European Heart Journal - Cardiovascular Imaging最新文献

{"title":"Response to 'Prognostic value of lesion-specific pericoronary adipose tissue attenuation? Importantly, but not yet!'","authors":"S E van Rosendael, J J Bax","doi":"10.1093/ehjci/jeae319","DOIUrl":"https://doi.org/10.1093/ehjci/jeae319","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CT-derived Extracellular Volume Fraction in Aortic Stenosis, Cardiac Amyloidosis and Dual Pathology.","authors":"Masafumi Kidoh, Seitaro Oda, Noriaki Tabata, Naoto Kuyama, Tetsuya Oguni, Seiji Takashio, Hidetaka Hayashi, Shinpei Yamaguchi, Takeshi Nakaura, Yasunori Nagayama, Kengo Nakato, Yasuhiro Izumiya, Kenichi Tsujita, Toshinori Hirai","doi":"10.1093/ehjci/jeae320","DOIUrl":"https://doi.org/10.1093/ehjci/jeae320","url":null,"abstract":"<p><strong>Aims: </strong>To investigate CT-derived extracellular volume fraction (CT-ECV) in patients with lone aortic stenosis (AS), dual pathology of AS and transthyretin cardiac amyloidosis (AS-ATTR), and lone ATTR, and to examine the diagnostic performance and optimal cutoff values of CT-ECV for differentiating between patients with lone AS and AS-ATTR, and between patients with lone AS and lone ATTR.</p><p><strong>Methods and results: </strong>This retrospective study included consecutive patients with severe AS (including lone AS and AS-ATTR) and lone ATTR who underwent CT-ECV analysis and technetium 99m pyrophosphate (99mTc-PYP) scintigraphy. The diagnostic performance of CT-ECV for detecting cardiac amyloidosis was evaluated using the area under the receiver operating characteristic curve (AUC). Of 138 patients (mean age, 80 ± 8; 96 men), 55 had lone AS, 19 had AS-ATTR and 64 had lone ATTR. CT-ECV of patients with lone AS was 31 ± 5%. CT-ECV was significantly lower in patients with AS-ATTR than lone ATTR (45 ± 12% vs 53 ± 13%, P =.04). The AUC for differentiating patients with AS-ATTR from lone AS was lower than for lone ATTR from lone AS (0.90 [95% CI: 0.81, 0.96] vs 0.95 [95% CI: 0.90, 0.98]). The cutoff values of CT-ECV for differentiation between patients with lone AS and AS-ATTR were lower than those between patients with lone AS and lone ATTR (36.6% vs 38.5% [Youden index]). There was no significant difference in the proportion of 99mTc-PYP scintigraphy grade between patients with AS-ATTR and lone-ATTR (P = .20).</p><p><strong>Conclusion: </strong>Despite no significant difference in degree of ATTR between patients with AS-ATTR and lone ATTR, CT-ECV of patients with dual AS-ATTR pathology was significantly lower than that of patients with lone ATTR. The diagnostic performance and optimal cutoff values of CT-ECV for differentiating between patients with lone AS and AS-ATTR were lower than those between patients with lone AS and lone ATTR.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of coronary atherosclerosis in middle-aged and older athletes: the MARC-2 study.","authors":"Kristian Berge, Sylvan L J E Janssen, Birgitta K Velthuis, Peder Langeland Myhre, Arend Mosterd, Torbjørn Omland, Thijs M H Eijsvogels, Vincent L Aengevaeren","doi":"10.1093/ehjci/jeae317","DOIUrl":"https://doi.org/10.1093/ehjci/jeae317","url":null,"abstract":"<p><strong>Aims: </strong>Exercise improves cardiovascular health, but high-volume high-intensity exercise is associated with increased coronary artery atherosclerosis and calcification (CAC). We aimed to identify predictors of CAC in athletes.</p><p><strong>Methods and results: </strong>We assessed the association of traditional and non-traditional cardiovascular risk factors with CAC using linear and logistic regression. 