Bo Li, Linlin Dai, Yujie Liu, Zijuan Han, Yun Tang, Xingrui Chen, Aoxiang Zhang, Xuan Ma, Pengyu Zhou, Xi Jia, Wenqing Xu, Kaisaierjiang Aisikaier, Shengyao Han, Fen Sa, Kai Yang, Kankan Zhao, Chaowu Yan, Shihua Zhao, Xiuyu Chen
{"title":"Impact of the Extent, Pattern, and Location of Replacement Myocardial Fibrosis on Clinical Outcomes in Aortic Regurgitation.","authors":"Bo Li, Linlin Dai, Yujie Liu, Zijuan Han, Yun Tang, Xingrui Chen, Aoxiang Zhang, Xuan Ma, Pengyu Zhou, Xi Jia, Wenqing Xu, Kaisaierjiang Aisikaier, Shengyao Han, Fen Sa, Kai Yang, Kankan Zhao, Chaowu Yan, Shihua Zhao, Xiuyu Chen","doi":"10.1093/ehjci/jeag285","DOIUrl":"https://doi.org/10.1093/ehjci/jeag285","url":null,"abstract":"<p><strong>Aims: </strong>The prognostic significance of late gadolinium enhancement (LGE)-detected replacement myocardial fibrosis in aortic regurgitation (AR) remains incompletely understood. This study aims to explore the association between the extent, pattern, and location of LGE and clinical outcomes in patients with chronic AR.</p><p><strong>Methods and results: </strong>Between 2010 and 2024, consecutive patients with moderate-to-severe AR and no significant coronary artery stenosis who underwent contrast-enhanced cardiac magnetic resonance (CMR) were included. The primary endpoint was major adverse cardiovascular events (MACE), defined as cardiovascular mortality, heart transplantation, or rehospitalization for heart failure. The association between LGE characteristics and MACE was evaluated. Overall, 363 patients (mean age 52.6 ± 14.2 years; 54 female) were included. Over a median follow-up of 56.6 months, 73 patients experienced MACE. LGE was present in 200 patients (55.1%). An LGE extent threshold of 2.6% provided robust risk stratification, yielding the highest C-index of 0.797, a likelihood ratio chi-square of 97.30, and the lowest Akaike information criterion of 681.06. Furthermore, predominant subendocardial-involved LGE was present in 13.5% of LGE-positive patients and was independently associated with MACE after adjusting for LGE extent (HR 3.028; 95% CI 1.216-7.539; P = 0.017). Kaplan-Meier analysis demonstrated that patients with both LGE extent >2.6% and predominant subendocardial-involved LGE pattern were at the highest risk of MACE.</p><p><strong>Conclusions: </strong>In AR, an LGE extent > 2.6% predicts MACE better than LGE presence alone. Furthermore, non-ischemic predominant subendocardial-involved LGE is independently associated with MACE. The coexistence of both features further amplifies the risk of MACE.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149180232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Santiago Fernández-Gordón Sánchez, José López Aguilera, Ana Mª González González, Candy Ceballos Gómez, Pedro Cabeza Lainez, María José Valle Caballero, Marinela Chaparro-Muñoz, José Manuel García-Pinilla, Ainhoa Robles-Mezcua, Carlos Gómez-Navarro, María Luisa Peña Peña, Dolores Mesa Rubio
{"title":"Diagnostic Yield of a Systematic IWT Score-Guided Echocardiographic Pathway for Cardiac Amyloidosis in Patients with Increased Left Ventricular Wall Thickness: A Prospective Multicentre Study.","authors":"Santiago Fernández-Gordón Sánchez, José López Aguilera, Ana Mª González González, Candy Ceballos Gómez, Pedro Cabeza Lainez, María José Valle Caballero, Marinela Chaparro-Muñoz, José Manuel García-Pinilla, Ainhoa Robles-Mezcua, Carlos Gómez-Navarro, María Luisa Peña Peña, Dolores Mesa Rubio","doi":"10.1093/ehjci/jeag277","DOIUrl":"https://doi.org/10.1093/ehjci/jeag277","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nick R Bijsterveld, Maarten van Diepen, Willem de Ronde, Harald T Jørstad
