Journal of Korean Endocrine Society最新文献

{"title":"A Case of Carcinoma Showing Thymus-Like Differentiation (CASTLE) in the Thyroid","authors":"Eun Hee Kim, J. Jeong, Eui Young Kim, Sang A Lee, K. Kim, J. Yim, Won Gu Kim, Tae Yong Kim, S. Kim, G. Gong, Y. Shong, W. Kim","doi":"10.3803/JKES.2008.23.4.272","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.4.272","url":null,"abstract":"Carcinoma Showing Thymus-Like Differentiation (CASTLE) is a very rare malignant neoplasm of the thyroid, and this resembles lymphoepithelioma or squamous cell carcinoma of the thymus. It originates from ectopic thymic tissue or remnants of the branchial pouches. We recently experienced a case of CASTLE in the thyroid gland of a 61-year-old woman. She presented with an asymptomatic mass in the right thyroid gland and she was diagnosed with 'poorly differentiated carcinoma' of the thyroid by fine needle aspiration cytology (FNAC). Total thyroidectomy was performed for both diagnostic and therapeutic purposes. Histologic examination of the resected tumor showed that the tumor was lobulated with expanding fibrous bands, and it was infiltrated by lymphocytes and plasma cells. The tumor cells had oval, large vesicular nuclei and prominent nucleoli, and the immunohistochemical staining was positive for CD5 and bcl-2, so the patient was diagnosed with thyroid CASTLE. We report here on a case of CASTLE in the thyroid gland treated by surgery and external neck radiation therapy. (J Korean Endocr Soc 23:272~276, 2008)","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126358407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Simvastatin on the Growth and Invasion of Anaplastic Thyroid Cancer Cells Lines","authors":"Hyun-jeung Choi, Tae Yong Kim, Eui Young Kim, Won Gu Kim, W. Kim, Y. Shong","doi":"10.3803/JKES.2008.23.4.238","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.4.238","url":null,"abstract":"Background: Anaplastic thyroid carcinoma has grave prognosis with most patient dying within 6 months of diagnosis. 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors have been reported to have an anticancer effect in experimental and clinical studies. In this study, we investigated the effect of HMG-CoA reductase inhibitors on cell growth, invasiveness, adherence and signal transduction to evaluate the possibility of simvastatin as an agent for treatment of thyroid cancer. Methods: The viability of simvastatin treated 3 thyroid cancer cell lines (FRO, WRO, and ARO) were determined. We evaluated the cell migration, anchorage-independent growth and invasion ability in anaplastic thyroid cell line. The expression and phosphorylation of focal adhesion kinase (FAK) and extracellular signal-regurated kinase (ERK) were determined by immunoblot analysis. Results: Three thyroid cancer cell lines showed concentration dependent decrease of viability after treatment with 100~200 mM of simvastatin. Anaplastic ARO cell line showed the most predominant decrease in viability. In ARO cell lines, cell migration was decreased by concentration dependent manner after treatment with simvastatin (concentration ≥ 5 mM). Anchorage independent colony formation also decreased after simvastatin (≥ 10 mM). Finally, immunoblot analysis revealed that the phosphorylation status of FAK and ERK decreased in time dependent manner following treatment with 10 mM of simvastatin. Conclusion: The results of this study suggest that simvstatin exerts a favorable effect on