European Heart Journal最新文献_第8页

Dietary carbohydrate quality, fibre-rich food intake, and left ventricular structure and function: the CARDIA study. 膳食碳水化合物质量、富含纤维的食物摄入与左心室结构和功能：CARDIA研究。

IF 39.3 1区医学

European Heart Journal Pub Date : 2025-07-08 DOI: 10.1093/eurheartj/ehaf406

So-Yun Yi,Lyn M Steffen,Weihua Guan,Daniel Duprez,Kamakshi Lakshminarayan,David R Jacobs

{"title":"Dietary carbohydrate quality, fibre-rich food intake, and left ventricular structure and function: the CARDIA study.","authors":"So-Yun Yi,Lyn M Steffen,Weihua Guan,Daniel Duprez,Kamakshi Lakshminarayan,David R Jacobs","doi":"10.1093/eurheartj/ehaf406","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf406","url":null,"abstract":"BACKGROUND AND AIMSIdentifying lifestyle risk factors related to abnormal cardiac phenotypes, including structure and function, will be essential to prevent or slow down the progression to heart failure. Little is known about intakes of macronutrients and food groups, particularly carbohydrate (CHO) quality and fibre-rich foods, relative to cardiac phenotypes. Therefore, the association between CHO quality and cardiac phenotypes was examined in the Coronary Artery Risk Development in Young Adults (CARDIA) study.METHODSTrained interviewers conducted the CARDIA Diet History to gather dietary intake at exam years 0, 7, and 20. Cardiac phenotype measures were collected at exam years 25 and 30 via echocardiography. Linear mixed effects regression models were used to evaluate the association of CHO quality and fibre-rich food score averaged across years 0, 7, and 20 with cardiac phenotype measures at years 25 and 30.RESULTSAmong the 3171 CARDIA participants, quartiles of CHO quality (defined using CHO:fibre ratio) were favourably associated with left ventricular (LV) mass index (Ptrend < .001) and global longitudinal strain (Ptrend < .001) after adjusting for demographic and lifestyle factors. Similarly, quartiles of fibre-rich food score (created based on daily intakes of whole grains, fruit, vegetables, nuts, and legumes) were favourably associated with LV mass index (Ptrend < .001), LV ejection fraction (Ptrend = .008), global longitudinal strain (Ptrend < .001), E/e' ratio (Ptrend = .02), and left atrial volume index (Ptrend = .02). Cardiac phenotype effect sizes between 10% and 26% of their respective standard deviations.CONCLUSIONSHigher quality of CHO and intake of fibre-rich foods were favourably associated with LV structure and function.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"23 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144578668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis of early-stage cardiac amyloidosis: is atrial biopsy a new opportunity? 早期心脏淀粉样变性的诊断：心房活检是一个新的机会吗？

IF 39.3 1区医学

European Heart Journal Pub Date : 2025-07-08 DOI: 10.1093/eurheartj/ehaf455

Arnela Saljic,Alisha Niskala,Thomas Jespersen

引用次数: 0

Endothelial plasticity and fibrosis in atrial fibrillation: reframing the therapeutic landscape for targeted interventions. 心房颤动的内皮可塑性和纤维化：重新构建靶向干预的治疗景观。

IF 39.3 1区医学

European Heart Journal Pub Date : 2025-07-08 DOI: 10.1093/eurheartj/ehaf428

Guillermo Luxán,Samuel Sossalla

引用次数: 0

Ignorance is not bliss: the importance of lipoprotein(a) testing. 无知并非幸福：脂蛋白(a)检测的重要性。

IF 39.3 1区医学

European Heart Journal Pub Date : 2025-07-08 DOI: 10.1093/eurheartj/ehaf422

Michelle L O'Donoghue,Victorien Monguillon

引用次数: 0

Correction to: Pregnancies in women after peri-partum cardiomyopathy: the global European Society of Cardiology EuroObservational Research Programme Peri-Partum Cardiomyopathy Registry. 更正：围产期心肌病后妇女怀孕：全球欧洲心脏病学会欧洲观察研究计划围产期心肌病登记处。

IF 37.6 1区医学

European Heart Journal Pub Date : 2025-07-07 DOI: 10.1093/eurheartj/ehaf301

引用次数: 0

Critical medications in cardiology: strategic policy of the European Medicines Agency. 心脏病学中的关键药物：欧洲药品管理局的战略政策。

