European Heart Journal最新文献

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Expanding the triglyceride range in clinical trials: therapeutic opportunities.
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-02-14 DOI: 10.1093/eurheartj/ehaf074
Ask T Nordestgaard, Aruna D Pradhan, Brendan M Everett, Jean G MacFadyen, Deepak L Bhatt, Frank L J Visseren, Peter Libby, Raul D Santos, Steven E Nissen, Børge G Nordestgaard, Paul M Ridker
{"title":"Expanding the triglyceride range in clinical trials: therapeutic opportunities.","authors":"Ask T Nordestgaard, Aruna D Pradhan, Brendan M Everett, Jean G MacFadyen, Deepak L Bhatt, Frank L J Visseren, Peter Libby, Raul D Santos, Steven E Nissen, Børge G Nordestgaard, Paul M Ridker","doi":"10.1093/eurheartj/ehaf074","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf074","url":null,"abstract":"<p><strong>Background and aims: </strong>Guidelines focus on individuals with triglycerides between 2.3 and 5.6 mmol/L (200 and 499 mg/dL). The hypotheses that triglycerides across the full biological range and within this constrained range associated with cardiovascular risk were re-assessed.</p><p><strong>Methods: </strong>Multivariable-adjusted hazard ratios for major cardiovascular events and death according to baseline triglycerides among 119 573 individuals with triglycerides across the full biological range from the Copenhagen General Population Study, among 27 757 individuals with baseline triglycerides between 2.3 and 5.6 mmol/L from the Copenhagen General Population Study and the Women's Health Study cohorts, and among 31 272 individuals with mild-to-moderate hypertriglyceridaemia from the PROMINENT, REDUCE-IT, and STRENGTH trials were calculated.</p><p><strong>Results: </strong>Increasing triglycerides across the full range (0.3 to 11.2 mmol/L) were associated with an increasing risk of major cardiovascular events (N = 12 241). In the cohorts, combined hazard ratios [95% confidence interval (triglyceride range in mmol/L)] for major cardiovascular events (N = 3928) from lowest to highest triglyceride quartile were 1.0 [referent (range: < 2.5)], 0.95 [0.87-1.04 (range: 2.5 to <3.0)], 1.04 [0.95-1.13 (range: 3.0 to <3.6)], and 1.13 [1.04-1.23 (range: ≥ 3.6)]. In the three contemporary trials, the corresponding hazard ratios (N = 4265 cardiovascular events) from lowest to highest quartile were 1.0 [referent (ranges for PROMINENT/REDUCE-IT/STRENGTH: < 2.6/2.0/2.2)], 1.01 [0.93-1.10 (ranges: 2.6 to <3.1/2.0 to <2.5/2.2 to <2.7)], 1.05 [0.96-1.14 (ranges: 3.1 to <3.9/2.5 to <3.1/2.7 to < 3.5)] and 1.09 [1.00-1.19 (ranges: ≥ 3.9/3.1/3.5)]. In neither cohorts nor trials were triglycerides across this range strongly associated with risk of cardiovascular or all-cause death.</p><p><strong>Conclusions: </strong>Individuals with mild-to-moderate hypertriglyceridaemia may not express the same magnitude of cardiovascular risk as that observed across the full range of plasma triglycerides. Future triglyceride-lowering therapy trials may want to consider enrolment across a wider range of triglyceride levels if there is no prior history of pancreatitis nor excessive alcohol intake.</p>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Weekly Journal Scan: An EPIC comparison of edoxaban vs. dual antithrombotic therapy in atrial fibrillation and stable coronary artery disease. 每周杂志扫描:edo沙班与双重抗血栓治疗房颤和稳定冠状动脉疾病的EPIC比较。
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-02-14 DOI: 10.1093/eurheartj/ehae787
Giovanna Liuzzo, Carlo Patrono
{"title":"Weekly Journal Scan: An EPIC comparison of edoxaban vs. dual antithrombotic therapy in atrial fibrillation and stable coronary artery disease.","authors":"Giovanna Liuzzo, Carlo Patrono","doi":"10.1093/eurheartj/ehae787","DOIUrl":"10.1093/eurheartj/ehae787","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"669-671"},"PeriodicalIF":37.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiac sarcoidosis with multiple intracardiac masses diagnosed by rectus femoris biopsy. 通过股直肌活检诊断出伴有多个心内肿块的心脏肉样瘤病。
