European Heart Journal最新文献

{"title":"Minimizing emissions through minimally invasive valve replacement.","authors":"Sanjay Rajagopalan,Rakesh C Arora,Sadeer Al-Kindi","doi":"10.1093/eurheartj/ehaf425","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf425","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"190 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic biomarkers related to cardiac disease in childhood cancer survivors: a case-control study.","authors":"Naïla Aba,Gwénaël Le Teuff,Brice Fresneau,Serge Koscielny,Shaima Belhechmi,Boris Schwartz,Chiraz El-Fayech,Carole Rubino,Rodrigue S Allodji,Eric Morel,Delphine Dayde,Pierre de la Grange,Ariane Jolly,Noémie Pata-Merci,Camille Cordero,Isabelle Aerts,François Pein,Giao Vu-Bezin,Florent De Vathaire,Nadia Haddy","doi":"10.1093/eurheartj/ehaf617","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf617","url":null,"abstract":"BACKGROUND AND AIMSCardiotoxic treatments like anthracyclines and heart-directed radiotherapy increase the risk of cardiac diseases (CDs) in childhood cancer survivors (CCSs), but individual differences in CD incidence are not fully understood. This study aims to identify transcriptomic biomarkers associated with CD occurrence after childhood cancer treatment.METHODSA matched case-control study was conducted on a sample of 330 CCS: 165 cases with CD and 165 CD-free controls. The expression of 8557 genes was investigated to select those associated with CD and heart failure (HF), using three stabilization approaches derived for the conditional logistic regression with Lasso (Percentile lasso, Bolasso, and Sublasso). The intersection of the three selected gene sets formed the final selection. The interactions between cancer treatment doses and selected genes were investigated.RESULTSOne promising gene, NFE2L2, constituted the final selection, and its expression was lower in cases than in controls [CD: odds ratio (OR) .16, 95% confidence interval (CI) .09-.29; HF: OR .11, 95% CI .03-.37]. No interaction between treatment doses and NFE2L2 expression levels was found in our study. Incorporating NFE2L2 gene expression into prognostic models improved discrimination between cases and controls compared with models based solely on clinical and treatment variables [CD: area under the curve (AUC) .85 vs .66; HF: AUC .87 vs .77].CONCLUSIONSUsing high-dimensional data selection methods has enabled the identification of the gene NFE2L2, associated with CD and HF in CCS. Further research is needed to validate this finding and achieve a better understanding of the biological mechanisms leading to cardiac toxicities and so to develop risk-adapted treatment and surveillance strategies.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"26 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian rhythms in cardiovascular disease.","authors":"Ilse R Kelters, Yvonne Koop, Martin E Young, Andreas Daiber, Linda W van Laake","doi":"10.1093/eurheartj/ehaf367","DOIUrl":"10.1093/eurheartj/ehaf367","url":null,"abstract":"<p><p>Circadian rhythms, controlled by the suprachiasmatic nucleus and peripheral clocks, regulate 24-h cycles in biological processes such as the cardiovascular system. Circadian rhythms influence autonomic balance, with parasympathetic dominance during sleep supporting cardiac recovery and sympathetic activation during the day supporting circulatory demand. Congruent with systemic and cellular circadian rhythmicity, 24-h patterns arise in the pathophysiology of cardiovascular diseases, including ischaemic heart disease, heart failure, and arrhythmias. Daily variations influence the timing and outcome of myocardial infarction, with studies reporting patterns in infarct size depending on the time of onset. Similar daily patterns are observed in cardio- and cerebrovascular complications. In heart failure, circadian rhythms are dampened but remain intact, suggesting the potential for incorporating timing in diagnostics and therapies. Sudden cardiac death follows a distinct pattern, with a higher incidence in the morning. Atrial fibrillation onset, on the other hand, occurs more frequently at night. Risk factors and modifiers, such as physiological, psychological, lifestyle, and environmental factors and comorbidities interact with circadian rhythms, thereby impacting cellular pathomechanisms and development of cardiovascular health and disease. Chronotherapy, which aligns treatments with circadian rhythms, has demonstrated potential for improving the efficacy of cardiovascular therapies. This review examines the influence of circadian rhythms on cardiovascular health in the context of specific cardiac diseases and risk factors, and it highlights the therapeutic opportunities informed by circadian patterns.</p>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"3532-3545"},"PeriodicalIF":35.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12450527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Focus on the importance of vaccination in cardiovascular prevention and on the role of late gadolinium enhancement in predicting sudden death.","authors":"Filippo Crea","doi":"10.1093/eurheartj/ehaf664","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf664","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"1 1","pages":"3509-3512"},"PeriodicalIF":39.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coffee and cardiovascular disease.","authors":"Thomas A Dewland, Rob M van Dam, Gregory M Marcus","doi":"10.1093/eurheartj/ehaf421","DOIUrl":"10.1093/eurheartj/ehaf421","url":null,"abstract":"<p><p>While rigorous longitudinal study of a widely and enthusiastically consumed dietary substance has it challenges, recent exponential growth in the scientific evaluation of coffee consumption has resulted in a clearer appreciation of the link between this common drink and health outcomes. Coffee has complex effects that can vary between individuals depending on both inherited predispositions as well as consumption habits. Despite the common concern and conventional 'wisdom' that coffee can promote various cardiovascular diseases, the available data suggest that moderate coffee consumption is associated with a reduced risk of hypertension, type 2 diabetes, myocardial infarction, arrhythmias, heart failure, and even overall mortality. Some exceptions have emerged, including the potentially harmful effects of unfiltered coffee with respect to LDL cholesterol and randomized controlled data demonstrating an acute increase in frequency of premature ventricular contractions with coffee consumption. In many instances, the beneficial effects of coffee appear to be independent of caffeine. Given the ubiquity of coffee consumption and the growing prevalence of cardiovascular disease, translating the latest science into accessible knowledge has the capability to tremendously empower patients and impact global health.