European Heart Journal最新文献

{"title":"From locus to lipase: LIPA as a paradigm for post-GWAS mechanistic and translational research in CAD.","authors":"Philipp S Wild,Tanja Zeller","doi":"10.1093/eurheartj/ehaf732","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf732","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"112 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145247097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Equal tools, unequal tolls: should sex influence decision-making for aortic valve stenosis?","authors":"Tommaso Gori,Hendrik Treede","doi":"10.1093/eurheartj/ehaf762","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf762","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"1 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left ventricular geometry, brain architecture, and cognition: an observational study.","authors":"Pier-Giogio Masci,Maxim Freydin,Gianni Andreozzi,Esther Puyol-Anton,Aqeel T Mohamed,Bram Ruijsink,Francois Deharo,Vasileios Stylianidis,Marc Modat,Liane Dos Santos Canas,Jon Cleary,Marina Cecilja,Philip Chowienczyk,Valentina Lorenzoni,Alistair Young,Alexander Hammers,Amedeo Chiribiri,Reza Razavi,Claire J Steves,Andrew P King","doi":"10.1093/eurheartj/ehaf722","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf722","url":null,"abstract":"BACKGROUND AND AIMSCardiovascular (CV) diseases and dementia share common risk factors and often coexist in older adults. Understanding the CV-brain interaction is essential for tackling their interconnected burden. This study investigated the link between CV phenotypes, brain architecture, and cognition.METHODSOverall, 15 519 UK Biobank participants without neurodegenerative diseases or stroke (median age 64 years, 49% female) were analysed. Confirmatory factor analysis aggregated 18 CV magnetic resonance imaging (MRI) biomarkers into latent variables for left ventricular systolic function (gSyst), diastolic (gDiast) function, and geometry (gGeom); arterial compliance was measured by aortic distensibility (AoD). Multivariable linear regression models evaluated associations with brain MRI phenotypes, including grey matter volume, white matter hyperintensities, MRI diffusion white matter microstructure, and hippocampal volume. Models were adjusted for age, body mass index, height, mean blood pressure, and CV risk factors. Exploratory mediation models evaluated whether hippocampal volume accounted for associations between CV phenotypes and cognition.RESULTSgGeom, reflecting greater myocardial mass, wall thickness, and ventricular volumes, showed the strongest association with hippocampal volume [β = 0.082 (0.048-0.117) in females; β = 0.039 (0.006-0.071) in males] and was the only CV phenotype associated with better cognition, including higher fluid intelligence and faster reaction time. Hippocampal volume significantly accounted for the positive relationship between gGeom and cognition across sexes. In contrast, gSyst, gDiast, and AoD demonstrated weaker and less consistent associations with brain structure and were unrelated to cognition.CONCLUSIONSVentricular geometry emerged as the CV phenotype most strongly associated with brain architecture and cognition. Hippocampal volume may help explain this association, but further studies are needed to investigate causality.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"101 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statin therapy during pregnancy.","authors":"Paulina E Stürzebecher, Ulrich Laufs","doi":"10.1093/eurheartj/ehaf666","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf666","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":35.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertrophic cardiomyopathy: changing the paradigm of exercise prescription and competitive sport participation.","authors":"Mattia Zampieri,Sara Saberi,Flavio D'Ascenzi,Michael Papadakis,Antonio Pelliccia,Iacopo Olivotto","doi":"10.1093/eurheartj/ehaf770","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf770","url":null,"abstract":"Historically, individuals with hypertrophic cardiomyopathy (HCM) have been systematically excluded from vigorous exercise and competitive sports due to concerns about increased sudden cardiac death (SCD) risk. However, emerging evidence has challenged this paradigm. Observational studies and randomized trials demonstrate improvements in functional capacity, quality of life, and overall cardiovascular and psychological health with tailored exercise in HCM populations -including competitive sports in low-risk individuals-in the absence of safety signals. Low-risk individuals are defined by the lack of well-established adverse features such as a high European Society of Cardiology HCM SCD risk score, exercise-induced syncope, severe left ventricular outflow tract obstruction and ventricular arrhythmias. The concept that this low-risk subset can safely engage in competitive sports is becoming widely accepted internationally, although local differences exist in terms of regulations and clinical approaches. For individuals who do not meet low-risk criteria, evidence is more limited. Nevertheless, participation in competitive sports may still be considered on an individual basis, after appropriate risk mitigation strategies (including treatment of obstruction and ICD implantation when indicated). A contemporary approach to HCM should be based on individualized, goal-oriented exercise prescription, supported by multidisciplinary counselling and shared decision-making, recognizing the importance of aligning medical recommendations with individual safety, values, goals, and quality of life. In this review, we critically appraise the emerging evidence surrounding vigorous exercise and competitive sports in HCM and explore how novel data are reshaping clinical practice and international guidelines, setting the stage for a paradigm in the field.