European Heart Journal最新文献

{"title":"Weekly Journal Scan: REDEFINing the next generation of obesity pharmacotherapy.","authors":"Giovanna Liuzzo,Carlo Patrono","doi":"10.1093/eurheartj/ehaf628","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf628","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"90 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145089836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weekly Journal Scan: Reframing inflammaging across the population spectrum.","authors":"Daniela Pedicino,Giovanna Liuzzo","doi":"10.1093/eurheartj/ehaf626","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf626","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"38 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145089837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weekly Journal Scan: a real-world study in China shows that a tight control of blood pressure reduces all-cause dementia.","authors":"Giovanna Gallo,Massimo Volpe","doi":"10.1093/eurheartj/ehaf640","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf640","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"28 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145089835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early antiplatelet treatment for minor stroke following thrombolysis: the EAST trial.","authors":"Hui-Sheng Chen,Yu Cui,Xiao-Qiu Li,Xin-Hong Wang,Chang-Hao Jiang,Jing Li,Zhi-Mei Yuan,Li-Wei Zhao,Nan Kong,Hai-Ning Mi,Jiang Lu,Hong Zhang,You-Jun Liu,Er-Qiang Wang,Yan Yang,Cheng-Guang Song,Yi Zhang,Shu-Yao Wang,Hong-Guo Dai,Yi Yang,Shi-Mei Geng,Rong Yin,Duo-Lao Wang,Thanh N Nguyen","doi":"10.1093/eurheartj/ehaf702","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf702","url":null,"abstract":"BACKGROUND AND AIMSAntiplatelet treatment is recommended to start 24 h after intravenous thrombolysis due to concerns about haemorrhagic transformation. This study aimed to investigate the potential benefit of early antiplatelet after intravenous thrombolysis in minor stroke.METHODSA multicentre, double-blind, randomized trial was conducted in China between 7 August 2022 and 1 August 2024, to evaluate the efficacy and safety of early antiplatelet in acute ischaemic stroke patients presenting with mild neurological deficits, as indicated by a National Institutes of Health Stroke Scale (NIHSS) score of 0-5, who received intravenous thrombolysis. Patients were randomly assigned to receive either clopidogrel and aspirin or placebo within 6 h after intravenous thrombolysis. The primary endpoint was an excellent functional outcome at 90 days, indicated by a modified Rankin Scale (mRS) score of 0-1. Statistical analysis was based on a modified intention-to-treat population. Symptomatic intracranial haemorrhage, any intracranial haemorrhage, and major systemic bleeding were safety endpoints.RESULTSThe primary endpoint was not met in this study. Of the randomly assigned 1022 patients, 995 patients were included in the modified intention-to-treat analysis (503 with early antiplatelet treatment and 492 with placebo). The primary endpoint occurred in 89.7% (451/503) of patients receiving early antiplatelet vs 89.6% (441/492) of those receiving placebo with no significant difference (odds ratio 1.00, 95% confidence interval .67-1.51, P = .99). Similar safety profiles were found between the two groups.CONCLUSIONSAmong Chinese patients with acute minor ischaemic stroke who received intravenous thrombolysis, early antiplatelet treatment with clopidogrel plus aspirin was safe but did not improve already excellent functional outcome (mRS 0-1) at 90 days.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"39 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145089767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel DES cardiomyopathy presenting with lifelong syncope: diagnostic breakthrough via multimodal imaging and insertable cardiac monitor.","authors":"Lei Bi,Yi Yi,Yilu Wang","doi":"10.1093/eurheartj/ehaf700","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf700","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"84 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145089770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrial fibrillation burden is underestimated by non-invasive monitoring: the CIRCA-DOSE trial.","authors":"Martin Aguilar,Laurent Macle,Geoffroy Ditac,Karim Benali,Sewanou H Honfo,Paul Khairy,Alexandre Raymond-Paquin,Marc W Deyell,Nathaniel M Hawkins,Richard G Bennett,Jason G Andrade","doi":"10.1093/eurheartj/ehaf647","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf647","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"29 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145089769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not all atrial fibrillations are born equal: the impact of chronobiology.","authors":"Andreas Goette","doi":"10.1093/eurheartj/ehaf582","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf582","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"41 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145089771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination lipid-lowering strategies after acute coronary syndrome: reconsidering cholesterol targets.","authors":"Paola Gargiulo,Kausik K Ray,Pasquale Perrone-Filardi","doi":"10.1093/eurheartj/ehaf615","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf615","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"77 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145089774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Missing 'lncs': how insufficient scrutiny can lead to misrepresentation of long non-coding RNAs (lncRNAs) and their function in cardiovascular disease.","authors":"Matthew Bennett, Igor Ulitsky, Andrew H Baker","doi":"10.1093/eurheartj/ehaf115","DOIUrl":"10.1093/eurheartj/ehaf115","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"3434-3436"},"PeriodicalIF":35.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating proteins and incident myocardial infarction: appraising sex-specific differences and causality.","authors":"Olga E Titova, Shuai Yuan, Liisa Byberg, John A Baron, Lars Lind, Karl Michaëlsson, Susanna C Larsson","doi":"10.1093/eurheartj/ehaf113","DOIUrl":"10.1093/eurheartj/ehaf113","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"3502-3503"},"PeriodicalIF":35.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}