Seth Uretsky, Linda Gillam, Robert W W Biederman, Yuchi Han, Ron Jacob, Edward T Martin, Michael Langer, Andrew D Choi, Ibrahim Sultan, Joao L Cavalcante, Dipan J Shah, Matthew S Tong, Steven D Wolff, Sakul Sakul, Marco Guglielmo, Gianluca Pontone
{"title":"Sex Differences in Pre- and Post-Surgical Left Ventricular Remodeling and Outcomes in Degenerative Mitral Regurgitation.","authors":"Seth Uretsky, Linda Gillam, Robert W W Biederman, Yuchi Han, Ron Jacob, Edward T Martin, Michael Langer, Andrew D Choi, Ibrahim Sultan, Joao L Cavalcante, Dipan J Shah, Matthew S Tong, Steven D Wolff, Sakul Sakul, Marco Guglielmo, Gianluca Pontone","doi":"10.1093/ehjci/jeaf151","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf151","url":null,"abstract":"<p><strong>Background: </strong>Studies suggest that females have worse post-surgical left ventricular (LV) reverse remodeling and clinical outcomes than males in primary mitral regurgitation (MR). These studies were retrospective, used linear dimensions of the LV, and did not account for MR severity. This study is to determine if there are sex differences with respect to pre- and post-surgical LV remodeling and clinical outcomes.</p><p><strong>Methods: </strong>There were 143 prospectively enrolled patients (60 ± 12yrs, males 70%) with primary MR who underwent pre- and post-surgical CMR evaluation. Clinical outcomes were ascertained by patient interview and chart review. Adverse outcomes were a composite of heart failure hospitalizations, need for reoperation, and death.</p><p><strong>Results: </strong>MRV and MRF were independent predictors of pre-surgical LVEDV and post-surgical change in LVEDV and sex was not an independent predictor. For each 1ml increase in MRV there was an increase in pre-surgical LVEDV of 0.93ml for males and 1.0ml for females and a post-surgical decrease in LVEDV of 1.1ml for males and 1.0ml for females. Over a mean follow-up period of 3.3±2.6 years there were 10 (7%) patients with adverse events and no significant difference in the event rate between males and females (6 vs 11%, p=0.5).</p><p><strong>Conclusion: </strong>In primary MR there were no sex differences in the degree of pre-surgical LV dilatation or post-surgical LV reverse remodeling. There were no sex differences in adverse clinical events. These findings highlight that males and females benefit similarly from mitral valve surgery and females should be referred for mitral valve surgery when appropriate.(Clinical Trials: NCT04038879, NCT03012178, NCT04051411).</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Silvio Henrique Barberato, Nuno Cardim, Daniela do Carmo Rassi, Anna Baritussio, Adenalva Lima de Souza Beck, Bernard Cosyns, Alex Felix, Luna Gargani, André L C Almeida, Maria Carmo Pereira Nunes, Marcelo Luiz Campos Vieira, Marc R Dweck, Steffen Erhard Petersen
{"title":"Cardiac Imaging in Patients With Tropical Diseases. A Scientific Statement of the European Association of Cardiovascular Imaging (EACVI) of the ESC and the Cardiovascular Imaging Department of the Brazilian Society of Cardiology (DICSBC).","authors":"Silvio Henrique Barberato, Nuno Cardim, Daniela do Carmo Rassi, Anna Baritussio, Adenalva Lima de Souza Beck, Bernard Cosyns, Alex Felix, Luna Gargani, André L C Almeida, Maria Carmo Pereira Nunes, Marcelo Luiz Campos Vieira, Marc R Dweck, Steffen Erhard Petersen","doi":"10.1093/ehjci/jeaf154","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf154","url":null,"abstract":"<p><p>Tropical diseases (TDs), or neglected tropical diseases, affect over one billion subjects globally, primarily in impoverished regions. Despite their impact, these diseases are often overlooked on the global health agenda, with limited resources allocated to their control. TDs are caused by various pathogens, including viruses, protozoa, helminths, and bacteria. Climate change and migration have led to the spread of TDs beyond tropical regions, highlighting the need for healthcare providers worldwide to address their management. The World Health Organization (WHO) has released a road map for the prevention, control, and elimination of TDs by 2030. Cardiovascular involvement in TDs, including myocarditis, pericardial disease, pulmonary hypertension, obstructions caused by cysts, myocardial ischemia, and cardiomyopathies, complicates disease prognosis. However, cardiovascular complications of TDs are often underrecognized and understudied. This