the progression and metastasis of thyroid cancer. However, further studies are needed to elucidate the related mechanisms and signal transductions prior to its therapeutic application. (J Korean Endocr Soc 23:238~244, 2008)","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130018409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Panhypopituitarism and Central Diabetes Insipidus Caused by Primary Central Nervous System Lymphoma","authors":"M. Ahn, Soon Sun Kim, Tae-Ho Kim, S. Han, D. Kim, Hugh C. Kim, Se-Hyuk Kim, J. Han, Ho Sung Kim, Y. Chung","doi":"10.3803/JKES.2008.23.4.260","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.4.260","url":null,"abstract":"Primary central nervous system (CNS) lymphoma is an uncommon neoplasm. However, the incidence of primary CNS lymphoma has increased more than 10-fold over the past three decades, and continues to accelerate. Currently, primary CNS lymphoma represents 4 to 7 percent of all newly diagnosed primary CNS tumors. Primary CNS lymphoma may arise from different parts of the brain, with deep hemispheric periventricular white matter being the most common site of origin. The presenting symptoms in primary CNS lymphoma vary depending on the location of the mass. Involvement of the hypothalamic-pituitary axis may cause hypopituitarism, diabetes insipidus, headache, diplopia, and blurred vision. We experienced a case of a 58-year-old woman who developed central diabetes insipidus and panhypopituitarism secondary to primary CNS lymphoma. Hypothalamic and thalamic involvement were suspected based on brain MRI, and primary CNS lymphoma was confirmed by a CT-guided stereotactic biopsy. Through performing a water deprivation test and a combined pituitary stimulation test, we diagnosed complete type central diabetes insipidus and panhypopituitarism. Symptomatic relief was obtained with desmopressin, levothyroxine, hydrocortisone, and high-dose methotrexate-based chemotherapy. The thalamic and hypothalamic masses were significantly decreased in size after chemotherapy. We report the details of this case along with a review of the literature concerning primary CNS lymphom (J Korean Endocr Soc 23:260~265, 2008)","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121301523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of the Brachial-Ankle Pulse Wave Velocity (baPWV) in Patients with Type 2 Diabetes Mellitus","authors":"Seong Woo Lee, Kyung Won Yun, Yunjie Yu, H. Lim, Yung Pil Bae, Byung Do Lee, B. Kim, C. Lee","doi":"10.3803/JKES.2008.23.4.253","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.4.253","url":null,"abstract":"Background: Pulse wave velocity (PWV) correlates with arterial distensibili ty and stiffness and is a useful method for evaluating the severity of systemic atherosclerosis in adults. Brachial-ankle PWV (baPWV) is affected by many different factors such as age, systolic blood pressure (SBP), sex, body mass index, waist to hip ratio, and HbA1c. We evaluated the determinants of baPWV in patients with type 2 diabetes mellitus. Methods: The study included 803 type 2 diabetic patients over age 30 who had their ankle brachial pressure index (ABI) and baPWV measured at Busan St. Mary's Medical Center, Busan, Korea. Anthropometric parameters, blood pressure, pulse pressure, fasting plasma glucose, fasting insulin, HbA1c, lipid profile, high sensitivity C-reactive protein (hs-CRP), and microalbuminuria were checked concurrently. We also investigated tobacco