</p>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"3546-3554"},"PeriodicalIF":35.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased longevity in adults with congenital heart disease and the need for 'extended transition' of care.","authors":"Silvia Favilli, Gaia Spaziani, Iacopo Olivotto","doi":"10.1093/eurheartj/ehaf498","DOIUrl":"10.1093/eurheartj/ehaf498","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"3515-3516"},"PeriodicalIF":35.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The next generation of cardio-oncologists.","authors":"Massimiliano Camilli, Trecy Gonçalves, Wouter C Meijers","doi":"10.1093/eurheartj/ehaf452","DOIUrl":"10.1093/eurheartj/ehaf452","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"3513-3514"},"PeriodicalIF":35.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left bundle branch area pacing vs right ventricular pacing for atrioventricular block: the MELOS RELOADED study.","authors":"Marek Jastrzębski,Grzegorz Kiełbasa,Oscar Cano,Karol Curila,Francesco Zanon,Catalin Pestrea,Jan De Pooter,Justin Luermans,Leonard M Rademakers,David Žižek,Domenico Grieco,Wim Huybrechts,Philipp Krisai,Zachary I Whinnett,Paweł Moskal,Valérian Valiton,Javier Navarrete-Navarro,Petr Stros,Francesco Deluca,Ecaterina Cicala,Emine Özpak,Kevin Vernooy,Haran Burri","doi":"10.1093/eurheartj/ehaf699","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf699","url":null,"abstract":"BACKGROUND AND AIMSLeft bundle branch area pacing (LBBAP) promotes physiological synchronous activation of the left ventricle and may be particularly beneficial in patients with atrioventricular block (AVB), but its mortality benefit remains unclear. This study aims to compare long-term survival in AVB patients receiving either LBBAP or right ventricular pacing (RVP) and to analyse predictors of mortality during LBBAP.METHODSMELOS RELOADED, a multicentre European collaboration, was a registry-based study of pacemaker patients with AVB, left ventricular ejection fraction (LVEF) >40% and ventricular pacing >20%. The primary outcome was all-cause mortality based on national registries. A 1:1 propensity score matching was performed between the RVP and LBBAP groups. Kaplan-Meier curves and multivariable Cox proportional hazards models were used to estimate survival.RESULTSIn total, 3382 patients receiving LBBAP or RVP were matched. At 4-year follow-up, the Kaplan-Meier curve showed an absolute difference in survival of 11.8% in favour of LBBAP (P < .001). LBBAP was a robust predictor of reduced mortality with a hazard ratio (HR) of 0.53 (95% confidence interval 0.42-0.65, P < .001). Within the LBBAP group, the following independent predictors of increased mortality were identified: lack of confirmed left bundle branch capture (HR 1.85, P < .001), lower percentage of ventricular pacing (HR 1.12), and age.CONCLUSIONSThis is the first large study demonstrating the long-term survival benefit of LBBAP. This strengthens the use of LBBAP in AVB patients with preserved/mildly reduced LVEF while awaiting the results of randomized trials. Confirmation of left bundle branch capture seems advisable to achieve optimal results with LBBAP.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"37 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ESC journals randomized study: extended-follow-up analysis.","authors":"Ricardo Ladeiras-Lopes,Filippo Crea,Thomas F Lüscher","doi":"10.1093/eurheartj/ehaf183","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf183","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"20 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plaque fissure and calcified nodule: histopathological findings","authors":"Teruo Sekimoto, Alyssa Grogan, Rika Kawakami, Tatsuya Shiraki, Kazuhiro Fujiyoshi, Anna Madra, Renu Virmani, Aloke V Finn","doi":"10.1093/eurheartj/ehaf672","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf672","url":null,"abstract":"Coronary artery disease remains a leading cause of morbidity and mortality. Precise definitions of the distinct plaque morphologies that contribute to coronary artery disease are essential for a comprehensive understanding of plaque progression and vulnerability. This review clarifies critical and often conflated plaque phenotypes: specifically, plaque fissure vs rupture and calcified nodules vs nodular calcification. Furthermore, it contextualizes these pathologies by examining shifting acute coronary syndrome presentations and evolving culprit lesion morphologies and explores how advanced coronary imaging technologies are revolutionizing their detection and treatment. Plaque fissures are characterized by a lateral tear in an eccentric lesion that traverses a thick fibrous cap and ends in a small necrotic core. In contrast to ruptures, fissures are accompanied by an intraplaque thrombus, typically composed of fibrin, platelets, and red cells, while luminal thrombus is usually absent or small if present. In ruptures, a thin fibrous cap is disrupted and associated with significant infiltration of macrophages and T-lymphocytes. Calcified nodules are fragments of dense calcium interspersed by fibrin that protrude into the vessel lumen and trigger a luminal thrombus that is usually non-occlusive and composed of fibrin and platelets. Calcified nodules typically appear as eccentric lesions with a convex luminal surface that is devoid of fibrous tissue or endothelium. While nodular calcifications have a similar morphology, the overlying thick fibrous cap is intact, lined by endothelial cells, and devoid of thrombus. Clarifying these fundamental differences is crucial for an improved understanding of the pathogenesis of coronary artery disease and developing personalized treatment strategies.","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":"76 1","pages":""},"PeriodicalIF":39.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145089619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}