IF 37.6 1区医学

European Heart Journal Pub Date : 2025-07-07 DOI: 10.1093/eurheartj/ehaf134

Dobromir Dobrev, Juan Tamargo, Piotr Szymański

引用次数: 0

Scpep1 inhibition attenuates myocardial infarction-induced dysfunction by improving mitochondrial bioenergetics. 抑制Scpep1通过改善线粒体生物能量学减轻心肌梗死引起的功能障碍。

IF 37.6 1区医学

European Heart Journal Pub Date : 2025-07-07 DOI: 10.1093/eurheartj/ehaf032

Guilin Chen, Jing Gan, Fan Wu, Zengxian Zhou, Zikun Duan, Ke Zhang, Songxue Wang, Hua Jin, Yulin Li, Chi Zhang, Zhuofeng Lin

{"title":"Scpep1 inhibition attenuates myocardial infarction-induced dysfunction by improving mitochondrial bioenergetics.","authors":"Guilin Chen, Jing Gan, Fan Wu, Zengxian Zhou, Zikun Duan, Ke Zhang, Songxue Wang, Hua Jin, Yulin Li, Chi Zhang, Zhuofeng Lin","doi":"10.1093/eurheartj/ehaf032","DOIUrl":"10.1093/eurheartj/ehaf032","url":null,"abstract":"Background and aims: Myocardial infarction (MI) is an ischaemic cardiovascular disease associated with increased morbidity and mortality. Previous studies have suggested that serine carboxypeptidase 1 (Scpep1) is involved in vascular diseases; however, its role in cardiac diseases remains unclear. This study aims to explore the role of Scpep1 in regulating cardiac homeostasis during MI.Methods: The impact of Scpep1 deficiency or cardiac-specific knock-down and Scpep1 overexpression on heart function was evaluated in mice with MI. Its downstream functional mediators of Scpep1 were elucidated using proteomic analysis and confirmed by employing loss- and gain-of-function strategies.Results: Circulating and cardiac Scpep1 levels were up-regulated in mice with MI. Genetic ablation or cardiac-specific knock-down of Scpep1 alleviated MI-induced cardiac dysfunction and damage in mice. In contrast, cardiac-specific Scpep1 overexpression aggravated these adverse effects. Mechanistically, Scpep1 exacerbated MI-induced cardiac dysfunction and damage by impaired mitochondrial bioenergetics via binding to Pex3 to promote its degradation, ultimately contributing to mitochondrial fission and apoptosis. Moreover, the expressional profiles of Scpep1 in plasma samples and heart tissues of patients with MI or ischaemic cardiomyopathy were in line with those observed in the mouse models. In addition, pharmaceutical inhibition of Scpep1 notably improved MI-induced cardiac dysfunction and damage by improving mitochondrial fragmentation and bioenergetics post-MI.Conclusions: Scpep1 deficiency mitigates MI by improving Pex3-mediated mitochondrial fission and subsequent cardiomyocyte apoptosis. Scpep1 constitutes a potential therapeutic target for attenuating MI.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"2579-2594"},"PeriodicalIF":37.6,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leaders in cardiology: Molly Stevens. 心脏病学的领军人物：莫莉·史蒂文斯。

IF 37.6 1区医学

European Heart Journal Pub Date : 2025-07-07 DOI: 10.1093/eurheartj/ehaf140

Judith Ozkan

引用次数: 0

Ischaemic heart disease: focus on colchicine, drug-coated balloons, and novel therapeutic targets. 缺血性心脏病：秋水仙碱、药物包被气球和新的治疗靶点的研究

IF 39.3 1区医学

European Heart Journal Pub Date : 2025-07-07 DOI: 10.1093/eurheartj/ehaf419

Filippo Crea

引用次数: 0

Correction to: 2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): Developed by the task force for the management of atrial fibrillation of the European Society of Cardiology (ESC), with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Endorsed by the European Stroke Organisation (ESO). 与欧洲心胸外科协会（EACTS）合作制定的2024 ESC房颤管理指南：由欧洲心脏病学会（ESC）房颤管理工作组制定，并得到了ESC的欧洲心律协会（EHRA）的特殊贡献。由欧洲中风组织（ESO）认可。