Daniel J Hammersley, Srinjay Mukhopadhyay, Xiuyu Chen, Leanne Cheng, Richard E Jones, Lukas Mach, Lara Curran, Momina Yazdani, Alma Iacob, Amrit S Lota, Zohya Khalique, Antonio De Marvao, Resham Baruah, Kaushik Guha, James S Ware, John Gregson, Shihua Zhao, Dudley J Pennell, Upasana Tayal, Sanjay K Prasad, Brian P Halliday
{"title":"Comparative prognostic importance of measures of left atrial structure and function in non-ischaemic dilated cardiomyopathy.","authors":"Daniel J Hammersley, Srinjay Mukhopadhyay, Xiuyu Chen, Leanne Cheng, Richard E Jones, Lukas Mach, Lara Curran, Momina Yazdani, Alma Iacob, Amrit S Lota, Zohya Khalique, Antonio De Marvao, Resham Baruah, Kaushik Guha, James S Ware, John Gregson, Shihua Zhao, Dudley J Pennell, Upasana Tayal, Sanjay K Prasad, Brian P Halliday","doi":"10.1093/ehjci/jeae080","DOIUrl":"10.1093/ehjci/jeae080","url":null,"abstract":"<p><strong>Aims: </strong>This study aimed to compare the association between measures of left atrial (LA) structure and function, derived from cardiovascular magnetic resonance (CMR), with cardiovascular death or non-fatal heart failure events in patients with non-ischaemic dilated cardiomyopathy (DCM).</p><p><strong>Methods and results: </strong>CMR studies of 580 prospectively recruited patients with DCM in sinus rhythm [median age 54 (interquartile range 44-64) years, 61% men, median left ventricular ejection fraction 42% (30-51%)] were analysed for measures of LA structure [LA maximum volume index (LAVImax) and LA minimum volume index (LAVImin)] and function (LA emptying fraction, LA reservoir strain, LA conduit strain (LACS), and LA booster strain]. Over a median follow-up of 7.4 years, 103 patients (18%) met the primary endpoint. Apart from LACS, each measure of LA structure and function was associated with the primary endpoint after adjusting for other important prognostic variables. The addition of each LA metric to a baseline model containing the same important prognostic covariates improved model discrimination, with LAVImin providing the greatest improvement [C-statistic improvement: 0.702-0.738; χ2 test comparing likelihood ratio P < 0.0001; categorical net reclassification index: 0.210 (95% CI 0.023-0.392)]. Patients in the highest tercile of LAVImin had similar event rates to those with persistent atrial fibrillation. Measures of LA strain did not enhance model discrimination above LA volumetric measures.</p><p><strong>Conclusion: </strong>Measures of LA structure and function offer important prognostic information in patients with DCM and enhance the prediction of adverse outcomes. LA strain was not incremental to volumetric analysis for risk prediction.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1566-1574"},"PeriodicalIF":6.7,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140140167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carmen C Beladan, Francisco Gual-Capllonch, Andreea C Popescu, Bogdan A Popescu
{"title":"Diagnosing diastolic dysfunction and heart failure with preserved ejection fraction in patients with atrial fibrillation: a clinical challenge.","authors":"Carmen C Beladan, Francisco Gual-Capllonch, Andreea C Popescu, Bogdan A Popescu","doi":"10.1093/ehjci/jeae160","DOIUrl":"10.1093/ehjci/jeae160","url":null,"abstract":"<p><p>Left ventricular (LV) diastolic dysfunction, atrial fibrillation (AF), and heart failure with preserved ejection fraction (HFpEF) share common risk factors and are closely related to one another and to adverse cardiovascular events. Exertional dyspnoea in patients with AF should trigger a comprehensive LV diastolic function evaluation since AF frequently precedes incident HFpEF. An echocardiographic assessment of LV diastolic function in patients with AF is challenging, mainly because of variability in cycle length, the absence of atrial contraction, and the frequent occurrence of left atrial enlargement regardless of LV filling pressures (LVFPs). The algorithm of the 2016 recommendations for the evaluation of LV diastolic function cannot be directly applied in this setting. This review discusses the modalities available for diastolic function assessment and HFpEF diagnosis in patients with AF. Based on currently available data, a reasonable clinical target of diastolic function evaluation in AF would be to reach a binary conclusion: LVFP elevated or not. Recently, a two-step algorithm that combined several echocardiographic parameters plus the inclusion of body mass index has been proposed to differentiate normal from elevated LVFP in patients with AF. The echocardiographic evaluation must be complemented by a thorough clinical evaluation along with natriuretic peptides and cardiac catheterization in selected cases. If a diagnosis of HFpEF cannot be ascertained, a close follow-up for timely identification of diastolic dysfunction markers, along with monitoring and correction of modifiable risk factors, is recommended.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1546-1553"},"PeriodicalIF":6.7,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A floating mass in the heart: a rare case of renal carcinoma with intracardiac extension.","authors":"Zhitong Ge, Xiao Yang, Hongyan Wang, Jianchu Li","doi":"10.1093/ehjci/jeae163","DOIUrl":"10.1093/ehjci/jeae163","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"e263"},"PeriodicalIF":6.7,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141497513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea Bonelli, Anna Degiovanni, Angelica Cersosimo, Enrico Guido Spinoni, Manuel Bosco, Gabriele Dell'Era, Antonella Moreo, Benedetta Carla De Chiara, Lorenzo Gigli, Francesca Salghetti, Gianmarco Arabia, Carlo Mario Lombardi, Elisa Brangi, Cristina Giannattasio, Giuseppe Patti, Antonio Curnis, Marco Metra, Riccardo M Inciardi