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-02-14 DOI: 10.1093/eurheartj/ehae840
Toshifumi Tamura, Satonori Tsuneta, Toshiyuki Nagai
{"title":"Cardiac sarcoidosis with multiple intracardiac masses diagnosed by rectus femoris biopsy.","authors":"Toshifumi Tamura, Satonori Tsuneta, Toshiyuki Nagai","doi":"10.1093/eurheartj/ehae840","DOIUrl":"10.1093/eurheartj/ehae840","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"667"},"PeriodicalIF":37.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of strategies for vascular ACCESS closure after Transcatheter Aortic Valve Implantation: the ACCESS-TAVI randomized trial. 经导管主动脉瓣植入术后血管 ACCESS 关闭策略的比较:ACCESS-TAVI 随机试验。
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-02-14 DOI: 10.1093/eurheartj/ehae784
Tobias Rheude, Hendrik Ruge, Niklas Altaner, Costanza Pellegrini, Hector Alvarez Covarrubias, Patrick Mayr, Salvatore Cassese, Sebastian Kufner, Yousuke Taniguchi, Christian Thilo, Markus Klos, Magdalena Erlebach, Simon Schneider, Martin Jurisic, Karl-Ludwig Laugwitz, Rüdiger Lange, Heribert Schunkert, Adnan Kastrati, Markus Krane, Erion Xhepa, Michael Joner
{"title":"Comparison of strategies for vascular ACCESS closure after Transcatheter Aortic Valve Implantation: the ACCESS-TAVI randomized trial.","authors":"Tobias Rheude, Hendrik Ruge, Niklas Altaner, Costanza Pellegrini, Hector Alvarez Covarrubias, Patrick Mayr, Salvatore Cassese, Sebastian Kufner, Yousuke Taniguchi, Christian Thilo, Markus Klos, Magdalena Erlebach, Simon Schneider, Martin Jurisic, Karl-Ludwig Laugwitz, Rüdiger Lange, Heribert Schunkert, Adnan Kastrati, Markus Krane, Erion Xhepa, Michael Joner","doi":"10.1093/eurheartj/ehae784","DOIUrl":"10.1093/eurheartj/ehae784","url":null,"abstract":"<p><strong>Background and aims: </strong>Data from randomized trials investigating different access closure strategies after transfemoral transcatheter aortic valve implantation (TF-TAVI) remain scarce. In this study, two vascular closure device (VCD) strategies to achieve haemostasis after TF-TAVI were compared.</p><p><strong>Methods: </strong>The ACCESS-TAVI (Comparison of Strategies for Vascular ACCESS Closure after Transcatheter Aortic Valve Implantation) is a prospective, multicentre trial in which patients undergoing TF-TAVI were randomly assigned to a strategy with a combined suture-/plug-based VCD strategy (suture/plug group) using one ProGlide™/ProStyle™ (Abbott Vascular) and one Angio-Seal® (Terumo) vs. a suture-based VCD strategy (suture-only group) using two ProGlides™/ProStyles™. The primary endpoint was a composite of major or minor access site-related vascular complications during index hospitalization according to Valve Academic Research Consortium 3 criteria. Key secondary endpoints included time to haemostasis, bleeding type ≥ 2, and all-cause mortality over 30 days.</p><p><strong>Results: </strong>Between September 2022 and April 2024, 454 patients were randomized. The primary endpoint occurred in 27% (62/230) in the suture/plug group and 54% (121/224) in the suture-only group [relative risk .55 (95% confidence interval: .44, .68); P < .001]. Time to haemostasis was significantly shorter in the suture/plug group compared with the suture-only group (108 ± 208 s vs. 206 ± 171 s; P < .001). At 30 days, bleeding type ≥ 2 occurred less often in the suture/plug group compared with the suture-only group [6.2% vs. 12.1%, relative risk .66 (.43, 1.02); P = .032], with no significant difference in mortality.</p><p><strong>Conclusions: </strong>With regard to the composite of major or minor access site-related vascular complications, a combined suture-/plug-based VCD strategy was superior to a suture-based VCD strategy for vascular access closure in patients undergoing TF-TAVI.</p>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"635-645"},"PeriodicalIF":37.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plugging the gap: vascular access closure after transfemoral transcatheter aortic valve implantation. 堵塞间隙:经股主动脉瓣置入术后血管通路关闭。
