Natalie Marrero, Kunal Jha, Jelani Grant, Alexander C Razavi, Matthew J Budoff, Sanjiv J Shah, Jerome I Rotter, Roger S Blumenthal, Wendy S Post, Leslee J Shaw, George Thanassoulis, Michael J Blaha, Seamus P Whelton
{"title":"Impact of Age on Aortic Valve Calcium Progression and Risk for Aortic Stenosis: Multi-Ethnic Study of Atherosclerosis.","authors":"Natalie Marrero, Kunal Jha, Jelani Grant, Alexander C Razavi, Matthew J Budoff, Sanjiv J Shah, Jerome I Rotter, Roger S Blumenthal, Wendy S Post, Leslee J Shaw, George Thanassoulis, Michael J Blaha, Seamus P Whelton","doi":"10.1093/ehjci/jeaf279","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf279","url":null,"abstract":"<p><strong>Background: </strong>Aortic valve calcium (AVC) is strongly associated with the risk for severe aortic stenosis (AS). The prevalence of AVC increases with age, but the impact of age on the progression of AVC and its association with moderate-severe AS is unknown.</p><p><strong>Methods: </strong>Our study included 6,810 participants (52.9% women) without overt cardiovascular disease between ages 45 and 84 from the Multi-Ethnic Study of Atherosclerosis. AVC was measured using non-contrast cardiac CT at Visit 1. Progression was calculated as the change in AVC divided by years between CT scans (2-10 years). Incident moderate-severe AS was adjudicated using medical chart review and echocardiogram data from Visit 6 (median follow-up of 16 years). The association between AVC and moderate-severe AS was assessed using multivariable adjusted Cox proportional hazards ratios.</p><p><strong>Results: </strong>There were 5,899 participants with AVC =0 and 911 with AVC >0. There were 3,834 participants age <65 years and 2,979 age ≥65 years. The median AVC was 34.1 AU (IQR 13-1,113) for participants <65 versus 69.0 AU (IQR 23-2,453) for participants ≥65. Participants <65 and ≥65 years had no significant difference in median annualized AVC progression within the baseline AVC categories of 1-99 (10 versus 12 AU/year, p=0.303) and AVC ≥100 (50 versus 47 AU/year, p=0.846). AVC >0 was associated with a similar significantly higher risk of incident moderate-severe AS for both younger (HR 13.37; 95% CI 5.67-31.52) and older participants (HR 10.59, 95% CI 6.77-16.56).</p><p><strong>Conclusion: </strong>AVC progression was significantly associated with baseline AVC burden and was similar for younger versus older persons after accounting for baseline AVC. The presence of AVC was significantly associated with a higher long-term risk for moderate-severe AS among both younger and older participants.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dimitrios Kotzadamis, Efstathios D Pagourelias, Vasilios P Vassilikos
{"title":"Left ventricular thrombus: To detect and to protect.","authors":"Dimitrios Kotzadamis, Efstathios D Pagourelias, Vasilios P Vassilikos","doi":"10.1093/ehjci/jeaf277","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf277","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Law of Parsimony in MRI measures of cardiac deformation.","authors":"Gaurav S Gulsin","doi":"10.1093/ehjci/jeaf274","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf274","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anatomical Variations in Permanent Pacemaker Requirement after TAVI in Bicuspid Anatomy.","authors":"Yue Yin, Zhengang Zhao, Xuechen Qiao, Mengyun Yan, Yuheng Jia, Weiya Li, Ying Zhang, Yan Wang, Zheng Chai, Yu Tang, Shuoding Wang, Xingzhou Pu, Shiqin Peng, Junpeng Ran, Jing Zhou, Sirui Tang, Yuan Feng, Mao Chen","doi":"10.1093/ehjci/jeaf270","DOIUrl":"https://doi.org/10.1093/ehjci/jeaf270","url":null,"abstract":"<p><strong>Aims: </strong>We sought to illustrate the varying risk of permanent pacemaker implantation (PPMI) following self-expanding TAVI among BAV subtypes, and to categorize BAV anatomical variations based on the risk of PPMI.