Gal Tsaban, Giovanni Benfari, Benjamin A Essayagh, Eunjung Lee, Manuel A Montoya Hernandez, Prabin Thapa, Vuyisile T Nkomo, Sorin V Pislaru, Hector I Michelena, Maurice Enriquez-Sarano
{"title":"Decoding the complexity of tricuspid regurgitation prognostic drivers using explainable artificial intelligence.","authors":"Gal Tsaban, Giovanni Benfari, Benjamin A Essayagh, Eunjung Lee, Manuel A Montoya Hernandez, Prabin Thapa, Vuyisile T Nkomo, Sorin V Pislaru, Hector I Michelena, Maurice Enriquez-Sarano","doi":"10.1093/ehjci/jeag168","DOIUrl":"10.1093/ehjci/jeag168","url":null,"abstract":"<p><strong>Aims: </strong>Prognosis in tricuspid regurgitation (TR) is shaped by complex clinical and haemodynamic interactions, complicating risk stratification. We aimed to use explainable artificial intelligence (EAI) to model these relationships and identify key predictors of outcomes.</p><p><strong>Methods and results: </strong>We analysed long-term all-cause mortality in a large prospective registry of patients with native TR across the full severity spectrum. Patients underwent detailed clinical evaluation and quantitative Doppler-echocardiography. Supervised EAI models were applied to identify and rank predictors of mortality under medical therapy, capturing non-linear associations and interactions among baseline characteristics.Among 9761 patients [mean age 73 ± 15 years; 56.9% women; effective regurgitant orifice area (EROA) 40 (30-56) mm2; regurgitant volume 39 (29-53) mL/beat; 42% severe TR], 2676 deaths occurred during 3.8 ± 4.6 years of follow-up. EAI identified and ranked 20 prognostic determinants of survival. Haemodynamic measures, led by elevated pulmonary-artery systolic and right-atrial pressures, were strongest, followed by age and comorbidity. TR-related variables ranked next, led by right ventricular dysfunction and EROA, which outperformed integrative TR grade and TRIScore. Left-ventricular parameters were less influential. Non-linear effects, including those involving ejection fraction, and interactions such as higher EROA-related risk with elevated pulmonary pressures or lower TRIScore (both P < 0.03) were observed. Proportional hazards models confirmed EROA as the strongest TR severity marker (P < 0.0001), with excess mortality beginning at 40 mm2 and increasing further at 60 mm2.</p><p><strong>Conclusion: </strong>EAI ranked mortality predictors in TR, highlighting patient factors, haemodynamics, TR-specific measures, and left-ventricular function. Among TR-specific measures, EROA and TRIScore were most prognostic. Recognizing their impact can refine risk stratification, guide intervention timing, and inform long-term management.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1830-1841"},"PeriodicalIF":6.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148338236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reply to: Achieved LDL-C strata do not establish NIRS as a treatment-benefit marker.","authors":"Yu Kataoka, Stephen J Nicholls, Teruo Noguchi","doi":"10.1093/ehjci/jeag217","DOIUrl":"10.1093/ehjci/jeag217","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1897-1898"},"PeriodicalIF":6.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Imaging REASSESSment of embolic events before antibiotic discontinuation in infective endocarditis: REASSESS-IE study.","authors":"Valentin Maury, Soumaya Sridi-Cheniti, Melchior Jonveaux, Marina Dijos, Marine Bouchat, Gaultier Marnat, Johann Cattan, Edouard Gerbaud, Hélène Chaussade, Carine Greib, Fabrice Camou, Olivia Peuchant, Gaetane Wirth, Claire Roubaud-Baudron, Ghoufrane Tlili, Antoine Beurton, Tanguy Cariou, Thomas Modine, Nahéma Issa, Julien Ternacle","doi":"10.1093/ehjci/jeag234","DOIUrl":"10.1093/ehjci/jeag234","url":null,"abstract":"<p><strong>Introduction: </strong>Embolic events (EEs) in infective endocarditis (IE) are frequent and associated with poor prognosis. Follow-up imaging is not standardized despite the risk of persistent extracardiac foci. We aimed to assess the therapeutic impact of imaging reassessment before antibiotic discontinuation.</p><p><strong>Methods and results: </strong>Prospective multicentre study including patients with definite or possible IE complicated by EEs (2013-2022). Asymptomatic or clinically stable patients who underwent follow-up imaging before antibiotic discontinuation to reassess IE-related EEs were included, whereas those imaged for clinical reasons were excluded. The primary endpoint was therapeutic impact: antibiotic modification and/or intervention. Secondary endpoints included all-cause mortality. Overall, 54% (n = 700/1300) of the entire cohort had IE-related EEs. Among them, 554 patients (mean age 65.7 years, 76% male) under antibiotic therapy were included: 49% with cerebral and 79% with extracerebral EEs, mainly ischaemic stroke (42%) and splenic embolism (40%). Follow-up imaging before antibiotic discontinuation (median, 6 weeks) was performed in 51% (n = 281/554), leading treatment modification in 5.7% (16/281), mainly in patients with Staphylococcus aureus IE complicated by abscess. In-hospital and 5-year mortality were 9.4% and 30.8%, respectively. Haemodynamic instability and comorbidities were associated with long-term mortality, whereas only cardiac surgery was associated with improved survival.