Marco Guglielmo, Francesca Coraducci, Anna Giulia Pavon
{"title":"When Coronary Plaque Is Found in Everyone: Is Anyone Really at Risk?","authors":"Marco Guglielmo, Francesca Coraducci, Anna Giulia Pavon","doi":"10.1093/ehjci/jeaf137","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf137","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Albert Alonso Tello, Antonia Sambola, Filippa Valente, Augusto Sao, Eduard Ródenas-Alesina, Pau Rello, Manel Maymi, José A Barrabés, Imanol Otaegui, Bruno García Del Blanco, Carlos Igor Morr-Verenzuela, Daniel Lorenzatti, Nerea Pérez-Solé, José Gavara, Victor Marcos-Garcés, José T Ortiz-Pérez, Vicente Bodí, José F Rodríguez-Palomares, Ignacio Ferreira-González
{"title":"Sex-based differences in adverse left ventricular remodelling and clinical outcomes after ST-segment elevation myocardial infarction.","authors":"Albert Alonso Tello, Antonia Sambola, Filippa Valente, Augusto Sao, Eduard Ródenas-Alesina, Pau Rello, Manel Maymi, José A Barrabés, Imanol Otaegui, Bruno García Del Blanco, Carlos Igor Morr-Verenzuela, Daniel Lorenzatti, Nerea Pérez-Solé, José Gavara, Victor Marcos-Garcés, José T Ortiz-Pérez, Vicente Bodí, José F Rodríguez-Palomares, Ignacio Ferreira-González","doi":"10.1093/ehjci/jeaf048","DOIUrl":"10.1093/ehjci/jeaf048","url":null,"abstract":"<p><strong>Aims: </strong>The impact of sex on adverse left ventricular remodelling (LVR) after ST-elevation myocardial infarction (STEMI) is unclear due to conflicting results. This study sought to establish sex-based differences in adverse LVR using cardiovascular magnetic resonance (CMR) among STEMI patients and their impact on clinical outcomes.</p><p><strong>Methods and results: </strong>The study included patients with a first STEMI who underwent primary percutaneous coronary intervention (PCI). Cardiovascular magnetic resonance was performed at 6 days (interquartile range [IQR]: 4-9 days) and after 6 months (6.42 months; IQR: 5.98-7.47 months). Follow-up was 6.94 years (IQR: 4.48-9.32 years). The primary endpoint was the presence of adverse LVR (>15% of LV end-diastolic volume and a decrease of >3% in LV ejection fraction) at 6 months. The secondary endpoint was major adverse cardiac events (MACEs), defined as a combined variable: cardiovascular death, heart failure admission, or ventricular arrhythmias. One thousand sixty-seven patients were included (17.5% women; mean age: 58.71 ± 11.85 years). Women were older and had more cardiovascular risk factors (CVRF). There was no association between sex and adverse LVR [OR: 0.80; 95% confidence interval (CI), 0.39-1.64; P = 0.536]. Major adverse cardiac events occurred in 177 patients (16.7%) and was more frequent in women (22.6% vs. 15.4%; P = 0.017). However, after adjusting for baseline differences and CVRF, the female sex was not associated with MACE (hazard ratio: 1.21; 95% CI, 0.81-1.81; P = 0.343).</p><p><strong>Conclusion: </strong>The higher rate of MACE after STEMI in women compared to men appears to be associated with a higher prevalence of CVRF and comorbidities rather than a more significant occurrence of adverse LVR.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"775-783"},"PeriodicalIF":6.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael Rietz, Bram Beun, Ivan Dimov, Aurelia David-Cojocariu, Philippe Unger
{"title":"Unveiling type B aortic dissection in Loeys-Dietz syndrome by transthoracic echocardiography: back to the root.","authors":"Michael Rietz, Bram Beun, Ivan Dimov, Aurelia David-Cojocariu, Philippe Unger","doi":"10.1093/ehjci/jeaf020","DOIUrl":"10.1093/ehjci/jeaf020","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"933"},"PeriodicalIF":6.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laust D Rasmussen, Samuel Emil Schmidt, Juhani Knuuti, Jon Spiro, Adil Rajwani, Pedro M Lopes, Maria Rita Lima, António M Ferreira, Teemu Maaniitty, Antti Saraste, David Newby, Pamela S Douglas, Morten Bøttcher, Lohendran Baskaran, Simon Winther
{"title":"Clinical likelihood models calibrated against observed obstructive coronary artery disease on computed tomography angiography.","authors":"Laust D Rasmussen, Samuel Emil Schmidt, Juhani Knuuti, Jon Spiro, Adil Rajwani, Pedro M Lopes, Maria Rita Lima, António M Ferreira, Teemu Maaniitty, Antti Saraste, David Newby, Pamela S Douglas, Morten Bøttcher, Lohendran Baskaran, Simon Winther","doi":"10.1093/ehjci/jeaf049","DOIUrl":"10.1093/ehjci/jeaf049","url":null,"abstract":"<p><strong>Aims: </strong>Models predicting the likelihood of obstructive coronary artery disease (CAD) on invasive coronary angiography exist. However, as stable patients with new-onset chest pain frequently have lower clinical likelihood and preferably undergo index testing by non-invasive tests such as coronary computed tomography angiography (CCTA), clinical likelihood models calibrated against observed obstructive CAD at CCTA are warranted. The aim was to develop CCTA-calibrated risk-factor- and coronary artery calcium score-weighted clinical likelihood models (i.e. RF-CLCCTA and CACS-CLCCTA models, respectively).