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Possible perspectives for cardiovascular events following coronavirus disease 2019 vaccination.
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-03-07 DOI: 10.1093/eurheartj/ehaf112
Xue-Yan Gong, James Cheng-Chung Wei, Li-Yun Zhang
{"title":"Possible perspectives for cardiovascular events following coronavirus disease 2019 vaccination.","authors":"Xue-Yan Gong, James Cheng-Chung Wei, Li-Yun Zhang","doi":"10.1093/eurheartj/ehaf112","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf112","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advanced understanding of immune mechanisms in acute myocardial infarction: coronary extracellular vesicles trigger NETosis. 丙二醛特异性天然 IgM 可抑制心肌梗死患者冠状动脉细胞外囊泡引发的 NETosis。
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-03-07 DOI: 10.1093/eurheartj/ehae554
Teresa Gerhardt, Ulf Landmesser
{"title":"Advanced understanding of immune mechanisms in acute myocardial infarction: coronary extracellular vesicles trigger NETosis.","authors":"Teresa Gerhardt, Ulf Landmesser","doi":"10.1093/eurheartj/ehae554","DOIUrl":"10.1093/eurheartj/ehae554","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"940-942"},"PeriodicalIF":37.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pushing boundaries: the uncharted territory of managing a 110-year-old patient.
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-03-07 DOI: 10.1093/eurheartj/ehaf030
Antoni Bayes-Genis
{"title":"Pushing boundaries: the uncharted territory of managing a 110-year-old patient.","authors":"Antoni Bayes-Genis","doi":"10.1093/eurheartj/ehaf030","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf030","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An update on the European Society of Cardiology Council of Cardio-Oncology.
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-03-07 DOI: 10.1093/eurheartj/ehaf052
Teresa López-Fernández, Peter van der Meer, Alexander R Lyon
{"title":"An update on the European Society of Cardiology Council of Cardio-Oncology.","authors":"Teresa López-Fernández, Peter van der Meer, Alexander R Lyon","doi":"10.1093/eurheartj/ehaf052","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf052","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of aggressive lipid-lowering therapy on plaque stabilization in femoropopliteal disease, assessed using near-infrared spectroscopy intravascular ultrasound. 利用近红外光谱血管内超声评估积极降脂治疗对股腘动脉疾病斑块稳定的疗效。
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-03-07 DOI: 10.1093/eurheartj/ehae900
Yusuke Sato, Tetsuji Morishita, Hiroshi Tada
{"title":"Efficacy of aggressive lipid-lowering therapy on plaque stabilization in femoropopliteal disease, assessed using near-infrared spectroscopy intravascular ultrasound.","authors":"Yusuke Sato, Tetsuji Morishita, Hiroshi Tada","doi":"10.1093/eurheartj/ehae900","DOIUrl":"10.1093/eurheartj/ehae900","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"983"},"PeriodicalIF":37.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence and mortality prediction in acute coronary syndromes. 人工智能与急性冠状动脉综合征的死亡率预测。
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-03-07 DOI: 10.1093/eurheartj/ehae475
Zachi I Attia, Paul A Friedman
{"title":"Artificial intelligence and mortality prediction in acute coronary syndromes.","authors":"Zachi I Attia, Paul A Friedman","doi":"10.1093/eurheartj/ehae475","DOIUrl":"10.1093/eurheartj/ehae475","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"955-957"},"PeriodicalIF":37.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arterial conduits for coronary bypass grafting: the set-point concept. 冠状动脉旁路移植术的动脉导管：设定点概念。
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-03-07 DOI: 10.1093/eurheartj/ehae908
Antonio M Calafiore, Sotirios Prapas, Mario Gaudino