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-02-14 DOI: 10.1093/eurheartj/ehae876
Daniel T Y Ang, M Mitchell Lindsay
{"title":"Plugging the gap: vascular access closure after transfemoral transcatheter aortic valve implantation.","authors":"Daniel T Y Ang, M Mitchell Lindsay","doi":"10.1093/eurheartj/ehae876","DOIUrl":"10.1093/eurheartj/ehae876","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"646-648"},"PeriodicalIF":37.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular magnetic resonance imaging in mitral valve disease. 二尖瓣疾病的心血管磁共振成像。
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-02-14 DOI: 10.1093/eurheartj/ehae801
Pankaj Garg, Anna Giulia Pavon, Martin Penicka, Seth Uretsky
{"title":"Cardiovascular magnetic resonance imaging in mitral valve disease.","authors":"Pankaj Garg, Anna Giulia Pavon, Martin Penicka, Seth Uretsky","doi":"10.1093/eurheartj/ehae801","DOIUrl":"10.1093/eurheartj/ehae801","url":null,"abstract":"<p><p>This paper describes the role of cardiovascular magnetic resonance (CMR) imaging in assessing patients with mitral valve disease. Mitral regurgitation (MR) is one of the most prevalent valvular heart diseases. It often progresses without significant symptoms, leading to left ventricular overload, dysfunction, frequent decompensated heart failure episodes, and excess mortality. Cardiovascular magnetic resonance assessment is recommended for MR when routine ultrasound imaging information is insufficient or discordant. A well-planned CMR can provide an in-depth assessment of the mitral valve apparatus, leaflet morphology, and papillary muscles. In addition, it can precisely inform the impact of MR on left atrial and ventricular remodelling. The review aims to highlight established and emerging techniques for morphological assessment, flow assessment (including regurgitation and stenosis), myocardial assessment, and haemodynamic assessment of mitral valve disease by CMR. It also proposes a simplified clinical flow chart for CMR assessment of the mitral valve.</p>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"606-619"},"PeriodicalIF":37.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wearable device-measured moderate to vigorous physical activity and risk of degenerative aortic valve stenosis. 可穿戴设备测量的中度至剧烈运动与退行性主动脉瓣狭窄的风险。
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-02-14 DOI: 10.1093/eurheartj/ehae406
Ziang Li, Sijing Cheng, Bo Guo, Lu Ding, Yu Liang, Yinghan Shen, Jinyue Li, Yiqing Hu, Tianxin Long, Xinli Guo, Junbo Ge, Runlin Gao, Philippe Pibarot, Bin Zhang, Haiyan Xu, Marie-Annick Clavel, Yongjian Wu
{"title":"Wearable device-measured moderate to vigorous physical activity and risk of degenerative aortic valve stenosis.","authors":"Ziang Li, Sijing Cheng, Bo Guo, Lu Ding, Yu Liang, Yinghan Shen, Jinyue Li, Yiqing Hu, Tianxin Long, Xinli Guo, Junbo Ge, Runlin Gao, Philippe Pibarot, Bin Zhang, Haiyan Xu, Marie-Annick Clavel, Yongjian Wu","doi":"10.1093/eurheartj/ehae406","DOIUrl":"10.1093/eurheartj/ehae406","url":null,"abstract":"<p><strong>Background and aims: </strong>Physical activity has proven effective in preventing atherosclerotic cardiovascular disease, but its role in preventing degenerative valvular heart disease (VHD) remains uncertain. This study aimed to explore the dose-response association between moderate to vigorous physical activity (MVPA) volume and the risk of degenerative VHD among middle-aged adults.