{"title":"Reversible remodelling, residual questions: the anabolic-steroid-exposed heart under longitudinal imaging.","authors":"Nick R Bijsterveld, Maarten van Diepen, Willem de Ronde, Harald T Jørstad","doi":"10.1093/ehjci/jeag239","DOIUrl":"https://doi.org/10.1093/ehjci/jeag239","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rang Abdullah, Astrid Bjørnebekk, Ingunn R Hullstein, Per M Thorsby, Thomas Helle-Valle, Thor Edvardsen, Kristina H Haugaa, Vibeke M Almaas
{"title":"Cardiovascular effects of continued vs. discontinued anabolic-androgenic steroid use: a longitudinal follow-up study.","authors":"Rang Abdullah, Astrid Bjørnebekk, Ingunn R Hullstein, Per M Thorsby, Thomas Helle-Valle, Thor Edvardsen, Kristina H Haugaa, Vibeke M Almaas","doi":"10.1093/ehjci/jeag238","DOIUrl":"https://doi.org/10.1093/ehjci/jeag238","url":null,"abstract":"<p><strong>Aims: </strong>Anabolic-androgenic steroid (AAS) use is prevalent among men engaged in strength training and is associated with adverse structural and functional cardiac changes, but longitudinal data are lacking. This follow-up study examined myocardial effects of AAS with continued use and reversibility following discontinuation.</p><p><strong>Methods and results: </strong>Participants of a previously published cohort (2017-19) of 101 AAS users and 71 non-using weightlifting controls (WLCs) were invited for a follow-up study and underwent interviews, hormonal profiling, and transthoracic echocardiography. Current AAS users at baseline were continued or discontinued users at follow-up, while former users at baseline were those with continued abstinence and those who relapsed.Among those re-enrolled, 70 were AAS users, of whom 35 continued, 15 discontinued, 14 maintained abstinence, and 6 relapsed, and 35 were WLCs. Continued AAS users had persistent indexed left ventricular mass (LVMI 119 ± 30 g/m2), reduced LV ejection fraction (LVEF 48 ± 10%), and worsened diastolic function. Continued AAS users receiving antihypertensive therapy showed improved LVEF compared with untreated users (Δ = 5 ± 8 vs. -4 ± 8%, P = 0.005). Discontinued AAS users showed reduction in LVMI (Δ = -21 g/m2, P = 0.01) and improved LVEF (Δ = 6%, P < 0.001). At follow-up, these changes were comparable with WLCs, which showed statistically but clinically insignificant differences.</p><p><strong>Conclusion: </strong>Continued AAS use was associated with sustained LV hypertrophy, LV systolic dysfunction, and worsening diastolic function. Antihypertensive therapy among ongoing AAS users was associated with improved LV systolic function. Discontinuation of AAS use was associated with improvement in cardiac structure and function towards values observed in WLCs.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gaurav S Gulsin, Bharath Ambale-Venkatesh, Leon Axel, David A Bluemke, Gabriella Captur, João L Cavalcante, Daniel B Ennis, Frederick H Epstein, Bernhard Gerber, Kate Hanneman, Nadine Kawel-Boehm, Sebastian Kelle, Christopher M Kramer, Joao A C Lima, Hildo J Lamb, Minjie Lu, Thomas H Marwick, Simone Romano, Alistair A Young, Gerry P McCann
{"title":"Cardiovascular magnetic resonance derived myocardial strain: applications, acquisition techniques, analysis, and reporting.","authors":"Gaurav S Gulsin, Bharath Ambale-Venkatesh, Leon Axel, David A Bluemke, Gabriella Captur, João L Cavalcante, Daniel B Ennis, Frederick H Epstein, Bernhard Gerber, Kate Hanneman, Nadine Kawel-Boehm, Sebastian Kelle, Christopher M Kramer, Joao A C Lima, Hildo J Lamb, Minjie Lu, Thomas H Marwick, Simone Romano, Alistair A Young, Gerry P McCann","doi":"10.1093/ehjci/jeag228","DOIUrl":"https://doi.org/10.1093/ehjci/jeag228","url":null,"abstract":"<p><p>Myocardial strain imaging enables quantification of cardiac deformation. Cardiovascular magnetic resonance imaging (CMR) is well suited for strain assessment due