</p><p><strong>Methods: </strong>We retrospectively analyzed 300 BAV patients with severe aortic stenosis who underwent self-expanding TAVI. Based on leaflet morphology and calcification severity at the commissure between right coronary cusp (RCC) and non-coronary cusp (NCC), BAVs were classified into two subtypes: BAV with MS below commissure (BAV-MSBC) and BAV with MS below leaflet (BAV-MSBL). Univariate and multivariate logistic regressions were performed to identify potential risk factors of PPMI.</p><p><strong>Results: </strong>PPMI rate differed significantly between BAV-MSBC and BAV-MSBL (32.8% [42 of 128] vs. 5.8% [10 of 172], p<0.001). Multivariate analysis identified BAV-MSBC (odds ratio [OR]=10.15, 95% confidence interval [CI]: 4.07∼25.34, p<0.001), previous AVB I (OR=4.15, 95% CI: 1.32∼13.04, p=0.015) and RBBB (OR=26.39, 95% CI: 4.81∼144.82, p<0.001) as risk factors of PPMI, while △MSID-RCC (OR=0.78, 95% CI: 0.70∼0.86, p<0.001) was protective. The multivariate model had an AUC of 0.887 (95% CI: 0.843∼0.930).</p><p><strong>Conclusions: </strong>PPMI risk differs significantly between BAV subtypes, possibly due to variations in MS proximity to the stent. The new BAV classification method may improve PPMI risk prediction and patient management.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christos Feloukidis, Diamantis Kosmidis, Alexandra Arvanitaki, Vasileios Anastasiou, Andreas S Papazoglou, Thomas Chrysochoidis-Trantas, Sophia-Anastasia Mouratoglou, Matthaios Didagelos, Vasileios Grosomanidis, Antonios Ziakas, George Giannakoulas, Vasileios Kamperidis
{"title":"Echocardiographic right-ventricular global wasted work predicts hemodynamics and risk profile in pulmonary arterial hypertension.","authors":"Christos Feloukidis, Diamantis Kosmidis, Alexandra Arvanitaki, Vasileios Anastasiou, Andreas S Papazoglou, Thomas Chrysochoidis-Trantas, Sophia-Anastasia Mouratoglou, Matthaios Didagelos, Vasileios Grosomanidis, Antonios Ziakas, George Giannakoulas, Vasileios Kamperidis","doi":"10.1093/ehjci/jeaf272","DOIUrl":"10.1093/ehjci/jeaf272","url":null,"abstract":"<p><strong>Aims: </strong>Novel echocardiographic indices of right ventricular myocardial work (RVMW) are gaining ground for the evaluation of pulmonary arterial hypertension (PAH). However, their role in predicting hemodynamics and risk profile remains unclear. This study aimed to assess whether RVMW indices can identify patients at high risk for mortality and those with a worse hemodynamic profile as determined by right heart catheterization (RHC).</p><p><strong>Methods & results: </strong>Patients with PAH, confirmed by RHC, with available echocardiographic images for RVMW estimation were analysed. Patients' risk profile was determined according to guidelines. RVMW indices were measured and correlated with four RHC parameters (mean pulmonary artery pressure [mPAP], pulmonary vascular resistance [PVR], stroke volume index [SVI], pulmonary arterial compliance [PAC]). RVMW analysis was completed in 58 PAH patients (58±14 years old, 72% female). RV global wasted work (RVGWW) was significantly increased, while RV global work efficiency (RVGWE) was significantly decreased in the 'high risk' group. RVGWW correlated with mPAP (R=0.46; p <0.001), PVR (R=0.51; p <0.001), SVI (R=-0.3; p=0.024) and PAC (R=-0.31; p=0.02). Specific cut-off values of RVGWW emerged as predictors of worse hemodynamics based on spline curves; <60 mmHg % indicated low-probability of PVR >5 WU, >83-84 mmHg % indicated high-probability of PAC <2.3 ml/mmHg and mPAP >40 mmHg, >120 mmHg % indicated SVI <31 ml/m2 in RHC. Furthermore, RVGWW values >175 mmHg % were associated with patients at high-risk for mortality.</p><p><strong>Conclusion: </strong>RVGWW correlated well with invasive hemodynamic parameters and was found to predict a worse hemodynamic and high-risk profile in a prospective cohort of PAH patients.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}