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"60 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood pressure, plasma proteins, and cardiovascular diseases: a network Mendelian randomization and observational study.","authors":"Devendra Meena,Jingxian Huang,Alexander Smith,James Yarmolinsky,Siwei Wu,Fotios Koskeridis,Yi-Hsuan Ko,Marie-Joe Dib,Charalabos Antonatos,Yiannis Vasilopoulos,Xinzhu Yu,Georg W Otto,Dipender Gill,Manuel Mayr,Paul Elliott,Abbas Dehghan,Ioanna Tzoulaki","doi":"10.1093/eurheartj/ehaf725","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf725","url":null,"abstract":"BACKGROUND AND AIMSThe biological pathways leading to elevated blood pressure (BP) and subsequent cardiovascular diseases (CVDs) remain incompletely understood. Investigating the proteomic landscape of BP and its overlap with CVD could provide critical insights into the molecular determinants and pathways involved in BP regulation and its subsequent effect on CVD.METHODSA proteome-wide Mendelian randomization (MR) study was conducted by leveraging genetic instruments from 2007 plasma proteins to assess their causal effects on BP (systolic and diastolic BP). Proteins showing strong associations with BP were further analyzed for potential causal effects on coronary artery disease (CAD) and stroke subtypes. Network MR was performed to estimate the proportion of CVD risk mediated through BP. Bayesian colocalization was applied to determine whether identified associations share common causal variants. Observational associations were examined in UK Biobank participants to assess associations between proteins, BP, and incident CVD events using linear regression and Cox proportional hazard models.RESULTSProteome-wide MR identified 242 proteins associated with BP, of which 48 were also linked to CAD or stroke, with four (ACOX1, FGF5, FURIN, MST1) also supported by genetic colocalization analyses (FDR 5% and PP ≥70%). Genetically predicted FURIN and FGF5 were strongly associated with BP and stroke risk, while ACOX1, FGF5, and MST1 exhibited potential causal effects on CAD. Network MR suggested that a substantial proportion of their effect on CAD and stroke (30.5%-77.2%) was mediated through BP regulation. Observational analyses further supported these findings.CONCLUSIONSThis study identifies key plasma proteins with potential causal roles in BP regulation and CVD risk, highlighting BP as a major mediator of their effects on CAD and stroke. These findings provide novel insights into the molecular mechanisms underlying hypertension-related CVD and identify promising protein targets for further investigation.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"26 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145246998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why Africa needs its own criteria for heart valve prosthesis selection.","authors":"Valdano Manuel","doi":"10.1093/eurheartj/ehaf494","DOIUrl":"10.1093/eurheartj/ehaf494","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"3677-3679"},"PeriodicalIF":35.6,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subcutaneous implantable cardiac defibrillator in Brugada syndrome: a prospective multicentre study.","authors":"Jean-Baptiste Gourraud,Frédéric Sacher,Nicolas Badenco,Jacques Mansourati,Fabrice Extramiana,Béatrice Guyomarch,Nathalie Behar,Jean-Claude Deharo,Nefissa Hammache,Philippe Chevalier,Sylvain Ploux,François Wiart,Olivier Geoffroy,Nathalie Drapier,Jacob Tfelt-Hansen,Boris Rudic,Philippe Maury,Imen Fellah,Aurélie Thollet,Christelle Marquié,Bertrand Pierre,Gaël Clerici,Vincent Probst","doi":"10.1093/eurheartj/ehaf743","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf743","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"81 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The fast-changing world of obesity, diabetes, and systemic metabolic disorders.","authors":"Filippo Crea","doi":"10.1093/eurheartj/ehaf696","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf696","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"78 1","pages":"3673-3676"},"PeriodicalIF":39.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145235754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EAPC sports cardiology course 2025: join us in Madrid!","authors":"Silvia Castelletti, Jonathan H Kim, Michael Papadakis","doi":"10.1093/eurheartj/ehaf686","DOIUrl":"10.1093/eurheartj/ehaf686","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"3682-3684"},"PeriodicalIF":35.6,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}