes of the Myval, Sapien, and Evolut THV series, focusing on hemodynamic performance and valve durability.</p><p><strong>Methodology: </strong>The LANDMARK trial is a prospective, randomised, multicentre, open-label, non-inferiority trial comparing 384 patients implanted with Myval THV series to 384 receiving Sapien and Evolut THV series. Hemodynamic assessments followed Valve Academic Research Consortium-3 recommendations.</p><p><strong>Results: </strong>At 30-day, hemodynamic device success rates were 85.9%, 77.8, and 85.4% for Myval, Sapien, and Evolut THV series, respectively (PMyval-Sapien=0.02 and PMyval-Evolut>0.99). Significant improvements in peak aortic flow velocity, pressure gradients, effective orifice area(EOA), Doppler velocity index(DVI), and cardiac indices were observed across all groups, except for unchanged left ventricular ejection fraction. Moderate prosthesis-patient mismatch (PPM) was less frequent with Myval THV series(10.7%) versus Sapien THV series(22.5%), but higher than Evolut THV series (6.0%)(PMyval-Sapien=0.0006, PMyval-Evolut=0.12), while severe PPM showed no significant differences(4.3% vs 6.5% vs 1.8%; PMyval-Sapien=0.40, PMyval-Evolut=0.23). Total aortic regurgitation (≥moderate) showed no significant difference for Myval (2.6%), Sapien(1.8%) or Evolut THV series (6.3%)(PMyval-Sapien=0.76, PMyval-Evolut=0.06). Myval THV series required minimal oversizing compared to Evolut THV series (P<0.0001).</p><p><strong>Conclusion: </strong>The Myval THV series demonstrates short-term hemodynamic performance comparable to Evolut THV series and superior to Sapien THV series in moderate PPM incidence. Including intermediate sizes minimizes oversizing, underscoring its potential as an alternative for TAVI patients. Long-term follow-up is necessary to confirm these findings.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexandre Altes, Vincent Hanet, Bérengère Cardot, David Vancraeynest, Agnès Pasquet, François Delelis, Achwaq Lebouazda, Fanny Tartare, Domitille Tristram, Manuel Toledano, Valentina Silvestri, Bernhard L Gerber, Sylvestre Maréchaux
{"title":"Relationship between the Left-to-right Ventricular Volume Ratio and Aortic Regurgitation Severity: An Echocardiographic and Cardiac Magnetic Resonance Imaging Study.","authors":"Alexandre Altes, Vincent Hanet, Bérengère Cardot, David Vancraeynest, Agnès Pasquet, François Delelis, Achwaq Lebouazda, Fanny Tartare, Domitille Tristram, Manuel Toledano, Valentina Silvestri, Bernhard L Gerber, Sylvestre Maréchaux","doi":"10.1093/ehjci/jeaf251","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf251","url":null,"abstract":"<p><strong>Background: </strong>Left ventricular (LV) enlargement in chronic aortic regurgitation (AR) is commonly assessed using diameters and volumes. However, these measures are influenced by body size, sex, and age. The left-to-right ventricular end-diastolic volume ratio (LV/RV ratio), assessed by cardiac magnetic resonance imaging (CMR) and known to remain close to 1 in healthy individuals, could provide a more individualized marker of LV remodeling in chronic AR.</p><p><strong>Methods and results: </strong>This bi-center study included 258 patients with chronic AR (median age: 55 years, 18% women) who underwent echocardiography (Echo) and CMR. LV and RV volumes were measured from cine-CMR images. Associations between the LV/RV ratio, conventional LV measures, and significant AR, defined as grade 3-4 on Echo or Regurgitant fraction (AR-RegFrac) ≥ 33% on CMR, were analyzed using area under the curves (AUC) and logistic regression. The median LV/RV ratio was 1.5 [1.3-1.9], increased with AR severity (p<0.001), and correlated more strongly with AR-RegFrac (r=0.67, p<0.001) than conventional LV measures. The LV/RV ratio identified significant AR with good accuracy (Echo: AUC 0.77, CMR: AUC 0.83). A threshold of 1.5 provided balanced sensitivity and specificity (Se 71-84%, Sp 77-75%), while 1.8 ruled in significant AR with high specificity (Sp 91% for both modalities). The LV/RV ratio did not vary significantly by age or sex and showed consistent performance across subgroups.