</p><p><strong>Conclusion: </strong>Imaging reassessment of IE-related EEs before stopping antibiotics may lead to therapeutic modification in asymptomatic or clinically stable patients using a risk-stratified individualized imaging strategy guided by the endocarditis teams, rather than a uniform approach. Prospective studies are needed to define standardized imaging algorithms.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1873-1884"},"PeriodicalIF":6.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexandre Pfeffer, Jérôme Garot, Suzanne Duhamel, Philippe Garot, Francesca Sanguineti, Thomas Hovasse, Stéphane Champagne, Thierry Unterseeh, Mariama Akodad, Antoinette Neylon, Riccardo Mager, Paul-Jun Martial, Aicha Kante, Alexandre Unger, Jeremy Florence, Emmanuel Gall, Antoine Léquipar, Elsa Richard de Vesvrotte, Julien Hudelo, Claire Baladi, Jean Guillaume Dillinger, Patrick Henry, Valérie Bousson, Théo Pezel, Solenn Toupin, Trecy Gonçalves
{"title":"Stress CMR ischaemic burden and long-term mortality in left ventricular systolic dysfunction: a multicentre registry study.","authors":"Alexandre Pfeffer, Jérôme Garot, Suzanne Duhamel, Philippe Garot, Francesca Sanguineti, Thomas Hovasse, Stéphane Champagne, Thierry Unterseeh, Mariama Akodad, Antoinette Neylon, Riccardo Mager, Paul-Jun Martial, Aicha Kante, Alexandre Unger, Jeremy Florence, Emmanuel Gall, Antoine Léquipar, Elsa Richard de Vesvrotte, Julien Hudelo, Claire Baladi, Jean Guillaume Dillinger, Patrick Henry, Valérie Bousson, Théo Pezel, Solenn Toupin, Trecy Gonçalves","doi":"10.1093/ehjci/jeag189","DOIUrl":"10.1093/ehjci/jeag189","url":null,"abstract":"<p><strong>Aims: </strong>Stress perfusion cardiovascular magnetic resonance (CMR) integrates the assessment of myocardial ischaemia, scar, and function. Its incremental prognostic value in patients with left ventricular (LV) systolic dysfunction remains uncertain.</p><p><strong>Methods and results: </strong>We analysed a prospective multicentre registry of consecutive patients undergoing vasodilator stress perfusion CMR at three French centres (2008-24). Patients with CMR-derived LVEF < 50% were included. The primary end point was all-cause mortality. Associations were estimated with multivariable Cox models. Incremental prognostic value of ischaemia and late gadolinium enhancement (LGE) beyond clinical factors and LVEF was assessed by likelihood ratio χ2, continuous net reclassification improvement (NRI), and integrated discrimination improvement (IDI). Among 5977 patients (79% men; age 66 ± 12 years, mean LVEF 42 ± 7%), inducible ischaemia was present in 19% (mean extent 2.4 ± 1.2 segments). Over a median follow-up of 9 years, 1343 patients (22%) died. Ischaemic segment extent was independently associated with mortality (HR per segment 1.11; 95% CI, 1.06-1.15; P < 0.001). Adding ischaemia and LGE to clinical factors and LVEF improved model fit and reclassification (global χ2 increased from 707 to 728; NRI 0.217; IDI 0.004; all P < 0.001). Findings were consistent across LVEF subgroups (40-50% and <40%). In secondary analyses among patients with ischaemia, outcomes differed by subsequent revascularization status; these findings are observational and hypothesis-generating.</p><p><strong>Conclusion: </strong>In patients with LVEF < 50%, ischaemic burden on stress CMR is independently associated with long-term mortality beyond clinical factors, LVEF and LGE. Integrating ischaemia and scar metrics provides incremental prognostic information that may aid risk stratification using stress CMR in LV systolic dysfunction.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1803-1814"},"PeriodicalIF":6.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Myocardial perfusion imaging and ischaemic ventricular dysfunction: new insights for an old conundrum?","authors":"Michael Jerosch-Herold, Raymond Y Kwong","doi":"10.1093/ehjci/jeag199","DOIUrl":"10.1093/ehjci/jeag199","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1815-1816"},"PeriodicalIF":6.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148619039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Achieved LDL-C strata do not establish NIRS as a treatment-benefit marker.","authors":"Yue Chang","doi":"10.1093/ehjci/jeag216","DOIUrl":"10.1093/ehjci/jeag216","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1896"},"PeriodicalIF":6.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148790012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Three caveats to the independent prognostic value of myocardial perfusion reserve in type 2 diabetes-reply.","authors":"Noor Sharrack, Gaurav S Gulsin, Sven Plein","doi":"10.1093/ehjci/jeag210","DOIUrl":"10.1093/ehjci/jeag210","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1901-1902"},"PeriodicalIF":6.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148711444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}