289 male athletes from the MARC-2 study were included, with a median age of 60 [Q1-3 56-66] years, lifelong weekly training load of 26 [17-35] MET-hours, BMI of 24.5 [22.9-26.6] kg/m2, systolic blood pressure of 139±18 mmHg, and reported 0.0 [0.0-8.0] smoking pack years. Thirty-one percent had a CAC score >100 and 13% >400. Among traditional cardiovascular risk factors, higher age, systolic blood pressure, smoking pack years, and family history of coronary artery disease independently predicted greater CAC scores, while body mass index, LDL cholesterol, and diabetes mellitus did not. Among non-traditional risk factors, higher training loads, serum phosphate, and lower adjusted energy intake and fat percentage of energy intake independently predicted greater CAC scores. The full model with all traditional and non-traditional risk factors had higher accuracy in predicting CAC>100 (ROC-AUC 0.76, 95%CI [0.70-0.82]) and CAC>400 (0.85 [0.77-0.92]) than traditional cardiovascular risk factors alone (0.72 [0.65-0.78], p=0.012, and 0.81 [0.74-0.90], p=0.038, respectively).</p><p><strong>Conclusion: </strong>Non-traditional risk factors, including training load, dietary patterns, and serum phosphate, were independently associated with CAC in aging male athletes. Prediction accuracy for CAC increased when including these variables in a prediction model with traditional risk factors.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating inflammatory risk in atherosclerotic cardiovascular disease: plaque over plasma?","authors":"Maxim E Annink, Jordan M Kraaijenhof, Cheyenne Y Y Beverloo, Reindert F Oostveen, Hein J Verberne, Erik S G Stroes, Nick S Nurmohamed","doi":"10.1093/ehjci/jeae314","DOIUrl":"https://doi.org/10.1093/ehjci/jeae314","url":null,"abstract":"<p><p>Inflammation is an important driver of disease in the context of atherosclerosis, and several landmark trials have shown that targeting inflammatory pathways can reduce cardiovascular event rates. However, the high cost and potentially serious adverse effects of anti-inflammatory therapies necessitate more precise patient selection. Traditional biomarkers of inflammation, such as high-sensitivity C-reactive protein (hsCRP), show an association with cardiovascular risk on a population level, but do not have specificity for local plaque inflammation. Nowadays, advancements in non-invasive imaging of the vasculature enable direct assessment of vascular inflammation. Positron emission tomography (PET) tracers such as 18F-fluorodeoxyglucose (18F-FDG) enable detection of metabolic activity of inflammatory cells but are limited by low specificity and myocardial spillover effects. 18F-sodium fluoride (18F-NaF) is a tracer that identifies active microcalcification in plaques, indicating vulnerable plaques. 68Ga-DOTATATE targets pro-inflammatory macrophages by binding to somatostatin receptors, which enhances specificity for plaque inflammation. Coronary computed tomography angiography (CCTA) provides high-resolution images of coronary arteries, identifying high-risk plaque features. Measuring pericoronary adipose tissue attenuation (PCATa) on CCTA represents a novel marker of vascular inflammation. This review examines both established and emerging methods for assessing atherosclerosis-related inflammation, emphasizing the role of advanced imaging in refining risk stratification and guiding personalized therapies. Integrating these imaging modalities with measurements of systemic and molecular biomarkers could shift atherosclerotic cardiovascular disease management toward a more personalized approach.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Longitudinal Strain is a Predictor of Mortality in Patients with Cardiogenic Shock.","authors":"Kristoffer Berg-Hansen, Saki Ito, Jae Oh, Jeong Hoon Yang, Henrik Wiggers, Jacob C Jentzer","doi":"10.1093/ehjci/jeae316","DOIUrl":"https://doi.org/10.1093/ehjci/jeae316","url":null,"abstract":"<p><strong>Aims: </strong>Cardiogenic shock (CS) is a critical manifestation of severe cardiac dysfunction, necessitating precise evaluation of left ventricular function by transthoracic echocardiography. The prognostic value of global longitudinal strain (GLS) has not been examined in patients with CS. Therefore, we aimed to assess the prognostic significance of GLS in patients with CS.