</p><p><strong>Methods and results: </strong>Based on age, sex, symptoms, and cardiovascular risk factors, an advanced machine learning algorithm utilized a training cohort (n = 38 269) of symptomatic outpatients with suspected obstructive CAD to develop both a RF-CLCCTA model and a CACS-CLCCTA model to predict observed obstructive CAD on CCTA. The models were validated in several cohorts (n = 28 340) and compared with a currently endorsed basic pre-test probability (Basic PTP) model. For both the training and pooled validation cohorts, observed obstructive CAD at CCTA was defined as >50% diameter stenosis. Observed obstructive CAD at CCTA was present in 6443 (22.7%) patients in the pooled validation cohort. While the Basic PTP underestimated the prevalence of observed obstructive CAD at CCTA, the RF-CLCCTA and CACS-CLCCTA models showed superior calibration. Compared with the Basic PTP model, the RF-CLCCTA and CACS-CLCCTA models showed superior discrimination (area under the receiver operating curves 0.71 [95% confidence interval (CI) 0.70-0.72] vs. 0.74 (95% CI 0.73-0.75) and 0.87 (95% CI 0.86-0.87), P < 0.001 for both comparisons).</p><p><strong>Conclusion: </strong>CCTA-calibrated clinical likelihood models improve calibration and discrimination of observed obstructive CAD at CCTA.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"802-813"},"PeriodicalIF":6.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Martina De Raffele, Albert Teis, German Cediel, Jerremy Weerts, Cristina Conte, Gladys Juncà, Gizem Kasa, Elena Ferrer-Sistach, Matteo Bertini, Antoni Bayes-Genis, Victoria Delgado
{"title":"Left atrial remodelling and function in various left ventricular hypertrophic phenotypes.","authors":"Martina De Raffele, Albert Teis, German Cediel, Jerremy Weerts, Cristina Conte, Gladys Juncà, Gizem Kasa, Elena Ferrer-Sistach, Matteo Bertini, Antoni Bayes-Genis, Victoria Delgado","doi":"10.1093/ehjci/jeaf033","DOIUrl":"10.1093/ehjci/jeaf033","url":null,"abstract":"<p><strong>Aims: </strong>How the underlying aetiology and pathophysiology of left ventricular (LV) hypertrophy affects left atrial (LA) remodelling and function remains unexplored. The present study aims to investigate the influence of various hypertrophic phenotypes on LA remodelling and function.</p><p><strong>Methods and results: </strong>Patients with LV hypertrophy who underwent cardiac magnetic resonance (CMR) were compared to a control group. CMR data were analysed retrospectively to assess LA strain, volume, sphericity, and left atrioventricular coupling index (LACI). Independent clinical associates of LA strain were assessed using multivariable linear regression analysis. A total of 375 individuals were included: 148 with hypertrophic cardiomyopathy (HCM), 35 with cardiac amyloidosis (CA), 41 with hypertensive (HTN) heart disease, 97 with severe asymptomatic aortic stenosis (AS), and 54 with normal CMR. Indexed LA end-systolic (iLVmax), diastolic volumes, and LA sphericity were the largest in patients with CA (59.1 ± 16.9 mL/m2, 46.8 ± 16.4 mL/m2, and 83.2 ± 2.1%, respectively). Patients with CA presented a higher LACI when compared with other groups (58 ± 2% vs. 42 ± 2% in HCM, 39 ± 2% in HTN heart disease, 37 ± 2% in AS, and 22 ± 1% in normal), while no differences were observed across others. Patients with CA showed the lowest LA reservoir [9.6% (0.6-18.6%)] and booster strain (9.1 ± 5.4%), whereas no differences were observed across other groups. LACI and iLAVmax were independently correlated with LA reservoir (β = 0.15 and β = -39.33, respectively), LA conduit (β = 0.08 and β = -17.08, respectively), and LA booster strains (β = 0.1 and β = -28.69, respectively). LA sphericity was independently correlated with LA reservoir strain (β = -0.51). Finally, LV global longitudinal strain was independently correlated with LA reservoir (β = -0.43), conduit (β = -0.20), and booster strain (β = -0.24).</p><p><strong>Conclusion: </strong>LA characteristics differ among LV hypertrophic phenotypes. LACI and iLAVmax are independently correlated with LA function, while LA sphericity correlates independently with LA reservoir strain.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"853-862"},"PeriodicalIF":6.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C Noel Bairey Merz, Robert O Bonow, Mercedes Carnethon, Filippo Crea, Joseph A Hill, Harlan M Krumholz, Roxana Mehran, Erica S Spatz
{"title":"The Role of Cardiovascular Disease Journals in Reporting Sex and Gender in Research.","authors":"C Noel Bairey Merz, Robert O Bonow, Mercedes Carnethon, Filippo Crea, Joseph A Hill, Harlan M Krumholz, Roxana Mehran, Erica S Spatz","doi":"10.1093/ehjci/jeaf094","DOIUrl":"10.1093/ehjci/jeaf094","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"773-774"},"PeriodicalIF":6.7,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}