and alcohol use by means of questionnaire. We then retrospectively analyzed the relationships between baPWV and various risk factors. Results: Differences between men and women were measured using the independence sample probate. Pearson correlation analysis confirmed the factors affecting the baPWV as follows: SBP, diastolic blood pressure, pulse pressure, age, waist circumference, gender, and duration of diabetes mellitus were positively correlated, and height and weight were negatively correlated. On aged-adjusted partial correlation, HbA1c, SBP, diastolic blood pressure, and pulse pressure were correlated. By multiple linear regression analysis, SBP, age, HbA1c, and weight were independent predictors of baPWV. Conclusion: The baPWV is principally affected by SBP and age in patients with type 2 diabetes mellitus. (J Korean Endocr Soc 23:253~259, 2008)","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126598695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Family Case of Complete Androgen Insensitivity Syndrome in Sisters due to a Novel Mutation in the Androgen Receptor Gene","authors":"J. Sung, Hyung-Young Yoon, Hyon J. Kim, Mi Ran Kim, T. H. Lee, H. Joo, W. Park, Y. Chung","doi":"10.3803/JKES.2008.23.4.277","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.4.277","url":null,"abstract":"Androgen insensitivity syndrome (AIS) is a hereditary disorder that's characterized by the female phenotype in spite of the 46, XY karyotype, and this is caused by mutation of the androgen receptor gene. We experienced a case of the complete type of AIS. A 20-yr-old woman was evaluated for primary amenorrhea. The patient had external genitalia of the female phenotype, but she had no ovaries or uterus. The abdominal computed tomography scan revealed suspected testes in the pelvic cavity. The chromosome analysis was reported as 46, XY. We identified an androgen receptor gene novel mutation, including CAT deletion at the position 1925~1927 and AG deletion at the position 2129~2130 of exon 5, in both the proband and her sister. The patient underwent laparoscopic gonadectomy due to the possibility of malignant tumor developing in the testes. The subject is now on estrogen supplementation and she is under regular follow-up; she is in a good condition. (J Korean Endocr Soc 23:277~283, 2008) ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏ Key Word: androgen-insensitivity syndrome, androgen receptor, novel mutatio","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129607470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Treatment of Obesity.","authors":"S. Yoo","doi":"10.3803/JKES.2008.23.4.223","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.4.223","url":null,"abstract":"","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122254172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Change in Thyroid Autoantibodies According to the Clinical Course of Painless Thyroiditis Excluding Postpartum Thyroiditis","authors":"I. Lee, Y. Jo, B. Ku, M. Shong, Young Kun Kim, H. Ro","doi":"10.3803/JKES.2008.23.4.245","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.4.245","url":null,"abstract":"Background: Painless thyroiditis is characterized by painless, destructive inflammation of the thyroid gland. Although thyroid autoantibodies are frequently detected in patients suffering from this condition, the clinical significance of these antibodies is not well understood. Therefore, this study was conducted to