Journal of Korean Endocrine Society最新文献_第8页

A Case of Methimazole-induced Agranulocytosis and Kikuchi's Disease in a Patient with Graves' Disease 甲巯咪唑致格雷夫斯病患者粒细胞缺乏症和菊池病1例

Journal of Korean Endocrine Society Pub Date : 2008-12-01 DOI: 10.3803/JKES.2008.23.6.420

Seung Eun Lee, Jihyun Ahn, Jaetaek Kim, Yeon-sahng Oh, Y. Chung

{"title":"A Case of Methimazole-induced Agranulocytosis and Kikuchi's Disease in a Patient with Graves' Disease","authors":"Seung Eun Lee, Jihyun Ahn, Jaetaek Kim, Yeon-sahng Oh, Y. Chung","doi":"10.3803/JKES.2008.23.6.420","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.6.420","url":null,"abstract":"Methimazole-induced agranulocytosis is a rare, but critical side effect that should be recognized as soon as possible since it may induce a life-threatening condition when it was overlooked. Histiocytic necrotizing lymphadenitis is also called Kikuchi’s lymphadenitis, and this is a rare form of lymphadenitis with a self-limited clinical course and this illness is accompanied by cervical lymph node enlargement, fever and malaise. We recently experienced a patient with methimazole-induced agranulocytosis and Graves' disease, and this was accompanied by Kikuchi's disease; the patient presented with sore throat and multiple enlarged cervical lymph nodes. To the best of our knowledge, there is no previous report on methimazole-induced agranulocytosis combined with Kikuchi's disease. Therefore, we report here on this very rare case along with a brief review of the relevant literature. (J Korean Endocr Soc 23:420~424, 2008) ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏ","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122425124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Patient with Primary Amyloidosis Misrecognized as Thyrotoxicosis-induced Heart Failure 原发性淀粉样变性误诊为甲状腺毒症引起的心力衰竭1例

Journal of Korean Endocrine Society Pub Date : 2008-10-01 DOI: 10.3803/JKES.2008.23.5.332

Seok Ju Lee, Seung‐Hwan Lee, J. Chin, Youn-Mi Song, Sung Won Lee, Minhi Kim, Mi-Ja Kang, K. Lee, H. Kwon, K. Yoon, H. Son, B. Cha

{"title":"A Patient with Primary Amyloidosis Misrecognized as Thyrotoxicosis-induced Heart Failure","authors":"Seok Ju Lee, Seung‐Hwan Lee, J. Chin, Youn-Mi Song, Sung Won Lee, Minhi Kim, Mi-Ja Kang, K. Lee, H. Kwon, K. Yoon, H. Son, B. Cha","doi":"10.3803/JKES.2008.23.5.332","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.5.332","url":null,"abstract":"Amyloidosis is caused by deposition of insoluble amyloid protein in the extracellular space of organs and tissues. The causes of amyloidosis are classified as primary, secondary, and hereditary, and symptoms develop according to which organ is involved. Cardiac amyloidosis induces cardiomyopathy and is developed by deposition of amyloid proteins in cardiac tissue. We diagnosed a patient with rhabdomyolysis and thyrotoxicosis with underlying Graves' disease 5 years ago. The patient was readmitted recently complaining of general weakness and mild dyspnea, and was diagnosed as relapsed thyrotoxicosis. An echocardiogram was performed for the evaluation of dyspnea and the findings were compatible with infiltrative cardiomyopathy due to amyloidosis. A biopsy of the abdominal subcutaneous fat and rectal mucosa was performed, and diagnosis was amyloidosis with histologic findings. The cause of heart failure was therefore cardiac amyloidosis rather than thyrotoxicosis. This case indicates the importance of evaluating the cause of heart failure in patients with thyrotoxicosis. (J Korean Endocr Soc 23:332~336, 2008)","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122289287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Graves' Disease Presenting with Chorea Graves病伴舞蹈病1例

Journal of Korean Endocrine Society Pub Date : 2008-10-01 DOI: 10.3803/JKES.2008.23.5.342

C. Ku, H. Park, S. Hong, D. Y. Shin, Jin Ha Lee, Moon Jae Chung, M. Cho, T. Noh, B. Lee, Eun Jig Lee

引用次数: 2

Primary Hypogonadism Associated with Ankylosing Spondylitis 原发性性腺功能减退与强直性脊柱炎相关

Journal of Korean Endocrine Society Pub Date : 2008-10-01 DOI: 10.3803/JKES.2008.23.5.352

B. Jun, Guk Jin Lee, Ji-Hyun Kim, Jung Min Lee, S. Chang

引用次数: 2

Age-dependent Kisspeptin Effects on the GnRH Neurons in Male and Female Mice 年龄依赖性Kisspeptin对雌雄小鼠GnRH神经元的影响

Journal of Korean Endocrine Society Pub Date : 2008-10-01 DOI: 10.3803/JKES.2008.23.5.302