scientific statement, prepared by the European Association of Cardiovascular Imaging (EACVI) and the Cardiovascular Imaging Department of the Brazilian Society of Cardiology (DICSBC), reviews the current understanding of the use of cardiovascular imaging in TDs, underscores gaps of knowledge, and proposes potential solutions. Although limited evidence is available, cardiovascular imaging techniques are valuable in diagnosing and managing cardiac manifestations of TDs. The scientific statement addresses some of the main tropical infections today, such as Dengue, Malaria, Schistosomiasis, and Tuberculosis, but excludes Chagas disease and rheumatic fever, which have been extensively covered in other documents. When used effectively, cardiovascular imaging can potentially aid in early diagnosis, prevention of complications, and management of cardiovascular impairment due to TDs, improving healthcare systems and patient care.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marko A Taipale, Markku O Pentikäinen, Laura A Martelius, Aino Mutka, Soili I Kytölä, Matti Kankainen, Juha I Peltonen, Simo O Syrjälä, Arttu J I Lahtiharju, Jyri J Lommi, Timo J Jahnukainen, Karl B Lemström, Tiina H Ojala
{"title":"Cardiac Magnetic Resonance in Heart Transplant Recipients: Histological, Clinical and Cell-Free DNA Validation.","authors":"Marko A Taipale, Markku O Pentikäinen, Laura A Martelius, Aino Mutka, Soili I Kytölä, Matti Kankainen, Juha I Peltonen, Simo O Syrjälä, Arttu J I Lahtiharju, Jyri J Lommi, Timo J Jahnukainen, Karl B Lemström, Tiina H Ojala","doi":"10.1093/ehjci/jeaf145","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf145","url":null,"abstract":"<p><strong>Aims: </strong>Cardiac magnetic resonance (CMR) presents a promising non-invasive method for evaluating acute rejection in heart transplant recipients. As indicators of myocardial injury, T1 and T2 mapping values are crucial for comprehending rejection patterns in heart transplants. This study aims to define CMR T1 and T2 mapping values in heart transplant patients both with and without acute rejection.</p><p><strong>Methods and results: </strong>In this blinded prospective study, we analyzed CMR data from 244 scans of 58 pediatric and adult heart transplant recipients, 1-24 months post-transplant. Rejection status was defined by endomyocardial biopsy, clinical data, and donor-derived cell-free DNA (dd-cfDNA). Over the 24 months post-transplant, global T1 and T2 values decreased significantly (T1: β = -9.1/log(month), p < 0.001; T2: β = -0.5/log(month), p < 0.001) demonstrating the gradual recovery from transplant-related myocardial injury. During acute rejection, T1 values significantly increased compared to rejection-free studies in both children (estimates at one month post-transplant 1188 ms [95% CI: 1161-1215] vs. 1079 [95% CI: 1061-1097], p < 0.001) and adults (1087 ms [95% CI: 1045-1129] vs. 1016 [95% CI: 1005-1027], p = 0.007). T1 and T2 values were positively associated with dd-cfDNA (p < 0.001 and p = 0.014, respectively), and T2 values with worse left ventricular global longitudinal strain (p < 0.001).</p><p><strong>Conclusion: </strong>We provide essential T1 and T2 mapping values across cardiac segments, as well as left ventricular myocardial strain, both with and without acute rejection. These findings establish a reliable foundation for non-invasive heart transplant rejection screening.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cvetan Trpkov, Aaisha Ferkh, Mariama Akodad, Brian Chiang, Andrew Chatfield, David Meier, Julius Jelisejevas, Soohyun A Chang, Robert Moss, Kevin Ong, Janarthanan Sathananthan, David A Wood, Anson Cheung, Jian Ye, Maggie Yu, John Webb, Gnalini Sathananthan
{"title":"Clinical impact of residual gradient and 3D orifice area after trans-catheter mitral valve-in-valve implantation.","authors":"Cvetan Trpkov, Aaisha Ferkh, Mariama Akodad, Brian Chiang, Andrew Chatfield, David Meier, Julius Jelisejevas, Soohyun A Chang, Robert Moss, Kevin Ong, Janarthanan Sathananthan, David A Wood, Anson Cheung, Jian Ye, Maggie Yu, John Webb, Gnalini Sathananthan","doi":"10.1093/ehjci/jeaf152","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf152","url":null,"abstract":"<p><strong>Aims: </strong>The mitral-valve-in-valve (MVIV) procedure has emerged as an important therapy in failing surgical bioprosthetic valves. We aimed to evaluate factors associated with outcome following MVIV intervention, specifically the impact of 30-day MVIV gradient. We also explored the value of intraprocedural MVIV 3-dimensional-anatomic orifice area (3D-AOA) by transesophageal echocardiography (TEE) in a subset of patients (n=68).