</p><p><strong>Methods and results: </strong>This was a retrospective study of patients with CS from 2007 to 2018 who had a transthoracic echocardiography performed within 24 hours of admission. GLS was measured and conventional parameters were obtained. Left ventricular dysfunction was categorized by GLS: >9.7% (Quartile 1), 7.0%<GLS≤9.7% (Quartile 2), 5.0%<GLS≤7.0% (Quartile 3), and ≤5.0% (Quartile 4). Outcomes included in-hospital and 1-year all-cause mortality. Among 623 CS patients with median LVEF of 31% (IQR: 24% to 41%) and median GLS of 7.0% (IQR: 5.0% to 9.7%), in-hospital mortality was 29%. Mortality increased across GLS quartiles: Quartile 1: 17%; Quartile 2: 22%; Quartile 3: 35%; and Quartile 4: 42%. GLS remained the only independent echocardiographic predictor of in-hospital mortality after adjusting for clinical covariates (adjusted odds ratio: 1.23 per 1% decrease, 95%CI: 1.04 to 1.46, P=0.015). GLS independently predicted 1-year all-cause mortality (P<0.001). The prognostic value of GLS was superior in acute coronary syndrome cases. A classification and regression tree analysis identified GLS as the most important echocardiographic variable for predicting in-hospital mortality.</p><p><strong>Conclusion: </strong>GLS independently predicted short- and long-term mortality in CS patients, surpassing conventional echocardiographic parameters in prognostic value, supporting its potential role in risk stratification in this population.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noninvasive myocardial work in severe aortic regurgitation: implications for postoperative left ventricular dysfunction.","authors":"Yu-Ting Tan, Yao-Ling Wang, Abudukadier Abulipizi, Xiang Ji, Rui-Ze Zhang, Ruo-Han Zhao, Quan-Fei Hou, Tian-Shu Liu, Shu-Kun He, Jia-Wei Shi, Yu-Man Li, Ling-Yun Fang, Li Zhang, Li Qiu, Jing Zhang, Ming-Xing Xie, Jing Wang","doi":"10.1093/ehjci/jeae312","DOIUrl":"https://doi.org/10.1093/ehjci/jeae312","url":null,"abstract":"<p><strong>Aims: </strong>Noninvasive myocardial work offers a promising echocardiographic method to evaluate left ventricular (LV) function as it integrates myocardial deformation and afterload. The study sought to investigate the association of myocardial work indices with post-operative LV dysfunction in patients with chronic severe aortic regurgitation (AR).</p><p><strong>Methods and results: </strong>Pre-operative LV ejection fraction (LVEF), LV global work index (LV GWI), LV global constructive work (LV GCW), LV global wasted work (LV GWW), and LV global work efficiency (LV GWE) were measured. Post-operative LV dysfunction was defined as LVEF < 50% at 12 months after surgery. One hundred and forty-one patients with chronic severe AR and preserved LVEF (52 (42-58) years; 74.5 % men) who underwent aortic valve surgery were studied. Twenty-six patients (18%) developed post-operative LV dysfunction. Patients with post-operative LV dysfunction had lower LV GWI, LV GCW, and LV GWE compared to those without (all P < 0.05). In multivariate analysis, LV GWI (adjusted odds ratio (OR): 0.99; 95% CI: 0.98-1.00; P < 0.001), and LV GCW (adjusted OR: 0.99; 95% CI: 0.99-1.00; P < 0.001) were associated with post-operative LV dysfunction. Moreover, a multivariate logistic regression model with LV GWI (Akaike information criterion = 108.023, Bayesian information criterion = 119.818, C-statistics = 0.836) showed the best capability in predicting post-operative LV dysfunction. The comparative analysis of C-statistics across the three models-LV GWI, LV GCW, and LV GLS-did not reveal statistically significant differences (all P > 0.05).