J. Bhattarai, S. Park, Hua Yin, S. Park, J. Jeon, Kee-Wan Chang, So Young Lee, P. Ryu, S. Han

{"title":"Age-dependent Kisspeptin Effects on the GnRH Neurons in Male and Female Mice","authors":"J. Bhattarai, S. Park, Hua Yin, S. Park, J. Jeon, Kee-Wan Chang, So Young Lee, P. Ryu, S. Han","doi":"10.3803/JKES.2008.23.5.302","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.5.302","url":null,"abstract":"Background: The gonadotropin releasing hormone (GnRH) neurons play a pivotal role in the central regulation of fertility. Kisspeptin binds to the G-protein coupled receptor 54 (GPR54) and GPR54 has been shown to be essential for puberty and subsequent fertility in humans. The recent in vivo studies have proved that kisspeptin is an extremely potent activator of GnRH neurons. However, the precise mechanism of action of kisspeptin on the GnRH neurons and the age-dependent kisspeptin effects are not yet fully understood. In this study, we investigated the effects of kisspeptin on the GnRH neurons over the developmental stages in male and female mice. Methods: Young ( P35) GnRH-GFP transgenic mice expressing green fluorescent protein were used in this study. Acute coronal brain slices containing the preoptic area were prepared, and the identified GnRH neurons were recorded using the gramicidin perforated-patch clamp technique. Results: In young mice, GnRH neurons were excited by bath application of kisspeptin in 36% (13/36) in male, 17% (4/23) in female tested neurons. In adult mice, GnRH neurons were excited in the majority (30/40, 75%) in male, (21/31, 68%) in female neurons tested. However, there was no significant difference between the effects of kisspeptin in male and female mice. In addition, we tested kisspeptin effects in diestrus, proestrus and estrus animals. There were no significant differences of kisspeptin effects over the estrous cycle. Kisspeptin failed to induce excitatory effects on GnRH neurons (6/7, 86%) neurons) by pretreatment of U73122, a protein lipase C (PLC) inhibitor and kisspeptin-induced excitatory effects were decreased by U73122 application (n = 2). Conclusion: These results demonstrated that kisspeptin-induced membrane excitability was increased after puberty and this supports a previous suggestion that GPR54 is essential for puberty and subsequent fertility. (J Korean Endocr Soc 23:302~309, 2008)","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116212252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Brown Tumor of the Ulna and Radius: An Unusual Presentation of Primary Hyperparathyroidism 尺骨和桡骨棕色肿瘤:原发性甲状旁腺功能亢进的一种不寻常的表现

Journal of Korean Endocrine Society Pub Date : 2008-10-01 DOI: 10.3803/JKES.2008.23.5.347

Hyun Park, G. Kang, S. Kim, Jun Jae Kim, N. Baek, D. Kim, S. Cho, W. Lee, K. Ko, B. Rhee

引用次数: 1

Calpain-10 Polymorphism in Korean Women with Polycystic Ovary Syndrome 韩国女性多囊卵巢综合征患者Calpain-10多态性

Journal of Korean Endocrine Society Pub Date : 2008-10-01 DOI: 10.3803/JKES.2008.23.5.319

Hyejin Lee, Gun Woo Pyun, E. Byun, J. Oh, Jee-young Oh, Y. Hong, Y. Sung, H. Chung

{"title":"Calpain-10 Polymorphism in Korean Women with Polycystic Ovary Syndrome","authors":"Hyejin Lee, Gun Woo Pyun, E. Byun, J. Oh, Jee-young Oh, Y. Hong, Y. Sung, H. Chung","doi":"10.3803/JKES.2008.23.5.319","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.5.319","url":null,"abstract":"Background: Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation, hyperandrogenism and insulin resistance, and PCOS is known to be associated with an increased risk of type 2 diabetes mellitus (DM). PCOS has also been proposed to share a common genetic background with type 2 DM. The calpain 10 (CAPN10) gene is known to be associated with type 2 DM in several different population. We examined the association of CAPN10 gene polymorphisms and their influence on the metabolic abnormalities in Korean women who suffer with PCOS. Methods: One hundred sixty four women with PCOS and 325 control women were studied. The CAPN10 gene polymorphisms were genotyped by amplifying the genomic DNA. Anthropometric measures, a 75g oral glucose tolerance test and measurement of insulin sensitivity by the euglycemic hyperinsulinemic clamp technique were performed. Results: The frequencies of CAPN10 UCSNP-43, UCSNP-19, UCSNP-63 and the haplotype combinations were not different between the women with PCOS and the control subjects. In the women with PCOS and who had the UCSNP-43 GA genotype, the post-load 90 minute plasma glucose level was significantly greater and the HDL cholesterol and insulin mediated glucose uptake were significantly lower compared to the women with PCOS and who had the GG genotype. Conclusion: The CAPN10 UCSNP-43 genotype might be responsible for insulin resistance, yet further study is required to confirm the role of this genetic polymorphism in the development of PCOS and the presentation of its disease features.","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132071726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Effect of Leptin Level Fluctuations by a Repeated Fasting/Refeeding on the Leptin Sensitivity in OLETF Rats 反复禁食/复食对OLETF大鼠瘦素敏感性的影响