</p><p><strong>Methods and results: </strong>Consecutive MVIV patients from a single institution with 30-day transthoracic echocardiography (TTE) were included (N=100). Clinical and echocardiographic variables were evaluated. The primary outcome was one-year composite of all-cause mortality, heart failure hospitalization or reintervention. Multivariable analysis was performed to determine predictors of primary outcome. Mean age was 77.3±10.6 years and pre-intervention mean mitral gradient was 11.5±4.0 mmHg. 30-day MVIV mean gradient was 7.4±2.6 mmHg with ≤1+ residual regurgitation in 99.0% of patients. Multivariable analysis identified MVIV mean gradient as the only independent determinant of the primary outcome (HR 1.31, CI 1.07-1.61, p=0.009). MVIV 3D-AOA was associated with a 30-day MVIV mean gradient of > 7 mmHg by TTE (ROC-AUC 0.8, p<0.001), and patients with 3D-AOA >2 cm2 had significantly lower 1-year all-cause mortality (2.5% vs. 18.7% Kaplan Meier log-rank p=0.03).</p><p><strong>Conclusion: </strong>Elevated 30-day mean gradient is associated with worse outcomes after MVIV, and smaller intraprocedural MVIV 3D-AOA is associated with a higher 30-day mean gradient and worse mortality. Optimizing MVIV orifice area at the time of procedure may improve valve hemodynamics and patient outcomes.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kristian Sørensen, Solveig Fadnes, Wadi Mawad, Matthew Henry, Hans Martin Flade, Andreas Østvik, Tor Åge Myklebust, Idar Kirkeby-Garstad, Lasse Løvstakken, Luc Mertens, Siri Ann Nyrnes
{"title":"Intraventricular Pressure Difference Estimation based on Blood Speckle Tracking - Invasive Validation and Early Clinical Application.","authors":"Kristian Sørensen, Solveig Fadnes, Wadi Mawad, Matthew Henry, Hans Martin Flade, Andreas Østvik, Tor Åge Myklebust, Idar Kirkeby-Garstad, Lasse Løvstakken, Luc Mertens, Siri Ann Nyrnes","doi":"10.1093/ehjci/jeaf149","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf149","url":null,"abstract":"<p><strong>Aims: </strong>Ventricular relaxation creates an intraventricular pressure difference (IVPD) and resultant diastolic suction. Non-invasive estimation by echocardiographic techniques would allow to clinically evaluate IVPD as an important component of diastolic functional assessment. The aims of the current study were to evaluate the accuracy of IVPD estimation based on Blood Speckle Tracking (BST) echocardiography compared to invasive pressure measurements and to clinically apply the method in children with univentricular hearts (UVH) and controls.</p><p><strong>Methods and results: </strong>The accuracy of BST-based IVPD-estimates was assessed in an open-chest porcine model, comparing BST-based IVPD with simultaneous repeated invasive pressure measurements in six pigs using micromanometer catheters. BST-based IVPD assessment during early diastolic filling was performed in 83 healthy controls and 44 patients with UVH and compared between the groups.The validation in pigs included 103 measurements, demonstrating a mean difference of -0.01 mmHg (p=0.33) and high correlation (r = 0.95, p-value < 0.001) between IVPD from BST (-1.31 ± 0.28 mmHg) and invasive measurements (-1.30 ± 0.31 mmHg). In the pediatric patients, age range 6 months-17.76 years, feasibility was 93.9 % in controls and 88.6% in UVH patients. Median IVPD was significantly higher in controls compared to UVH (-1.82 vs -0.88 mmHg, p < 0.001). Intraclass correlation coefficients for variability of clinical BST-data were 0.99 (interobserver) and 0.98 (intraobserver) respectively.</p><p><strong>Conclusion: </strong>BST echocardiography provides accurate estimation of IVPD in early diastole. IVPD was significantly lower in children with UVH compared to controls suggesting lower diastolic suction which can impact overall filling dynamics.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Self-Expanding or Balloon-Expandable Valves: A Trade-Off Between Paravalvular Leak and Durability?","authors":"Eric Van Belle, Shirin Bakhtari, Flavien Vincent","doi":"10.1093/ehjci/jeaf148","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf148","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}