</p><p><strong>Conclusion: </strong>In patients with chronic severe AR and preserved LVEF, impaired myocardial work indices are associated with post-operative LV dysfunction. Myocardial work has potential value for risk stratification and surgical decision-making in such a population.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodality imaging sheds light on an atypical presentation of Type I Truncus Arteriosus.","authors":"Ramona Ghenghea, Clément Karsenty, Yves Dulac, Philippe Acar, Khaled Hadeed","doi":"10.1093/ehjci/jeae304","DOIUrl":"https://doi.org/10.1093/ehjci/jeae304","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel algorithm for non-invasive estimation of left atrial pressure in patients with atrial fibrillation.","authors":"Jiwon Seo, Hee Tae Yu, In-Soo Kim, Tae-Hoon Kim, Boyoung Joung, Hui-Nam Pak, Iksung Cho, Chi Young Shim, Geu-Ru Hong, Jong-Won Ha","doi":"10.1093/ehjci/jeae311","DOIUrl":"https://doi.org/10.1093/ehjci/jeae311","url":null,"abstract":"<p><strong>Aims: </strong>Determining elevated left atrial (LA) pressure is crucial in patients with atrial fibrillation (AF), yet non-invasive estimation using echocardiography remains unclear. This study aimed to identify useful echocardiographic indices for identifying elevated LA pressure in patients with AF.</p><p><strong>Methods and results: </strong>Patients with paroxysmal or persistent AF referred for catheter ablation at two tertiary hospitals were prospectively enrolled. Mean LA pressure was measured immediately after transseptal puncture. Elevated mean LA pressure was defined as ≥15 mmHg. Transthoracic echocardiography was performed to acquire the guideline-recommended parameters. A total of 176 patients were included, and 63 (36%) patients had a mean LA pressure ≥15 mmHg. Patients with elevated LA pressure had more frequent hypertension, larger LA, higher septal E/e', and worse LA strain than the remaining patients. The correlations between mean LA pressure and each echocardiographic parameter were weak. Septal E/e' ratio showed the best correlation with mean LA pressure (r = 0.351, P < 0.001), and septal E/e' ratio ≥11 was the best parameter (area under the curve = 0.7, sensitivity = 65%, specificity = 73%, accuracy = 70%) to identify elevated mean LA pressure. A hierarchical algorithm consisting of septal E/e' ratio, LA reservoir strain, and LA volume index improved identification of patients with elevated mean LA pressure (sensitivity = 61%, specificity = 91%, accuracy = 80%).</p><p><strong>Conclusion: </strong>In patients with AF, the septal E/e' ratio was the best single parameter for identifying elevated mean LA pressure. A hierarchical algorithm combining the septal E/e' ratio, LA reservoir strain, and LA volume index helps identify elevated LA pressure in patients with AF.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrial and ventricular functional mitral regurgitation: prevalence, characteristics, outcomes, and disease progression.","authors":"Qin-Fen Chen, Xi Zhou, Christos S Katsouras, Chao Ni, Han Zhu, Chenyang Liu, Yangdi Peng, Hang-Bin Ge, Chenglv Hong, Wei-Hong Lin, Xiao-Dong Zhou","doi":"10.1093/ehjci/jeae309","DOIUrl":"https://doi.org/10.1093/ehjci/jeae309","url":null,"abstract":"<p><strong>Aims: </strong>Limited data exist on the natural history of functional mitral regurgitation (FMR), including atrial (AFMR), ventricular (VFMR), and dual FMR. This study examined the prevalence, characteristics, outcomes, and progression of these FMR subtypes.