Journal of Korean Endocrine Society最新文献

{"title":"Effects of Peroxisome Proliferator-Activated Receptor (PPAR) Delta on the Growth and Invasion of a Thyroid Cancer Cell Line","authors":"Won Gu Kim, Hyunji Choi, Eui Young Kim, Tae Yong Kim, W. Kim, Seong Chul Kim, Y. Shong","doi":"10.3803/JKES.2009.24.1.25","DOIUrl":"https://doi.org/10.3803/JKES.2009.24.1.25","url":null,"abstract":"Background: Peroxisome proliferator-activated receptor delta (PPAR-δ) is a ligand-activated nuclear transcription factor that is associated with many diseases, such as diabetes, obesity, metabolic syndrome, and cancer. However, the function of PPAR-δ is controversial in carcinogenesis since its ligands may inhibit or promote the growth of cancer cells. The purpose of this study was to determine the effect of GW501516, the specific agonist of PPAR-δ, in the growth and invasiveness of thyroid cancer cell lines by modulation of the target genes, ANGPTL-4 and MCP-1. Methods: Three kinds of human cancer cell lines, FRO (thyroid anaplastic carcinoma), NPA (melanoma), and ARO (colon cancer) were treated with GW501516 in serum-free media. Cell viability was assayed using a colorimetric cell counting kit-8 assay. The changes in the level of expression of PPAR-δ and its target genes, angiopoietin-like protein-4 (ANGPTL-4) and monocyte chemotactic protein-1 (MCP-1), were determined by RT-PCR analysis and invasiveness was assessed by a cell invasion assay kit. Results: GW501516 inhibited the cell growth of cancer cell lines in a dose-dependent manner and modulated the stimulation of ANGPTL-4, as well as inhibition of MCP-1. These effects were more prominent in NPA and ARO, but less effective in the thyroid cancer cell l ine, which had higher PPAR-δ and lower ANGPTL-4 mRNA levels. The inhibitory effects of GW501516 on cancer invasiveness had a similar pattern. Conclusion: The activation of PPAR-δ by GW501516 reduced the cell growth and invasiveness of the thyroid cancer cell line. This effect of GW501516 was associated with a stimulatory effect of ANGPTL4 and an inhibitory effect of MCP-1 in cancer cell lines. GW501516 was less effective in the thyroid cancer cell line, which had a low basal ANGPTL-4 mRNA level. The findings of our study serve as an impetus for further studies to elucidate the precise role of ANGPTL-4 and PPAR-δ in carcinogenesis. (J Korean Endocr","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115941463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Painful Hashimoto's Thyroiditis Successfully Treated with Total Thyroidectomy","authors":"H. Kim, Hong-Joon Shin, Ho-Cheol Kang","doi":"10.3803/JKES.2008.23.6.438","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.6.438","url":null,"abstract":"Painful Hashimoto’s thyroiditis (HT) is a subtype of HT characterized by thyroid pain with overt elevation in inflammatory markers and thyroid autoantibodies. The differential diagnosis of painful HT with subacute granulomatous thyroiditis is often difficult because initial clinical findings are very similar. Findings that favor the diagnosis of painful HT include preceding history of chroni c goiter or autoimmune thyroid diseases, a high titer of thyroid autoantibodies, and repeated painful attacks even with chronic glucocorticoid therapy. Surgery is often needed to relieve the thyroid pain. We report a case of painful HT who received only temporary relief from steroid therapy and required total thyroidectomy for relapsing thyroid pain. The clinical response s to steroid and surgical therapy are described, with a literature review emphasizing the differential diagnosis with subacute granulomatous thyroiditis. To our knowledge, this is the first case report of painful HT treated with total thyroidectomy in the Korean literature.","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":"89 11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116303785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Thyroid Nodules Detected by Ultrasonography in Adults for Health Check-Ups and Analysis of Fine Needle Aspiration Cytology","authors":"Won Jun Kim, J. Kim, D. Park, C. Lee, Yongsoo Park, Dong Kim, W. Choi, Tae Wha Kim, Y. Ahn","doi":"10.3803/JKES.2008.23.6.413","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.6.413","url":null,"abstract":"Background: The purpose of this study