investigate the relationship between thyroid function and thyroid autoantibodies in painless thyroiditis according to clinical course. Methods: Patients proven to have painless thyroiditis were retrospectively included in this study. We analyzed their clinical features, thyroid function and titers of thyroid autoantibodies according to clinical course, which was divided into three phases; thyrotoxic, hypothyroid and recovery. Results: Of the 21 patients included in this study, 2 were male and 19 were female. During the thyrotoxic phase, the mean free T4 concentration was 4.03 (2~6.8) ng/mL and the mean concentration of thyroid stimulating hormone (TSH) was 0.02 (0.01~0.07) U/mL. In addition, the titer of antithyroglobulin antibody and antithyroid peroxidase antibody was 298 (4.8~995) U/mL and 3318 (0.1~25280) U/mL, respectively during this phase. During the hypothyroid phase, the mean TSH was 16.3 (4.3-49.5) U/mL and was found to be positively correlated with the level of free T4 observed during the thyrotoxic phase (r = 0.523, P = 0.031). During the recovery phase, the titer of antithyroglobulin antibody was significantly reduced to 180 (38~487) U/mL when compared with the titer taken during the thyrotoxic phase (P = 0.016). Additionally, during the hypothyroid phase, patients found to have antithyroid peroxidase antibody had a higher titer of TSH than those that did not (23.9 (6.5~49.5) vs. 11.2 (5.3~18.2) U/mL, P = 0.004). Conclusion: The titer of free T4 and the presence of antithyroid peroxidase observed during the thyrotoxic phase were related to the titer of TSH during hypothyroid phase. Additionally, the titer of antithyroglobulin antibody was significantly reduced during the recovery phase. (J Korean Endocr Soc 23:245~252, 2008)","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125054938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 2 Diabetes Mellitus and Arterial Stiffness","authors":"S. Choi","doi":"10.3803/JKES.2008.23.4.234","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.4.234","url":null,"abstract":"234 전 세계적으로 제2형 당뇨병 환자의 가장 중요한 사망 원 인은 심혈관계 질환으로 전체 당뇨병 사망의 40% 이상을 심근경색 및 뇌경색 등이 차지하고 있다[1]. 미국의 자료를 보면, 연간 95만명 이상이 심혈관질환으로 사망하고 있으며, 이것은 약 34초당 1명꼴로 심근경색이나 뇌경색으로 당뇨병 환자들이 생명을 잃고 있다는 것이 된다[1]. 따라서 2형 당 뇨병 환자에서 조기에 동맥경화증 및 심혈관계 위험인자를 선별하여 적극적인 예방 및 치료를 하는 것이 매우 중요하 다. 동맥경화증을 비침습적으로 진단하는 방법으로는 죽상동 맥경화반(atheromatous plaque) 및 경동맥 내중막두께 (intima-medial thickness) 등을 확인할 수 있는 경동맥초음 파검사(carotid artery Doppler ultrasound)[2,3]와 관상동맥 의 초기 동맥경화증까지 확인할 수 있는 다중채널관상동맥 단층촬영(Multi-detector coronary computed tomography) 등이 있으며, 혈관의 신전성(distensibility)와 경직도(stiffness) 를 측정할 수 있는 방법으로 맥파 전달속도(pulse wave velocity; PWV) 측정[4]과 혈류의존성 혈관확장반응(flow mediated dilatation; FMD)이 널리 사용되고 있다. 이 중에서 혈관의 신전성 저하와 경직도 증가는 노화, 혈 압, 당뇨병, 흡연, 비만, 고지혈증[5] 등과 많은 연관이 있는 것으로 알려져 있는데, 이는 여러 가지 요인에 의하여 혈관 자체의 손상, 혈관의 결체조직과 평활근의 증식, 비대 등이 일어나면서 나타나게 된다. 혈관의 경직도가 증가되면 결과 적으로 수축기혈압과 이완기 혈압의 차이인 맥압(pulse pressure)의 상승을 가져오게 되고, 이는 심실과 심근에 부 담을 주어 심박출량을 감소시키고 동맥벽에 손상을 가속화 하여 동맥경화증을 가속화하게 된다[6,7]. 최근 연구에 의하 면 이러한 맥압의 상승 자체가 관상동맥질환의 중요한 연관 인자인 것으로 알려져 있으며[8~10], 노인에서의 수축기고 혈압(isolated systolic hypertension)의 중요한 원인이다. PWV는 혈관에서 맥파가 전달될 때 두 지점 간의 맥파가 이 동하는 시간(ΔT) 과 두 지점 간의 거리(L)를 측정하여 구하 게 되는 것으로, 두 혈관 지점의 거리를 전파하는 맥파의 전 달속도를 계산하게 된다(L/ΔT = m/sec or cm/sec). 혈관의 신전성이 저하되고 경직도가 증가되면 맥파 전달속도는 같 은 지점을 통과하는 동안 커지게 되며, 이는 마치 딱딱한 파 이프를 통해서 전달하는 전파속도가 신전성이 큰 고무관을 통해서 전달하는 속도보다 커지는 원리와 같다[11]. 