</p><p><strong>Methods and results: </strong>Consecutive patients with ≥mild to moderate FMR were included and classified as AFMR, VFMR, or dual FMR. AFMR is characterized by left atrial enlargement, while VFMR involves left ventricular enlargement or reduced left ventricular ejection fraction. Dual FMR combines features of both. Clinical outcome was all-cause mortality and heart failure (HF) hospitalization. Echocardiographic outcome was the progression from mild-moderate/moderate to severe FMR and from AFMR/VFMR to dual FMR. Of 22 814 patients, AFMR, VFMR, and dual FMR were identified in 39%, 14%, and 47%, respectively. Most (84%) had mild-moderate to moderate FMR. Over a median clinical follow-up of 4.7 years, dual FMR has the highest risk of all-cause mortality and HF hospitalization. Compared with AFMR, patients with VFMR have a higher incidence of all-cause mortality (adjusted HR = 1.73, 95%CI 1.54-1.94, P < 0.001) and HF hospitalization (adjusted HR = 1.23, 95%CI 1.15-1.32, P < 0.001). In the serial cohort with 2.4 (1.0-4.9) years echocardiogram follow-up, VFMR was associated with a 1.51-fold and 3.08-fold increase in the risk of progressing to severe FMR and dual FMR than AFMR (both P < 0.001). Sensitivity analyses did not change these findings.</p><p><strong>Conclusion: </strong>AFMR and VFMR have significant differences in survival and disease progression. Dual FMR is a common and distinct disease process that occurs in the progression of AFMR or VFMR and is associated with a poor prognosis.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between Duke, ESC-2015, ISCVID-2023 and ESC-2023 criteria for the diagnosis of TAVR-related infective endocarditis.","authors":"Inès Boufoula, Mary Philip, Florent Arregle, Laetitia Tessonnier, Serge Cammilleri, Sandrine Hubert, Jean-Paul Casalta, Frédérique Gouriet, Laurence Camoin-Jau, Alberto Riberi, Yassine Lemrini, Julien Mancini, Adrien Lemaignen, Fanny Dion, Nicolas Chane-Sone, Claire Lucas, Sébastien Renard, Anne-Claire Casalta, Olivier Torras, Pierre Ambrosi, Frédéric Collart, Anne Bernard, Gilbert Habib","doi":"10.1093/ehjci/jeae310","DOIUrl":"https://doi.org/10.1093/ehjci/jeae310","url":null,"abstract":"<p><strong>Background: </strong>Transcatheter aortic valve replacement-related infective endocarditis (TAVR-IE) is associated with a poor prognosis. TAVR-IE diagnosis is challenging, and benefits of the most recent classifications (ESC-2015, ISCVID-2023 and ESC-2023) have not been compared with the conventional Duke criteria on this population.</p><p><strong>Objectives: </strong>The primary objective was to compare the diagnostic value of the Duke, ESC-2015, ISCVID-2023, and ESC-2023 criteria for the diagnosis of TAVR-IE.The secondary objectives were to determine which criteria increase the diagnostic accuracy of each classification and to evaluate in-hospital and 1-year mortality of TAVR-IE.</p><p><strong>Methods: </strong>From January 2015 to May 2022, 92 patients with suspected TAVR-IE were retrospectively included in 2 French centers, including 82 patients with definite TAVR-IE and 10 patients with rejected TAVR-IE as defined by expert consensus.</p><p><strong>Results: </strong>Duke classification yielded a sensitivity of 65% (95%, CI: 53%-75%) and a specificity of 100% (95%, CI: 69%-100%) for the diagnosis of TAVR-IE. ESC-2015 classification increased Duke criteria sensitivity from 65% to 73% (p=0.016) but decreased specificity from 100% to 90%. ISCVID-2023 and ESC-2023 also increased Duke criteria sensitivity, from 65% to 76% (p=0.004) and 77% (p=0.002), respectively but also decreased specificity from 100% to 90%. A positive 18F-FDG PET/CT was the most helpful criterion, as 10 patients (11%) were correctly reclassified. In-hospital mortality after TAVR-IE was 21% and one-year mortality was 38%.</p><p><strong>Conclusions: </strong>A multimodality imaging approach, including 18F-FDG PET/CT and gated cardiac CT, is the cornerstone of TAVR-IE diagnosis and explains the higher sensitivity of ESC-2015 and recent classifications compared with Duke criteria.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}