to the ability to image in any given plane with high spatial and contrast resolution. CMR strain measures have incremental diagnostic and prognostic utility over conventional clinical imaging parameters across disease states. Routine integration of CMR strain assessment in clinical practice has been hindered by the lack of agreement on imaging protocols and analysis methods, variability due to noise sensitivity, and a paucity of robust normative age-, sex- and ethnicity-specific reference ranges. In recognition of the expanding applications of strain techniques in clinical and research CMR, this joint SCMR/RSNA/EACVI scientific statement integrates data from original research studies, guidelines, and opinions from experts across the field to guide responsible and evidence-based utilization of CMR strain.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Erwan Donal, Adrien A L Wazzan, Olivier Lairez, Philippe Charron, Nicolas Piriou, Loic Biere, Patricia Reant, Ombeline Paglia, Fabien Labombarda, Jean-Christophe Eicher, Gilles Barone-Rochette, Hélène Ridon, Gilbert Habib, Olivier Huttin, Nadia Aissaoui, Damien Logeart, Charles Fauvel, Nathan Mewton, Elena Galli, Eve Cariou, Anne Bernard, Jean-Sébastien Hulot, Laurent Fauchier, Pascale Palassin, Jean-Christophe Ferre, Anne Ganivet, Alexandre Mansour, Emmanuel Oger
{"title":"Rivaroxaban for Stroke Prevention in Hypertrophic Cardiomyopathy Without Atrial Fibrillation and With Impaired Left Atrial Reservoir Strain: Design and Rationale of the LA-HCM Randomized Trial.","authors":"Erwan Donal, Adrien A L Wazzan, Olivier Lairez, Philippe Charron, Nicolas Piriou, Loic Biere, Patricia Reant, Ombeline Paglia, Fabien Labombarda, Jean-Christophe Eicher, Gilles Barone-Rochette, Hélène Ridon, Gilbert Habib, Olivier Huttin, Nadia Aissaoui, Damien Logeart, Charles Fauvel, Nathan Mewton, Elena Galli, Eve Cariou, Anne Bernard, Jean-Sébastien Hulot, Laurent Fauchier, Pascale Palassin, Jean-Christophe Ferre, Anne Ganivet, Alexandre Mansour, Emmanuel Oger","doi":"10.1093/ehjci/jeag280","DOIUrl":"https://doi.org/10.1093/ehjci/jeag280","url":null,"abstract":"<p><strong>Background: </strong>Current stroke prevention strategies in hypertrophic cardiomyopathy (HCM) rely on the detection of atrial fibrillation (AF), although thromboembolic events may occur before arrhythmia is documented. These observations support atrial cardiomyopathy as the substrate for thrombogenesis and highlight the need for imaging-guided risk stratification. Left atrial reservoir strain (LARS), derived from speckle-tracking echocardiography, detects atrial dysfunction earlier than left atrial enlargement and has been associated with AF and thromboembolic events. The LA-HCM trial evaluates whether rivaroxaban reduces thromboembolic events in patients with HCM, sinus rhythm, no documented AF, and impaired LARS. LA-HCM is a prospective, multicentre, randomized, open-label trial with blinded endpoint adjudication (PROBE design), sponsored by Rennes University Hospital and conducted in 17 French centres. A total of 532 adults with HCM, sinus rhythm, no documented AF, and core-laboratory-confirmed LARS ≤20% are randomized 1:1 to rivaroxaban or standard care. Participants are followed for 24 months. The primary endpoint is the composite of all-cause death, myocardial infarction, ischemic stroke-including newly detected silent cerebral infarction on paired baseline and 24-month brain MRI-and systemic embolism at 24 months. LA-HCM tests whether rivaroxaban improves outcomes in a population with HCM, no documented AF, and impaired LARS. It evaluates a LARS-based treatment-allocation strategy but is not designed to validate the predictive utility or optimal threshold of LARS.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}