</p><p><strong>Methods: </strong>A full week of accelerometer-derived MVPA data from 87 248 UK Biobank participants (median age 63.3, female: 56.9%) between 2013 and 2015 were used for primary analysis. Questionnaire-derived MVPA data from 361 681 UK Biobank participants (median age 57.7, female: 52.7%) between 2006 and 2010 were used for secondary analysis. The primary outcome was the diagnosis of incident degenerative VHD, including aortic valve stenosis (AS), aortic valve regurgitation (AR), and mitral valve regurgitation (MR). The secondary outcome was VHD-related intervention or mortality.</p><p><strong>Results: </strong>In the accelerometer-derived MVPA cohort, 555 incident AS, 201 incident AR, and 655 incident MR occurred during a median follow-up of 8.11 years. Increased MVPA volume showed a steady decline in AS risk and subsequent AS-related intervention or mortality risk, levelling off beyond approximately 300 min/week. In contrast, its association with AR or MR incidence was less apparent. The adjusted rates of AS incidence (95% confidence interval) across MVPA quartiles (Q1-Q4) were 11.60 (10.20, 13.20), 7.82 (6.63, 9.23), 5.74 (4.67, 7.08), and 5.91 (4.73, 7.39) per 10 000 person-years. The corresponding adjusted rates of AS-related intervention or mortality were 4.37 (3.52, 5.43), 2.81 (2.13, 3.71), 1.93 (1.36, 2.75), and 2.14 (1.50, 3.06) per 10 000 person-years, respectively. Aortic valve stenosis risk reduction was also observed with questionnaire-based MVPA data [adjusted absolute difference Q4 vs. Q1: AS incidence, -1.41 (-.67, -2.14) per 10 000 person-years; AS-related intervention or mortality, -.38 (-.04, -.88) per 10 000 person-years]. The beneficial association remained consistent in high-risk populations for AS, including patients with hypertension, obesity, dyslipidaemia, and chronic kidney disease.</p><p><strong>Conclusions: </strong>Higher MVPA volume was associated with a lower risk of developing AS and subsequent AS-related intervention or mortality. Future research needs to validate these findings in diverse populations with longer durations and repeated periods of activity monitoring.</p>","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"649-664"},"PeriodicalIF":37.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How can we counsel patients desiring subsequent pregnancy after peripartum cardiomyopathy?
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-02-14 DOI: 10.1093/eurheartj/ehae888
Olayinka Agboola, Garima Sharma
{"title":"How can we counsel patients desiring subsequent pregnancy after peripartum cardiomyopathy?","authors":"Olayinka Agboola, Garima Sharma","doi":"10.1093/eurheartj/ehae888","DOIUrl":"https://doi.org/10.1093/eurheartj/ehae888","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exercise in primary, secondary and tertiary prevention of aortic stenosis. 运动在主动脉狭窄的一级、二级和三级预防中的作用。
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-02-14 DOI: 10.1093/eurheartj/ehae627
Martin Halle, Simon Wernhart, Markus Krane
{"title":"Exercise in primary, secondary and tertiary prevention of aortic stenosis.","authors":"Martin Halle, Simon Wernhart, Markus Krane","doi":"10.1093/eurheartj/ehae627","DOIUrl":"10.1093/eurheartj/ehae627","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":"665-666"},"PeriodicalIF":37.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The potential role of apolipoprotein A-1 amyloid in aortic dissection.
IF 37.6 1区 医学
European Heart Journal Pub Date : 2025-02-14 DOI: 10.1093/eurheartj/ehaf096
Hiroyuki Otsuka, Nobuhiro Tahara, Eiki Tayama
{"title":"The potential role of apolipoprotein A-1 amyloid in aortic dissection.","authors":"Hiroyuki Otsuka, Nobuhiro Tahara, Eiki Tayama","doi":"10.1093/eurheartj/ehaf096","DOIUrl":"https://doi.org/10.1093/eurheartj/ehaf096","url":null,"abstract":"","PeriodicalId":11976,"journal":{"name":"European Heart Journal","volume":" ","pages":""},"PeriodicalIF":37.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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