{"title":"Determinants of invasive left atrial pressure in patients with atrial fibrillation.","authors":"Andrea Bonelli, Anna Degiovanni, Angelica Cersosimo, Enrico Guido Spinoni, Manuel Bosco, Gabriele Dell'Era, Antonella Moreo, Benedetta Carla De Chiara, Lorenzo Gigli, Francesca Salghetti, Gianmarco Arabia, Carlo Mario Lombardi, Elisa Brangi, Cristina Giannattasio, Giuseppe Patti, Antonio Curnis, Marco Metra, Riccardo M Inciardi","doi":"10.1093/ehjci/jeae194","DOIUrl":"10.1093/ehjci/jeae194","url":null,"abstract":"<p><strong>Aims: </strong>Estimation of left ventricular (LV) filling pressures in patients with a history of atrial fibrillation (AF) is challenging due to lack of reliable parameters. This study investigates the association between cardiac structure and function and invasive mean left atrial pressure (LAP).</p><p><strong>Methods and results: </strong>This is a multi-centre prospective study enrolling patients undergoing transcatheter ablation for AF. The invasive measurement of LAP was performed at the time of the procedure while the echocardiography within the previous 24 h. A mean LAP ≥ 15 mmHg was considered as increased. Overall, 101 patients were included (mean age 65.8 ± 8.5 years, 68% male, mean LV ejection fraction 56.6 ± 8.0%). No significant differences regarding clinical characteristics were detected between the group of patients with normal (n = 47) or increased LAP (n = 54). The latter showed lower values of LV global longitudinal strain, larger left atrial volumes (LAVs) and worse right ventricular (RV) function. After multivariable adjustment, higher E/e' ratio (P = 0.041) and minimal LAV index (LAVI min) (P = 0.031), lower peak atrial longitudinal strain (P = 0.030), and RV free wall longitudinal strain (P = 0.037), but not maximal LAV index (LAVI max) (P = 0.137), were significantly associated with mean LAP. The associations were not modified by cardiac rhythm. Overall, LAVI min showed the best diagnostic accuracy to predict elevated LAP (area under the curve 0.703).</p><p><strong>Conclusion: </strong>LA structure and function assessment well correlates with mean LAP in patients with a history of AF. These measures may be used in the assessment of filling pressure in these patients.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1590-1598"},"PeriodicalIF":6.7,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cuitláhuac Arroyo-Rodríguez, Imery Arlet Pérez-Pérez, José Eduardo Navarro-Ruiz, Jesús-Francisco López-Borbón, León Felipe Sandoval-García
{"title":"Stroke and takotsubo syndrome as the initial presentation of Takayasu arteritis.","authors":"Cuitláhuac Arroyo-Rodríguez, Imery Arlet Pérez-Pérez, José Eduardo Navarro-Ruiz, Jesús-Francisco López-Borbón, León Felipe Sandoval-García","doi":"10.1093/ehjci/jeae193","DOIUrl":"10.1093/ehjci/jeae193","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"e270"},"PeriodicalIF":6.7,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141765823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Imaging and mechanisms of heart failure with preserved ejection fraction: a state-of-the-art review.","authors":"Tomonari Harada, Atsushi Tada, Barry A Borlaug","doi":"10.1093/ehjci/jeae152","DOIUrl":"10.1093/ehjci/jeae152","url":null,"abstract":"<p><p>Understanding of the pathophysiology of heart failure with preserved ejection fraction (HFpEF) has advanced rapidly over the past two decades. Currently, HFpEF is recognized as a heterogeneous syndrome, and there is a growing movement towards developing personalized treatments based on phenotype-guided strategies. Left ventricular dysfunction is a fundamental pathophysiological abnormality in HFpEF; however, recent evidence also highlights significant roles for the atria, right ventricle, pericardium, and extracardiac contributors. Imaging plays a central role in characterizing these complex and highly integrated domains of pathophysiology. This review focuses on established evidence, recent insights, and the challenges that need to be addressed concerning the pathophysiology of HFpEF, with a focus on imaging-based evaluations and opportunities for further research.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1475-1490"},"PeriodicalIF":6.7,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Left atrial volume as risk marker: is minimum volume superior to maximum volume?","authors":"Otto A Smiseth, Camilla K Larsen, Einar Hopp","doi":"10.1093/ehjci/jeae136","DOIUrl":"10.1093/ehjci/jeae136","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1575-1576"},"PeriodicalIF":6.7,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141087343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}