Journal of Korean Endocrine Society Pub Date : 2008-10-01 DOI: 10.3803/JKES.2008.23.5.310

Sung Chul Park, Y. Park, S. Park, Jong-Yeon Kim, Yoon-Ki Park, Tae Hyung Lee, K. Won, Yong-Woon Kim

{"title":"The Effect of Leptin Level Fluctuations by a Repeated Fasting/Refeeding on the Leptin Sensitivity in OLETF Rats","authors":"Sung Chul Park, Y. Park, S. Park, Jong-Yeon Kim, Yoon-Ki Park, Tae Hyung Lee, K. Won, Yong-Woon Kim","doi":"10.3803/JKES.2008.23.5.310","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.5.310","url":null,"abstract":"Background: Leptin resistance is a common feature in obese subjects and animals, and this is commonly accompanied with hyperleptinemia. We speculated that one of the causes of leptin resistance is a persistently elevated leptin concentration and then we hypothesized that fluctuations of serum leptin would increase leptin sensitivity in the leptin-resistant state. Methods: We used a repeated fasting and refeeding (RFR) protocol to produce fluctuation in leptin levels in 7 month-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats and Long-Evans Tokushima Otsuka (LETO) rats, We then measured the leptin sensitivity following an intracerebroventricular (i.c.v.) infusion of leptin. Results: The OLETF rats exhibited severe visceral fat deposition, hyperleptinemia and leptin resistance. However, in the OLETF-RFR rats, the anorexic effect following i.c.v. leptin infusion was restored. Moreover, the visceral fat mass and serum leptin levels decreased, while the serum adiponectin levels were elevated in the OLETF-RFR rats compared to the OLETF-Control rats. The leptin receptor content in the hypothalamus increased in the OLETF-RFR rats compared to the OLETF-Control rats, and the leptin receptor content in the OLETF-RFR rats decreased compared to that in the the LETO-Control rats. Conclusions: These results suggest that the intermittent suppression of the serum leptin level reversed the leptin resistance in OLEFT rats, and this may have occurred due to an increased number of leptin receptors in the hypothalamus. (J Korean Endocr Soc 23:310~318, 2008)","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132236550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Intensive Glucose Control and Cardiovascular Outcomes: Focused on Recent Clinical Trials 强化血糖控制和心血管预后:近期临床试验的重点

Journal of Korean Endocrine Society Pub Date : 2008-10-01 DOI: 10.3803/JKES.2008.23.5.289

W. Lee, K. Ko, B. Rhee

{"title":"Intensive Glucose Control and Cardiovascular Outcomes: Focused on Recent Clinical Trials","authors":"W. Lee, K. Ko, B. Rhee","doi":"10.3803/JKES.2008.23.5.289","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.5.289","url":null,"abstract":"심혈관 질환은 제2형 당뇨병 환자의 가장 중요한 사망원 인이며 많게는 제2형 당뇨병 환자의 75%가 결국 심혈관 질 환으로 사망한다[1]. 당뇨병으로 인한 합병증 발생은 고혈당 정도와 상관 관계가 있으며, 고혈당이 지속되면 당뇨병 환자 의 미세혈관 합병증 및 대혈관 합병증 발생이 증가하는 것 으로 알려져 있다[2]. 제1형 당뇨병 환자를 대상으로 한 Diabetes Control and Complications Trial (DCCT)[3]과 제2형 당뇨병 환자를 대 상으로 한 United Kingdom Prospective Diabetes Study (UKPDS)[4]를 통해 혈당을 철저히 조절하면 제1형과 제2 형 당뇨병 모두 미세혈관 합병증의 발생을 줄이고 진행 속 도를 늦출 수 있음을 확인하였다. 하지만 두 연구 모두 혈당 을 철저히 조절한 경우에도 대혈관 합병증 발생은 의미 있 게 줄이지 못하였다. “당뇨병 환자, 특히 제2형 당뇨병 환자를 대상으로 혈당 을 철저히 조절하면 심혈관 질환 발생을 줄일 수 있을까?” 라는 질문에 대한 답은 아직 불확실하다. 하지만 최근 이 같 은 질문에 일부 답 할 수 있는 연구 결과들[5~9]이 발표되어 많은 관심을 끌고 있다. 본 강좌에서는 최근 발표된 대규모 임상연구 결과를 자세 히 살펴보고, 이러한 연구들이 갖는 의미와 연구 결과를 당 뇨병 환자 진료에 어떻게 적용할 것인지에 대해 생각해보고 자 한다.","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116152600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Case of Painful Graves' Disease 一例痛苦的格雷夫斯病

Journal of Korean Endocrine Society Pub Date : 2008-10-01 DOI: 10.3803/JKES.2008.23.5.337

J. Jeong, Tae Yong Kim, Eun Hee Kim, Eui Young Kim, Sang A Lee, J. Yim, K. Kim, W. Kim, Y. Shong

引用次数: 2