was to assess the prevalence of thyroid nodules in healthy adults without a history of thyroid disease and the results of fine needle aspiration cytology (FNAC). Methods: We retrospectively studied 4,832 adults (2,427 women, 2,405 men) over the age of 20 who had visited our health care center from January, 2005, to March, 2008. Subjects with previous thyroid disease were excluded. All were screened by thyroid ultrasonography and FNAC was performed on large or potentially malignant nodules. Results: Thyroid nodules were present in 686 women (28.3%) and 396 men ( 16.5%), with a female predominance (odds ratio = 1.47, 95% CI = 1.35~1.60). The prevalence of a thyroid nodule was significantly correlated with age in both women and men (P < 0.001). Multinodularity also increased according to age in both groups. Ninety patients were tested with conventional FNAC and 195 underwent ultrasonography-guided FNAC. The rate of inadequate cytology by ultrasonographic guidance was lower than by freehand methods, and the total rate of malignant cytology per patient was 17.9%. Ultrasonographic characteristics that significantly correlated with histologically-confirmed papillary carcinoma included a solid component, hypoechogenecity, irregular margin, and the presence of microcalcification or macrocalcification. Conclusion: The prevalence of thyroid nodules detected by ultrasonography was 28.3% in healthy women and 16.5% in healthy men population. The prevalence and multinodularity was significantly correlated with age in both groups. It’s useful to examine thyroid by ultrasonography because of detecting more nodules, providing guidance of FNAC, achieving more adequate sampling and not missing small malignant nodules. (J Korean","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124123588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two Cases of the Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma","authors":"Hee-Kwan Won, Myoung Jun Lee, J. Park, In Girl Song, Go Eun Lee, Ji-Hyun Jeong, Jee-Young Cheon, H. Sul, Dong Mi Lim, Keun-Young Park","doi":"10.3803/JKES.2008.23.6.430","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.6.430","url":null,"abstract":"The diffuse sclerosing variant of papillary thyroid carcinoma (DSPTC) is a rare histological subtype characterized by diffuse involvement of one or both thyroid lobes, widespread lymphatic permeation, prominent fibrosis, squamous metaplasia, abundant psammoma body and lymphatic infiltration. This subtype usually occurs in young female, and exhibits a higher frequency of cervical and distant metastasis. DSPTC clinically resembles Hashimoto’s thyroiditis, and often delays the correct diagnosis. We experienced two patients with DSPTC: the one patient presented with a neck mass lasting for a month, and in the other patient, a thyroid lesion was incidentally found during a medical examination. (J Korean Endocr Soc 23:430~437, 2008)","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":"494 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115686651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of MELAS Syndrome Manifested by Insulin-deficient Diabetes Mellitus","authors":"H. Jeong, Ji-young Kang, Hyun Kim, Kyu-Ho Lee, Dal-Sic Lee, G. Choi, Tae Geun Oh, Hyen Jeong Jeon","doi":"10.3803/JKES.2008.23.6.444","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.6.444","url":null,"abstract":"MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes) syndrome is characterized by stroke-like episodes before the age of 40, encephalopathy, seizures, dementia and lactic acidosis, and is caused by mutations in mitochondrial DNA. Diabetes mellitus and cardiac involvement are also frequently seen in MELAS syndrome. It is a classic mitochondrial disorder that shows a slow, chronic, progressive course, and presents with multiple organ involvement including the central nervous system, skeletal muscle, eye, cardiac muscle and gastrointestinal system. Here, we report a case of 33 year-old woman with insulin-deficient diabetes mellitus and sensorineural hearing loss experiencing repeated stroke-like episodes. MELAS syndrome with an A3243G point mutation was confirmed by mitochondrial DNA sequencing analysis. (J Korean Endocr Soc 23:444~449, 2008) ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏ","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116098291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discrepancy between the Growth Hormone and Insulin-like Growth Factor-I Concentrations in Patients with Acromegaly.","authors":"J. Yoon, M. Kang, H. Y. Ahn, J. An, S. W. Kim, C. Shin, K. Park, H. Jang, B. Cho, Hong-Kyu Lee, S. Kim","doi":"10.3803/JKES.2008.23.6.395","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.6.395","url":null,"abstract":"Background: This study was performed to evaluate the frequency and clinical characteristics of patients with active acromegaly and who show discordance of the growth hormone (GH) level and the insulin-like growth factor-I (IGF-I) level. Methods: We reviewed the medical records of the patients who were diagnosed with acromegaly between 01/01/1995 and 6/30/2007 at Seoul National University Hospital. We selected only the patients whose basal GH and IGF-I levels were available. We investigated the pre- and post-operative clinical characteristics, as well as the blood concentrations of GH and IGF-I. The concordance rate between the two hormones was examined. The patients were considered to have active disease on the basis of their IGF-I levels above the normal range, after adjustment for age and gender, and their mean basal GH value was ≥ 2.5 μg/L. The hormone levels and the clinical parameters were compared between the hormone concordant and discordant groups. Results: We reviewed the preoperative records of 103 acromegalic patients, and these patients met the above-mentioned criteria. 53 postoperative patients who were not cured by operation were monitored without them receiving radiation or medical therapy. Both the basal GH and IGF-I levels were above normal in 103 patients preoperatively, and the discordant rate was 0% (0/103 cases). Postoperatively, the discordant rate between the two hormones was increased to 30.2% (16/53 cases). Age, gender, body mass index and tumor size were insignificantly different between the concordant and discordant groups. However, postoperative residual tumors were less frequently observed in the discordant group (P = 0.006). Conclusion: For the patients with acromegaly, unlike the 0% discordance preoperatively, 30.2% of patients showed a discrepancy between their GH and IGF-I levels postoperatively. The patients who had hormonal discrepancy were less likely to have residual tumors after operation. Considering the frequency of this hormonal discrepancy, both hormone levels should be measured to evaluate the disease activity after treatment. Further, oral glucose tolerance testing should be performed and especially for the patients with an increased GH level, but who have a normal IGF-I concentration. (J Korean Endocr Soc 23:395~403, 2008)","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133551757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Thyrotoxic Periodic Paralysis with Rhabdomyolysis","authors":"Seo-hee Lee, S. Kim, Hae Ri Lee, J. Kang, O. Ryu, C. Kim, B. Lee, Seong-Jin Lee, E. Hong, H. Kim, D. Kim, J. Yu, S. Ihm, M. Choi, H. Yoo","doi":"10.3803/JKES.2008.23.6.425","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.6.425","url":null,"abstract":"Hyperthyroidism combined with rhabdomyolysis is extremely rare. There are only 6 reported cases of hyperthyroidism accompanied with rhabdomyolysis in the medical literature. Rhabdomyolysis is a syndrome involving the breakdown of skeletal muscle, and this causes myoglobin and intracellular protein to leak into the circulation. The causes of rhabdomyolysis include trauma, electrolyte abnormality, infection, drug, toxin and hypothyroidism. We report here on a patient who presented with thyrotoxic periodic paralysis and rhabdomyolysis with hypokalemia. He complained of lower leg paralysis along with muscle tenderness, and the laboratory findings showed elevated creatine kinase (CK) levels. After treatment by hydration, potassium replacement and drug medication, including propylthiouracil and beta-blocker, his CK levels were normalized and his symptoms were much improved. For patient with thyrotoxic periodic paralysis and muscle tenderness, the possibility of rhabdomyolysis should be clarified by examining the CK levels. (J Korean Endocr Soc","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127548053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Methimazole-induced