Hyun Jin Ahn, Seokhun Yang, Jae Wook Jung, Sang-Hyeon Park, Jinlong Zhang, Keehwan Lee, Doyeon Hwang, Kyu-Sun Lee, Sang-Hoon Na, Joon-Hyung Doh, Chang-Wook Nam, Tae Hyun Kim, Eun-Seok Shin, Eun Ju Chun, Su-Yeon Choi, Hyun Kuk Kim, Young Joon Hong, Hun-Jun Park, Song-Yi Kim, Mirza Husic, Jess Lambrechtsen, Jesper M Jensen, Bjarne L Nørgaard, Daniele Andreini, Pal Maurovich-Horvat, Bela Merkely, Martin Penicka, Bernard de Bruyne, Abdul Ihdayhid, Brian Ko, Georgios Tzimas, Jonathon Leipsic, Javier Sanz, Mark G Rabbat, Farhan Katchi, Moneal Shah, Nobuhiro Tanaka, Ryo Nakazato, Taku Asano, Mitsuyasu Terashima, Hiroaki Takashima, Tetsuya Amano, Yoshihiro Sobue, Hitoshi Matsuo, Hiromasa Otake, Takashi Kubo, Masahiro Takahata, Takashi Akasaka, Teruhito Kido, Teruhito Mochizuki, Hiroyoshi Yokoi, Taichi Okonogi, Tomohiro Kawasaki, Koichi Nakao, Tomohiro Sakamoto, Taishi Yonetsu, Tsunekazu Kakuta, Yohei Yamauchi, Charles A Taylor, Jeroen J Bax, Peter H Stone, Jagat Narula, Leslee J Shaw, Bon-Kwon Koo
{"title":"Sex Differences in Detection of Acute Coronary Syndrome Culprit Lesion Using Conventional and AI-Enhanced Coronary CT Angiography.","authors":"Hyun Jin Ahn, Seokhun Yang, Jae Wook Jung, Sang-Hyeon Park, Jinlong Zhang, Keehwan Lee, Doyeon Hwang, Kyu-Sun Lee, Sang-Hoon Na, Joon-Hyung Doh, Chang-Wook Nam, Tae Hyun Kim, Eun-Seok Shin, Eun Ju Chun, Su-Yeon Choi, Hyun Kuk Kim, Young Joon Hong, Hun-Jun Park, Song-Yi Kim, Mirza Husic, Jess Lambrechtsen, Jesper M Jensen, Bjarne L Nørgaard, Daniele Andreini, Pal Maurovich-Horvat, Bela Merkely, Martin Penicka, Bernard de Bruyne, Abdul Ihdayhid, Brian Ko, Georgios Tzimas, Jonathon Leipsic, Javier Sanz, Mark G Rabbat, Farhan Katchi, Moneal Shah, Nobuhiro Tanaka, Ryo Nakazato, Taku Asano, Mitsuyasu Terashima, Hiroaki Takashima, Tetsuya Amano, Yoshihiro Sobue, Hitoshi Matsuo, Hiromasa Otake, Takashi Kubo, Masahiro Takahata, Takashi Akasaka, Teruhito Kido, Teruhito Mochizuki, Hiroyoshi Yokoi, Taichi Okonogi, Tomohiro Kawasaki, Koichi Nakao, Tomohiro Sakamoto, Taishi Yonetsu, Tsunekazu Kakuta, Yohei Yamauchi, Charles A Taylor, Jeroen J Bax, Peter H Stone, Jagat Narula, Leslee J Shaw, Bon-Kwon Koo","doi":"10.1093/ehjci/jeag270","DOIUrl":"https://doi.org/10.1093/ehjci/jeag270","url":null,"abstract":"<p><strong>Aims: </strong>Acute coronary syndrome (ACS) exhibits marked sex-related differences in clinical presentation and underlying pathophysiology. However, whether these differences translate into variations in culprit lesion prediction remains unclear. We investigated the sex-specific performance of conventional coronary computed tomography angiography (CCTA) and artificial intelligence-enabled quantitative coronary plaque and hemodynamic assessment (AI-QCPHA) for ACS culprit detection.</p><p><strong>Methods and results: </strong>In this sub-study of the EMERALD II trial (NCT03591328), patients with ACS who underwent CCTA 1 month to 3 years prior to the event were analyzed. Culprit and non-culprit lesions were defined by invasive coronary angiography at the time of ACS. Diagnostic performance of obstructive stenosis (CAD-RADS ≥3) and high-risk plaque (HRP) criteria was compared between women and men. Information gain-based feature selection identified sex-specific AI-QCPHA best predictors across five feature clusters, and their incremental predictive value was evaluated using receiver operating characteristics reported as area under the curve (AUC). A total of 351 patients (90 women, 261 men) with 2,451 lesions were included. Conventional CCTA performed similarly across sexes for obstructive stenosis, whereas HRP differed by sex. AI-QCPHA identified the same best features for ACS culprit prediction in both sexes, and integration of these features improved discriminatory performance beyond conventional CCTA (women AUC 0.84 vs. 0.78, p = 0.002; men 0.82 vs. 0.75, p < 0.001). Among individual predictors, delta FFRCT yielded the highest discriminatory performance in both women and men.</p><p><strong>Conclusion: </strong>AI-QCPHA enhances culprit lesion prediction in obstructive ACS beyond conventional CCTA in both sexes, supporting its potential role for improved culprit-lesion discrimination.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reply to: \"Vessels Are Not Independent Observations in a Sex-Interaction Analysis\".","authors":"Yipu Ding, Jeroen J Bax, Alexander van Rosendael","doi":"10.1093/ehjci/jeag262","DOIUrl":"10.1093/ehjci/jeag262","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julio I Farjat-Pasos, Juan H Del Portillo, Laurent Biertho, Simon Marceau, Benoît M Labbé, David Belzile, Kim O'Connor, Jonathan Beaudoin, Mathieu Bernier, Jean-Michel Paradis, Stephan Langevin, Erwan Salaun, Josep Rodés-Cabau
