Andrea Barbieri, Francesca Bursi, Francesca Mantovani, Chiara Pedone, Concetta Zito, Fabrizio Celeste, Giulia Passarini, Alessandro Malagoli, Maria Cristina Turina, Licia Formigaro, Claudia Concilio, Lorenzo Pistelli, Giovanni Benfari, Ylenia Bartolacelli, Quirino Ciampi, Federico Fortuni, Giuseppe Boriani, Francesco Antonini-Canterin, Pompilio Faggiano, Scipione Carerj, Mauro Pepi
{"title":"Resolution of left ventricular thrombus assessed by echocardiography: insights from a contemporary multicentre prospective registry.","authors":"Andrea Barbieri, Francesca Bursi, Francesca Mantovani, Chiara Pedone, Concetta Zito, Fabrizio Celeste, Giulia Passarini, Alessandro Malagoli, Maria Cristina Turina, Licia Formigaro, Claudia Concilio, Lorenzo Pistelli, Giovanni Benfari, Ylenia Bartolacelli, Quirino Ciampi, Federico Fortuni, Giuseppe Boriani, Francesco Antonini-Canterin, Pompilio Faggiano, Scipione Carerj, Mauro Pepi","doi":"10.1093/ehjci/jeaf156","DOIUrl":"10.1093/ehjci/jeaf156","url":null,"abstract":"<p><strong>Aims: </strong>How to detect and monitor left ventricular thrombus (LVT) remains complex since clinicians can rely only on retrospective, single-centre data. To characterize the incidence and independent associates of LVT resolution (assessed with echocardiography) and its clinical implications on long-term follow-up in a contemporary cohort of consecutive patients with LVT.</p><p><strong>Methods and results: </strong>Ten centres were involved in this observational prospective multicentre study. The use of different anti-thrombotic regimens and ultrasound contrast was left at the discretion of attending physicians. Echocardiographic follow-up was performed on days 16 ± 8, 48 ± 13, and 132 ± 99 days from LVT detection. Resolution was defined as a complete disappearance of LVT on all echocardiographic views at the last available follow-up. Clinical endpoints included all-cause mortality, embolic complications, and bleeding events. From October 2020 to September 2022, 154 consecutive patients with LVT (mean age 67 ± 11 years, 79% men) were enrolled. Different anti-coagulant regimens were used, and the median duration of anti-coagulation was 6 (3-12) months. LVT resolution was achieved in 68% at a median follow-up of 36 (IQR 15-74) days. At baseline assessment, LVT characteristics like smaller LVT area and mobile LVT were independent predictors of LVT resolution. At follow-up echocardiogram, greater LV global and apical mechanical function were independently associated with LVT resolution (OR, 1.04, 95% CI 1.01-1.07, P = 0.026 for LVEF and 0.94, 95% CI 0.89-0.99, P = 0.025 for apical wall motion score index). During a median follow-up of 1.91 (IQR, 1.32-2.83) years, patients with LVT resolution showed a significantly lower risk of embolic events (adjusted HR, 0.36 95% CI 0.13-0.99, P = 0.04) and death (adjusted HR, 0.36 95% CI 0.14-0.95, P = 0.03) compared with those without resolution. Moreover, LVT resolution was not associated with bleeding complications.</p><p><strong>Conclusion: </strong>The present longitudinal multicentre registry reveals that LVT persists in nearly one-third of patients after initial detection, even with anti-coagulation therapy, and is associated with a poorer prognosis. Additionally, it offers valuable insights into echocardiographic predictors of LVT persistence, which could inform personalized follow-up strategies and treatment approaches.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1406-1417"},"PeriodicalIF":6.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kristian Sørensen, Solveig Fadnes, Wadi Mawad, Matthew Henry, Hans Martin Flade, Andreas Østvik, Tor Åge Myklebust, Idar Kirkeby-Garstad, Lasse Løvstakken, Luc Mertens, Siri Ann Nyrnes
{"title":"Intraventricular pressure difference estimation based on blood speckle tracking-invasive validation and early clinical application.","authors":"Kristian Sørensen, Solveig Fadnes, Wadi Mawad, Matthew Henry, Hans Martin Flade, Andreas Østvik, Tor Åge Myklebust, Idar Kirkeby-Garstad, Lasse Løvstakken, Luc Mertens, Siri Ann Nyrnes","doi":"10.1093/ehjci/jeaf149","DOIUrl":"10.1093/ehjci/jeaf149","url":null,"abstract":"<p><strong>Aims: </strong>Ventricular relaxation creates an intraventricular pressure difference (IVPD) and resultant diastolic suction. Non-invasive estimation by echocardiographic techniques would allow to clinically evaluate IVPD as an important component of diastolic functional assessment. The aims of the current study were to evaluate the accuracy of IVPD estimation based on Blood Speckle Tracking (BST) echocardiography compared with invasive pressure measurements and to clinically apply the method in children with univentricular hearts (UVH) and controls.</p><p><strong>Methods and results: </strong>The accuracy of BST-based IVPD-estimates was assessed in an open-chest porcine model, comparing BST-based IVPD with simultaneous repeated invasive pressure measurements in six pigs using micromanometer catheters. BST-based IVPD assessment during early diastolic filling was performed in 83 healthy controls and 44 patients with UVH and compared between the groups. The validation in pigs included 103 measurements, demonstrating a mean difference of -0.01 mmHg (P = 0.33) and high correlation (r = 0.95, P value < 0.001) between IVPD from BST (-1.31 ± 0.28 mmHg) and invasive measurements (-1.30 ± 0.31 mmHg). In the paediatric patients, age range 6 months-17.76 years, feasibility was 93.9% in controls and 88.6% in UVH patients. Median IVPD was significantly higher in controls compared with UVH (-1.82 vs. -0.88 mmHg, P < 0.001). Intraclass correlation coefficients for variability of clinical BST-data were 0.99 (interobserver) and 0.98 (intraobserver) respectively.</p><p><strong>Conclusion: </strong>BST echocardiography provides accurate estimation of IVPD in early diastole. IVPD was significantly lower in children with UVH compared with controls suggesting lower diastolic suction, which can impact overall filling dynamics.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1346-1357"},"PeriodicalIF":6.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmed Sayed, Mahmoud Al Rifai, Maria Alwan, Mouaz H Al-Mallah