Agranulocytosis and Kikuchi's Disease in a Patient with Graves' Disease","authors":"Seung Eun Lee, Jihyun Ahn, Jaetaek Kim, Yeon-sahng Oh, Y. Chung","doi":"10.3803/JKES.2008.23.6.420","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.6.420","url":null,"abstract":"Methimazole-induced agranulocytosis is a rare, but critical side effect that should be recognized as soon as possible since it may induce a life-threatening condition when it was overlooked. Histiocytic necrotizing lymphadenitis is also called Kikuchi’s lymphadenitis, and this is a rare form of lymphadenitis with a self-limited clinical course and this illness is accompanied by cervical lymph node enlargement, fever and malaise. We recently experienced a patient with methimazole-induced agranulocytosis and Graves' disease, and this was accompanied by Kikuchi's disease; the patient presented with sore throat and multiple enlarged cervical lymph nodes. To the best of our knowledge, there is no previous report on methimazole-induced agranulocytosis combined with Kikuchi's disease. Therefore, we report here on this very rare case along with a brief review of the relevant literature. (J Korean Endocr Soc 23:420~424, 2008) ꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏꠏ","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122425124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence Based Medicine in Endocrinology","authors":"S. Rhee, Young Seol Kim","doi":"10.3803/JKES.2008.23.6.379","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.6.379","url":null,"abstract":"역학에 있어 임상역학(clinical epidemiology)은 매우 중 요한 개념이다. 임상역학은 임상의학의 다양한 문제점에 대 해 역학적 기법을 이용하여 해결하려는 과학으로 1938년 질 병이 발생되기 쉬운 상황에 대해 연구하는 과학이라는 의미 에서 처음 도입된 후, 의학의 발전에 따라 1970년대에 역학 적 기법을 이용하여 진료, 검사, 치료의 유효성과 효율성을 평가하는 학문으로 정의, 발전되었다. 최근의 거의 모든 의학 분야에서 이러한 임상역학적 접근 이 주목 받고 있는 것은 1991년 Guyatt가 근거중심의학 (EBM)이라는 용어를 제창한 이후부터이다. 근거중심의학에 서는 임상 진료가 의사의 개인적 경험이나 기호에 의해서가 아닌 일정한 진료지침에 의거하여 이루어져야 한다. 이를 위 해 각각의 환자에 대한 의사 개인의 경험적 치료가 아닌, 명 확한 최종 목적에 따라 계획된 진료를 시행하고 이를 통해 얻어진 데이터에 근거한 표준화된 진료지침이 필요하게 되 었다. 그러므로 각각의 진료 지침들은 기본적으로 여러 역학 연구들에 근거하여 작성되어야 하게 되었다. 이러한 역학 연구 들이 바로 근거중심의학(evidence based medicine, EBM)을 이루는 기본 요소이다. 역학 연구는 본태적으로 불확실성을 가지고 있는 임상의 학의 약점을 극복하기 위한 필수적인 검증 단계이다. 예를 들어, 고혈압은 연령 증가에 따라 필수적으로(essential) 발생 하는 현상이므로 고혈압을 치료하면 장기 손상이 일어난다고 생각했던 시절이 있었다. 하지만, 역학연구를 통하여 고혈압 치료가 뇌졸중이나 심혈관 질환과 같은 치명적인 중증 질환 을 예방할 수 있다는 것이 근거로 증명되었기 때문에 혈압 강하 치료는 일상 진료에 필수적인 의료 행위가 되었다. 이렇듯 EBM의 기조는 전 세계적으로 폭넓게 확산되고 있어 향후 임상의 여러 분야에서 보다 엄격한 EBM이 적용 될 것으로 전망되고 있다. 그리고 이는 의학의 여러 영역에 있어 다양한 임상 역학 연구들이 폭넓게 시행될 것임을 의 미한다. 실제 이러한 추세에 따라 내분비-대사내과의 여러 분야에서 전 세계적으로 광범위한 EBM 연구가 이루어지고 있다. 하지만 이러한 연구들은 주로 당뇨병, 고지혈증, 골다 공증 분야에 한정된 편이며, 전통적인 내분비 질환들의 진단 과 치료에 대한 연구는 아직 부족한 실정이다. 특히, 우리나라에서는 한국인의 고유한 특성에 대한 역학 연구가 많지 않은 실정으로 대부분 외국의 연구 결과를 이 용한 진료를 시행하고 있다. 한국인의 유전적, 생활환경이 구미인과 많은 차이가 있으므로 한국인을 위한 진정한 EBM 의 실현을 위해 우리나라만의 독자적인 근거 구축이 필요하 다고 생각된다. 이에 저자들은 우리나라 내분비분야에서의 EBM의 활성을 기대하며 그간의 문헌에 보고된 연구 성과 들을 정리하고 현시점에서의 가치관이 어떠한가를 제시하고 자 한다.","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128147309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Retroperitoneal Paraganglioma Manifested as Intractable Constipation with Paralytic Ileus and Aggravated Hyperglycemia","authors":"S. Hwang, Mikwang Kwon, S. Chon","doi":"10.3803/JKES.2008.23.6.450","DOIUrl":"https://doi.org/10.3803/JKES.2008.23.6.450","url":null,"abstract":"Paragangliomas are extra-adrenal pheochromocytomas that arise from specialized neural crest cells. They are distributed anywhere from the upper neck to the pelvic floor, a nd they are classified on the basis of their anatomic origin. Functioning paragangliomas can cause the same clinical manifestations as pheochromocytoma, such as hypertension, diabetes mellitus, hyperadrenergic spells and so on. We experienced a retroperitoneal paraganglioma that was found in 66 year-old male who suffered from intractable constipation, and his constipation was caused by paralytic ileus and uncontrolled hyperglycemia. After he was diagnosed, removal of the paraganglioma was done and his clinical symptoms and sustained hyperglycemia were successfully","PeriodicalId":119859,"journal":{"name":"Journal of Korean Endocrine Society","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123788335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}