{"title":"Usefulness of oesophageal irrigation during transoesophageal echocardiographic guidance for structural heart interventions.","authors":"Julio I Farjat-Pasos, Juan H Del Portillo, Laurent Biertho, Simon Marceau, Benoît M Labbé, David Belzile, Kim O'Connor, Jonathan Beaudoin, Mathieu Bernier, Jean-Michel Paradis, Stephan Langevin, Erwan Salaun, Josep Rodés-Cabau","doi":"10.1093/ehjci/jeag167","DOIUrl":"10.1093/ehjci/jeag167","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1890-1892"},"PeriodicalIF":6.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thomas Anderton, Bradley Chambers, Maryum Farooq, Chin Yit Soo, Mehak Asad, Michelle Gibbs, Peter Harrison, Osama Tariq, Wasim Javed, Erica Dall'Armellina, Peter Kellman, Sven Plein, Peter P Swoboda, Masafumi Takafuji
{"title":"Impact of rate-pressure product correction of myocardial blood flow on the prognostic relevance in patients with heart failure.","authors":"Thomas Anderton, Bradley Chambers, Maryum Farooq, Chin Yit Soo, Mehak Asad, Michelle Gibbs, Peter Harrison, Osama Tariq, Wasim Javed, Erica Dall'Armellina, Peter Kellman, Sven Plein, Peter P Swoboda, Masafumi Takafuji","doi":"10.1093/ehjci/jeag193","DOIUrl":"10.1093/ehjci/jeag193","url":null,"abstract":"<p><strong>Aims: </strong>Quantitative perfusion cardiac magnetic resonance (QP-CMR) allows estimation of myocardial blood flow (MBF) and myocardial perfusion reserve (MPR). Resting MBF values are often corrected for the rate-pressure product (RPP). We aimed to assess the effect of RPP correction on MBF values and the prognostic value of QP-CMR in patients with heart failure (HF).</p><p><strong>Methods and results: </strong>QP-CMR data from 641 prospectively recruited patients with HF and 184 healthy volunteers were analysed. Rest MBF was corrected for RPP (MBFcorr = rest MBFuncorr×10 000/RPP). Corrected MPR was defined as uncorrected stress MBF/rest MBFcorr. The primary endpoint was a composite of heart failure hospitalization (HFH) and all-cause mortality. RPP correction increased rest MBF and decreased MPR to a greater extent in healthy volunteers than in patients. During median follow-up of 3.5 years, 101 events occurred (55 deaths and 46 HFH). Patients who reached the primary endpoint had significantly higher rest MBFuncorr and lower MPRuncorr. Rest MBFuncorr (adjusted hazard ratio per 1 mL/g/min increase, 3.97, 95% confidence interval [CI] 1.93-8.16, P < 0.001) and MPRuncorr (adjusted hazard ratio per 1-unit increase, 0.74, 95% CI 0.57-0.95, P = 0.024) were significantly associated with the primary endpoint in univariate and multivariate models. After RPP correction, these associations were no longer significant. Kaplan-Meier analysis revealed significant differences in event-free survival for rest MBFuncorr (P = 0.005), MPRuncorr (P < 0.001), and MPRcorr (P = 0.044), but not for rest MBFcorr (P = 0.076).</p><p><strong>Conclusion: </strong>Uncorrected rest MBF and MPR by QP-CMR are independently predictive of adverse outcomes in patients with HF. RPP correction changes MBF and MPR values and attenuates their predictive value.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1817-1826"},"PeriodicalIF":6.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148583832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katsuji Inoue, Lars-Egil R Hammersboen, Otto A Smiseth
{"title":"Diastolic function and HFpEF: are classifications and probability scores enough?","authors":"Katsuji Inoue, Lars-Egil R Hammersboen, Otto A Smiseth","doi":"10.1093/ehjci/jeag201","DOIUrl":"10.1093/ehjci/jeag201","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1885-1886"},"PeriodicalIF":6.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}