{"title":"Arterial conduits for coronary bypass grafting: the set-point concept.","authors":"Antonio M Calafiore, Sotirios Prapas, Mario Gaudino","doi":"10.1093/eurheartj/ehae908","DOIUrl":"10.1093/eurheartj/ehae908","url":null,"abstract":"<p><p>Endothelial cells control the vascular tone of arterial grafts used for coronary artery bypass surgery and react to changes in local shear stress. The vascular adaptations induced by endothelial cell activation affect the outcome of surgical grafts and can be predicted based on the set-point theory. In this Hypothesis piece, it is proposed that the set-point concept should inform surgical decision making for coronary artery bypass surgery.</p>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"922-925"},"PeriodicalIF":37.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PIEZO1 attenuates Marfan syndrome aneurysm development through TGF-β signaling pathway inhibition via TGFBR2. PIEZO1通过TGFBR2抑制TGF-β信号通路，从而减轻马凡综合征动脉瘤的发展。
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-03-07 DOI: 10.1093/eurheartj/ehae786
Peiwen Yang, Hao Liu, Shilin Wang, Xiaoyue Xiao, Lang Jiang, Sheng Le, Shanshan Chen, Ping Ye, Jiahong Xia
{"title":"PIEZO1 attenuates Marfan syndrome aneurysm development through TGF-β signaling pathway inhibition via TGFBR2.","authors":"Peiwen Yang, Hao Liu, Shilin Wang, Xiaoyue Xiao, Lang Jiang, Sheng Le, Shanshan Chen, Ping Ye, Jiahong Xia","doi":"10.1093/eurheartj/ehae786","DOIUrl":"10.1093/eurheartj/ehae786","url":null,"abstract":"<p><strong>Background and aims: </strong>Marfan syndrome (MFS) is a hereditary disorder primarily caused by mutations in the FBN1 gene. Its critical cardiovascular manifestation is thoracic aortic aneurysm (TAA), which poses life-threatening risks. Owing to the lack of effective pharmacological therapies, surgical intervention continues to be the current definitive treatment. In this study, the role of Piezo-type mechanosensitive ion channel component 1 (Piezo1) in MFS was investigated and the activation of PIEZO1 was identified as a potential treatment for MFS.</p><p><strong>Methods: </strong>PIEZO1 expression was detected in MFS mice (Fbn1C1041G/+) and patients. Piezo1 conditional knockout mice in vascular smooth muscle cells of MFS mice (MFS × CKO) was generated, and bioinformatics analysis and experiments in vitro and in vivo were performed to investigate the role of Piezo1 in MFS.</p><p><strong>Results: </strong>PIEZO1 expression decreased in the aortas of MFS mice; MFS × CKO mice showed aggravated TAA, inflammation, extracellular matrix remodelling, and TGF-β pathway activation compared to MFS mice. Mechanistically, PIEZO1 knockout exacerbated the activation of the TGF-β signalling pathway by inhibiting the endocytosis and autophagy of TGF-β receptor 2 mediated by Rab GTPase 3C. Additionally, the pharmacological activation PIEZO1 through Yoda1 prevented TGF-β signalling pathway activation and reversed TAA in MFS mice.</p><p><strong>Conclusions: </strong>Piezo1 deficiency aggravates MFS aneurysms by promoting TGF-β signalling pathway activation via TGF-β receptor 2 endocytosis and a decrease in autophagy. These data suggest that PIEZO1 may be a potential therapeutic target for MFS treatment.</p>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"958-974"},"PeriodicalIF":37.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A novel percutaneous technique for closing anomalous left coronary artery origin from the pulmonary artery using the Fustar™ Steerable Introducer.
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-03-07 DOI: 10.1093/eurheartj/ehaf090
Shubo Song, Liyun Zhao, Taibing Fan
{"title":"A novel percutaneous technique for closing anomalous left coronary artery origin from the pulmonary artery using the Fustar™ Steerable Introducer.","authors":"Shubo Song, Liyun Zhao, Taibing Fan","doi":"10.1093/eurheartj/ehaf090","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf090","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gender-specific associations and circulating proteins in myocardial infarction: potential causal relationships.
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-03-07 DOI: 10.1093/eurheartj/ehaf111
Yi Xu, Tianpu Feng, Yuanyuan Huang
{"title":"Gender-specific associations and circulating proteins in myocardial infarction: potential causal relationships.","authors":"Yi Xu, Tianpu Feng, Yuanyuan Huang","doi":"10.1093/eurheartj/ehaf111","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf111","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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