</p><p><strong>Conclusion: </strong>The LV/RV ratio is a reliable and individualized marker of LV remodeling in chronic AR. These findings support its potential role in clinical assessment and further evaluation in outcome studies.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mark Hinderks, Solenn Toupin, Robin Nijveldt, Suzanne Duhamel, Francesca Sanguineti, Thomas Hovasse, Stéphane Champagne, Thierry Unterseeh, Myriam Akodad, Antoinette Neylon, Trecy Gonçalves, Paul-Jun Martial, Sonia Houssany-Pissot, Emmanuel Gall, Jean Guillaume Dillinger, Patrick Henry, Valérie Bousson, Philippe Garot, Peter Damman, Jérôme Garot, Théo Pezel
{"title":"The role of stress cardiovascular magnetic resonance in patients with Diabetes Mellitus.","authors":"Mark Hinderks, Solenn Toupin, Robin Nijveldt, Suzanne Duhamel, Francesca Sanguineti, Thomas Hovasse, Stéphane Champagne, Thierry Unterseeh, Myriam Akodad, Antoinette Neylon, Trecy Gonçalves, Paul-Jun Martial, Sonia Houssany-Pissot, Emmanuel Gall, Jean Guillaume Dillinger, Patrick Henry, Valérie Bousson, Philippe Garot, Peter Damman, Jérôme Garot, Théo Pezel","doi":"10.1093/ehjci/jeaf249","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf249","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to evaluate the prognostic value of stress perfusion cardiovascular magnetic resonance (CMR) in diabetic versus non-diabetic patients, and then in symptomatic versus asymptomatic diabetics.</p><p><strong>Background: </strong>Diabetic individuals are at increased risk of coronary atherosclerosis. A significant percentage of diabetics fail to perceive the typical symptoms of myocardial ischemia. Screening methods such as coronary computed tomography (CCTA) or single-photon emission computed tomography (SPECT) have not shown clear benefits in asymptomatic diabetics. The role of stress CMR in this population is not well established.</p><p><strong>Methods: </strong>Between 2008 and 2018, all consecutive diabetic and non-diabetic patients without known cardiovascular disease referred for stress perfusion CMR in two tertiary centers were included. Propensity-score matching was used to create a cohort of diabetic versus non-diabetic patients with similar baseline characteristics. All patients were followed for the occurrence of major adverse cardiovascular events (MACE), defined as cardiovascular death or non-fatal myocardial infarction. Diabetic patients were categorized into symptomatic and asymptomatic patients.</p><p><strong>Results: </strong>Out of 3,485 eligible patients, 1,359 diabetics and 1,359 non-diabetics (mean age 69±12 years, 57.4% women) with similar propensity scores were included. Over a median follow-up period of 6.5 (5.9-8.9) years, 386 (14.2%) experienced MACEs. Kaplan-Meier analysis for the occurrence of MACE indicated that the extent of ischemia or late gadolinium enhancement (LGE) involving ≥ 3 segments were independent predictors of the occurrence of MACEs (hazard ratio, HR: 7.14 [95% CI, 5.01-10.02]; and HR: 5.03 [95% CI, 3.47-7.29]; both p<0.001, respectively), with no significant differences between diabetics and non-diabetics. Asymptomatic diabetics (n=255) showed similar event rates as symptomatic patients (p=0.98).</p><p><strong>Conclusion: </strong>Stress CMR provides valuable prognostic information in diabetic patients, irrespective of symptoms. Further assessment is needed to determine whether stress CMR should be a standard screening tool for diabetic patients.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}