{"title":"The prognostic interplay between PET-derived resting myocardial blood flow and left ventricular ejection fraction.","authors":"Ahmed Sayed, Mahmoud Al Rifai, Maria Alwan, Mouaz H Al-Mallah","doi":"10.1093/ehjci/jeaf132","DOIUrl":"10.1093/ehjci/jeaf132","url":null,"abstract":"<p><strong>Aims: </strong>Whether the prognostic value of resting myocardial blood flow (MBFrest) and myocardial flow reserve (MFR) is modified by a patient's ejection fraction (EF) has not been studied.</p><p><strong>Methods and results: </strong>Consecutive patients undergoing stress/rest MPI using Rb-82 PET between 2019 and 2024 were included. The primary outcome was a composite of death and heart failure (HF) hospitalizations. Multivariable Andersen-Gill Cox models were used to assess the association with the primary outcome, adjusting for traditional risk factors and other PET parameters. Restricted cubic splines were used to allow non-linearity. The 50th percentile of MBFrest/MFR served as the reference, with the 25th and 75th percentiles representing low and high comparators respectively. A total of 8089 patients with a median follow-up of 519 days (IQR: 186-916 days), among whom 466 deaths and 819 HF hospitalizations ocurred. Both high MBFrest and low MFR were associated with an increased risk of the primary outcome (HRs of 1.39 [95% CI: 1.18-1.63] and 1.70 [95% CI: 1.41-2.04], respectively). There was a significant interaction with EF for both variables (P < 0.001), with greater prognostic value at higher EFs. At EFs of 40%, 50%, 60%, 70% the HRs for high vs. low MBFrest were 1.24, 1.61, 1.97, and 2.46, respectively and for low vs. high MFR were 1.57, 2.06, 2.59, and 3.13, respectively. Across the spectrum of EF, a higher MBFrest carried a greater risk of death or HF hospitalization at constant MFRs.</p><p><strong>Conclusion: </strong>The prognostic value of MBFrest and MFR is much more apparent at higher EFs, with a high MBFrest (and/or low MFR) identfying patients with a much higher risk than would be predicted based on their EF alone.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1333-1342"},"PeriodicalIF":6.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seth Uretsky, Linda D Gillam, Robert W W Biederman, Yuchi Han, Ron Jacob, Edward T Martin, Michael Langer, Andrew D Choi, Ibrahim Sultan, Joao L Cavalcante, Dipan J Shah, Matthew S Tong, Steven D Wolff, Sakul Sakul, Marco Guglielmo, Gianluca Pontone
{"title":"Sex differences in pre- and post-surgical left ventricular remodelling and outcomes in primary mitral regurgitation.","authors":"Seth Uretsky, Linda D Gillam, Robert W W Biederman, Yuchi Han, Ron Jacob, Edward T Martin, Michael Langer, Andrew D Choi, Ibrahim Sultan, Joao L Cavalcante, Dipan J Shah, Matthew S Tong, Steven D Wolff, Sakul Sakul, Marco Guglielmo, Gianluca Pontone","doi":"10.1093/ehjci/jeaf151","DOIUrl":"10.1093/ehjci/jeaf151","url":null,"abstract":"<p><strong>Aims: </strong>Studies suggest that females have worse post-surgical left ventricular (LV) reverse remodelling and clinical outcomes than males in primary mitral regurgitation (MR). These studies were retrospective, used linear dimensions of the LV, and did not account for MR severity. This study is to determine if there are sex differences with respect to pre- and post-surgical LV remodelling and clinical outcomes.</p><p><strong>Methods and results: </strong>There were 143 prospectively enrolled patients (60 ± 12 years, males 70%) with primary MR who underwent pre- and post-surgical CMR evaluation. Clinical outcomes were ascertained by patient interview and chart review. Adverse outcomes were a composite of heart failure hospitalisations, need for reoperation, and death. MR volume (MRV) and MR fraction (MRF) were independent predictors of pre-surgical LV end-diastolic volume (LVEDV) and post-surgical change in LVEDV and sex was not an independent predictor. For each 1 mL increase in MRV there was an increase in pre-surgical LVEDV of 0.93 mL for males and 1.0 mL for females and a post-surgical decrease in LVEDV of 1.1 mL for males and 1.0 mL for females. Over a mean follow-up period of 3.3 ± 2.6 years there were 10 (7%) patients with adverse events and no significant difference in the event rate between males and females (6% vs. 11%, P = 0.5).</p><p><strong>Conclusion: </strong>In primary MR there were no sex differences in the degree of pre-surgical LV dilatation or post-surgical LV reverse remodelling. There were no sex differences in adverse clinical events. These findings highlight that males and females benefit similarly from mitral valve surgery and females should be referred for mitral valve surgery when appropriate.(Clinical Trials: NCT04038879, NCT03012178, and NCT04051411).</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1429-1437"},"PeriodicalIF":6.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}