이전의 연구에는 경동맥과 대퇴동맥 간의 맥파전달속도를 측정하는 경동맥-대퇴동맥 PWV (carotid-femoral PWV)도 자주 사용 하였으나 혈압과 발목-상완 혈압비(ankle-brachial index; ABI)를 측정하기 어렵고, 측정시간이 많이 걸리며, 재현성 과 검사 방법이 어려운 등의 문제로 최근에는 주로 측정방 법이 간편하고 혈압과 ABI 등을 함께 잴 수 있는 상완-발목 맥파전달속도(baPWV)가 주로 사용되고 있다. PWV는 최근 많은 연구들을 통하여 경동맥 내중막 두께 와의 관련성, 관상동맥 질환의 중등도와 좌심실 수축기 부 전과 관련성이 있다는 것이 밝혀졌고[12~15], 심혈관질환 을 예측하는 독립적인 인자임을 보이는 연구들도 발표되 었다[15~18]. 우리나라 환자에서 PWV의 정상치를 구하기 위한 연구가 있었는데 박 등[19]이 2006년에 발표한 논문에 따르면, 우리나라 성인 검진 환자를 대상으로 PWV의 정상 값을 구하여 보았을 때 20대는 5.58 ± 0.96 m/sec에서 나이 에 따라 점차적으로 증가하였고, 60대는 8.5 ± 2.36 m/sec 의 평균값을 보였다. 이 연구는 SphygomoCoR 를 이용한 압평 혈압계(applanation tonometer) 방식의 측정으로 증대 지표(augmentation index)를 함께 측정하였으나, 경동맥-대 퇴동맥 PWV를 연구한 것이라 기존의 외국 연구의 정상 baPWV 값과 차이를 보이며 연령별 정상군의 n수가 매우 작았다. 따라서 우리나라에서도 대규모의 임상 연구를 통하 여 정상인의 연령별 PWV 수치를 정립하는 연구가 필요하 며, 이러한 수치를 한국인에서의 정상 기준으로 사용할 수 있을 것이다. baPWV 값의 범위에 따라 관상동맥 질환 또는 제2형 당뇨병과 동맥 경직도","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128023227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Regulation of Nuclear Receptors","authors":"E. Lee, Young Joo Park","doi":"10.3803/JKES.2008.23.3.155","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.3.155","url":null,"abstract":"당뇨병, 비만, 이상지질혈증, 고혈압, 인슐린 저항성 등은 공통된 체내 대사 조절의 이상에 의해 발생되는 “대사증후 군(metabolic syndrome)”이라는 병적 상태를 이루는 요소들 이다[1]. 이 대사증후군은 심혈관계 질환으로 인한 사망의 위험성을 높이는데[2], 미국에서는 그 유병률이 23.7%에 이 른다고 알려져 그 심각성이 대두되고 있다[3]. 최근 우리나 라에서 발표된 바에 따르면 대사증후군의 유병률이 29% 정 도이며, 주로 사회경제학적 상태가 낮을수록 더 흔한 것으로 알려지면서 이에 대한 그 치료와 예방에 대해 관심이 고조 되고 있다[4] 최근 핵수용체(nuclear receptor; NR)가 대사증후군의 병 태 생리에서 중요한 역할을 담당하고 있음이 밝혀지면서, 핵 수용체의 활성 조절 물질과 그 기전에 대한 연구 및 이를 통 한 대사증후군의 신약 개발에 대한 연구가 활발하게 진행되 고 있다. 핵수용체는 일종의 전사 인자(transcription factor)로 리간 드에 의해 리간드-수용체 반응에 의해 활성화되는 것이 특징 이다. 펩티드 리간드에 의해 반응하는 세포외 수용체와는 달 리, 세포 내로 들어온 지용성 호르몬 혹은 리간드와 직접 결 합하여 핵 안에 위치한 목표 유전자까지 이동하여 전사 기전 을 조절, 해당 유전자의 발현을 조절하는 것이 주된 작용 기 전으로 알려져 있다. 1985년 처음으로 glucocorticoid receptor (GR)가 밝혀진 이래[5], 현재까지 연구 방법의 기술적 발전과 더불어 여러 종류의 핵수용체와 리간드의 존재가 밝혀지고, 이들의 기능과 작용 기전에서 많은 지식이 축적되었다. 본고에서는 지금까지 보고된 연구 결과를 종합하여, 지질 및 당 대사 조절 과정에서 핵수용체가 어떠한 역할을 담당 하고 있으며, 어떤 조절 기전을 통하고 있는가에 대해서 소 개하고자 한다. 핵수용체와 유전자 발현의 조절","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122587895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Slipped Capital Femoral Epiphysis in Association with Panhypopituitarism after Treatment of Craniopharyngioma","authors":"J. Chung, S. Hong, D. Cho, D. Chung, M. Chung","doi":"10.3803/JKES.2008.23.3.193","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.3.193","url":null,"abstract":"Craniopharyngioma accounts for 2~5% of all primary intracranial neoplasms. It may present with a variety of manifestations including neurological, visual, and/or hypothalamic-pituitary dysfunction. Treatment options include radical surgery or radiotherapy, or a combination of these modalities. Craniopharyngioma ablation results in anterior and/or posterior pituitary hormone deficits. Slipped capital femoral epiphysis (SCFE), in which the femoral head slips downward and backward on the femoral neck at the epiphyseal plate, most commonly occurs during the rapid growth phase of puberty. Its actual cause is unknown, but the clinical association between SCFE and endocrine disorders is well known. We report a case of an adult male patient who developed SCFE in association with panhypopituitarism after treatment of a craniopharyngioma. (J Korean Endocr Soc 23:193~198, 2008)","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122866862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}